Frontiers in Integrative Neuroscience最新文献

{"title":"Editorial: Reproducibility in neuroscience.","authors":"Nafisa M Jadavji, Nele A Haelterman, Reeteka Sud, Alberto Antonietti","doi":"10.3389/fnint.2023.1271818","DOIUrl":"https://doi.org/10.3389/fnint.2023.1271818","url":null,"abstract":"COPYRIGHT © 2023 Jadavji, Haelterman, Sud and Antonietti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Reproducibility in neuroscience","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1271818"},"PeriodicalIF":3.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Touch may reduce cognitive load during assisted typing by individuals with developmental disabilities.","authors":"Giovanni Nicoli, Giulia Pavon, Andrew Grayson, Anne Emerson, Suvobrata Mitra","doi":"10.3389/fnint.2023.1181025","DOIUrl":"10.3389/fnint.2023.1181025","url":null,"abstract":"<p><p>Many techniques have attempted to provide physical support to ease the execution of a typing task by individuals with developmental disabilities (DD). These techniques have been controversial due to concerns that the support provider's touch can influence the typed content. The most common interpretation of assisted typing as an ideomotor phenomenon has been qualified recently by studies showing that users with DD make identifiable contributions to the process. This paper suggests a neurophysiological pathway by which touch could lower the cognitive load of seated typing by people with DD. The required sensorimotor processes (stabilizing posture and planning and executing manual reaching movements) and cognitive operations (generating and transcribing linguistic material) place concurrent demands on cognitive resources, particularly executive function (EF). A range of developmental disabilities are characterized by deficits in sensorimotor and EF capacity. As light touch has been shown to facilitate postural coordination, it is proposed that a facilitator's touch could assist the seated typist with sensorimotor and EF deficits by reducing their sensorimotor workload and thereby freeing up shared cognitive resources for the linguistic elements of the task. This is the first theoretical framework for understanding how a facilitator's touch may assist individuals with DD to contribute linguistic content during touch-assisted typing.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1181025"},"PeriodicalIF":2.6,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextualizing the impact of prenatal alcohol and tobacco exposure on neurodevelopment in a South African birth cohort: an analysis from the socioecological perspective.","authors":"Yingjing Xia,&nbsp;Vida Rebello,&nbsp;Stefanie C Bodison,&nbsp;Deborah Jonker,&nbsp;Babette Steigelmann,&nbsp;Kirsten A Donald,&nbsp;Weslin Charles,&nbsp;Dan J Stein,&nbsp;Jonathan Ipser,&nbsp;Hedyeh Ahmadi,&nbsp;Eric Kan,&nbsp;Elizabeth R Sowell,&nbsp;Katherine L Narr,&nbsp;Shantanu H Joshi,&nbsp;Hein J Odendaal,&nbsp;Kristina A Uban","doi":"10.3389/fnint.2023.1104788","DOIUrl":"10.3389/fnint.2023.1104788","url":null,"abstract":"<p><strong>Background: </strong>Alcohol and tobacco are known teratogens. Historically, more severe prenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) have been examined as the principal predictor of neurodevelopmental alterations, with little incorporation of lower doses or ecological contextual factors that can also impact neurodevelopment, such as socioeconomic resources (SER) or adverse childhood experiences (ACEs). Here, a novel analytical approach informed by a socio-ecological perspective was used to examine the associations between SER, PAE and/or PTE, and ACEs, and their effects on neurodevelopment.</p><p><strong>Methods: </strong><i>N</i> = 313 mother-child dyads were recruited from a prospective birth cohort with maternal report of PAE and PTE, and cross-sectional structural brain neuroimaging of child acquired via 3T scanner at ages 8-11 years. <i>In utero</i> SER was measured by maternal education, household income, and home utility availability. The child's ACEs were measured by self-report assisted by the researcher. PAE was grouped into early exposure (<12 weeks), continued exposure (>=12 weeks), and no exposure controls. PTE was grouped into exposed and non-exposed controls.</p><p><strong>Results: </strong>Greater access to SER during pregnancy was associated with fewer ACEs (maternal education: β = -0.293,<i>p</i> = 0.01; phone access: β = -0.968,<i>p</i> = 0.05). PTE partially mediated the association between SER and ACEs, where greater SER reduced the likelihood of PTE, which was positively associated with ACEs (β = 1.110,<i>p</i> = 0.01). SER was associated with alterations in superior frontal (β = -1336.036, <i>q</i> = 0.046), lateral orbitofrontal (β = -513.865, <i>q</i> = 0.046), caudal anterior cingulate volumes (β = -222.982, <i>q</i> = 0.046), with access to phone negatively associated with all three brain volumes. Access to water was positively associated with superior frontal volume (β=1569.527, <i>q</i> = 0.013). PTE was associated with smaller volumes of lateral orbitofrontal (β = -331.000, <i>q</i> = 0.033) and nucleus accumbens regions (β = -34.800, <i>q</i> = 0.033).