{"title":"Post-earthquake dizziness syndrome (PEDS): A comprehensive review of recent advances","authors":"Toru Miwa , Keishi Fujiwara , Hidetake Matsuyoshi , Yasuyuki Nomura","doi":"10.1016/j.anl.2025.04.003","DOIUrl":"10.1016/j.anl.2025.04.003","url":null,"abstract":"<div><div>Earthquakes pose significant health challenges, including post-earthquake dizziness syndrome (PEDS), which is characterized by dizziness, vertigo, imbalance, nausea, and motion sensations. This review aimed to examine the intricate relationships between earthquake characteristics, building types, and dizziness, with a particular focus on the function of the autonomic nervous system in mediating these effects. The prevalence of PEDS varies based on earthquake magnitude, demographics, and environmental conditions, affecting 20–40 % of the population in regions such as Hokkaido, Kumamoto, Türkiye, Georgia, Fukushima, and Nepal. Its pathophysiology involves vestibular dysfunction, such as otolithic disturbances and benign paroxysmal positional vertigo; environmental instability from tilted or damaged structures; and psychological stress, which disrupts the vestibular, proprioceptive, and autonomic systems. Building dynamics influence the symptoms, with high-rise swaying, rigid low-rise jolts, and damaged structures exacerbating vestibular overload. Low-frequency quakes affect tall buildings, whereas high-frequency quakes affect rigid buildings, with aftershocks prolonging recovery. The autonomic nervous system plays a crucial role, with heightened sympathetic activity linked to dizziness and stress, thereby creating a feedback loop. Management strategies include seismic retrofitting, vestibular rehabilitation therapy, and psychological interventions such as cognitive-behavioral therapy, pharmacological treatments, and environmental adjustments to reduce sensory conflicts. Public education and preparedness are vital for minimizing panic and improving resilience, emphasizing the need for multidisciplinary approaches that combine engineering, medical, and psychological strategies to mitigate earthquake-related dizziness.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 253-257"},"PeriodicalIF":1.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic surgical strategy for highly vascular pediatric sinonasal and pterygopalatine fossa tumors","authors":"Aiko Shimizu , Seiichiro Makihara , Minori Noda, Aya Murai, Mizuo Ando","doi":"10.1016/j.anl.2025.04.006","DOIUrl":"10.1016/j.anl.2025.04.006","url":null,"abstract":"<div><div>Pediatric sinonasal tumors are rare, and minimally invasive approaches are preferred because of unknown long-term effects on development. We report three cases of highly vascular pediatric sinonasal and pterygopalatine fossa tumors that were successfully removed using an endonasal endoscopic approach with transcatheter arterial embolization (TAE). The patients (9–11 years old) had contrast-enhanced tumors in the left ethmoid sinus near the sphenopalatine foramen in case 1, in the right nasal cavity near the sphenopalatine foramen in case 2, and in the right pterygopalatine fossa in case 3, with diameters of 32, 50, and 61 mm, respectively. Computed tomography and magnetic resonance imaging demonstrated tumors with strong contrast enhancement and flow voids in all cases. TAE was performed in all cases on the day of surgery, followed by endoscopic sinus surgery with nasal septal modification. Pathology revealed pyogenic granuloma, nasal polyps, and juvenile angiofibroma. After TAE, tumor reduction improved visualization in case 1. Nasal septum manipulation enabled medial traction and tumor base identification in cases 2 and 3. The combination of preoperative TAE and septal modification proved effective for achieving complete endoscopic tumor removal. No complications occurred, and follow-up at 1–1.5 years showed no tumor recurrence or developmental abnormalities.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 243-247"},"PeriodicalIF":1.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of intratympanic steroid injection as salvage therapy for idiopathic sudden sensorineural hearing loss","authors":"Yasutoshi Komatsubara , Tomoyasu Tachibana , Yuko Kataoka , Akifumi Kariya , Chieko Furukawa , Asuka Sato , Yuto Naoi , Mizuo Ando","doi":"10.1016/j.anl.2025.03.006","DOIUrl":"10.1016/j.anl.2025.03.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Although several studies have reported the benefits of intratympanic steroid injection (ISI) in the treatment of idiopathic sudden sensorineural hearing loss (SSHL), its effectiveness remains controversial. The purpose of this study was to evaluate the efficacy of ISI as a salvage therapy for SSHL and identify factors associated with treatment outcomes.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the medical records of 119 patients who received systemic steroids for the treatment of SSHL at our hospital between 2014 and 2023. Of the 76 patients who were not complete recovery after systemic administration, 56 were treated using ISI as a salvage therapy.