Auris Nasus Larynx最新文献

{"title":"Comparison of Mupirocin ointment and basic fibroblast growth factor gel in the treatment of pediatric recurrent anterior epistaxis: Randomized, controlled, single blind study","authors":"Zhengcai Lou ,&nbsp;Zihan Lou ,&nbsp;Zhengnong Chen","doi":"10.1016/j.anl.2025.07.004","DOIUrl":"10.1016/j.anl.2025.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to compare the short-and medium-term effectiveness of Mupirocin ointment (2 %) (MUO) and recombinant bovine basic fibroblast growth factor eye-gel (bFGF) in the treatment of recurrent anterior epistaxis (RAE) in children.</div></div><div><h3>Material and methods</h3><div>children with RAE were randomly allocated into MUO group or bFGF group. The recurrence epistaxis,epistaxis severity score (ESS),and visual analog scale (VAS) were compared among two groups at 4 weeks and 3 months.</div></div><div><h3>Results</h3><div>This study included 371 children with RAE.The recurrence epistaxis was 44.57 % in the MUO group and 30.81 % in the bFGF group at posttreatment 4 weeks (<em>P</em> &lt; 0.05). Also, the recurrence epistaxis rate was 63.59 % in the MUO group and 28.65 % in the bFGF group at posttreatment 3 months (<em>P</em> &lt; 0.001). Furthermore, in the MUO group, there was not significant difference in the recurrence epistaxis rate between the patients with AR and non-AR at posttreatment 4 weeks (<em>P</em> &gt; 0.05), while there was not significant difference in the recurrence epistaxis rate between the patients with AR and non-AR at posttreatment 4 weeks (<em>P</em> = 0.309) in the bFGF group. In the MUO group, 42.5 % patients reported the pricking of nasal cavity and discomfort in 70.4 %, whereas no any patients did in the bFGF group. Moreover, at each follow-up time point, the mean ESS score in the bFGF group was significantly lower than that in the MUO group.VAS scores for itchy nose or nasal crusts, the improvement in the bFGF group was better compared with the MUO group at 4 weeks and 3 months.</div></div><div><h3>Conclusion</h3><div>bFGF Gel has a lower rate of recurrent epistaxis and better short-and medium-term effectiveness in the treatment of RAE in children compared with Mupirocin ointment, additionally, bFGF has no the pricking and discomfort of nasal cavity,thus resulting in well children's compliance.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 516-521"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feingold syndrome with GJB2 variants","authors":"Yoshihiro Nitta ,&nbsp;Hajime Sano ,&nbsp;Yoshihiro Yoshimura ,&nbsp;Fumio Takada ,&nbsp;Taku Yamashita","doi":"10.1016/j.anl.2025.07.005","DOIUrl":"10.1016/j.anl.2025.07.005","url":null,"abstract":"<div><div>Congenital hearing loss is the most common birth defect, with genetic factors implicated in 50 % of prelingual cases. <em>GJB2</em> variant, causing up to 50 % of autosomal recessive non-syndromic hearing loss, typically show stable hearing profiles and favorable cochlear implant (CI) outcomes. In this case, however, the atypical clinical course prompted further evaluation. A 3-year-6-month-old girl, born at 35 weeks presented with profound bilateral hearing loss detected by auditory brainstem response. The patient had normal tympanic membranes, angulated ears, microcephaly, short stature, narrow palpebral fissures, and digital anomalies. CT revealed inner ear malformations including bilateral vestibular enlargement and cochlear nerve canal stenosis. Genetic testing showed a homozygous <em>GJB2</em> c.235delC (p.L79fs) variant. Initial hearing aids proved insufficient, leading to CI placement, which improved hearing thresholds. Language and social delays persisted. As her older sister, without a <em>GJB2</em> variant, had hearing loss and a family history of characteristic physical symptoms, further genetic analysis revealed a heterozygous <em>MYCN</em> variant (NM_005378:c.1138_1139del:p.S380fs), confirming Feingold syndrome type 1 (FS1). This report is a very rare report of FS 1 combined with severe hearing loss due to a <em>GJB2</em> variant. Early screening for malformations not detected by <em>GJB2</em> led to accurate diagnosis and provision of information to the family.