Auris Nasus Larynx最新文献

{"title":"Evaluation of real-time pharmacokinetics using fluorescence imaging system in Near-infrared photoimmunotherapy for head and neck cancer","authors":"Tsutomu Ueda ,&nbsp;Takayuki Taruya ,&nbsp;Nobuyuki Chikuie ,&nbsp;Akira Ishikawa ,&nbsp;Hiroaki Tahara ,&nbsp;Yuki Sato ,&nbsp;Takayoshi Hattori ,&nbsp;Takao Hamamoto ,&nbsp;Ishino Takashi ,&nbsp;Sachio Takeno","doi":"10.1016/j.anl.2025.05.001","DOIUrl":"10.1016/j.anl.2025.05.001","url":null,"abstract":"<div><h3>Objective</h3><div>Near-infrared photoimmunotherapy (NIR-PIT) is a molecular targeted therapy that utilizes an antibody-photoabsorber conjugate and excitation light. Herein, excitation of antibody-bound IR700 with near-infrared light at 690 nm causes IR700 to undergo a photochemical ligand reaction. IR700’s hydrophilic side chain is released, and the remaining molecules became hydrophobic and lost fluorescence.</div><div>NIR-PIT targeting the epidermal growth factor receptor using cetuximab sarotalocan sodium, and a laser system has been used to treat patients with unresectable head and neck cancers in Japan since 2021. Light irradiates planned treatment area based on preoperative diagnostic imaging; however, the actual drug accumulation and response status during treatment have not been confirmed.</div><div>This study aimed to investigate NIR-PIT’s fluorescence intensity and antitumor effects on head and neck cancer in humans using real-time fluorescence imaging system.</div></div><div><h3>Methods</h3><div>In this single-center prospective observational study, patients with lesions that could be monitored fluorescence were enrolled. Fluorescence intensity during NIR-PIT and tumor characteristics before and after treatment were examined.</div></div><div><h3>Results</h3><div>Seven patients were included. The fluorescence intensity of the irradiated area showed a rapid decrease in the early stage of treatment, followed by a gradual decrease, almost reaching a plateau before the end of light irradiation. The irradiated areas demonstrated no fluorescence following re-irradiation, and areas irradiated in duplicate tended to lose fluorescence more rapidly than the non-overlapping areas.</div></div><div><h3>Conclusion</h3><div>We observed and measured the drug accumulation and responses during treatment in humans using real-time fluorescence imaging. This information is expected to be applied to evaluate efficacy of NIR-PIT.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 346-353"},"PeriodicalIF":1.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial cell dynamics: Key drivers of type 2 inflammation in eosinophilic chronic rhinosinusitis","authors":"Tsuguhisa Nakayama,&nbsp;Yasuhiro Tsunemi,&nbsp;Takashi Kashiwagi","doi":"10.1016/j.anl.2025.05.009","DOIUrl":"10.1016/j.anl.2025.05.009","url":null,"abstract":"<div><div>Sinonasal mucosal epithelial cells act not only as a physical barrier, but also as dynamic regulators of immune responses through innate and acquired immunity. These cells play a key role in detecting environmental stimuli, such as pathogens, allergens, and pollutants, and in initiating the inflammatory cascade that shapes the overall immune response. By releasing cytokines, such as interleukin (IL)-25 and IL-33, and thymic stromal lymphopoietin, epithelial cells interact with immune cells and promote type 2 inflammation.</div><div>The pathogenesis of eosinophilic chronic rhinosinusitis (ECRS), which is driven by type 2 inflammation, is heterogeneous. While immune cells have traditionally been considered to be central to the disease pathogenesis, emerging evidence has indicated the critical role of epithelial cells. Furthermore, novel biologics targeting the IL-4/IL-13 signaling pathway have shown potential in alleviating epithelial dysfunction and inflammation. Eosinophilic mucins that accumulate in the sinuses impair mucociliary function, and especially eosinophil extracellular trap cell death (EETosis) stimulate epithelial cells and amplify eosinophilic inflammation. Eosinophilic mucin formation has been shown to significantly increase viscosity through EETosis, and novel biologics targeting the IL-5 signaling pathway hold promise for effectively mitigating this process.</div><div>To develop targeted interventions, it is important to explore the role of epithelial subpopulations, such as basal cells and tuft cells, in maintaining the balance between tissue repair and chronic inflammation. Single-cell transcriptomics and spatial transcriptomics technologies have provided significant insights into the complexity of epithelial cell-derived inflammation in ECRS. The heterogeneity of the pathogenesis of CRS with nasal polyps and ECRS across patient populations complicates the development of universal therapies, underscoring the need for stratified medicine approaches. Potential future therapeutic strategies include the restoration of epithelial integrity and immune balance by disrupting aberrant crosstalk between epithelial and immune cells, particularly in patients unresponsive to current treatments.