Auris Nasus Larynx最新文献

{"title":"Human otoacariasis by Amblyomma testudinarium identified with 16S rRNA gene sequencing","authors":"Mika Nakano ,&nbsp;Tomokatsu Udagawa ,&nbsp;Kayoko Yamaji ,&nbsp;Munenari Itoh ,&nbsp;Hirotaka Kanuka ,&nbsp;Mamoru Yoshikawa","doi":"10.1016/j.anl.2025.12.013","DOIUrl":"10.1016/j.anl.2025.12.013","url":null,"abstract":"<div><div>Human otoacariasis caused by tick bites in the external auditory canal is rarely reported in Japan, despite the recent increase in the movement of wild animals, known hosts of ticks into human living areas due to global warming. We report a case of human otoacariasis caused by <em>Amblyomma testudinarium</em>, genetically identified using 16S rRNA gene sequencing. A 43-year-old man presented to an urban hospital in Tokyo with left-sided otalgia. An endoscopic examination revealed a tick anchored to the skin of the external auditory canal, which showed erythema and swelling. Initial attempts to remove the tick were unsuccessful because it was firmly attached by a cement-like substance. Thereafter, the patient was treated with antibiotic and corticosteroid ear drops, which resulted in tick death and a reduction in inflammation. The shrunken tick was then successfully removed, and polymerase chain reaction analysis confirmed its species as <em>Amblyomma testudinarium</em>. Although a stereomicroscopic examination revealed a small defect in the tick mouthparts, no symptoms were observed during a follow-up period of more than one month. This case highlights the clinical importance of accurate tick species identification, even in urban environment, due to the potential risk of tick-borne diseases such as severe fever with thrombocytopenia syndrome.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 157-160"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron neutron capture therapy for unresectable residual external auditory canal carcinoma","authors":"Hideto Shigemi ,&nbsp;Yoshinori Kadowaki ,&nbsp;Teruhito Aihara ,&nbsp;Satoshi Takeno ,&nbsp;Misaki Iwata ,&nbsp;Kaoru Hashimoto ,&nbsp;Shohei Iwano ,&nbsp;Kazuhiro Yoshinaga ,&nbsp;Yumi Kizu ,&nbsp;Masashi Suzuki ,&nbsp;Takashi Hirano","doi":"10.1016/j.anl.2025.12.007","DOIUrl":"10.1016/j.anl.2025.12.007","url":null,"abstract":"<div><div>Boron neutron capture therapy (BNCT) is a radiation therapy that utilizes the alpha rays produced by the thermal neutron capture reaction of boron nuclei. With BNCT, only unresectable head and neck cancer (HNC) is currently covered by medical insurance in Japan. Some authors have reported the outcomes of BNCT for HNC, but individual case reports are lacking; therefore, the detailed clinical course of such patients remains poorly understood. Herein, we report a case of BNCT treatment for an unresectable residual lesion of external auditory canal carcinoma. A 59-year-old man was diagnosed with squamous cell carcinoma of the right auditory canal. He underwent right lateral temporal bone resection surgery followed by additional chemoradiotherapy; however, a residual preauricular lesion and an unresectable residual lesion deep in the middle ear were identified 2 months later. BNCT was administered for the middle ear and preauricular lesion. Although the preauricular lesion required an additional surgical excision, the middle ear lesion remained locally controlled at the 3-year follow-up. Grade 3 brain radiation necrosis and skin disorders occurred as late adverse events, however, the patient continued his daily activities without any impairment in his quality of life.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 50-54"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible patulous Eustachian tube: Clinical characteristics and diagnostic transition according to the Japan Otological Society criteria","authors":"Marin Yoshida ,&nbsp;Hidetoshi Oshima ,&nbsp;Hideshi Shindo ,&nbsp;Ryoji Hirai ,&nbsp;Takeshi Oshima","doi":"10.1016/j.anl.2025.11.005","DOIUrl":"10.1016/j.anl.2025.