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 522-526"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New evaluation method using sound stimulation for asymptomatic vestibular dysfunction","authors":"Masumi Kobayashi ,&nbsp;Naomi Katayama ,&nbsp;Tadao Yoshida ,&nbsp;Michihiko Sone","doi":"10.1016/j.anl.2025.07.006","DOIUrl":"10.1016/j.anl.2025.07.006","url":null,"abstract":"<div><div>The currently available evaluation methods for determining appropriate treatment strategies in patients with asymptomatic inner ear dysfunction are insufficient. Recently, we demonstrated the efficacy of 100-Hz sound stimulation for treating vestibular dysfunction in Meniere’s disease. This case report presents the utility of 100-Hz sound stimulation as a new method for evaluating cases with asymptomatic vestibular dysfunction and their potential for recovery with early medical intervention. We evaluated the change in cervical vestibular-evoked myogenic potential (cVEMP) amplitude before and after sound stimulation (75 dB at a frequency of 100 Hz for 5 to 10 min) in two female patients with endolymphatic hydrops (EH), comparing the change based on the presence of EH. One patient presented with hearing difficulty and the other with otalgia, and neither had hearing loss and vestibular symptoms. As a result, cVEMP amplitudes in ears without EH showed no changes after the stimulation. Conversely, cVEMP amplitudes showed significant increases in ears with vestibular EH compared with the values before stimulation. Application of a 100-Hz sound stimulus might be a new method for evaluating asymptomatic vestibular dysfunction associated with EH, and for providing information about the potential for recovery from the dysfunction, facilitating early medical intervention.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 527-530"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective study of lateral pharyngoplasty for the treatment of obstructive sleep apnoea syndrome","authors":"Shuyun Luo ,&nbsp;Haiyao Zheng ,&nbsp;Tao Mo ,&nbsp;Huicheng Gong ,&nbsp;Haoliang Zhang","doi":"10.1016/j.anl.2025.04.005","DOIUrl":"10.1016/j.anl.2025.04.005","url":null,"abstract":"<div><h3>Objectives</h3><div><span>To investigate the efficacy and postoperative reaction of lateral pharyngoplasty combined with </span>Uvulopalatopharyngoplasty<span> in patients with obstructive sleep apnoea syndrome.</span></div></div><div><h3>Methods</h3><div>A total of 127 obstructive sleep apnoea syndrome patients presenting with pharyngeal ring hypertrophy or lateral pharyngeal wall hypertrophy were included in this study. Among these, 63 patients in the case group underwent pharyngoplasty combined with Uvulopalatopharyngoplasty (UPPP), while 64 patients in the control group underwent UPPP alone. The team collected the objective data from polysomnography (PSG) and subjective patient evaluations and statistically compared preoperatively and six months postoperatively.</div></div><div><h3>Results</h3><div>In both groups, the mean age was 41.22±11.54years old (19–78 years), and the average BMI<span><span> was 27.21±2.79kg/m2(21.22–34.99kg/m2). After surgery, the Apnea Hypopnea Index (AHI) in the case group decreased from 50.18±21.48 to 22.57±17.34, while the Lowest </span>oxygen saturation (LSaO2) increased from (71.05±13.37) % to (75.98±10.76) %. The success rate was 74,6 % for the case group compared to 40.6 % for the control group. The pharyngeal cavity was significantly enlarged after the operation, with no serious complications reported.</span></div></div><div><h3>Conclusions</h3><div>In this study, lateral pharyngeal wall hypertrophy was treated by lateral pharyngoplasty concurrently with UPPP to enhance surgical outcomes further and prevent long-term recurrence. Postoperative symptoms were found to be acceptable, with no serious complications reported.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 490-495"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis on sarcopenia according to the site of head and neck cancer","authors":"Mutsukazu Kitano,&nbsp;Mitsuo Sato,&nbsp;Satoru Koike,&nbsp;Hisatomo Tamaki,&nbsp;Shusuke Iwamoto,&nbsp;Kazuhiro Miyamoto,&nbsp;Noriko Ohira,&nbsp;Takayuki Kimura,&nbsp;Daisuke Abe,&nbsp;Takahiro Wakasaki,&nbsp;Ryuji Yasumatsu","doi":"10.1016/j.anl.2025.07.002","DOIUrl":"10.1016/j.anl.2025.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>In cases of cancer patients with sarcopenia, many adverse effects such as postoperative complications and prognosis have been reported with head and neck cancer. We examined the prevalence and prognosis of sarcopenia according to the site in head and neck cancer in order to clarify the site that require early intervention as the primary endpoints.</div></div><div><h3>Methods</h3><div>From October 2016 to March 2021, we retrospectively studied 388 cases of 448 primary cases of head and neck cancer who visited our department and for whom measurement using bioelectrical impedance analysis (BIA) and grip strength were possible. 