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 354-361"},"PeriodicalIF":1.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review on postoperative voice therapy for benign vocal fold lesions","authors":"Maria Angela S. Dealino ,&nbsp;Rumi Ueha ,&nbsp;Mamiko Otsuka ,&nbsp;Asako Kaneoka ,&nbsp;Takao Goto ,&nbsp;Kenji Kondo","doi":"10.1016/j.anl.2025.04.016","DOIUrl":"10.1016/j.anl.2025.04.016","url":null,"abstract":"<div><h3>Objective</h3><div>This scoping review aims to identify and map the available evidence on postoperative voice therapy specifically for vocal fold nodules, polyps, cysts, Reinke’s edema, papilloma, and granuloma.</div></div><div><h3>Methods</h3><div>This scoping review followed the Preferred Reporting Items for Systematic reviews and Meta-Analysis extension for Scoping Reviews, 2018. A search of PubMed/MEDLINE, Scopus and Cochrane databases was conducted using Medical Subject Headings when appropriate, free text, and Boolean operators. Two reviewers manually screened each record, and each report was considered based on the predetermined inclusion and exclusion criteria. The same reviewers manually reviewed the collected data from each report. The following data were collected from each paper after piloting a data collection form: first author, year, geographic location, study design, number of participants, vocal fold lesion studied, details of voice therapy, outcome measures, results, and conclusion.</div></div><div><h3>Results</h3><div>The final number of articles included in the review was 22. The earliest article published included in the review was from 1988. Studies were clustered in certain geographic locations. Case series was the most frequent study design employed, and there was a dearth of experimental studies.</div></div><div><h3>Conclusion</h3><div>This scoping review reveals the paucity of literature on postoperative voice therapy techniques for benign vocal fold lesions. Standardization in outcome measures, use of multidimensional assessment, and improvement in reporting of interventions are needed. Strategies for postoperative voice therapy to improve voice function after phonosurgery have yet to be clearly established, and this is a clinical issue that needs to be addressed in the future.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 336-341"},"PeriodicalIF":1.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven cases of total laryngo-glossectomy combined with mandibulectomy: A retrospective case series from a single institution","authors":"Hidenori Kato ,&nbsp;Takao Hamamoto ,&nbsp;Hiroaki Tahara ,&nbsp;Takayoshi Hattori ,&nbsp;Yuki Sato ,&nbsp;Nobuyuki Chikuie ,&nbsp;Takayuki Taruya ,&nbsp;Takashi Ishino ,&nbsp;Shogo Nagamatsu ,&nbsp;Tsutomu Ueda ,&nbsp;Sachio Takeno","doi":"10.1016/j.anl.2025.05.003","DOIUrl":"10.1016/j.anl.2025.05.003","url":null,"abstract":"<div><h3>Objective</h3><div>In cases of tongue, gingival, or base of tongue cancer with mandibular tumor invasion, total laryngo-glossectomy and mandibulectomy may be necessary. However, since such cases are limited in number, very few cases have been reported. This study aimed to investigate the treatment strategy involving total laryngo-glossectomy combined with mandibulectomy.</div></div><div><h3>Methods</h3><div>This study included patients with head and neck cancer who underwent radical surgery involving total laryngo-glossectomy combined with partial mandibulectomy between January 2014 and December 2023. We investigated the sex, age, primary lesion location, tumor-node-metastasis classification, history of radiation exposure, preoperative/postoperative treatments, surgical methods for resection and reconstruction, extent of neck dissection, surgical duration, blood loss volume, perioperative complications, time to resume oral intake post-surgery, length of hospital stay, duration of follow-up observation, and outcomes.</div></div><div><h3>Results</h3><div>Seven patients who underwent total laryngo-glossectomy combined with partial mandibulectomy were included in this study. The median age at the time of surgery was 57 years (six males and one female). Four patients had floor of the mouth cancer, two had gingival cancer, and one had dual primary cancer involving the tongue and hypopharynx. Two patients had a history of radiation therapy for other head and neck cancers. Five patients received induction chemotherapy with docetaxel, cisplatin, and fluorouracil, and four patients received postoperative chemoradiotherapy with cisplatin. Four patients had direct tumor invasion necessitating concurrent resection of the facial skin. Among the patients without prior radiation therapy to the head and neck region, five underwent bilateral neck dissection (I–IV), whereas the remaining patients underwent neck dissection on the affected side only. Reconstruction in all patients involved the free rectus abdominis musculocutaneous flap and a titanium mandibular reconstruction plate. Two patients experienced major leakage owing to suture rupture, and both recovered following negative pressure wound therapy. The median time to resumption of oral intake after surgery was 12.5 days, and the median hospital stay was 38 days. The median follow-up period was 26 months, with four patients remaining disease-free, one experiencing recurrence, and two succumbing to their primary disease.