</p><p><strong>Conclusion: </strong>Research on neurodevelopment following community-levels of PAE and PTE should more regularly consider the ecological context to accelerate understanding of teratogenic outcomes. Further research is needed to replicate this novel conceptual approach with varying PAE and PTE patterns, to disentangle the interplay between dose, community-level and individual-level risk factors on neurodevelopment.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1104788"},"PeriodicalIF":3.5,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9934286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance beam crossing times are slower after noise exposure in rats.","authors":"Dylan Bartikofsky, Mikayla Jade Hertz, David S Bauer, Richard Altschuler, W Michael King, Courtney Elaine Stewart","doi":"10.3389/fnint.2023.1196477","DOIUrl":"10.3389/fnint.2023.1196477","url":null,"abstract":"<p><strong>Introduction: </strong>The vestibular system integrates signals related to vision, head position, gravity, motion, and body position to provide stability during motion through the environment. Disruption in any of these systems can reduce agility and lead to changes in ability to safely navigate one's environment. Causes of vestibular decline are diverse; however, excessive noise exposure can lead to otolith organ dysfunction. Specifically, 120 decibel (dB) sound pressure level (SPL) 1.5 kHz-centered 3-octave band noise (1.5 kHz 3OBN) causes peripheral vestibular dysfunction in rats, measured by vestibular short-latency evoked potential (VsEP) and reduced calretinin-immunolabeling of calyx-only afferent terminals in the striolar region of the saccule. The present study examined the functional impact of this noise exposure condition, examining changes in motor performance after noise exposure with a balance beam crossing task.</p><p><strong>Methods: </strong>Balance beam crossing time in rats was assessed for 19 weeks before and 5 weeks after noise exposure. Balance beam crossings were scored to assess proficiency in the task. When animals were proficient, they received a single exposure to 120 dB SPL 3-octave band noise.</p><p><strong>Results: </strong>During the initial training phase slower crossing times and higher scores, including multiple failures were observed. This was followed by a period of significant improvement leading to proficiency, characterized by fast and stable crossing times and consistently low scores. After noise exposure, crossing times were significantly elevated from baseline for 4-weeks. A total of 5 weeks after noise exposure, crossing times improved, and though still trending higher than baseline, they were no longer significantly different from baseline.</p><p><strong>Discussion: </strong>These findings show that the noise-induced peripheral vestibular changes we previously observed at cellular and electro-physiological levels also have an impact at a functional level. It has been previously shown that imbalance is associated with slower walking speed in older adults and aged rats. These findings in noise-exposed rats may have implications for people who experience noisy environments and for seniors with a history of noise exposure who also experience balance disorders and may be at increased fall risk.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1196477"},"PeriodicalIF":3.5,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visuo-spatial imagery in dreams of congenitally and early blind: a systematic review.","authors":"Katarina Ilic,&nbsp;Rita Bertani,&nbsp;Neda Lapteva,&nbsp;Panagis Drakatos,&nbsp;Alessio Delogu,&nbsp;Kausar Raheel,&nbsp;Matthew Soteriou,&nbsp;Carlotta Mutti,&nbsp;Joerg Steier,&nbsp;David W Carmichael,&nbsp;Peter J Goadsby,&nbsp;Adam Ockelford,&nbsp;Ivana Rosenzweig","doi":"10.3389/fnint.2023.1204129","DOIUrl":"10.3389/fnint.2023.1204129","url":null,"abstract":"<p><strong>Background: </strong>The presence of visual imagery in dreams of congenitally blind people has long been a matter of substantial controversy. We set to systematically review body of published work on the presence and nature of oneiric visuo-spatial impressions in congenitally and early blind subjects across different areas of research, from experimental psychology, functional neuroimaging, sensory substitution, and sleep research.</p><p><strong>Methods: </strong>Relevant studies were identified using the following databases: EMBASE, MEDLINE and PsychINFO.</p><p><strong>Results: </strong>Studies using diverse imaging techniques and sensory substitution devices broadly suggest that the \"blind\" occipital cortex may be able to integrate non-visual sensory inputs, and thus possibly also generate visuo-spatial impressions. Visual impressions have also been reported by blind subjects who had near-death or out-of-body experiences.</p><p><strong>Conclusion: </strong>Deciphering the mechanistic nature of these visual impression could open new possibility in utilization of neuroplasticity and its potential role for treatment of neurodisability.