339 cases that had undergone radical treatment were retrospectively examined.</div></div><div><h3>Result</h3><div>Of the 388 primary cases of head and neck cancer, 102 patients were diagnosed with sarcopenia. The most common site is oral cancer, followed by oropharyngeal cancer, and hypopharyngeal cancer. In terms of the patient background, sarcopenia was significantly more common in patients aged \"65 years or older,\" in those in \"stage III or higher, in those in \"T3 or higher,\" in those with a history of drinking alcohol and in those with \"site-related swallowing (oral cavity, oropharynx, and hypopharynx)\". The prevalence of sarcopenia in terms of stage classification was 25% or more in advanced cancer cases for all sites of head and neck cancers; however, it was observed from stage I or higher for oropharyngeal cancer and stage II or higher for hypopharyngeal cancer. The 3-year overall survival rate for oral cancer, oropharyngeal cancer, and hypopharyngeal cancer was significantly worse in sarcopenic patients than in non-sarcopenic patients; however, for laryngeal cancer and other cancers, while the 3-year overall survival rate was worse in sarcopenic patients than in non-sarcopenic patients, no significant difference was observed.</div></div><div><h3>Conclusion</h3><div>In cases of head and neck cancer, elderly patients and those with oral, oropharyngeal, or hypopharyngeal cancers, which are closely related to swallowing, tend to be more susceptible to sarcopenia. As prognosis of these sites is also affected by sarcopenia, careful attention should be paid to the presence or absence of sarcopenia. In particular, because patients with oropharyngeal cancer and/or hypopharyngeal cancer are prone to sarcopenia from an early stage, the presence or absence of sarcopenia should be confirmed in the event a suspected lesion is observed in the oropharynx and/or hypopharynx.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 507-515"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Course of a sudden sensorineural hearing loss case diagnosed as intra-labyrinthine hemorrhage with MRI in the early phase","authors":"Kenta Ide,&nbsp;Makoto Hosoya,&nbsp;Takanori Nishiyama,&nbsp;Marie N Shimanuki,&nbsp;Masafumi Ueno,&nbsp;Hiroyuki Ozawa,&nbsp;Naoki Oishi","doi":"10.1016/j.anl.2025.06.012","DOIUrl":"10.1016/j.anl.2025.06.012","url":null,"abstract":"<div><div>Intralabyrinthine hemorrhage (ILH) is a rare differential diagnosis of sudden sensorineural hearing loss. Investigations using magnetic resonance imaging (MRI) in the early phase from the onset are inevitable to diagnose ILH. However, MRI is not usually performed during the early phases of sudden sensorineural hearing loss. Hence, ILH is rarely diagnosed, and the hearing prognosis and vestibular function in patients have been poorly understood.</div><div>In the present study, we report the detailed course of ILH with relatively good hearing recovery. Additionally, vestibular function recovery was quantitatively examined using a video head impulse test. A 75-year-old man presented at our clinic with a chief complaint of dizziness, sudden hearing loss, left sensorineural hearing loss, and nystagmus. MRI 18 days after onset showed a left ILH. Following treatment with prednisone, the patient's hearing level partially recovered and nystagmus disappeared.</div><div>Our experience emphasizes that MRI in the early phase is crucial for diagnosing ILH. Furthermore, MRI in the early phase should be considered in cases of sudden sensorineural hearing loss or dizziness and is beneficial for investigating ILH as a subpopulation of sudden sensorineural hearing loss.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 479-483"},"PeriodicalIF":1.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of cochlear implantation in adolescents with early-onset hearing loss","authors":"Haruo Yoshida ,&nbsp;Yukihiko Kanda ,&nbsp;Satomi Shojinaga ,&nbsp;Chisei Satoh ,&nbsp;Yoshihiko Kumai ,&nbsp;Haruo Takahashi","doi":"10.1016/j.anl.2025.06.010","DOIUrl":"10.1016/j.anl.2025.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>Neonatal hearing screening (NHS) has long-term beneficial effects on the outcomes of cochlear implantation (CI); however, some adolescents still require CI evaluation because of progressive hearing loss. This study aimed to investigate long-term postoperative effects and to identify prognostic factors in adolescents with CI.