Frontiers in Integrative Neuroscience最新文献

{"title":"Neuropsychiatric feature-based subgrouping reveals neural sensory processing spectrum in female FMR1 premutation carriers: A pilot study.","authors":"Jordan E Norris,&nbsp;Lauren M Schmitt,&nbsp;Lisa A De Stefano,&nbsp;Ernest V Pedapati,&nbsp;Craig A Erickson,&nbsp;John A Sweeney,&nbsp;Lauren E Ethridge","doi":"10.3389/fnint.2023.898215","DOIUrl":"https://doi.org/10.3389/fnint.2023.898215","url":null,"abstract":"<p><strong>Introduction: </strong>Fragile X Syndrome (FXS) is rare genetic condition characterized by a repeat expansion (CGG) in the Fragile X messenger ribonucleoprotein 1 (FMR1) gene where individuals with greater than 200 repeats are defined as full mutation. FXS clinical presentation often includes intellectual disability, and autism-like symptoms, including anxiety and sensory hypersensitivities. Individuals with 55 to <200 CGG repeats are said to have the FMR1 premutation, which is not associated with primary characteristics of the full mutation, but with an increased risk for anxiety, depression, and other affective conditions, as well as and impaired cognitive processing differences that vary in severity. Defining subgroups of premutation carriers based on distinct biological features may identify subgroups with varying levels of psychiatric, cognitive, and behavioral alterations.</p><p><strong>Methods: </strong>The current pilot study utilized 3 cluster subgroupings defined by previous k means cluster analysis on neuropsychiatric, cognitive, and resting EEG variables in order to examine basic sensory auditory chirp task-based EEG parameters from 33 females with the FMR1 premutation (ages 17-78).</p><p><strong>Results: </strong>Based on the predefined, neuropsychiatric three-cluster solution, premutation carriers with increased neuropsychiatric features and higher CGG repeat counts (cluster 1) showed decreased stimulus onset response, similar to previous ERP findings across a number of psychiatric disorders but opposite to findings in individuals with full mutation FXS. Premutation carriers with increased executive dysfunction and resting gamma power (cluster 2) exhibited decreased gamma phase locking to a chirp stimulus, similar to individuals with full mutation FXS. Cluster 3 members, who were relatively unaffected by psychiatric or cognitive symptoms, showed the most normative task-based EEG metrics.</p><p><strong>Discussion: </strong>Our findings suggest a spectrum of sensory processing characteristics present in subgroups of premutation carriers that have been previously understudied due to lack of overall group differences. Our findings also further validate the pre-defined clinical subgroups by supporting links between disturbances in well-defined neural pathways and behavioral alterations that may be informative for identifying the mechanisms supporting specific risk factors and divergent therapeutic needs in individuals with the FMR1 premutation.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"898215"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10766165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.","authors":"Isabelle F Witteveen,&nbsp;Emily McCoy,&nbsp;Troy D Holsworth,&nbsp;Catherine Z Shen,&nbsp;Winnie Chang,&nbsp;Madelyn G Nance,&nbsp;Allison R Belkowitz,&nbsp;Avery Dougald,&nbsp;Meghan H Puglia,&nbsp;Adema Ribic","doi":"10.3389/fnint.2023.1149159","DOIUrl":"https://doi.org/10.3389/fnint.2023.1149159","url":null,"abstract":"<p><p>Prematurity is among the leading risks for poor neurocognitive outcomes. The brains of preterm infants show alterations in structure and electrical activity, but the underlying circuit mechanisms are unclear. To address this, we performed a cross-species study of the electrophysiological activity in the visual cortices of prematurely born infants and mice. Using electroencephalography (EEG) in a sample of healthy preterm (<i>N</i> = 29) and term (<i>N</i> = 28) infants, we found that the maturation of the aperiodic EEG component was accelerated in the preterm cohort, with a significantly flatter 1/f slope when compared to the term infants. The flatter slope was a result of decreased spectral power in the theta and alpha bands and was correlated with the degree of prematurity. To determine the circuit and cellular changes that potentially mediate the changes in 1/f slope after preterm birth, we used <i>in vivo</i> electrophysiology in preterm mice and found that, similar to infants, preterm birth results in a flattened 1/f slope. We analyzed neuronal activity in the visual cortex of preterm (<i>N</i> = 6) and term (<i>N</i> = 9) mice and found suppressed spontaneous firing of neurons. Using immunohistochemistry, we further found an accelerated maturation of inhibitory circuits. In both preterm mice and infants, the functional maturation of the cortex was accelerated, underscoring birth as a critical checkpoint in cortical maturation. Our study points to a potential mechanism of preterm birth-related changes in resting neural activity, highlighting the utility of a cross-species approach in studying the neural circuit mechanisms of preterm birth-related neurodevelopmental conditions.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1149159"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9741771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: High levels of <i>Bifidobacteriaceae</i> are associated with the pathogenesis of Parkinson's disease.","authors":"ShuJia Zuo,&nbsp;HaiJing Wang,&nbsp;Qiang Zhao,&nbsp;Jie Tang,&nbsp;Min Wang,&nbsp;Yu Zhang,&nbsp;Ming Sang,&nbsp;Jing Tian,&nbsp;Puqing Wang","doi":"10.3389/fnint.2023.1229949","DOIUrl":"https://doi.org/10.3389/fnint.2023.1229949","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnint.2022.1054627.].