Auris Nasus Larynx最新文献

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Speaking fundamental frequency and Voice Handicap Index subscales after cricothyroid approximation in transgender women: A retrospective cohort study. 跨性别女性环甲环甲近似后的说话基本频率和声音障碍指数亚量表:一项回顾性队列研究。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-21 DOI: 10.1016/j.anl.2026.08.011
Yasunori Maeda, Kazuhiro Nakamura, Hisashi Hasegawa, Marin Yoshida, Marino Otsuka, Takeshi Oshima, Shinsuke Suzuki
{"title":"Speaking fundamental frequency and Voice Handicap Index subscales after cricothyroid approximation in transgender women: A retrospective cohort study.","authors":"Yasunori Maeda, Kazuhiro Nakamura, Hisashi Hasegawa, Marin Yoshida, Marino Otsuka, Takeshi Oshima, Shinsuke Suzuki","doi":"10.1016/j.anl.2026.08.011","DOIUrl":"https://doi.org/10.1016/j.anl.2026.08.011","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the speaking fundamental frequency (SFF) and Voice Handicap Index-30 (VHI-30) scores, including physical, functional, and emotional subscales in transgender women undergoing cricothyroid approximation (CTA) under local anesthesia.</p><p><strong>Methods: </strong>In this single-center, retrospective study, we enrolled 14 transgender women who underwent CTA between April 2019 and March 2024. All surgeries were performed under local anesthesia, with intraoperative voice monitoring. The SFF and VHI-30 scores were assessed preoperatively and at 3 months postoperatively. Data were expressed as medians and interquartile ranges [IQR; 25th-75th percentiles]. Statistical comparative analysis was performed using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>The SFF values significantly increased from 145.5 Hz [123.8-163.8] preoperatively to 212 Hz [206.5-231.3] postoperatively (P < 0.05). The total VHI-30 score decreased significantly from 62.5 [45.5-84.0] to 32 [15.3-59.8] (P < 0.05). Subscale analysis revealed significant improvements in the functional (21 [12.8-33.8] to 10.5 [8.0-19.8]) and emotional subscales (25 [18.3-30.8] to 8.5 [1.3-21.0]) (P < 0.05). However, no significant changes were observed in the physical subscale (15.5 [8.0-21.3] to 12 [7.3-18.5]; P = 0.14).</p><p><strong>Conclusion: </strong>CTA under local anesthesia significantly improved SFF and ameliorated voice-related distress, particularly in the functional and emotional subscales, whereas no significant changes were observed in the physical subscale. These findings underscore the utility of VHI-30 subscale analysis in identifying patient-specific concerns and support the development of personalized and gender-affirming voice interventions in transgender women.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic morphological changes in oropharyngeal secondary syphilis documented over 56 days. 口咽二期梅毒的动态形态学改变记录超过56天。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-18 DOI: 10.1016/j.anl.2026.09.004
Eri Takahashi, Masami Suzuki, Naohiro Yoshida
{"title":"Dynamic morphological changes in oropharyngeal secondary syphilis documented over 56 days.","authors":"Eri Takahashi, Masami Suzuki, Naohiro Yoshida","doi":"10.1016/j.anl.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.anl.2026.09.004","url":null,"abstract":"<p><p>Secondary syphilis is known for its diverse mucocutaneous manifestations; however, detailed chronological documentation of oropharyngeal lesions is extremely limited. We report the case of a man in his 20 s who presented with mucous patches that were initially suspected to represent an oropharyngeal tumor. Although syphilis was clinically suspected at the initial visit, the patient declined serological testing and was advised to refrain from sexual activity. Serial endoscopic observations over 56 days demonstrated dynamic morphological changes, including spontaneous regression, subsequent exacerbation, and near-complete resolution without treatment. Secondary syphilis was subsequently confirmed by serological testing. The prolonged untreated period resulted from the patient's refusal to undergo testing rather than a failure to recognize the disease. To our knowledge, this is the first report to document and illustrate the chronological morphological evolution of oropharyngeal lesions in a single patient with secondary syphilis through sequential endoscopic examinations. This case highlights that transient improvement does not exclude active disease and underscores the importance of considering syphilis in the differential diagnosis of fluctuating oropharyngeal lesions.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular targeted therapy for thyroid cancer in Japan: Current status and future perspectives. 日本甲状腺癌分子靶向治疗的现状与展望
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-18 DOI: 10.1016/j.anl.2026.09.003
Sueyoshi Moritani