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1204129"},"PeriodicalIF":3.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward reproducible models of sequence learning: replication and analysis of a modular spiking network with reward-based learning.","authors":"Barna Zajzon, Renato Duarte, Abigail Morrison","doi":"10.3389/fnint.2023.935177","DOIUrl":"10.3389/fnint.2023.935177","url":null,"abstract":"<p><p>To acquire statistical regularities from the world, the brain must reliably process, and learn from, spatio-temporally structured information. Although an increasing number of computational models have attempted to explain how such sequence learning may be implemented in the neural hardware, many remain limited in functionality or lack biophysical plausibility. If we are to harvest the knowledge within these models and arrive at a deeper mechanistic understanding of sequential processing in cortical circuits, it is critical that the models and their findings are accessible, reproducible, and quantitatively comparable. Here we illustrate the importance of these aspects by providing a thorough investigation of a recently proposed sequence learning model. We re-implement the modular columnar architecture and reward-based learning rule in the open-source NEST simulator, and successfully replicate the main findings of the original study. Building on these, we perform an in-depth analysis of the model's robustness to parameter settings and underlying assumptions, highlighting its strengths and weaknesses. We demonstrate a limitation of the model consisting in the hard-wiring of the sequence order in the connectivity patterns, and suggest possible solutions. Finally, we show that the core functionality of the model is retained under more biologically-plausible constraints.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"935177"},"PeriodicalIF":2.6,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No evidence for differential saccadic adaptation in children and adults with an Autism Spectrum diagnosis.","authors":"K. Tarrit, E. Freedman, A. Francisco, D. J. Horsthuis, S. Molholm, John J. Foxe","doi":"10.1101/2023.05.31.23290682","DOIUrl":"https://doi.org/10.1101/2023.05.31.23290682","url":null,"abstract":"Background: Differential eye-movements during scene exploration, and gaze preferences in social settings, have long been noted as features of the Autism phenotype. While these are typically attributed to differences in social engagement and interests (e.g., preferences for inanimate objects over face stimuli), there are also reports of differential saccade measures to non-social stimuli, raising the possibility that fundamental differences in visuo-sensorimotor processing may be at play. Here, we tested the plasticity of the eye-movement system using a classic saccade-adaptation paradigm to assess whether individuals with ASD make typical adjustments to their eye-movements in response to experimentally introduced errors. Saccade adaptation can be measured in infants as young as 10 months, raising the possibility that such measures could be useful as early neuromarkers of ASD risk. Methods: Saccade amplitudes were measured while children and adults with ASD (N=41) and age-matched typically developing (TD) individuals (N=68) made rapid eye-movements to peripherally presented (20-degrees) targets. During adaptation trials, the target was relocated to 15-degrees from fixation once a saccade to the original target location was initiated, a manipulation that leads to systematic reduction in saccade amplitudes in typical observers. Results: Neither children nor adults with ASD showed any differences relative to TD peers in their abilities to appropriately adapt saccades in the face of persistently introduced errors. Conclusions: Of the three studies to date of saccade adaptation in ASD, none have shown frank deficits in saccade adaptation. Unlike prior studies, we found no evidence for a slower adaptation rate during the early adaptation phase, and no evidence greater variance of saccade amplitudes in ASD. In post-hoc analysis, there was evidence for larger primary saccades to non-adapted targets, a finding requiring replication in future work.","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"1 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43267276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain is not mental! coupling neuronal and immune cellular processing in human organisms.","authors":"Anna Ciaunica, Evgeniya V Shmeleva, Michael Levin","doi":"10.3389/fnint.2023.1057622","DOIUrl":"10.3389/fnint.2023.1057622","url":null,"abstract":"<p><p>Significant efforts have been made in the past decades to understand how mental and cognitive processes are underpinned by neural mechanisms in the brain. This paper argues that a promising way forward in understanding the nature of human cognition is to zoom out from the prevailing picture focusing on its neural basis. It considers instead how neurons work in tandem with other type of cells (e.g., immune) to subserve biological self-organization and adaptive behavior of the human organism as a whole. We focus specifically on the immune cellular processing as key actor in complementing neuronal processing in achieving successful self-organization and adaptation of the human body in an ever-changing environment. We overview theoretical work and empirical evidence on \"basal cognition\" challenging the idea that only the neuronal cells in the brain have the exclusive ability to \"learn\" or \"cognize.