</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1229949"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9921040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of integrative neuroscience: The big questions.","authors":"Catalin V Buhusi,&nbsp;Sorinel A Oprisan,&nbsp;Mona Buhusi","doi":"10.3389/fnint.2023.1113238","DOIUrl":"https://doi.org/10.3389/fnint.2023.1113238","url":null,"abstract":"COPYRIGHT © 2023 Buhusi, Oprisan and Buhusi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The future of integrative neuroscience: The big questions","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1113238"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9155206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain in motion-cognitive effects of simultaneous motor activity.","authors":"Maren Schmidt-Kassow,&nbsp;Jochen Kaiser","doi":"10.3389/fnint.2023.1127310","DOIUrl":"https://doi.org/10.3389/fnint.2023.1127310","url":null,"abstract":"<p><p>During the last 30 years, a large number of behavioral studies have investigated the effect of simultaneous exercise on cognitive functions. The heterogeneity of the results has been attributed to different parameters, such as intensity or modality of physical activity, and the investigated cognitive processes. More recent methodological improvements have enabled to record electroencephalography (EEG) during physical exercise. EEG studies combining cognitive tasks with exercise have described predominantly detrimental effects on cognitive processes and EEG parameters. However, differences in the underlying rationale and the design of EEG versus behavioral studies make direct comparisons between both types of studies difficult. In this narrative review of dual-task experiments we evaluated behavioral and EEG studies and discuss possible explanations for the heterogeneity of results and for the discrepancy between behavioral and EEG studies. Furthermore, we provide a proposal for future EEG studies on simultaneous motion to be a useful complement to behavioral studies. A crucial factor might be to find for each cognitive function the motor activity that matches this function in terms of attentional focus. This hypothesis should be investigated systematically in future studies.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1127310"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular prosthesis: from basic research to clinics.","authors":"Enrique Soto,&nbsp;Adriana Pliego,&nbsp;Rosario Vega","doi":"10.3389/fnint.2023.1161860","DOIUrl":"https://doi.org/10.3389/fnint.2023.1161860","url":null,"abstract":"<p><p>Balance disorders are highly prevalent worldwide, causing substantial disability with high personal and socioeconomic impact. The prognosis in many of these patients is poor, and rehabilitation programs provide little help in many cases. This medical problem can be addressed using microelectronics by combining the highly successful cochlear implant experience to produce a vestibular prosthesis, using the technical advances in micro gyroscopes and micro accelerometers, which are the electronic equivalents of the semicircular canals (SCC) and the otolithic organs. Reaching this technological milestone fostered the possibility of using these electronic devices to substitute the vestibular function, mainly for visual stability and posture, in case of damage to the vestibular endorgans. The development of implantable and non-implantable devices showed diverse outcomes when considering the integrity of the vestibular pathways, the device parameters (current intensity, impedance, and waveform), and the targeted physiological function (balance and gaze). In this review, we will examine the development and testing of various prototypes of the vestibular implant (VI). The insight raised by examining the state-of-the-art vestibular prosthesis will facilitate the development of new device-development strategies and discuss the feasibility of complex combinations of implantable devices for disorders that directly affect balance and motor performance.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1161860"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9923194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The time is ripe for the renaissance of autism treatments: evidence from clinical practitioners.","authors":"Elizabeth B Torres,&nbsp;Goldie Twerski,&nbsp;Hannah Varkey,&nbsp;Richa Rai,&nbsp;Mona Elsayed,&nbsp;Miriam Tirtza Katz,&nbsp;Jillian Tarlowe","doi":"10.3389/fnint.2023.1229110","DOIUrl":"https://doi.org/10.3389/fnint.2023.1229110","url":null,"abstract":"<p><strong>Introduction: </strong>Recent changes in diagnostics criteria have contributed to the broadening of the autism spectrum disorders and left clinicians ill-equipped to treat the highly heterogeneous spectrum that now includes toddlers and children with sensory and motor issues.</p><p><strong>Methods: </strong>To uncover the clinicians' critical needs in the autism space, we conducted surveys designed collaboratively with the clinicians themselves. Board Certified Behavioral Analysts (BCBAs) and developmental model (DM) clinicians obtained permission from their accrediting boards and designed surveys to assess needs and preferences in their corresponding fields.