发布求助
文献互助 智能选刊 最新文献

Organic Process Research & Development最新文献

筛选
英文 中文
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions
IF 3.4 3区 化学
Organic Process Research & Development Pub Date : 2025-03-06 DOI: 10.1021/acs.oprd.4c00489
Viktor Klöpfer, Leonie Roithmeier, Manuel Kobras, Peter Kreitmeier, Oliver Reiser
{"title":"Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions","authors":"Viktor Klöpfer, Leonie Roithmeier, Manuel Kobras, Peter Kreitmeier, Oliver Reiser","doi":"10.1021/acs.oprd.4c00489","DOIUrl":"https://doi.org/10.1021/acs.oprd.4c00489","url":null,"abstract":"We report the iodoamination of alkenes in continuous flow under metal-free, visible-light-mediated conditions with commercially available <i>N</i>-iodosuccinimide and protected amines. Unactivated and activated alkenes as well as Michael acceptors are amenable substrate classes for this process, allowing the synthesis of 1,2-iodoamines with a broad scope and in high yields (59–94%). The steadiness of the protocol is demonstrated in a continuous flow experiment over 4.5 h for the coupling of styrene, NIS, and <i>N</i>-tosyl-amine, which gave rise to 14 g (91%) of the iodoaminated product, corresponding to a productivity of 3.1 g h<sup>–1</sup>. Additionally, the direct conversion of the products without prior isolation into aziridines, enamines, amino alcohols, or azidoamines is possible, underscoring the synthetic value of this approach. Variation of the reaction conditions by adding typical impurities in reagents or solvents or changing the irradiation from green to blue light had a minimal effect on the yield, giving credit to the robustness of the process.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"53 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Process Development of Bersacapavir, Part 3: Safety and Late-Stage Development Considerations Linked to Chloroform Generated in Haloform-Type Amidation
IF 3.4 3区 化学
Organic Process Research & Development Pub Date : 2025-03-04 DOI: 10.1021/acs.oprd.4c00516
David Kossler, Micha Peeters, Florian Medina, Erika De Bie, Brecht Egle, Cheng Cheng Huang, William M. Maton, Johan Weerts, Jean-Pierre Bongartz, Magnus Eriksson, Koen Wegsteen, Els Keppens
{"title":"Process Development of Bersacapavir, Part 3: Safety and Late-Stage Development Considerations Linked to Chloroform Generated in Haloform-Type Amidation","authors":"David Kossler, Micha Peeters, Florian Medina, Erika De Bie, Brecht Egle, Cheng Cheng Huang, William M. Maton, Johan Weerts, Jean-Pierre Bongartz, Magnus Eriksson, Koen Wegsteen, Els Keppens","doi":"10.1021/acs.oprd.4c00516","DOIUrl":"https://doi.org/10.1021/acs.oprd.4c00516","url":null,"abstract":"This manuscript describes the chemical process development for the synthesis of a crucial amide intermediate and the improvements that were achieved over previous processes. Careful studies guided by distillation modeling revealed an advantage of put-and-take operation compared to continuous volume and led to the discrete distillation values to successfully capture CHCl<sub>3</sub> in the distillate, which can then be disposed of separately. Optimization of the workup conditions and crystallization resulted in higher yields and simplified waste treatment. The process is robust and has been successfully scaled up in multiple production campaigns.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"67 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Process Development of Bersacapavir, Part 3: Safety and Late-Stage Development Considerations Linked to Chloroform Generated in Haloform-Type Amidation
IF 3.1 3区 化学
Organic Process Research & Development Pub Date : 2025-03-04 DOI: 10.1021/acs.oprd.4c0051610.1021/acs.oprd.4c00516
