Auris Nasus Larynx最新文献

{"title":"Sialendoscopy for the management of sialolithiasis in Japan","authors":"Miki Takahara","doi":"10.1016/j.anl.2025.10.004","DOIUrl":"10.1016/j.anl.2025.10.004","url":null,"abstract":"<div><div>Sialolithiasis, the formation of calculi in the major salivary glands, is the leading cause of obstructive salivary disease and occurs predominantly in the submandibular gland. Traditional management of hilar or parenchymal stones has often required submandibular gland excision, which carries the risk of visible scarring and potential facial nerve injury. Sialendoscopy has emerged as a minimally invasive alternative for both diagnosis and treatment. Since its introduction in the 1990s and subsequent refinement, it has become standard therapy in Europe and North America, but in Japan, despite national insurance coverage since 2014, adoption remains limited because of technical complexity, high cost of consumables, and limited endoscope durability. A review of the literature and our own 144-case experience demonstrated a 40 % success rate for stone removal using sialendoscopy alone in Japan. Stone mobility was the most important predictor of success, while size greater than about 7.5 mm and parenchymal location markedly reduced success rates. Complications were generally mild and self-limiting: transient glandular swelling and lingual nerve paresis resolved within months, though occasional ranula formation or recurrence required secondary procedures. Similar factors predict outcomes in parotid stones, with reported endoscopic success of about 30–50 %. Fourier transform infrared spectrophotometry of 133 stones showed calcium phosphate and protein as the main components, and a higher calcium phosphate fraction correlated with stronger ductal adhesion and lower success rates. Sialendoscopy is therefore a safe, effective, and cosmetically advantageous alternative to gland excision, and we hope that this review will help lay the groundwork for its broader adoption and continued advancement in Japan.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 764-768"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a comprehensive national auditory implant registry in Japan: Trends and demographics from the first two years (2023–2024)","authors":"Ayu Akazawa ,&nbsp;Takeshi Fujita ,&nbsp;Kensuke Uraguchi ,&nbsp;Megumi Kitayama ,&nbsp;Taku Ito ,&nbsp;Yasuhiro Osaki ,&nbsp;Kyoko Shirai ,&nbsp;Haruo Yoshida ,&nbsp;Norio Yamamoto ,&nbsp;Katsumi Doi ,&nbsp;Satoshi Iwasaki ,&nbsp;Naoki Oishi","doi":"10.1016/j.anl.2025.09.009","DOIUrl":"10.1016/j.anl.2025.09.009","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the establishment and initial findings of Japan’s first comprehensive nationwide registry covering cochlear implants (CIs), active middle ear implants (AMEIs), and bone conduction implants (BCIs), launched in 2023. The registry aims to improve national data collection, support evidence-based policymaking, and track trends in surgical practice and patient demographics.</div></div><div><h3>Methods</h3><div>A web-based electronic data capture (EDC) system was implemented to replace the previous paper-based reporting system. Between January 2023 and December 2024, data were voluntarily submitted by participating facilities across Japan. Collected data included patient demographics, implant types, hearing thresholds, etiologies, and manufacturer information. Registry completeness was assessed by comparison with Japan’s National Database of Health Insurance Claims (NDB).</div></div><div><h3>Results</h3><div>A total of 1880 patients were registered, and 1809 patients with surgical information entered from 104 facilities were selected for analysis, comprising 1723 CI cases and 86 AMEI or BCI cases (11 VSB, 22 BB, 53 Baha). Among 605 pediatric CI recipients, early-age implantation was increasingly observed, with 58 patients (10 %) aged under 1 year and 183 (30 %) aged 1 year. Among adult CI recipients, 271 patients were aged 75 years or older, including 40 patients aged 85 years or older. Additionally, simultaneous bilateral CI surgery was performed in 265 patients, of whom 175 were children, reflecting the expanding indications. Patients with better ear thresholds &lt;90 dB HL accounted for 33 % of adults and 29 % of children. Congenital hearing loss predominated in children, while acquired causes were more common in adults. Among cases with a known etiology, hereditary deafness was the most common (24.5 %), although 39.6 % of etiologies were unknown. CI data completeness reached 73 % compared with NDB, indicating strong nationwide participation and a high level of data reliability.