{"title":"Molecular targeted therapy for thyroid cancer in Japan: Current status and future perspectives.","authors":"Sueyoshi Moritani","doi":"10.1016/j.anl.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.anl.2026.09.003","url":null,"abstract":"<p><p>Since the introduction of sorafenib in 2014 and lenvatinib in 2015, multikinase inhibitors (MKIs) have substantially advanced systemic therapy for patients with radioactive iodine-refractory differentiated thyroid cancer (RAI-R DTC) in Japan. More recently, the clinical introduction of molecularly targeted agents, including BRAF/MEK inhibitors, selective RET inhibitors, and TRK inhibitors, has shifted therapeutic strategies from predominantly histology-based treatment toward molecularly guided precision medicine. However, because most driver alterations in thyroid cancer are mutually exclusive, only a limited subset of patients is eligible for each targeted agent. Therefore, in addition to appropriate molecular testing for treatment selection, optimizing the selection and sequencing of MKIs and genotype-directed therapies has become an important challenge in improving clinical outcomes. This review summarizes the current evidence supporting targeted therapies available in Japan, the roles of companion diagnostics and comprehensive genomic profiling (CGP), and treatment strategies based on actionable driver alterations. We further discuss emerging therapeutic approaches, including redifferentiation therapy, neoadjuvant therapy, and conversion surgery, as well as the remaining challenges and future directions of precision medicine for thyroid cancer.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct cerebellar and inner-ear phenotypes in Atoh1 promoter-proximal deletion mice. Atoh1启动子-近端缺失小鼠不同的小脑和内耳表型。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-18 DOI: 10.1016/j.anl.2026.09.005
Susumu Sakamoto, Tomoko Kita, Mayumi Yamada, Itaru Imayoshi, Tomoko Tateya
{"title":"Distinct cerebellar and inner-ear phenotypes in Atoh1 promoter-proximal deletion mice.","authors":"Susumu Sakamoto, Tomoko Kita, Mayumi Yamada, Itaru Imayoshi, Tomoko Tateya","doi":"10.1016/j.anl.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.anl.2026.09.005","url":null,"abstract":"<p><strong>Objective: </strong>Atoh1 is essential for the development of the cerebellum and inner ear, but the in vivo role of its promoter-proximal region remains incompletely understood. We generated deletion lines targeting the Atoh1 promoter-proximal region containing C sites and examined their phenotypes in the cerebellum and inner ear.</p><p><strong>Methods: </strong>Using the CRISPR-Cas9 genome editing method, mice with deletions in the Atoh1 promoter-proximal region containing C sites were generated, and four independent deletion lines were established. Gross morphology and histology of the cerebellum and inner ear were examined in 2-month-old mice.</p><p><strong>Results: </strong>Four independent deletion alleles were obtained and designated line A to line D in ascending order of deletion size. In the cerebellum, gross examination and sagittal sections showed progressively more severe hypoplasia from line A to line D, accompanied by reduced foliation and disorganization of cortical architecture. The granule cell layer was progressively reduced, whereas Purkinje cells were relatively preserved. Behavioral abnormalities were detected only in the most severely affected line. In the inner ear, the maculae of the otolith organs were relatively preserved across all lines. The ampullary cristae were relatively preserved in lines A-C but showed hair-cell loss in line D. Cochlear phenotypes were more severe: line A retained relatively preserved inner hair cells with reduced outer hair cells, whereas lines B-D showed near-complete loss of hair cells and marked disruption of the organ of Corti in the analyzed regions. Descriptive quantitative analyses of available specimens supported progressive cerebellar hypoplasia, relative macular preservation, line D crista involvement, and severe cochlear hair-cell loss in lines B-D.</p><p><strong>Conclusion: </strong>Deletion of the Atoh1 promoter-proximal region produced distinct tissue-specific phenotypes in vivo. These findings suggest that the Atoh1 promoter-proximal region is differentially required in the cerebellum and inner ear and that its contribution varies among vestibular and cochlear sensory organs.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative pregabalin within an enhanced recovery pathway and postoperative quality of recovery after head and neck cancer surgery with free-flap reconstruction: A pilot study. 围手术期普瑞巴林在头颈癌游离皮瓣重建手术后增强恢复途径和术后恢复质量中的作用:一项初步研究
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-16 DOI: 10.1016/j.anl.2026.09.006
Takayuki Imai, Ayako Nakanome, Sinkichi Morita, Yuya Miyakura, Kento Sasaki, Kohtaro Eguchi, Takeshi Shinozaki, Junya Matsumi, Yukinori Asada, Seiichi Yoshimoto, Kazuto Matsuura