</div></div><div><h3>Results</h3><div>Among the 76 patients who were not complete recovery after systemic administration, a short period between onset and systemic steroid administration (<4 days) showed favorable treatment effects (<em>p</em> = 0.020). We focused on the 56 patients treated using salvage ISI therapy to evaluate the prognostic factors affecting the efficacy of ISI therapy. The mean hearing loss values were 84.1 dB at the initial visit, 70.7 dB on completion of systemic steroid administration, and 61.8 dB at the final evaluation after ISI. In the univariate analysis, patients who received ISI <23 days after SSHL onset, those who had a hearing loss of ≥60 dB at the initial visit, and those who presented with vertigo at the initial presentation had better hearing recovery with ISI than those who did not (<em>p</em> < 0.01, <em>p</em> = 0.021, and <em>p</em> = 0.052, respectively). Multivariate analysis revealed that a period of <23 days from onset to salvage therapy was independently associated with favorable ISI effects (<em>p</em> = 0.032).</div></div><div><h3>Conclusions</h3><div>In patients with SSHL, the introduction of salvage ISI therapy <23 days after onset contributes to good hearing recovery. In addition, salvage ISI therapy might be an optional treatment for patients whose hearing loss is ≥60 dB at the initial visit or who present with vertigo at the initial examination.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 248-252"},"PeriodicalIF":1.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Speech-swallow dissociation in velopharyngeal closure for differentiating amyotrophic lateral sclerosis and myasthenia gravis","authors":"Hiroshi Yaguchi , Shinji Miyagawa , Ryoji Nakada , Sumire Yamamoto , Kenichi Sakuta","doi":"10.1016/j.anl.2025.03.003","DOIUrl":"10.1016/j.anl.2025.03.003","url":null,"abstract":"<div><h3>Objective</h3><div>Speech-swallow dissociation (SSD) in velopharyngeal closure on laryngoscopy is a sign of pseudobulbar palsy. We hypothesized that this finding could differentiate amyotrophic lateral sclerosis (ALS) from myasthenia gravis (MG). This study aimed to identify laryngoscopic findings useful in differentiating these two diseases.</div></div><div><h3>Methods</h3><div>ALS and MG patients with bulbar symptoms who underwent fiberoptic laryngoscopy in our hospital were retrospectively examined. The following laryngoscopic items were evaluated: velopharyngeal incompetence (VPI) in phonation and swallowing, pharyngeal constriction, vocal cord movement, and salivary status.</div></div><div><h3>Results</h3><div>One hundred seven patients (70 with ALS and 37 with MG) were included for analysis. The prevalence of VPI in phonation was significantly higher in the ALS group (40 % vs. 19 %; <em>P</em> = 0.027). The prevalence of SSD in velopharyngeal closure was also significantly higher in the ALS group (33 % vs. 3 %; <em>P</em> < 0.001). The other laryngoscopic findings did not differ between the groups. Multivariate logistic regression showed that SSD in velopharyngeal closure was independently associated with ALS (odds ratio, 26.64; 95 % confidence interval, 2.24–317.58; <em>P</em> = 0.009).</div></div><div><h3>Conclusion</h3><div>SSD in velopharyngeal closure is useful for differentiating ALS from MG.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 239-242"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of detecting and autotransplanting parathyroid gland with near-infrared imaging during total laryngectomy with total thyroidectomy","authors":"Takeshi Takahashi , Kohei Otaki , Shusuke Ohshima , Yuto Takahashi , Ryoko Tanaka , Kohei Saijo , Jo Omata , Yusuke Yokoyama , Ryusuke Shodo , Yushi Ueki , Keisuke Yamazaki , Hiroshi Matsuyama , Arata Horii","doi":"10.1016/j.anl.2025.03.004","DOIUrl":"10.1016/j.anl.2025.03.004","url":null,"abstract":"<div><h3>Objective</h3><div>Persistent postoperative hypoparathyroidism (hypoPT) after total thyroidectomy (TT) is a serious complication necessitating lifelong treatment. HypoPT would be more serious when combined with total laryngectomy (TL), since in situ preservation nor autotransplantation of parathyroid glands (PGs) is not always attempted. This study examined the accuracy of identifying PGs using near-infrared fluorescence imaging (NIFI) and assessed the oncological safety and impact of PG autotransplantation on hypoPT in TL+TT.</div></div><div><h3>Methods</h3><div>This prospective study was conducted between June 2020 and November 2023 at three hospitals in Niigata, Japan. Twelve patients who underwent TL+TT were included. Specimens were evaluated for autofluorescence (AF) using NIFI ex vivo followed by histological examination. Levels of albumin-corrected calcium and intact parathyroid hormone (PTH) were monitored postoperatively.</div></div><div><h3>Results</h3><div>Twenty-nine AF-positive tissues were identified as possible PGs using NIFI. Histological examination revealed that 27 were PGs and 2 were adipose tissues: 0–5 (median=2) PGs were autotransplanted per patient. All 272 tissues isolated as lymph nodes by the surgeon's visual inspection were negative for AF, none of which were PGs by histological examinations. Therefore, NIFI exhibited 100 % sensitivity and 99 % specificity for PG identification. The rate of persistent postoperative hypoPT was 33 % (4/12). After a median follow-up of 42 months (range 16–54 months), no tumor recurrence was observed in the sites of parathyroid autotransplantation.