David Kossler, Micha Peeters*, Florian Medina, Erika De Bie, Brecht Egle, Cheng Cheng Huang, William M. Maton, Johan Weerts, Jean-Pierre Bongartz, Magnus Eriksson, Koen Wegsteen and Els Keppens, 
{"title":"Process Development of Bersacapavir, Part 3: Safety and Late-Stage Development Considerations Linked to Chloroform Generated in Haloform-Type Amidation","authors":"David Kossler,&nbsp;Micha Peeters*,&nbsp;Florian Medina,&nbsp;Erika De Bie,&nbsp;Brecht Egle,&nbsp;Cheng Cheng Huang,&nbsp;William M. Maton,&nbsp;Johan Weerts,&nbsp;Jean-Pierre Bongartz,&nbsp;Magnus Eriksson,&nbsp;Koen Wegsteen and Els Keppens,&nbsp;","doi":"10.1021/acs.oprd.4c0051610.1021/acs.oprd.4c00516","DOIUrl":"https://doi.org/10.1021/acs.oprd.4c00516https://doi.org/10.1021/acs.oprd.4c00516","url":null,"abstract":"<p >This manuscript describes the chemical process development for the synthesis of a crucial amide intermediate and the improvements that were achieved over previous processes. Careful studies guided by distillation modeling revealed an advantage of put-and-take operation compared to continuous volume and led to the discrete distillation values to successfully capture CHCl<sub>3</sub> in the distillate, which can then be disposed of separately. Optimization of the workup conditions and crystallization resulted in higher yields and simplified waste treatment. The process is robust and has been successfully scaled up in multiple production campaigns.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"29 3","pages":"632–639 632–639"},"PeriodicalIF":3.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Preparation of Trifluoromethyl Diazomethane in Flow Using In-Line Membrane Phase Separation─Application to the Catalytic Asymmetric Cyclopropanation of Substituted Styrenes
IF 3.4 3区 化学
Organic Process Research & Development Pub Date : 2025-03-03 DOI: 10.1021/acs.oprd.4c00477
Tyler K. Allred, Olga A. Mukhina, Oleg Epstein, Jie Yan, Kevin Crossley, Matthew G. Beaver, Michael J. Frohn, James I. Murray, David Bauer
{"title":"Continuous Preparation of Trifluoromethyl Diazomethane in Flow Using In-Line Membrane Phase Separation─Application to the Catalytic Asymmetric Cyclopropanation of Substituted Styrenes","authors":"Tyler K. Allred, Olga A. Mukhina, Oleg Epstein, Jie Yan, Kevin Crossley, Matthew G. Beaver, Michael J. Frohn, James I. Murray, David Bauer","doi":"10.1021/acs.oprd.4c00477","DOIUrl":"https://doi.org/10.1021/acs.oprd.4c00477","url":null,"abstract":"Trifluoromethyl diazomethane (TFDM) is a versatile reagent in organic synthesis and medicinal chemistry efforts. The utility of TFDM is hampered by safety concerns on scale. A novel method for the generation of dry, acid-free concentrated solutions of TFDM in a flow is reported here. The inclusion of an in-line liquid–liquid phase separator was a critical component in the flow scheme. The resulting dry stream could be coupled to a reactor containing a chiral ruthenium catalyst and styrene substrate to enantioselectively construct <i>trans</i>-trifluoromethyl-substituted cyclopropanes in a plug flow reactor–batch train. This system was utilized to access a variety of enantioenriched <i>trans</i>-trifluoromethyl-substituted cyclopropanes.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"14 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Preparation of Trifluoromethyl Diazomethane in Flow Using In-Line Membrane Phase Separation─Application to the Catalytic Asymmetric Cyclopropanation of Substituted Styrenes
IF 3.1 3区 化学
Organic Process Research & Development Pub Date : 2025-03-03 DOI: 10.1021/acs.oprd.4c0047710.1021/acs.oprd.4c00477
Tyler K. Allred*, Olga A. Mukhina, Oleg Epstein, Jie Yan, Kevin Crossley, Matthew G. Beaver, Michael J. Frohn, James I. Murray and David Bauer, 