{"title":"Perioperative pregabalin within an enhanced recovery pathway and postoperative quality of recovery after head and neck cancer surgery with free-flap reconstruction: A pilot study.","authors":"Takayuki Imai, Ayako Nakanome, Sinkichi Morita, Yuya Miyakura, Kento Sasaki, Kohtaro Eguchi, Takeshi Shinozaki, Junya Matsumi, Yukinori Asada, Seiichi Yoshimoto, Kazuto Matsuura","doi":"10.1016/j.anl.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.anl.2026.09.006","url":null,"abstract":"<p><strong>Objective: </strong>Patients undergoing major head and neck cancer surgery with free tissue transfer reconstruction (HNS-FTTR) frequently experience impaired postoperative quality of recovery (QoR) despite implementation of Enhanced Recovery After Surgery (ERAS) pathways. Pregabalin has been reported to reduce postoperative pain and opioid consumption and may exert beneficial effects beyond conventional analgesia. This pilot study evaluated the association between perioperative pregabalin administration and postoperative recovery following HNS-FTTR.</p><p><strong>Methods: </strong>This retrospective observational cohort study included 179 patients who underwent HNS-FTTR between January 2022 and June 2026. Twenty-four patients received perioperative pregabalin and were compared with 155 historical controls. To address potential temporal bias, a sensitivity analysis was performed using a contemporary control cohort of 24 patients treated after April 2025. Because this was an exploratory pilot study, no single confirmatory primary endpoint was prespecified. Postoperative recovery was evaluated using the Japanese version of the Quality of Recovery-40 questionnaire (QoR-40J), with global and domain scores assessed on postoperative days (PODs) 2, 4, and 7. Additional exploratory outcomes included pain and postoperative nausea and vomiting (PONV) visual analogue scale (VAS) scores, postoperative analgesic requirements, and serum C-reactive protein levels.</p><p><strong>Results: </strong>In the historical cohort analysis, QoR-40J global scores were significantly higher in the pregabalin cohort on POD2 (150.7 ± 21.9 vs. 140.5 ± 21.4, p = 0.039) and POD7 (164.9 ± 19.9 vs. 154.5 ± 18.0, p = 0.013). Improvements were observed in the Physical Comfort, Emotional State, Physical Independence, and Patient Support domains. No significant differences were identified in postoperative pain or PONV VAS scores. In the sensitivity analysis, improvements in global QoR on POD7 (164.9 ± 19.9 vs. 153.8 ± 16.4, p = 0.048), as well as in the Physical Comfort and Physical Independence domains, were reproduced despite the absence of significant differences in postoperative pain scores. Differences in postoperative analgesic consumption were inconsistent between the historical and contemporary cohort analyses.</p><p><strong>Conclusion: </strong>Perioperative pregabalin administration was associated with improved postoperative QoR following HNS-FTTR, particularly in the domains of physical comfort and physical independence, despite limited effects on postoperative pain intensity. Given the retrospective design, small sample size, and potential for residual confounding, these findings should be considered preliminary and hypothesis-generating and warrant confirmation in prospective randomized controlled trials.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful salvage surgery for BNCT-induced hypopharyngeal fistula with carotid artery protection using a pedicled pectoralis major muscle flap. 应用带蒂胸大肌瓣保护颈动脉,成功挽救bnct诱导的下咽瘘。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-15 DOI: 10.1016/j.anl.2026.09.001
Kenji Shinmi, Shimpei Miyamoto, Makoto Shiraishi, Daichi Kurita, Kou Fujisawa, Mutsumi Okazaki
{"title":"Successful salvage surgery for BNCT-induced hypopharyngeal fistula with carotid artery protection using a pedicled pectoralis major muscle flap.","authors":"Kenji Shinmi, Shimpei Miyamoto, Makoto Shiraishi, Daichi Kurita, Kou Fujisawa, Mutsumi Okazaki","doi":"10.1016/j.anl.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.anl.2026.09.001","url":null,"abstract":"<p><p>Boron Neutron Capture Therapy (BNCT) is an emerging treatment for locally advanced or recurrent head and neck cancer, but severe late complications, including pharyngeal fistula and carotid blowout, may occur. We report a 71-year-old man with a hypopharyngeal fistula 2 mm from the common carotid artery after BNCT for hypopharyngeal squamous cell carcinoma. Progressive necrosis posed a high risk of carotid exposure and rupture, prompting urgent salvage surgery. After debridement, a 15 × 20 mm full-thickness pharyngeal wall defect remained adjacent to the carotid artery. A pedicled pectoralis major muscle flap was wrapped around the carotid artery for circumferential protection, and the mucosal edge was sutured to the muscle body to close the fistula. The exposed muscle surface subsequently epithelialized. Oral intake was resumed after swallowing rehabilitation, with no fistula recurrence, surgical-site complications, or tumor recurrence by postoperative month 9. In carefully selected cases with a localized defect suitable for secondary epithelialization and high risk of carotid blowout, a pedicled muscle flap may represent a useful reconstructive option for carotid protection and fistula closure.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practice patterns and decision-making in pediatric adenoid and/or tonsil surgery in Türkiye: A cross-sectional survey of ENT physicians. <s:1> kiye儿科腺样体和/或扁桃体手术的实践模式和决策:对耳鼻喉科医生的横断面调查。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-08 DOI: 10.1016/j.anl.2026.08.003