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>The 2016 diagnostic criteria for patulous Eustachian tube (PET) proposed by the Japan Otological Society classify cases as “definite” or “possible.” However, the clinical characteristics and natural course of possible cases remain unclear. This study aimed to clarify the clinical profiles and diagnostic transition of possible PET by subclassifying them into two groups.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the records of 292 patients diagnosed as possible PET at their first visit to our specialized outpatient clinic between June 2019 and May 2025. Patients were categorized as group A (symptom relief with Eustachian tube–closing maneuvers but lacking objective findings) or group B (objective findings present but without symptom relief). Clinical features, symptom profiles, and diagnostic transitions were analyzed. Survival analyses using the Kaplan–Meier method, Cox proportional hazards model, Weibull parametric model, and restricted mean survival time (RMST) were conducted to evaluate transition to definite PET.</div></div><div><h3>Results</h3><div>Voice autophony (81.8%¦vs. 59.9%) and breathing autophony (47.1%¦vs. 35.3%) were significantly more frequent in group A, whereas hearing loss was more common in group B (34.1%¦vs. 16.5%, p &lt; 0.001). During follow-up, 30 patients (25 in group A, 5 in group B) progressed to definite PET. Kaplan–Meier analysis showed a significantly higher transition rate in group A (log-rank, p &lt; 0.0001). Cox regression demonstrated a nearly five-fold higher hazard of progression in group A (HR = 4.95, 95% CI: 1.89–12.95, p = 0.001). RMST analysis indicated that group B required on average 1.5 more visits to reach diagnosis. Weibull analysis revealed that most group A patients were diagnosed by the third visit, whereas group B patients frequently remained undiagnosed.</div></div><div><h3>Conclusion</h3><div>Possible PET cases comprise heterogeneous conditions, with group A containing a higher proportion of true PET and group B including more non-PET cases with hearing loss. Careful follow-up and additional testing are warranted for group A, while differential diagnosis should be prioritized in group B. Subgroup-based evaluation may contribute to a more precise and practical diagnostic process for PET.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 55-60"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic impact of sarcopenia and systemic inflammation in head and neck cancer patients treated with immune checkpoint inhibitors","authors":"Ken Kasahara ,&nbsp;Takeyuki Kono ,&nbsp;Yoichiro Sato ,&nbsp;Keisuke Okubo ,&nbsp;Ayaka Sasaki ,&nbsp;Ko Hentona ,&nbsp;Yutaro Mokudai ,&nbsp;Keigo Oguchi ,&nbsp;Motoki Izawa ,&nbsp;Seiichi Shinden ,&nbsp;Hiroyuki Ozawa","doi":"10.1016/j.anl.2025.11.006","DOIUrl":"10.1016/j.anl.2025.11.006","url":null,"abstract":"<div><h3>Objective</h3><div>Sarcopenia and systemic inflammatory markers predict prognosis in various cancers, including head and neck cancer (HNC) treated with surgery or chemoradiotherapy. Their significance in patients receiving immune checkpoint inhibitors (ICIs), however, remains unclear. This study aims to determine whether skeletal muscle loss and systemic inflammation influence treatment response and survival in ICI-treated HNC, and whether composite indices provide prognostic value.</div></div><div><h3>Methods</h3><div>A retrospective cohort of 179 patients with histologically confirmed recurrent or metastatic (R/M) HNC who received ICI therapy between April 2017 and July 2024 was analyzed. Sarcopenia was assessed using the lumbar skeletal muscle index (LSMI), calculated from cervical CT images. Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were derived from pre-treatment blood samples. Overall survival (OS) and progression-free survival (PFS) were evaluated using Kaplan–Meier estimates, and prognostic factors were identified through Cox regression analysis.