\" The focus on cellular rather than neural, brain processing underscores the idea that flexible responses to fluctuations in the environment require a carefully crafted orchestration of multiple cellular and bodily systems at multiple organizational levels of the biological organism. Hence cognition can be seen as a multiscale web of dynamic information processing distributed across a vast array of complex cellular (e.g., neuronal, immune, and others) and network systems, operating across the entire body, and not just in the brain. Ultimately, this paper builds up toward the radical claim that cognition should not be confined to one system alone, namely, the neural system in the brain, no matter how sophisticated the latter notoriously is.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1057622"},"PeriodicalIF":2.6,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9939987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging event-related potentials with behavioral studies in motor learning.","authors":"Xueqian Deng, Chen Yang, Jingyue Xu, Mengzhan Liufu, Zina Li, Juan Chen","doi":"10.3389/fnint.2023.1161918","DOIUrl":"10.3389/fnint.2023.1161918","url":null,"abstract":"<p><p>Behavioral approaches and electrophysiology in understanding human sensorimotor systems have both yielded substantial advancements in past decades. In fact, behavioral neuroscientists have found that motor learning involves the two distinct processes of the implicit and the explicit. Separately, they have also distinguished two kinds of errors that drive motor learning: sensory prediction error and task error. Scientists in electrophysiology, in addition, have discovered two motor-related, event-related potentials (ERPs): error-related negativity (ERN), and feedback-related negativity (FRN). However, there has been a lack of interchange between the two lines of research. This article, therefore, will survey through the literature in both directions, attempting to establish a bridge between these two fruitful lines of research.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1161918"},"PeriodicalIF":2.6,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call to leverage a health equity lens to accelerate human neuroscience research.","authors":"Vida Rebello, Kristina A Uban","doi":"10.3389/fnint.2023.1035597","DOIUrl":"10.3389/fnint.2023.1035597","url":null,"abstract":"<p><p>Investigation of health inequities tend to be examined, in human neurosciences, as biological factors at the level of the individual. In actuality, health inequities arise, due largely in part, to deep-seated structural factors. Structural inequality refers to the systemic disadvantage of one social group compared to others with whom they coexist. The term encompasses policy, law, governance, and culture and relates to race, ethnicity, gender or gender identity, class, sexual orientation, and other domains. These structural inequalities include but are not limited to social segregation, the intergenerational effects of colonialism and the consequent distribution of power and privilege. Principles to address inequities influenced by structural factors are increasingly prevalent in a subfield of the neurosciences, i.e., cultural neurosciences. Cultural neuroscience articulates the bidirectional relationship between biology and environmental contextual factors surrounding research participants. However, the operationalization of these principles may not have the intended spillover effect on the majority of human neurosciences: this limitation is the overarching focus of the present piece. Here, we provide our perspective that these principles are missing and very much needed in all human neuroscience subdisciplines to accelerate our understanding of the human brain. Furthermore, we provide an outline of two key tenets of a health equity lens necessary for achieving research equity in human neurosciences: the social determinants of health (SDoH) framework and how to deal with confounders using counterfactual thinking. We argue that these tenets should be prioritized across future human neuroscience research more generally, and doing so is a pathway to further gain an understanding of contextual background intertwined with the human brain, thus improving the rigor and inclusivity of human neuroscience research.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1035597"},"PeriodicalIF":3.5,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9410330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}