</div></div><div><h3>Conclusion</h3><div>Long-term survival can be anticipated with appropriate treatment, even in cases of total laryngo-glossectomy combined with partial mandibulectomy. In addition, to facilitate post-treatment oral intake, it is crucial to thoroughly evaluate the reconstruction methods, materials, and forms in a larger number of cases.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 327-335"},"PeriodicalIF":1.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a ground truth for a convolutional neural network-based segmentation of anatomical structures in endoscopic ear surgery videos","authors":"Mickey Kondo ,&nbsp;Carlo Russo ,&nbsp;Matthew Fadhil ,&nbsp;Ben Hunter ,&nbsp;Leon Chen ,&nbsp;Rhea Darbari Kaul ,&nbsp;Priyanka Rana ,&nbsp;Yang Song ,&nbsp;Nicholas Jufas ,&nbsp;Antonio Di Ieva ,&nbsp;Nirmal Patel","doi":"10.1016/j.anl.2025.04.013","DOIUrl":"10.1016/j.anl.2025.04.013","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop a ground truth for a convolutional neural network-based segmentation of the stapes, chorda tympani and facial nerve in endoscopic ear surgery videos, and to evaluate the accuracy of artificial intelligence (AI) predictions on test videos.</div></div><div><h3>Methods</h3><div>Forty prospectively-gathered endoscopic ear tympanotomy videos were segmented to establish a ground truth. This ground truth was used to prime a convolutional neural network (CNN) to predict the stapes, chorda tympani and facial nerve. The CNN was then tested on an unlabeled series of videos, and the accuracy of predictions compared to ground truth labeling by calculating Dice scores, sensitivity and specificity.</div></div><div><h3>Results</h3><div>An overall Dice score of 77.94 % across all three elements was obtained, with a sensitivity of 78.42 % and specificity of 99.79 %.</div></div><div><h3>Conclusion</h3><div>Convolutional neural network analysis is effective at identifying key anatomical structures in endoscopic ear surgery videos. Further validation of the CNN on additional video datasets is necessary to optimize model performance.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 342-345"},"PeriodicalIF":1.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital health technologies in swallowing care from screening to rehabilitation: A narrative review","authors":"Isaac L. Alter ,&nbsp;Carla Dias ,&nbsp;Jack Briano,&nbsp;Anaïs Rameau","doi":"10.1016/j.anl.2025.05.002","DOIUrl":"10.1016/j.anl.2025.05.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Digital health technologies (DHTs) have rapidly advanced in the past two decades, through developments in mobile and wearable devices and most recently with the explosion of artificial intelligence (AI) capabilities and subsequent extension into the health space. DHT has myriad potential applications to deglutology, many of which have undergone promising investigations and developments in recent years. We present the first literature review on applications of DHT in swallowing health, from screening to therapeutics. Public health interventions for swallowing care are increasingly needed in the setting of aging populations in the West and East Asia, and DHT may offer a scalable and low-cost solution.</div></div><div><h3>Methods</h3><div>A narrative review was performed using PubMed and Google Scholar to identify recent research on applications of AI and digital health in swallow practice. Database searches, conducted in September 2024, included terms such as “digital,” “AI,” “machine learning,” “tools” in combination with “deglutition,” “Otolaryngology,” “Head and Neck,” “speech language pathology,” “swallow,” and “dysphagia.” Primary literature pertaining to digital health in deglutology was included for review.</div></div><div><h3>Results</h3><div>We review the various applications of DHT in swallowing care, including prevention, screening, diagnosis, treatment planning and rehabilitation.</div></div><div><h3>Conclusion</h3><div>DHT may offer innovative and scalable solutions for swallowing care as public health needs grow and in the setting of limited specialized healthcare workforce. These technological advances are also being explored as time and resource saving solutions at many points of care in swallow practice. DHT could bring affordable and accurate information for self-management of dysphagia to broader patient populations that otherwise lack access to expert providers.