</div></div><div><h3>Methods</h3><div>Thirty-four patients with pre- or perilingual severe-to-profound hearing loss who underwent CI after the age of 10 years (adolescent group) were included. The pre- and postoperative outcomes of this group were compared with those of 138 patients with pre- or perilingual severe-to-profound hearing loss who underwent CI before the age of 10 years (pediatric group). We collected data on the age at diagnosis of hearing loss, age at initiating hearing aid (HA) use, age at CI, postoperative observation time, pure-tone hearing thresholds on the affected and unaffected sides, preoperative (HA) and postoperative (CI) aided hearing levels, speech discrimination scores (SDSs), and communication mode. The prognostic factors for CI in the adolescent group were investigated based on postoperative SDS. In patients who provided consent for a questionnaire survey, postoperative listening comprehension, articulation, satisfaction, and expectations after CI were also evaluated.</div></div><div><h3>Results</h3><div>In the adolescent group, significant improvements were noted in the aided hearing threshold and SDS after implantation (both <em>p</em> &lt; 0.001) except for two cases, but both variables were significantly worse in the adolescent group than in the pediatric group (both <em>p</em> &lt; 0.05). Postoperative SDS significantly correlated with preoperative SDS (ρ = 0.5056) and preoperative hearing level on the unaffected side (ρ = −0.3864; both <em>p</em> &lt; 0.05). The age at CI, age at diagnosis, and age at initiating HA use were not significantly different between the two groups. In the adolescent group, users of the auditory–verbal communication mode scored the highest and showed significant differences in preoperative and postoperative factors. The questionnaire survey findings indicated that postoperative listening and articulation were significantly worse in the adolescent group (both <em>p</em> &lt; 0.05), but satisfaction and expectations after CI did not significantly differ between the two groups.</div></div><div><h3>Conclusion</h3><div>CI appears to provide satisfactory long-term outcomes even among adolescents with hearing loss. Better preoperative SDS and hearing might be important for the outcomes of CI in this age group.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 471-478"},"PeriodicalIF":1.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential diagnosis of skull base osteomyelitis from malignancies focusing on the radiological features on HRCT","authors":"Kuniyuki Takahashi ,&nbsp;Ogawa Takahashi ,&nbsp;Takeshi Nakamura ,&nbsp;Shinsuke Ide ,&nbsp;Takashi Goto ,&nbsp;Takumi Okuda ,&nbsp;Yuka Morita ,&nbsp;Manabu Ogi ,&nbsp;Meiko Kitazawa ,&nbsp;Chihiro Yagi ,&nbsp;Tatsuya Yamagishi ,&nbsp;Shinsuke Ohshima ,&nbsp;Shuji Izumi ,&nbsp;Arata Horii","doi":"10.1016/j.anl.2025.06.011","DOIUrl":"10.1016/j.anl.2025.06.011","url":null,"abstract":"<div><h3>Objective</h3><div>Skull base osteomyelitis (SBO) is a rare but life-threatening inflammatory disease often misdiagnosed as a malignancy, such as nasopharyngeal carcinoma (NPC) and external auditory canal cancer (EACC), due to extensive bone destruction. This study aimed to identify the radiological features of SBO using high-resolution CT, which could help in the differential diagnosis of malignancies.</div></div><div><h3>Methods</h3><div>High-resolution CT findings of 14 patients with SBO, 25 with NPC, and 19 with EACC were retrospectively reviewed. Abnormal findings at seven sites: 1) external auditory canal, 2) mastoid portion, 3) petrous portion of the temporal bone, 4) clivus, 5) jugular foramen, 6) nasopharyngeal soft tissue thickness, and 7) torus tubarius shape were compared among the patient groups on axial slice of HRCT.</div></div><div><h3>Results</h3><div>When comparing SBO and NPC, there were significant differences in sites 1) (<em>p</em> = 0.0001), 3) (<em>p</em> = 0.0064), 5), and 7) (<em>p</em> &lt; 0.0001); among them, the most specific finding was the site 7). When comparing SBO and EACC, there were significant differences in sites 1) (<em>p</em> = 0.0084), 3) (<em>p</em> &lt; 0.0001), 4) (<em>p</em> = 0.0013), 5) (<em>p</em> = 0.0015), and 6) (<em>p</em> &lt; 0.0001); among them, the most specific finding was cortical bone destruction in site 3).</div></div><div><h3>Conclusion</h3><div>Our findings indicated that the bilateral preservation of “μ-shape sign” in the torus tubarius and bone destruction in the petrous portion on HRCT were the most specific signs differentiating SBO from NPC and EACC, respectively. Knowledge of these features can contribute to prompt diagnosis and treatment of SBO.