</div></div><div><h3>Results</h3><div>Among the 179 patients, 98 (54.7%) were classified as sarcopenic. These patients had significantly shorter median OS compared to non-sarcopenic patients (12.1 vs. 39.8 months; p &lt; 0.001). Univariate analysis identified sarcopenia, BMI, NLR, and PLR as significant predictors of OS. However, multivariate Cox analysis revealed that only sarcopenia remained an independent prognostic factor for both OS (HR 1.94; 95% CI: 1.15–3.27; p = 0.013) and PFS (HR 1.92; 95% CI: 1.33–2.75; p &lt; 0.001). Inflammatory markers and their composite indices failed to retain prognostic significance in adjusted models.</div></div><div><h3>Conclusion</h3><div>Sarcopenia independently predicts poor survival outcomes in patients with R/M HNC undergoing ICI therapy, whereas conventional inflammatory markers such as NLR, PLR, and LMR, alone or in combination with sarcopenia, lack independent prognostic value. Routine pre-treatment evaluation of skeletal muscle mass using CT imaging may offer a practical and effective tool for patient risk stratification.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 1-6"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VEXAS syndrome with cochleovestibular involvement","authors":"Keishi Fujiwara ,&nbsp;Shinya Morita ,&nbsp;Kimiko Hoshino ,&nbsp;Hideaki Takeda ,&nbsp;Kento Komatsuda ,&nbsp;Kaoru Kahata ,&nbsp;Yuji Nakamaru ,&nbsp;Akihiro Homma","doi":"10.1016/j.anl.2025.12.010","DOIUrl":"10.1016/j.anl.2025.12.010","url":null,"abstract":"<div><div>We report a case of VEXAS syndrome in a 71-year-old man presenting with auricular chondritis, scleritis, hearing loss, and vestibular dysfunction. Although the clinical picture initially suggested relapsing polychondritis, hematologic findings and <em>UBA1</em> variant confirmed VEXAS syndrome. Comprehensive audiovestibular testing revealed bilateral sensorineural hearing loss and global vestibular impairment. Steroid therapy led to partial improvement. This case highlights the potential for inner ear involvement in VEXAS syndrome, underscoring the importance of systematic audiovestibular evaluation and clinical awareness to differentiate it from similar conditions such as relapsing polychondritis.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 70-75"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage surgery following boron neutron capture therapy in a case of recurrent hypopharyngeal cancer after radiotherapy: Surgical and pathological insights","authors":"Akihisa Tanaka ,&nbsp;Kohtaro Eguchi ,&nbsp;Mitsuhiko Katoh ,&nbsp;Tatsuya Ito ,&nbsp;Azusa Sakai ,&nbsp;Toshihiko Sakai ,&nbsp;Chihiro Fushimi ,&nbsp;Go Omura ,&nbsp;Taisuke Mori ,&nbsp;Seiichi Yoshimoto","doi":"10.1016/j.anl.2025.10.013","DOIUrl":"10.1016/j.anl.2025.10.013","url":null,"abstract":"<div><div>Radiotherapy (RT) is a cornerstone management strategy for head and neck cancer (HNC); however, local recurrence often requires salvage surgery, which is associated with an elevated risk of complications, particularly in previously irradiated fields. Boron neutron capture therapy (BNCT) has broadened treatment options; however, the safety and feasibility of salvage surgery after BNCT remain unclear owing to the limited case number. Herein, we describe a rare case of hypopharyngeal squamous cell carcinoma initially treated with RT, followed by BNCT for local recurrence, and ultimately with successful salvage surgery. The patient experienced no significant intraoperative or postoperative complications, and has remained recurrence-free for three years while maintaining adequate activities of daily living. Histopathological examination revealed no abnormal fibrosis exceeding that typically observed following standard RT alone throughout the resected specimen. Instead, edematous changes predominated over fibrotic alterations exclusively within the tumor region, presumed to be most affected by BNCT, accompanied by strong expression of L-type amino acid transporter 1, a potential surrogate marker of BNCT indication, suggesting the tumor-specific therapeutic effect of BNCT. This is the first report of salvage surgery for an organ previously treated with RT and BNCT, which provides valuable clinical and histopathological insights into this condition.