</div></div><div><h3>Conclusion</h3><div>This study demonstrated the high accuracy of NIFI in identifying PGs during TL+TT. PG autotransplantation with NIFI assistance emerged as a viable technique for mitigating postoperative hypoPT in TL+TT procedures.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 234-238"},"PeriodicalIF":1.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detailed evaluation of the risk of infraorbital nerve injury in postoperative maxillary cyst surgery","authors":"Takashi Fukumura , Kosuke Takabayashi , Kosuke Akiyama , Yasushi Samukawa , Hiroshi Hoshikawa","doi":"10.1016/j.anl.2025.03.005","DOIUrl":"10.1016/j.anl.2025.03.005","url":null,"abstract":"<div><h3>Objective</h3><div>Postoperative maxillary cyst (POMC) develops as a delayed complication after radical surgery. The infraorbital nerve (ION) is a terminal branch of the trigeminal nerve and is one of the low-frequency collateral injuries that may occur in maxillary sinus surgery. The risk of ION injury may increase during POMC surgery due to anatomical variations: however, this has not yet been examined in detail. Therefore, we herein investigated variations in the ION in POMC cases with a focus on its relationship with the aperture site of the cyst, to clarify the risk of injury.</div></div><div><h3>Methods</h3><div>A multifacility retrospective study was conducted between May 2014 and December 2023 on patients who underwent POMC surgery in Kagawa Medical University or Japanese Red Cross Asahikawa Hospital. Preoperative coronal CT images were reviewed from the viewpoint of anatomical variations in the ION and the risk of nerve injury.</div></div><div><h3>Results</h3><div>Eighty-four patients (95 sides), including 11 bilateral cases, were eligible. The presence of several risk factors for nerve injury was evaluated. The following outcomes were noted: contact between the opening site and ION (27.4 %), bony erosion of the infraorbital canal (35.8 %), descent of the ION from the orbital floor (16.8 %), and obscuration of the nerve run (17.9 %). The risk of injury was classified based on the results of imaging evaluations as follows: no risk (69 cases, 72.6 %), low risk (16 cases, 16.8 %), moderate risk (6 cases, 6.3 %), and high risk (4 cases, 4.2 %). A retrospective review revealed that ION injury occurred in only 1 patient (1.4 %) who was categorized as high risk.</div></div><div><h3>Conclusion</h3><div>Although the overall risk of ION injury is not very high, it is important to note that it may occur in some cases without precautions. Therefore, detailed CT with a focus on the ION to preoperatively assess the risk of nerve injury is important.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 229-233"},"PeriodicalIF":1.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takuma Hisaoka , Jun Suzuki , Ryoukichi Ikeda , Ai Hirano-Kawamoto , Jun Ohta , Yukio Katori
{"title":"Association between the Hospital Anxiety and Depression Scale and Swallowing Function in Dysphagic Patients in Japan","authors":"Takuma Hisaoka , Jun Suzuki , Ryoukichi Ikeda , Ai Hirano-Kawamoto , Jun Ohta , Yukio Katori","doi":"10.1016/j.anl.2025.03.001","DOIUrl":"10.1016/j.anl.2025.03.001","url":null,"abstract":"<div><h3>Objective</h3><div><strong>:</strong> Dysphagia affects 2.3 %–16 % of the general population and increases with age. It can lead to malnutrition, weight loss, aspiration pneumonia, and emotional symptoms such as anxiety and depression. Mental health disorders impact appetite and muscle mass, further worsening dysphagia. Additionally, cultural and economic factors influence anxiety and depression, which can either result from or contribute to dysphagia. Studies on the relationship between anxiety, depression, and swallowing function using FEES are limited in Asian populations. The Hospital Anxiety and Depression Scale (HADS) is a useful tool for assessing mood disorders. Therefore, in this study, we aimed to investigate the associations among anxiety, depression, and swallowing function in Japanese patients with dysphagia using HADS.</div></div><div><h3>Methods</h3><div><strong>:</strong> Data on age; sex; HADS; Eating Assessment Tool-10 (EAT-10); Functional Oral Intake Scale (FOIS); tongue pressure; Hyodo score, a scoring system for evaluating the swallowing function determined by flexible endoscopic evaluation of swallowing (FEES); and videofluoroscopic dysphagia scale (VDS), assessed by videofluoroscopic swallowing study, were collected and analyzed from medical records. Hyodo score consists of four parameters: (1) salivary pooling in the vallecula and piriform sinuses; (2) glottal closure reflex or cough reflex induced by touching the epiglottis or arytenoid; (3) swallowing reflex induced by colored water; and (4) extent of pharyngeal clearance after colored water is swallowed. The Mann–Whitney U test, Fisher's exact test, and multiple logistic regression analyses were used to estimate associations between HADS and swallowing function.