{"title":"Continuous Preparation of Trifluoromethyl Diazomethane in Flow Using In-Line Membrane Phase Separation─Application to the Catalytic Asymmetric Cyclopropanation of Substituted Styrenes","authors":"Tyler K. Allred*,&nbsp;Olga A. Mukhina,&nbsp;Oleg Epstein,&nbsp;Jie Yan,&nbsp;Kevin Crossley,&nbsp;Matthew G. Beaver,&nbsp;Michael J. Frohn,&nbsp;James I. Murray and David Bauer,&nbsp;","doi":"10.1021/acs.oprd.4c0047710.1021/acs.oprd.4c00477","DOIUrl":"https://doi.org/10.1021/acs.oprd.4c00477https://doi.org/10.1021/acs.oprd.4c00477","url":null,"abstract":"<p >Trifluoromethyl diazomethane (TFDM) is a versatile reagent in organic synthesis and medicinal chemistry efforts. The utility of TFDM is hampered by safety concerns on scale. A novel method for the generation of dry, acid-free concentrated solutions of TFDM in a flow is reported here. The inclusion of an in-line liquid–liquid phase separator was a critical component in the flow scheme. The resulting dry stream could be coupled to a reactor containing a chiral ruthenium catalyst and styrene substrate to enantioselectively construct <i>trans</i>-trifluoromethyl-substituted cyclopropanes in a plug flow reactor–batch train. This system was utilized to access a variety of enantioenriched <i>trans</i>-trifluoromethyl-substituted cyclopropanes.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"29 3","pages":"716–722 716–722"},"PeriodicalIF":3.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up
IF 3.1 3区 化学
Organic Process Research & Development Pub Date : 2025-03-03 DOI: 10.1021/acs.oprd.5c0000710.1021/acs.oprd.5c00007
Christophe Allais, Louise Bernier, David C. Blakemore, Jeffrey Casavant, Xiayun Cheng, Chulho Choi, Matthew Chuba, Matthew S. Corbett, Kenneth J. Dirico, William Farrell, Scott P. France, Francois Godin, Roger M. Howard, Gajendra Ingle, Daniel W. Kung, David C. Limburg, Richard P. Loach*, Vincent M. Lombardo, Hadi Rezaei, Neal W. Sach, Alexandria P. Taylor and Haresh Thakellapalli, 
{"title":"Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up","authors":"Christophe Allais,&nbsp;Louise Bernier,&nbsp;David C. Blakemore,&nbsp;Jeffrey Casavant,&nbsp;Xiayun Cheng,&nbsp;Chulho Choi,&nbsp;Matthew Chuba,&nbsp;Matthew S. Corbett,&nbsp;Kenneth J. Dirico,&nbsp;William Farrell,&nbsp;Scott P. France,&nbsp;Francois Godin,&nbsp;Roger M. Howard,&nbsp;Gajendra Ingle,&nbsp;Daniel W. Kung,&nbsp;David C. Limburg,&nbsp;Richard P. Loach*,&nbsp;Vincent M. Lombardo,&nbsp;Hadi Rezaei,&nbsp;Neal W. Sach,&nbsp;Alexandria P. Taylor and Haresh Thakellapalli,&nbsp;","doi":"10.1021/acs.oprd.5c0000710.1021/acs.oprd.5c00007","DOIUrl":"https://doi.org/10.1021/acs.oprd.5c00007https://doi.org/10.1021/acs.oprd.5c00007","url":null,"abstract":"<p >Cyclopropanes play an important role in drug discovery, and synthetic access to variedly substituted systems is an ongoing challenge for chemistry teams. A variety of scalable synthetic routes were developed and optimized for the construction of 1,2-trans-disubstituted cyclopropyl esters. The use of a stable cyclopropyl trifluoroborate provided a path for the rapid exploration of heteroaryl substituent diversity. Two asymmetric approaches were subsequently enabled as viable alternatives. Our first approach led to the development of a novel sulfoximine-driven Johnson–Corey–Chaykovsky reaction of menthyl acrylates and is the first example of this chemistry for the enantio- and diastereostereoselective construction of trans-cyclopropanes. Ultimately, a scalable process route was fashioned through the optimization of an efficient ring opening/intramolecular C–O phosphate transfer and displacement cascade that builds the trans-cyclopropyl ester from a chiral epoxide with excellent stereocontrol.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"29 3","pages":"920–931 920–931"},"PeriodicalIF":3.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up
IF 3.4 3区 化学