Fatma Senturk, Zehra Didem Tıgdas
{"title":"Practice patterns and decision-making in pediatric adenoid and/or tonsil surgery in Türkiye: A cross-sectional survey of ENT physicians.","authors":"Fatma Senturk, Zehra Didem Tıgdas","doi":"10.1016/j.anl.2026.08.003","DOIUrl":"https://doi.org/10.1016/j.anl.2026.08.003","url":null,"abstract":"<p><strong>Objective: </strong>Practices in pediatric adenoid and tonsil surgery may vary substantially across healthcare systems, especially where institutional resources, perioperative support, and access to surgical technologies differ. However, the factors underlying this variability in routine practice remain insufficiently characterized. This study evaluated surgical practice patterns and decision-making factors among otorhinolaryngology (ENT) physicians in Türkiye, with particular emphasis on institutional, safety-related, technological, and medicolegal determinants.</p><p><strong>Methods: </strong>This nationwide, descriptive, cross-sectional, web-based survey used a structured questionnaire distributed through Google Forms. ENT physicians actively practicing in Türkiye were invited through professional platforms. The survey assessed demographic characteristics, surgical procedures and techniques, indications for surgery, reported complications, institutional and safety-related factors, and perceived trends in surgical frequency. Descriptive statistical analyses were performed.</p><p><strong>Results: </strong>A total of 213 ENT physicians were included. Most participants were male (59.2%), had ≥ 20 years of professional experience (55.4%), and worked in private healthcare settings (48.4%). The most frequently performed procedure was adenoidectomy combined with extracapsular tonsillectomy (57.3%). Traditional curettage and cold steel techniques were preferred by 67.1% of participants, and advanced technologies were used less frequently. The predominant indications were upper airway obstruction (95.8%) and recurrent infections (78.4%), consistent with guideline-supported indications. Overall, 88.3% of participants reported encountering at least one perioperative or postoperative complication, most commonly secondary hemorrhage. Institutional readiness, safety concerns, perioperative support, and medicolegal issues were identified as important determinants of surgical decision-making. A perceived decrease in surgical frequency was reported by 64.8% of participants.</p><p><strong>Conclusion: </strong>Decisions about pediatric adenoid and tonsil surgery in routine practice are shaped by guideline-supported clinical indications as well as institutional readiness, access to pediatric perioperative support, technology availability, reimbursement-related barriers, and medicolegal concerns. Although the findings originate from Türkiye, they may be relevant to other healthcare systems where pediatric airway surgery is performed in institutions with variable resources and support infrastructure. Standardized perioperative protocols and institutional capacity building may help reduce practice variability and improve patient safety.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vestibular schwannoma surgery with cochlear implantation under continuous monitoring using the auditory nerve testing system: Three cases with distinct clinical scenarios. 听神经检测系统持续监测下的前庭神经鞘瘤手术伴人工耳蜗植入:临床情况不同的3例。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-09-05 DOI: 10.1016/j.anl.2026.08.010
Makoto Hosoya, Ayumi Yamanaka, Marie N Shimanuki, Masafumi Ueno, Satoshi Suda, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi