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 785-789"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of histone acetyltransferase inhibitor against middle ear cholesteatoma in mouse model","authors":"Naotaro Akiyama ,&nbsp;Tomomi Yamamoto-Fukuda ,&nbsp;Hiromi Kojima","doi":"10.1016/j.anl.2025.09.006","DOIUrl":"10.1016/j.anl.2025.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>Middle ear cholesteatoma (Cholesteatoma) consists of proliferative epithelial cells. In the previous study, we demonstrated that histone H3 acetylation at lysine 27 (H3K27ac), associated with high transcriptional activation, was accumulated in the Cholesteatoma. In this study, we firstly investigated the expression of H3K27ac and histone acetyltransferase, p300 in human Cholesteatoma tissues. And then, we investigated the effects of a p300 inhibitor, C646, against Cholesteatoma growth.</div></div><div><h3>Methods</h3><div>Immunohistochemical analysis was demonstrated in the human Cholesteatoma specimens using anti-p300 and anti-H3K27ac antibodies and in the KGF-induced Cholesteatoma mouse model after p300 inhibitor administration using anti-p300, anti-H3K27ac, and anti-Ki67 antibodies.</div></div><div><h3>Results</h3><div>The expression levels of p300 were significantly increased and colocalized with H3K27ac in the human Cholesteatoma specimens. Moreover, C646 decreased proliferative activities of Cholesteatoma cells in the KGF-induced Cholesteatoma mouse model.</div></div><div><h3>Conclusion</h3><div>We demonstrated that inhibition of the H3K27ac may be a potential treatment strategy for Cholesteatoma from a new perspective.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 657-663"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trial for developing a reference extract for future standardization of Japanese cypress pollen extracts","authors":"Kengo Kanai ,&nbsp;Aiko Oka ,&nbsp;Hideaki Kouzaki ,&nbsp;Kento Kawakita ,&nbsp;Takuya Murao ,&nbsp;Takeshi Shimizu ,&nbsp;Takaya Higaki ,&nbsp;Aya Murai ,&nbsp;Mizuo Ando ,&nbsp;Kojiro Hirano ,&nbsp;Isao Suzaki ,&nbsp;Hitome Kobayashi ,&nbsp;Minoru Gotoh ,&nbsp;Kimihiro Okubo ,&nbsp;Mitsuhiro Okano","doi":"10.1016/j.anl.2025.10.001","DOIUrl":"10.1016/j.anl.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Japanese cedar pollinosis (JCP) is the most prevalent seasonal allergic rhinitis in Japan. Many JCP patients are also sensitized to Japanese cypress pollen (JCyP), and their symptoms become exacerbated and prolonged during the JCyP dispersal period after JCP. To date, there have been no reports on the development of JCyP-specific allergen immunotherapy. For the future development of a JCyP-specific skin test and immunotherapy, we sought to develop a reference extract for future standardization of JCyP extract determined by the average threshold dilution eliciting a positive response in the intradermal skin test.</div></div><div><h3>Methods</h3><div>A 1:20 antigen extract (Lot AA) was prepared from JCyP grains by the glycerin extraction method. The protein and allergen concentrations in the extract were determined. After confirming its safety, 3-fold serially diluted solutions of JCyP extract were prepared from Lot AA. The average threshold dilution eliciting a positive response in the intradermal skin test was determined among Japanese subjects with serum JCyP-specific IgE class of 2 or higher according to ImmunoCAP IgE assays or View39 IgE assays.</div></div><div><h3>Results</h3><div>The protein concentration in Lot AA was 4.7 mg/mL, and the allergen concentration was 18.8 μg/mL for Cha o 1 and 1.1 μg/mL for Cha o 3. In total, 85 individuals were registered for this study and finally, 55 subjects were left for the analysis. The threshold dilution for an intradermal reaction was 3⁶ in 32 individuals (58.2 %), 3⁷ in 8 individuals (14.6 %), 3⁸ in 4 individuals (7.3 %), and 3⁹ in 1 individual (1.8 %); no reaction was seen in 10 individuals (18.2 %). The average threshold dilution was 3^6.4, which is equivalent to a 1131-fold dilution. No serious adverse events were observed at any of the tested dilutions.</div></div><div><h3>Conclusion</h3><div>The results showed that Lot AA of JCyP extract exhibited <em>in vivo</em> allergic potency and was safe. Thus, it may be useful as a future standardized antigen of JCyP or a reference antigen for standardizing other JCyP extracts for the diagnosis and treatment of JCyP pollinosis.