Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols.

IF 2.6 3区医学 Q2 BEHAVIORAL SCIENCES

Frontiers in Integrative Neuroscience Pub Date : 2023-09-14 eCollection Date: 2023-01-01 DOI:10.3389/fnint.2023.1271005

Cristina Carresi, Antonio Cardamone, Anna Rita Coppoletta, Annachiara Mollace, Vincenzo Musolino, Micaela Gliozzi, Vincenzo Mollace

引用次数: 0

Abstract

Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases is of recent investigation, leaving many unanswered questions regarding the origin and consequences of the metabolic damage caused in grey and white matter during hypertension. Here we provide evidence for the influence of hypertension on NAA and Cho ratios in hypertensive rat thalamus and how the use of natural occurring compounds ameliorates the balance of thalamic metabolites.

Abstract Image

查看原文本刊更多论文

高血压实验模型中丘脑代谢产物的失衡：佛手柑多酚的作用。

脑代谢产物与脑组织中不同的生理和病理过程有关。其中，丘脑区域的N-乙酰天冬氨酸（NAA）和含胆碱化合物（Cho）的浓度被认为是脑损伤的重要预测标志物，并进行了分析。高血压、大脑代谢产物水平的调节和大脑疾病之间的关系是最近的研究，关于高血压期间灰质和白质代谢损伤的起源和后果，留下了许多未回答的问题。在这里，我们为高血压对高血压大鼠丘脑NAA和Cho比率的影响以及使用天然化合物如何改善丘脑代谢产物的平衡提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience

CiteScore

4.60

自引率

2.90%

发文量

148

审稿时长

14 weeks

期刊介绍： Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.