</div></div><div><h3>Conclusion</h3><div>This is the first comprehensive report from the national registry in Japan that includes not only CIs but also AMEIs and BCIs. The registry demonstrated reliable data capture and highlighted important trends in patient demographics and surgical practices. Continued data collection will enhance clinical decision-making and support policy development, ultimately improving care for auditory implant recipients.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 679-686"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the optimal approach for endoscopic neck dissection using Thiel cadavers","authors":"Takashi Maruo ,&nbsp;Toshifumi Tomioka ,&nbsp;Wataru Okano ,&nbsp;Takashi Mukaigawa ,&nbsp;Takahiro Fukuhara ,&nbsp;Hiromu Nakamura ,&nbsp;Takuma Takeuchi ,&nbsp;Munekazu Naito ,&nbsp;Naoyuki Hatayama ,&nbsp;Yasushi Fujimoto","doi":"10.1016/j.anl.2025.09.003","DOIUrl":"10.1016/j.anl.2025.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>Endoscopic neck dissection (END) has been developed in Asia; however, it is necessary to validate a technique that has a short learning curve and is easy to introduce. The purpose of this study was to determine the approach with the easiest introduction and shortest learning curve using donated cadavers fixed with the Thiel method.</div></div><div><h3>Methods</h3><div>A total of four different approaches were examined. Each approach was evaluated by a questionnaire administered to five head and neck surgeons, the extent of dissection was confirmed, and the number of dissected lymph nodes was counted.</div></div><div><h3>Results</h3><div>Endoscopic supra-omohyoid-neck dissection (SOHND) by entering from the anterior margin of the sternocleidomastoid muscle (SCM) through a retroauricular (RA) approach was the most highly rated in the questionnaire, and the extent of dissection and number of lymph nodes dissected were reasonable in this study. Jugular neck dissection (JND) by entering the anterior margin of the SCM from the subclavian was the second highest scoring approach, but further advances in instrument development and technique are needed.</div></div><div><h3>Conclusions</h3><div>Endoscopic SOHND by the RA approach was considered optimal. Endoscopic JND by the subclavian approach was the second most promising approach.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 643-650"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital readmission and mortality after discharge with pediatric tracheostomy: A one-year population-based cohort study in Taiwan","authors":"Chia-Hsuan Lee ,&nbsp;Che-Yi Lin ,&nbsp;Kun-Tai Kang ,&nbsp;Wei-Chung Hsu","doi":"10.1016/j.anl.2025.09.008","DOIUrl":"10.1016/j.anl.2025.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze hospital readmission and mortality rates within 1 year after discharge with pediatric tracheostomy.</div></div><div><h3>Methods</h3><div>Data were obtained from Taiwan’s National Health Insurance Research Database. All inpatients aged &lt;18 years who underwent tracheostomy between 2001 and 2019 were identified using <em>International Classification of Diseases</em> codes. All-cause readmission and mortality rates at 30, 90, 180, 270, and 365 days after pediatric tracheostomy were calculated, and factors associated with readmission and mortality at 1 year after tracheostomy were analyzed.</div></div><div><h3>Results</h3><div>A total of 1911 children who underwent tracheostomy were included. At 1 year after tracheostomy, 1485 (78 %) children experienced hospital readmission, and 273 (14 %) died. The accumulated readmission rates at 30, 90, 180, 270, and 365 days were 32 %, 56 %, 69 %, 74 %, and 78 %, respectively. The accumulated mortality rates at 30, 90, 180, 270, and 365 days were 2 %, 6 %, 9 %, 12 %, and 14 %, respectively. Children who experienced readmission within the 1-year follow-up period were significantly younger (8.3 vs 9.9 years) and less indicated for trauma or head injury (33 % vs 39 %), and they had longer intensive care unit stays (38 days vs 30 days) and hospital stays (62 days vs 51 days) than had those without readmission. Multivariable analysis revealed that infants (HR = 1.20, 95 % CI: 1.01 to 1.44) and toddlers (HR = 1.24, 95 % CI: 1.04 to 1.48) were at significantly greater risk of readmission than were adolescents during the 1-year follow-up period. Mortality risk within this period was significantly higher among infants, toddlers, preschoolers, and school-aged children than among adolescents.</div></div><div><h3>Conclusion</h3><div>Children at young ages are at greater risk of readmission and mortality following tracheostomy.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 664-671"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative symptom-guided plug size selection in sitting position Kobayashi plug surgery for patulous eustachian tube","authors":"Takeshi Oshima ,&nbsp;Marin Yoshida ,&nbsp;Hideshi Shindo ,&nbsp;Hidetoshi Oshima ,&nbsp;Ryoji Hirai","doi":"10.1016/j.anl.2025.09.007","DOIUrl":"10.1016/j.anl.2025.