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 805-810"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intratympanic administration of glucocorticoids on the guinea pig inner ear","authors":"Akinobu Kakigi ,&nbsp;Makoto Kinoshita ,&nbsp;Yuki Katsutani ,&nbsp;Toshihito Sahara ,&nbsp;Shinji Yamashita ,&nbsp;Kenji Kondo","doi":"10.1016/j.anl.2025.09.005","DOIUrl":"10.1016/j.anl.2025.09.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the effects of intratympanic glucocorticoid administration on the inner ear.</div></div><div><h3>Methods</h3><div>Fifteen Hartley guinea pigs were used and divided into five groups: dexamethasone-treated (<em>n</em> = 5), contralateral dexamethasone-treated (<em>n</em> = 5), hydrocortisone-treated (<em>n</em> = 5), contralateral hydrocortisone-treated (<em>n</em> = 5), and control (<em>n</em> = 5). In the control group, 1 ml of saline was injected into the right tympanic cavity via a ventral approach. In the dexamethasone-treated group, 1 ml of dexamethasone at a concentration of 3.3 mg/ml was injected into the right tympanic cavity using the same method, while the left ear of the dexamethasone-treated group remained intact. In the hydrocortisone-treated group, 1 ml of hydrocortisone at a concentration of 50 mg/ml was injected into the right tympanic cavity using the same technique, with the left ear of the hydrocortisone-treated group also remaining intact.</div><div>To assess the effects of glucocorticoids on the inner ear, we measured a cross-sectional area analysis of the scala media at three hours post-corticosteroids treatment using optical coherence tomography (OCT). The degree of a cross-sectional area change was quantitatively measured using a video digitizer.</div></div><div><h3>Results</h3><div>Ears treated with either dexamethasone or hydrocortisone showed extension of Reissner's membrane and endolymphatic hydrops. Statistical analysis indicated that a cross-sectional area of the scala media increased significantly compared to the contralateral hydrocortisone-treated and control groups.</div></div><div><h3>Conclusions</h3><div>This is the first report to investigate the effects of intratympanic administration of glucocorticoids on the guinea pig cochlea. Dilated endolymphatic space was observed in the steroid-treated ears. Although the underlying mechanism of these histological changes remains unclear, great care must be taken when administering steroids to patients with endolymphatic hydrops-related diseases, such as Meniere's disease.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 729-734"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New method; continuous water perfusion method during endoscopic resection for the superficial pharyngeal squamous cell carcinoma","authors":"Naohiro Nakamura ,&nbsp;Tomofumi Sakagami ,&nbsp;Kensuke Suzuki ,&nbsp;Takuo Fujisawa ,&nbsp;Takuya Shijimaya ,&nbsp;Sanshiro Kobayashi ,&nbsp;Masataka Masuda ,&nbsp;Yu Takahashi ,&nbsp;Tomomitsu Tahara ,&nbsp;Makoto Naganuma","doi":"10.1016/j.anl.2025.10.002","DOIUrl":"10.1016/j.anl.2025.10.002","url":null,"abstract":"<div><div>Recent development in endoscopic imaging has led to the detection of superficial laryngopharyngeal carcinomas and the effectiveness of endoscopic resection for superficial pharyngeal squamous cell carcinoma have been reported. However, the en bloc and complete resection rates were not sufficient. To identify the precise incision and dissection lines, ensuring a clear operating view is important. Although underwater condition during dissection is useful, saliva, bleeding, and produced floating matter make the operating view worse as the dissection process continues. We presented new method; continuous water perfusion method (CWPM) may contribute to ensuring a clear operating view during dissection of endoscopic resection for superficial pharyngeal squamous cell carcinomas.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 687-689"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}