</p><p><strong>Results: </strong>92.6% of BCBAs are open to diversified treatment combining aspects of multiple disciplines; 82.7% of DMs also favor this diversification with 21.8% valuing BCBA-input and 40.6% neurologists-input; 85.9% of BCBAs and 85.3% of DMs advocate the use of wearables to objectively track nuanced behaviors in social exchange; 76.9% of BCBAs and 57.0% DMs feel they would benefit from augmenting their knowledge about the nervous systems of Autism (neuroscience research) to enhance treatment and planning programs; 50.0% of BCBAs feel they can benefit for more training to teach parents.</p><p><strong>Discussion: </strong>Two complementary philosophies are converging to a more collaborative, integrative approach favoring scalable digital technologies and neuroscience. Autism practitioners seem ready to embrace the Digital-Neuroscience Revolutions under a new cooperative model.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1229110"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal phase slip patterns for visual evoked potentials, covert object naming tasks, and insight moments extracted from 256 channel EEG recordings.","authors":"Ceon Ramon,&nbsp;Uwe Graichen,&nbsp;Paolo Gargiulo,&nbsp;Frank Zanow,&nbsp;Thomas R Knösche,&nbsp;Jens Haueisen","doi":"10.3389/fnint.2023.1087976","DOIUrl":"https://doi.org/10.3389/fnint.2023.1087976","url":null,"abstract":"<p><p>Phase slips arise from state transitions of the coordinated activity of cortical neurons which can be extracted from the EEG data. The phase slip rates (PSRs) were studied from the high-density (256 channel) EEG data, sampled at 16.384 kHz, of five adult subjects during covert visual object naming tasks. Artifact-free data from 29 trials were averaged for each subject. The analysis was performed to look for phase slips in the theta (4-7 Hz), alpha (7-12 Hz), beta (12-30 Hz), and low gamma (30-49 Hz) bands. The phase was calculated with the Hilbert transform, then unwrapped and detrended to look for phase slip rates in a 1.0 ms wide stepping window with a step size of 0.06 ms. The spatiotemporal plots of the PSRs were made by using a montage layout of 256 equidistant electrode positions. The spatiotemporal profiles of EEG and PSRs during the stimulus and the first second of the post-stimulus period were examined in detail to study the visual evoked potentials and different stages of visual object recognition in the visual, language, and memory areas. It was found that the activity areas of PSRs were different as compared with EEG activity areas during the stimulus and post-stimulus periods. Different stages of the insight moments during the covert object naming tasks were examined from PSRs and it was found to be about 512 ± 21 ms for the 'Eureka' moment. Overall, these results indicate that information about the cortical phase transitions can be derived from the measured EEG data and can be used in a complementary fashion to study the cognitive behavior of the brain.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1087976"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remembrance of things perceived: Adding thalamocortical function to artificial neural networks.","authors":"Gerald E Loeb","doi":"10.3389/fnint.2023.1108271","DOIUrl":"https://doi.org/10.3389/fnint.2023.1108271","url":null,"abstract":"<p><p>Recent research has illuminated the complexity and importance of the thalamocortical system but it has been difficult to identify what computational functions it performs. Meanwhile, deep-learning artificial neural networks (ANNs) based on bio-inspired models of purely cortical circuits have achieved surprising success solving sophisticated cognitive problems associated historically with human intelligence. Nevertheless, the limitations and shortcomings of artificial intelligence (AI) based on such ANNs are becoming increasingly clear. This review considers how the addition of thalamocortical connectivity and its putative functions related to cortical attention might address some of those shortcomings. Such bio-inspired models are now providing both testable theories of biological cognition and improved AI technology, much of which is happening outside the usual academic venues.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1108271"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9180379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead.","authors":"Prangya Parimita Sahu,&nbsp;Philip Tseng","doi":"10.3389/fnint.2023.1146687","DOIUrl":"https://doi.org/10.3389/fnint.2023.1146687","url":null,"abstract":"<p><p>Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has been associated with cognitive declines in neurological diseases, such as memory dysfunction in Alzheimer's disease (AD). Recently, studies have attempted to artificially induce gamma oscillations by using 40 Hz sensory entrainment stimulation. These studies reported attenuation of amyloid load, hyper-phosphorylation of tau protein, and improvement in overall cognition in both AD patients and mouse models. In this review, we discuss the advancements in the use of sensory stimulation in animal models of AD and as a therapeutic strategy in AD patients. We also discuss future opportunities, as well as challenges, for using such strategies in other neurodegenerative and neuropsychiatric diseases.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1146687"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9779275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}