</div></div><div><h3>Results</h3><div><strong>:</strong> No significant relationships were observed between the EAT-10, FOIS, and VDS with HADS scores. Patients with depression were associated with a significantly higher percentage of anorexia complaints (<em>p</em> = 0.047). Lower tongue pressure was observed in patients with depression than in patients without depression (<em>p</em> = 0.002). Patients with anxiety had better swallowing function, as assessed by the Hyodo score (<em>p</em> = 0.047). Fluid clearance, a component of the Hyodo score, was significantly better in patients with anxiety (<em>p</em> = 0.03) even after propensity score matching adjusted for the effects of age, sex, and fluid clearance.</div></div><div><h3>Conclusion</h3><div><strong>:</strong> In patients with anxiety, swallowing function assessed by FEES was favorable, whereas a higher proportion of patients with depression reported decreased appetite, and lower tongue pressure. This discrepancy between subjective dysphagia and FEES findings suggests that patients with anxiety may underestimate their swallowing function.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 222-228"},"PeriodicalIF":1.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sae Hatomi, Makoto Hosoya, Masafumi Ueno, Marie N Shimanuki, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi
{"title":"A small vestibular schwannoma with preoperative facial palsy treated via retrolabyrinthine approach","authors":"Sae Hatomi, Makoto Hosoya, Masafumi Ueno, Marie N Shimanuki, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi","doi":"10.1016/j.anl.2025.03.002","DOIUrl":"10.1016/j.anl.2025.03.002","url":null,"abstract":"<div><div>Facial nerve paralysis caused by a vestibular schwannoma is a rare but critical symptom; however, few reports have focused on preoperative facial nerve palsy from the viewpoint of treatment. In addition, its mechanism is not fully understood. We report a rare case of preoperative facial nerve palsy that improved after the surgical resection of a small vestibular schwannoma with hearing preservation. A small vestibular schwannoma within the internal auditory canal caused acute deafness and facial paralysis in a 51-year-old woman. Conservative treatment was initially administered, but severe hearing loss and facial paralysis persisted for 3 months after onset. Subsequently, we performed tumor resection using the retrolabyrinthine approach. The tumor, which compressed the cochlear and facial nerves, was almost completely removed under continuous intraoperative monitoring to preserve the facial nerve function. “Wait and scan” is generally recommended for vestibular schwannomas within the internal auditory canal. However, this case suggests that early successful surgery, at least in selected cases, can improve paralysis without hearing deterioration and maintain the patient's quality of life.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 216-221"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Over three-year outcomes of Bonebridge implantation in children and adolescents with congenital bilateral conductive hearing loss","authors":"Yuan Wang, Jikai Zhu, Yujie Liu, Danni Wang, Shouqin Zhao","doi":"10.1016/j.anl.2025.02.007","DOIUrl":"10.1016/j.anl.2025.02.007","url":null,"abstract":"<div><h3>Objective</h3><div>Investigation of the long-term performance and safety of Bonebridge in children and adolescents with congenital bilateral conductive hearing loss (BCHL) over 3 years post-implantation.</div></div><div><h3>Methods</h3><div>20 children and adolescents diagnosed with congenital BCHL underwent Bonebridge implantation over 36 months were enrolled. Preoperative and final follow-up pure-tone average (PTA) results were recorded, and whether postoperative complications occurred. All patients tested under two listening conditions: (1) unaided, (2) Bonebridge aided. The speech reception thresholds (SRTs), speech discrimination scores (SDSs) and sound field hearing thresholds (SFHTs) were measured. The mean absolute error (MAE) of sound source localization was calculated to assess the sound localization accuracy.</div></div><div><h3>Results</h3><div>The median age of 20 patients underwent Bonebridge implantation was 9 years old, and follow-up time was 55 months. There were no difference in PTA air conduction and bone conduction between preoperative with postoperative. The performance in SRTs, SDSs and SFHTs were significantly higher in the Bonebridge aided condition than that in the unaided. Concerning sound source localization, the accuracy of localization exhibited a sharp decline when using a single side Bonebridge. However, their sound localization abilities on the Bonebridge implantation same side remained unaffected. One patient had implant exposure, and completed the experiment with the exposed Bonebridge, then underwent a revision surgery. All other complications were resolved by conservative treatment.</div></div><div><h3>Conclusion</h3><div>The performance and safety of Bonebridge were established in children and adolescents with congenital BCHL over 3 years post-implantation.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 207-215"},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}