Organic Process Research & Development最新文献_第8页

Leveraging Supercritical Fluid Chromatography for Monitoring the Formation of Methanol Adducts of AR-LDD Antagonist BMS-986409 in Spray-Dried Dispersion Materials 利用超临界液相色谱法监测AR-LDD拮抗剂BMS-986409在喷雾干燥分散材料中甲醇加合物的形成

IF 3.4 3区化学

Organic Process Research & Development Pub Date : 2025-01-17 DOI: 10.1021/acs.oprd.4c00448

Brian Lingfeng He, Xuejun Xu, Leon Liang

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引用次数: 0

Synergizing Process Conditions, Water Sensitivity, and Kinetic Mechanisms to Optimize Sodium Salicylate Yield in Sodium Phenol Carboxylation

IF 3.1 3区化学

Organic Process Research & Development Pub Date : 2025-01-17 DOI: 10.1021/acs.oprd.4c0038310.1021/acs.oprd.4c00383

Haodong Zhang, Junmei Zhang, Jingjing Ma, Maoqian Wu, Linbo Hu, Hongfu Chen and Zhenya Duan*,

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引用次数: 0

Synergizing Process Conditions, Water Sensitivity, and Kinetic Mechanisms to Optimize Sodium Salicylate Yield in Sodium Phenol Carboxylation 苯酚钠羧化水杨酸钠收率优化的协同工艺条件、水敏感性及动力学机制

IF 3.4 3区化学

Organic Process Research & Development Pub Date : 2025-01-17 DOI: 10.1021/acs.oprd.4c00383

Haodong Zhang, Junmei Zhang, Jingjing Ma, Maoqian Wu, Linbo Hu, Hongfu Chen, Zhenya Duan

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引用次数: 0

Leveraging Supercritical Fluid Chromatography for Monitoring the Formation of Methanol Adducts of AR-LDD Antagonist BMS-986409 in Spray-Dried Dispersion Materials

IF 3.1 3区化学

Organic Process Research & Development Pub Date : 2025-01-17 DOI: 10.1021/acs.oprd.4c0044810.1021/acs.oprd.4c00448

Brian Lingfeng He*, Xuejun Xu* and Leon Liang,

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引用次数: 0

OPR&D: An Exceptional Legacy and Exciting Opportunities for the Future of Process Chemistry OPR&D：过程化学未来的杰出遗产和激动人心的机遇

IF 3.4 3区化学

Organic Process Research & Development Pub Date : 2025-01-17 DOI: 10.1021/acs.oprd.4c00537

Margaret M. Faul

引用次数: 0

OPR&D: An Exceptional Legacy and Exciting Opportunities for the Future of Process Chemistry

IF 3.1 3区化学

Organic Process Research & Development Pub Date : 2025-01-17 DOI: 10.1021/acs.oprd.4c0053710.1021/acs.oprd.4c00537

Margaret M. Faul*,

引用次数: 0

Development of the Crystallization Process for Rivaroxaban–Oxalic Acid Cocrystal Preparation Using a Combination of Phase Diagrams and In Situ Measurements 用相图和原位测量相结合的方法研究利伐沙班-草酸共晶制备的结晶工艺

IF 3.4 3区化学

Organic Process Research & Development Pub Date : 2025-01-15 DOI: 10.1021/acs.oprd.4c00509

Erika Hriňová, Igor Čerňa, Eliška Zmeškalová, Luděk Ridvan, Miroslav Šoóš

{"title":"Development of the Crystallization Process for Rivaroxaban–Oxalic Acid Cocrystal Preparation Using a Combination of Phase Diagrams and In Situ Measurements","authors":"Erika Hriňová, Igor Čerňa, Eliška Zmeškalová, Luděk Ridvan, Miroslav Šoóš","doi":"10.1021/acs.oprd.4c00509","DOIUrl":"https://doi.org/10.1021/acs.oprd.4c00509","url":null,"abstract":"This study presents the development of the crystallization process for the rivaroxaban–oxalic acid cocrystal. The solvent screening was conducted by means of the crystallization of the cocrystal from a saturated solution of acetone, ethanol, isopropanol, acetonitrile, ethyl acetate, and ethyl formate. Two selected solvents, namely, ethyl formate and acetone, were subjected to ternary phase diagram construction in order to ascertain the system equilibrium and identify the boundaries for pure cocrystal crystallization. The crystallization process was subsequently examined through the utilization of an in situ Raman spectroscopy probe. It was observed that the rate of transformation decreased at higher temperatures, which is most probably due to lower saturation in terms of the cocrystal. The reaction mechanism was observed by an in situ imaging probe, showing that new crystals were growing directly from the solution instead of growing from the surface of existing crystals. These findings were employed in the development of a crystallization process for both solvents, resulting in enhanced time and cost efficiency. A notable difference in particle size was observed between solvents, with acetone producing larger crystals. Consequently, ethyl formate was selected as the optimal solvent for further scale-up of the process, given its favorable impact on dissolution enhancement.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"30 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of the Crystallization Process for Rivaroxaban–Oxalic Acid Cocrystal Preparation Using a Combination of Phase Diagrams and In Situ Measurements

IF 3.1 3区化学

Organic Process Research & Development Pub Date : 2025-01-15 DOI: 10.1021/acs.oprd.4c0050910.1021/acs.oprd.4c00509

Erika Hriňová*, Igor Čerňa, Eliška Zmeškalová, Luděk Ridvan and Miroslav Šoóš*,

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引用次数: 0

Correction to “Development of an Optimized Process for 2,4-Dichloro-5-fluoroacetophenone: A Key Intermediate of Ciprofloxacin” 对“环丙沙星关键中间体2,4-二氯-5-氟苯乙酮优化工艺的开发”的更正

IF 3.4 3区化学

Organic Process Research & Development Pub Date : 2025-01-15 DOI: 10.1021/acs.oprd.4c00545

Kai Yin, Youlan He, Hao Wu, Xubin He

引用次数: 0

Correction to “Development of an Optimized Process for 2,4-Dichloro-5-fluoroacetophenone: A Key Intermediate of Ciprofloxacin”

IF 3.1 3区化学

Organic Process Research & Development Pub Date : 2025-01-15 DOI: 10.1021/acs.oprd.4c0054510.1021/acs.oprd.4c00545

Kai Yin*, Youlan He, Hao Wu and Xubin He,

引用次数: 0