Organic Process Research & Development Pub Date : 2025-03-03 DOI: 10.1021/acs.oprd.5c00007
Christophe Allais, Louise Bernier, David C. Blakemore, Jeffrey Casavant, Xiayun Cheng, Chulho Choi, Matthew Chuba, Matthew S. Corbett, Kenneth J. Dirico, William Farrell, Scott P. France, Francois Godin, Roger M. Howard, Gajendra Ingle, Daniel W. Kung, David C. Limburg, Richard P. Loach, Vincent M. Lombardo, Hadi Rezaei, Neal W. Sach, Alexandria P. Taylor, Haresh Thakellapalli
{"title":"Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up","authors":"Christophe Allais, Louise Bernier, David C. Blakemore, Jeffrey Casavant, Xiayun Cheng, Chulho Choi, Matthew Chuba, Matthew S. Corbett, Kenneth J. Dirico, William Farrell, Scott P. France, Francois Godin, Roger M. Howard, Gajendra Ingle, Daniel W. Kung, David C. Limburg, Richard P. Loach, Vincent M. Lombardo, Hadi Rezaei, Neal W. Sach, Alexandria P. Taylor, Haresh Thakellapalli","doi":"10.1021/acs.oprd.5c00007","DOIUrl":"https://doi.org/10.1021/acs.oprd.5c00007","url":null,"abstract":"Cyclopropanes play an important role in drug discovery, and synthetic access to variedly substituted systems is an ongoing challenge for chemistry teams. A variety of scalable synthetic routes were developed and optimized for the construction of 1,2-trans-disubstituted cyclopropyl esters. The use of a stable cyclopropyl trifluoroborate provided a path for the rapid exploration of heteroaryl substituent diversity. Two asymmetric approaches were subsequently enabled as viable alternatives. Our first approach led to the development of a novel sulfoximine-driven Johnson–Corey–Chaykovsky reaction of menthyl acrylates and is the first example of this chemistry for the enantio- and diastereostereoselective construction of trans-cyclopropanes. Ultimately, a scalable process route was fashioned through the optimization of an efficient ring opening/intramolecular C–O phosphate transfer and displacement cascade that builds the trans-cyclopropyl ester from a chiral epoxide with excellent stereocontrol.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"211 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Ni(cod)(dq) (COD: 1,5-Cyclooctadiene; DQ: Duroquinone) for the Dehalogenative Coupling Polycondensation to π-Conjugated Polyarylenes
IF 3.4 3区 化学
Organic Process Research & Development Pub Date : 2025-03-02 DOI: 10.1021/acs.oprd.5c00012
Naoki Noda, Maho Umeda, Kentaro Okano, Kuei-Cheng Chen, Masaki Horie, Atsunori Mori
{"title":"The Use of Ni(cod)(dq) (COD: 1,5-Cyclooctadiene; DQ: Duroquinone) for the Dehalogenative Coupling Polycondensation to π-Conjugated Polyarylenes","authors":"Naoki Noda, Maho Umeda, Kentaro Okano, Kuei-Cheng Chen, Masaki Horie, Atsunori Mori","doi":"10.1021/acs.oprd.5c00012","DOIUrl":"https://doi.org/10.1021/acs.oprd.5c00012","url":null,"abstract":"Ni(cod)(dq) (COD: 1,5-cyclooctadiene; DQ: duroquinone) with an appropriate bipyridine ligand is available for the dehalogenative polycondensation of dihaloarenes to afford π-conjugated polymers. The reaction of 2,7-dibromo-9,9-di(<i>n</i>-hexylfluorene) with a nickel complex composed of Ni(cod)(dq) and 4,4′-di-<i>tert</i>-butyl-2,2′-bipyridine in DMF/toluene (1:4) proceeded at 120 °C for 72 h. Polyfluorene was obtained in 81% yield with <i>M</i><sub>n</sub> = 13,000 (<i>M</i><sub>w</sub>/<i>M</i><sub>n</sub> = 2.0). Ni(cod)(dq) was found to be stored under an ambient atmosphere at room temperature, the use of which after several months vs a freshly opened nickel complex resulted to afford the corresponding polymer in a comparable yield and molecular weight. Other dihaloarenes such as fluorene with different alkyl chain structures, 1,4- and 1,3-dihalobenzenes, 5,5′-dibromo-2,2′-bithiophene, and 2,6-dibromo-cyclopentadithiophene, also underwent dehalogenative polymerization to afford the corresponding conjugated polymers in excellent yields with an appropriate degree of polymerization.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"56 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Ni(cod)(dq) (COD: 1,5-Cyclooctadiene; DQ: Duroquinone) for the Dehalogenative Coupling Polycondensation to π-Conjugated Polyarylenes