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 319-326"},"PeriodicalIF":1.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement SPIO Award 2024","authors":"","doi":"10.1016/S0385-8146(25)00072-0","DOIUrl":"10.1016/S0385-8146(25)00072-0","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Page vi"},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of Reviewers(2024)","authors":"","doi":"10.1016/S0385-8146(25)00071-9","DOIUrl":"10.1016/S0385-8146(25)00071-9","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages iii-v"},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current treatment options for recurrent respiratory papillomatosis: A narrative review","authors":"Shigeyuki Murono","doi":"10.1016/j.anl.2025.04.014","DOIUrl":"10.1016/j.anl.2025.04.014","url":null,"abstract":"<div><div>Recurrent respiratory papillomatosis (RRP) is a chronic disease characterized by papillomatous growths in the airway, predominantly affecting the larynx and trachea. The disease is generally caused by the low-risk types of human papillomavirus (HPV), HPV6 and HPV11. The incidence and prevalence of RRP vary from country to country, and in Japan the incidence is estimated to be 0.20 per 100,000 adults, according to a recent nationwide survey. The most commonly affected region in the larynx is the true vocal folds. Surgery is the standard treatment, although preferred surgical instruments, such as the carbon dioxide laser, microdebrider, and cold instruments, have shifted over time. Currently the microdebrider is the most commonly used instrument in the United States and Europe, while cold instruments are the most common in Japan. The above-mentioned Japanese nationwide survey analyzed the outcomes of 150 newly diagnosed adult RRP patients who underwent surgery as an initial treatment, and showed that the estimated 1-year and 2-year recurrence-free rates according to the Kaplan-Meier curve were 55.8 % and 47.9 %, respectively. Recurrence was also significantly more common in patients with lesions in multiple regions than those with lesion(s) in a single region. Due to the intractable nature of the disease, adjuvant therapy is often required to control it. Although there are no standard drugs that are used with RRP, several agents have been used in clinical practice, including the intralesional injection of cidofovir, the intralesional or systemic injection of bevacizumab, and the HPV vaccine. Immunological approaches that enhance antitumor T-cell responses, such as immune checkpoint inhibitors, have also gained attention. To date, only a few small randomized controlled trials of surgery and pharmacotherapy for RRP have been published. Further research with larger cohorts and longer follow-up periods is needed to determine the appropriate treatment strategy for RRP.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratympanic steroid via saturated gelfoam vs. intratympanic injection for sudden sensorineural hearing loss","authors":"Hasan Canakci,&nbsp;Erhan Arslan,&nbsp;KamilGokce Tulaci,&nbsp;Hasmet Yazici","doi":"10.1016/j.anl.2025.04.015","DOIUrl":"10.1016/j.anl.2025.04.015","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the efficacy of a novel intratympanic steroid (ITS) therapy via saturated Gelfoam® (GSD) in sudden sensorineural hearing loss (SSNHL) by comparing with ITS injection therapy.</div></div><div><h3>Methods</h3><div>The patients with SSNHL who received initial ITS therapy with no prior systemic steroid treatment were divided into two groups: the ITS via injection group (Group 1) and the ITS via GSD group (Group 2). The groups were compared in terms of the patients’ demographic data, side of ear involvement, vertigo and tinnitus symptoms, comorbidities, initiation time of therapy, hearing level (HL) before and after therapy, word recognition score (WRS) before and after therapy, hearing gain (HG), WRS gain (WRSG), recovery rate (RR), tolerability of the applications and complications.</div></div><div><h3>Results</h3><div>HL and WRS scores were similar among the groups before therapy. Regarding the hearing outcomes after therapy HG and WRSG between the groups were not significant. In the comparison of RR, Group 2′s score (70 %) was significantly higher than that of Group 1 (42.4 %) (p = 0.028). In terms of the tolerability of applications, ITS via GSD application was significantly more tolerable than ITS via injection (p = 0.046). Regarding complications, no otorrhea was observed in any patient, and tympanic membrane perforation was observed in 1 patient (3.33 %) in Group 2, whereas no perforation was observed in Group 1.</div></div><div><h3>Conclusion</h3><div>Intratympanic GSD is a simple, effective and tolerable technique in the therapy of SSNHL, with success rates similar to those of ITS injection therapy and significant improvements in the RR scores.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 4","pages":"Pages 314-318"},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}