{"title":"Vestibular schwannoma surgery with cochlear implantation under continuous monitoring using the auditory nerve testing system: Three cases with distinct clinical scenarios.","authors":"Makoto Hosoya, Ayumi Yamanaka, Marie N Shimanuki, Masafumi Ueno, Satoshi Suda, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi","doi":"10.1016/j.anl.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.anl.2026.08.010","url":null,"abstract":"<p><p>During the simultaneous resection of vestibular schwannomas and cochlear implantation, acoustic nerve preservation is essential. A recent study highlighted the effectiveness of the Auditory Nerve Test System (ANTS) for evaluating cochlear nerve function following vestibular schwannoma resection and for determining its suitability for cochlear implantation. However, the use of this system for the continuous intraoperative monitoring of acoustic nerve preservation has only been documented in one case in the literature. We recently encountered three distinct clinical cases: a case of neurofibromatosis type 2, a medium-sized vestibular schwannoma with contralateral long-term idiopathic hearing loss, and a small vestibular schwannoma with bilateral mitochondrial hearing loss. In all cases, we successfully conducted continuous recordings of electrically evoked auditory brainstem responses during vestibular schwannoma resection. Subsequently, cochlear implantation was performed after tumor resection in all patients. Postoperatively, all three patients demonstrated successful hearing compensation. These findings suggest that the ANTS system is a reliable and effective tool for the continuous monitoring of acoustic nerve preservation during vestibular schwannoma surgery with ipsilateral cochlear implantation.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic criteria and clinical outcomes of chronic nasopharyngitis treated with nasopharyngeal abrasive therapy: A multicenter prospective study. 鼻咽磨料治疗慢性鼻咽炎的诊断标准和临床结果:一项多中心前瞻性研究。
IF 1.8 4区 医学
Auris Nasus Larynx Pub Date : 2026-08-31 DOI: 10.1016/j.anl.2026.08.008
Takumi Kumai, Kensuke Nishi, Ayaki Tanaka, Hitoshi Hagino, Yoshihiro Ohno, Hiroyuki Takezawa, Akira Sakakibara, Tomoko Shintani, Satsuki Araki, Daigo Komazawa, Manabu Mogitate, Yoshinao Nishida, Noriko Nishiwaki, Ryuzo Toriya, Hirobumi Ito, Toshiyuki Kusuyama, Osamu Hotta, Yasuaki Harabuchi
{"title":"Diagnostic criteria and clinical outcomes of chronic nasopharyngitis treated with nasopharyngeal abrasive therapy: A multicenter prospective study.","authors":"Takumi Kumai, Kensuke Nishi, Ayaki Tanaka, Hitoshi Hagino, Yoshihiro Ohno, Hiroyuki Takezawa, Akira Sakakibara, Tomoko Shintani, Satsuki Araki, Daigo Komazawa, Manabu Mogitate, Yoshinao Nishida, Noriko Nishiwaki, Ryuzo Toriya, Hirobumi Ito, Toshiyuki Kusuyama, Osamu Hotta, Yasuaki Harabuchi","doi":"10.1016/j.anl.2026.08.008","DOIUrl":"https://doi.org/10.1016/j.anl.2026.08.008","url":null,"abstract":"<p><strong>Objective: </strong>Chronic nasopharyngitis is an under-recognized clinical condition, although the nasopharynx may serve as a source of persistent local and systemic symptoms. This study aimed to define diagnostic criteria for chronic nasopharyngitis and to prospectively evaluate changes in symptoms and endoscopic changes following nasopharyngeal abrasive therapy (EAT).</p><p><strong>Methods: </strong>A multicenter prospective observational study. Patients with chronic nasopharyngitis treated between April 2022 and March 2025. Of 219 enrolled patients, 175 were included in the final analysis. EAT was administered weekly for two months using a transnasal or transoral cotton swab soaked in 1% zinc chloride. Nasopharyngeal endoscopic findings were prospectively graded using a three-point scoring system. Symptoms were assessed using a visual analog scale (VAS).</p><p><strong>Results: </strong>Chronic nasopharyngitis was defined as persistent nasopharyngeal-related local or systemic symptoms lasting longer than one month, refractory to pharmacologic therapy, with endoscopic evidence of nasopharyngeal inflammation. The most common chief complaints were postnasal drip, general fatigue, and globus sensation. Median VAS scores for chief complaints decreased from 90 at baseline to 60 after one month and to 25 after two months. Improvements in endoscopic findings and symptoms were observed across local and systemic manifestations, including in patients with long COVID. Patients with severe nasopharyngitis demonstrated less pronounced symptom improvement.</p><p><strong>Conclusion: </strong>This multicenter prospective study proposes diagnostic criteria for chronic nasopharyngitis and shows that EAT was associated with improvement in symptoms and endoscopic inflammation. These findings suggest that targeted nasopharyngeal therapy may represent a clinically relevant approach for chronic nasopharyngitis, including cases with systemic symptoms, although controlled studies are required to establish its therapeutic efficacy.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Announcement SPIO Award 2025 2025年SPIO大奖
IF 1.5 4区 医学
Auris Nasus Larynx Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI: 10.1016/S0385-8146(26)00080-5
{"title":"Announcement SPIO Award 2025","authors":"","doi":"10.1016/S0385-8146(26)00080-5","DOIUrl":"10.1016/S0385-8146(26)00080-5","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 3","pages":"Page vi"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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