IF 3.1 3区 化学
Organic Process Research & Development Pub Date : 2025-03-02 DOI: 10.1021/acs.oprd.5c0001210.1021/acs.oprd.5c00012
Naoki Noda, Maho Umeda, Kentaro Okano, Kuei-Cheng Chen, Masaki Horie and Atsunori Mori*, 
{"title":"The Use of Ni(cod)(dq) (COD: 1,5-Cyclooctadiene; DQ: Duroquinone) for the Dehalogenative Coupling Polycondensation to π-Conjugated Polyarylenes","authors":"Naoki Noda,&nbsp;Maho Umeda,&nbsp;Kentaro Okano,&nbsp;Kuei-Cheng Chen,&nbsp;Masaki Horie and Atsunori Mori*,&nbsp;","doi":"10.1021/acs.oprd.5c0001210.1021/acs.oprd.5c00012","DOIUrl":"https://doi.org/10.1021/acs.oprd.5c00012https://doi.org/10.1021/acs.oprd.5c00012","url":null,"abstract":"<p >Ni(cod)(dq) (COD: 1,5-cyclooctadiene; DQ: duroquinone) with an appropriate bipyridine ligand is available for the dehalogenative polycondensation of dihaloarenes to afford π-conjugated polymers. The reaction of 2,7-dibromo-9,9-di(<i>n</i>-hexylfluorene) with a nickel complex composed of Ni(cod)(dq) and 4,4′-di-<i>tert</i>-butyl-2,2′-bipyridine in DMF/toluene (1:4) proceeded at 120 °C for 72 h. Polyfluorene was obtained in 81% yield with <i>M</i><sub>n</sub> = 13,000 (<i>M</i><sub>w</sub>/<i>M</i><sub>n</sub> = 2.0). Ni(cod)(dq) was found to be stored under an ambient atmosphere at room temperature, the use of which after several months vs a freshly opened nickel complex resulted to afford the corresponding polymer in a comparable yield and molecular weight. Other dihaloarenes such as fluorene with different alkyl chain structures, 1,4- and 1,3-dihalobenzenes, 5,5′-dibromo-2,2′-bithiophene, and 2,6-dibromo-cyclopentadithiophene, also underwent dehalogenative polymerization to afford the corresponding conjugated polymers in excellent yields with an appropriate degree of polymerization.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"29 3","pages":"932–937 932–937"},"PeriodicalIF":3.1,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Fine Chemical Industry, 2000–2024
IF 3.4 3区 化学
Organic Process Research & Development Pub Date : 2025-02-28 DOI: 10.1021/acs.oprd.5c00010
Rosaria Ciriminna, Cristina Della Pina, Rafael Luque, Mario Pagliaro
{"title":"The Fine Chemical Industry, 2000–2024","authors":"Rosaria Ciriminna, Cristina Della Pina, Rafael Luque, Mario Pagliaro","doi":"10.1021/acs.oprd.5c00010","DOIUrl":"https://doi.org/10.1021/acs.oprd.5c00010","url":null,"abstract":"The fine chemical industry manufactures products that are used by many major industrial sectors, including the food and beverage, cosmetics, nutraceutical, pharmaceutical, electronics, paper, automotive, painting, and water industries. The industry saw significant changes in the first quarter of the current century, including the uptake of new “greener” production technology, digitalization, and changes in the structure and geographical distribution. Despite its relevance and significant annual growth rates lasting for decades, knowledge of this industry among chemistry and chemical engineering scholars, including graduate and undergraduate students, is often limited. Providing an updated critical insight into industry and the main changes that have occurred in the past 25 years, this study identifies the technology and policy drivers of change. The conclusions of the study may inform further practice-oriented education on industrial aspects of the chemical enterprise.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"11 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信