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 456-462"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tonsil-induced autoimmune/inflammatory syndrome: Current insights into the pathogenic role of tonsils in immunoglobulin a nephropathy, palmoplantar pustulosis and psoriasis","authors":"Yasuaki Harabuchi","doi":"10.1016/j.anl.2025.06.004","DOIUrl":"10.1016/j.anl.2025.06.004","url":null,"abstract":"<div><div>The tonsils, specifically the palatine tonsils, serve as a first line of defense against pathogenic microorganisms that enter the nasal or oral cavity. They release antigen-specific immune cells and antibodies that circulate not only in the upper respiratory tract but also throughout the rest of the body. Numerous clinical studies, including randomized prospective trials, have shown that tonsillectomy is highly effective in treating immunoglobulin A nephropathy (IgAN), palmoplantar pustulosis (PPP), and psoriasis. However, the precise pathogenic association of the tonsils with these diseases remains incompletely understood. The author previously proposed the concept of tonsil-induced autoimmune/inflammatory syndrome (TIAS) as a common underlying mechanism for these diseases. TIAS suggests that an excessive immune response initiated by the tonsils, often triggered by common bacteria such as α- and β-hemolytic streptococcus and <em>Haemophilus parainfluenzae</em>, which are indigenously present in the oral cavity, can become dysregulated. This immune response also involves unmethylated DNA sequences (CpG-ODN) that are shared among various bacteria. In reaction to these bacteria or CpG-ODN, tonsillar T-cell populations, including type 17 helper T (Th17), Th22, Th1, and cytotoxic T cells, become proliferative. Simultaneously, tonsillar B-cell populations responding to these triggers produce antibodies against epidermal keratins and heat shock proteins, or aberrant IgA1. These tonsillar T-cell populations and the antibodies then enter the systemic circulation, migrating to the kidneys or skin. Upon reaching the organs, they contribute to tissue damage, aided by various cytokine actions. IgAN, PPP, and psoriasis, which are representative disorders of TIAS, all share this common pathogenic mechanism. In this article, the author discusses the pathogenesis of TIAS based on recent research findings.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 463-470"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr virus (EBV) reactivation in post COVID-19","authors":"Eslam Farid Abu Shady ,&nbsp;Abdelhakim Fouad Ghallab ,&nbsp;Doaa Abdullah Shaker ,&nbsp;Rasha Abd Elhamid Elsayed","doi":"10.1016/j.anl.2025.06.009","DOIUrl":"10.1016/j.anl.2025.06.009","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if there is a link between prolonged COVID symptoms and the reactivation of EBV.</div></div><div><h3>Methods</h3><div>This study was an observational (case-control) analysis involving 140 patients who tested positive for COVID-19 and are experiencing persistent symptoms such as fatigue and post-exertional malaise. Additionally, a control group of 80 individuals, matched for age and gender, who have fully recovered from SARS-CoV-2 infection without these symptoms, was included. The research took place between December 2023 and March 2024 at Benha University Hospitals in Benha, Egypt. The reactivation of the Epstein–Barr virus (EBV) was identified by detecting EBV genetic material using TaqMan probes, along with at least one set of primers (<em>Bam</em>HI and LMP2).</div></div><div><h3>Results</h3><div>Initial hospitalization during acute COVID-19 infection is significantly associated with post-COVID fatigue <strong><em>(p-value 0.007*)</em></strong>. No significant associations were found for risk factors like diabetes and hypertension. EBV replication observed was due to EBV reactivation rather than primary infection. EBV-specific antibody titers EBNA-1 IgG (p-value 0.004*) and EA-D IgG <strong><em>(p-value 0.008*)</em></strong>. 40/140 (28.6 %) patients with COVID-19 with persistent fatigue showed EBV reactivation in contrast to 9/80 (11.3 %) of controls <strong><em>(P-value 0.003*)</em></strong> using the same detection methods.</div></div><div><h3>Conclusion</h3><div>EBV reactivation plays a role in Long-COVID syndrome following COVID-19 infection supporting the usage of EBV inhibitors for long-term COVID-19 treatment.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 442-446"},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}