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of Kobayashi Plug Surgery (KPS) for patulous Eustachian tube (PET) performed under local anesthesia in the sitting position, using intraoperative subjective symptoms to guide plug size selection, and to investigate its effect on revision surgery rates.</div></div><div><h3>Methods</h3><div>This retrospective study included 61 patients (73 ears) with refractory PET who underwent KPS between December 2023 and June 2025. All procedures were performed under local anesthesia with patients in the sitting position, allowing for real-time assessment of subjective symptoms immediately after plug placement. If symptoms persisted, the plug size was increased intraoperatively. Clinical data, surgical outcomes, plug sizes, and postoperative complications were analyzed. Long-term outcomes were assessed in 29 ears with follow-up exceeding 180 days using PHI-10, Eustachian tube function tests, and revision surgery rates.</div></div><div><h3>Results</h3><div>Plug placement was successful in 66 of 73 ears (90.4%). Plug size adjustment during initial surgery was performed in 5 ears (7.6%) based on persistent symptoms. Among 29 ears with long-term follow-up (median: 297.5 days), the overall revision surgery rate due to upsizing was 10.3%. However, among the 41 ears that presented with subjective symptoms at the time of surgery, only 1 case (2.4%) required revision surgery during follow-up. PHI-10 scores significantly improved from a median of 30 to 10 (p &lt; 0.001), and sonotubometry sound pressure levels increased from 85 dB to 99 dB (p &lt; 0.005). Tympanic membrane perforation was observed in one ear (preexisting), and ventilation tube placement for otitis media with effusion was required in 4 ears (13.8%).</div></div><div><h3>Conclusion</h3><div>KPS under local anesthesia in the sitting position allows for intraoperative symptom-based plug size selection, which may help reduce the need for revision surgery, especially in patients with active symptoms at the time of surgery. While the overall revision rate was 10.3%, it was markedly lower (2.4%) among symptomatic cases. Although the findings should be interpreted with caution due to the small sample size and retrospective design, this technique represents a promising approach for improving surgical outcomes in patients with refractory PET.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 704-708"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145326411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of esophageal fistula induced by lenvatinib in thyroid cancer using deltopectoral flap","authors":"Yuji Kanazawa ,&nbsp;Yoshiharu Kitani ,&nbsp;Maki Kitatsuji ,&nbsp;Yusuke Yamamoto ,&nbsp;Aya Matsubara ,&nbsp;Makoto Suzuki","doi":"10.1016/j.anl.2025.10.005","DOIUrl":"10.1016/j.anl.2025.10.005","url":null,"abstract":"<div><div>Lenvatinib, a multi-target tyrosine kinase inhibitor, has demonstrated efficacy in the treatment of various solid tumors, including thyroid cancer. However, life-threatening complications such as fistula formation have been observed in some cases. We report the case of a 47-year-old woman who developed an esophageal fistula following lenvatinib treatment for recurrent thyroid cancer. The patient initially underwent limited resection of the muscular layer of the cervical esophagus and preservation of the mucosa, followed by prophylactic radiotherapy because of inadequate surgical margins. Locoregional and pulmonary metastases developed 8 months postoperatively, and lenvatinib therapy was initiated at a dose of 24 mg. Subsequently, a fistula developed from the esophagus to the cervical skin. Esophageal fistula reconstruction was performed using a deltopectoral (DP) flap. Lenvatinib was resumed at a reduced dose of 14 mg two months after reconstruction. At 18 months after resuming lenvatinib, progression-free survival and adequate oral intake were achieved. The success of the DP flap reconstruction in this case highlights its potential as a durable solution for esophageal fistulas in patients receiving lenvatinib treatment. The robust blood supply provided by the DP flap may counteract the antiangiogenic effects of lenvatinib, thereby enabling continued treatment for locoregional recurrence.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 725-728"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck stiffness and its correlation with dysphagia after radiotherapy in head and neck cancer","authors":"Junki Ono ,&nbsp;Hideaki Nishi ,&nbsp;Sumie Takashima ,&nbsp;Shuntaro Soejima ,&nbsp;Ryo Toya ,&nbsp;Yoshihiko Kumai","doi":"10.1016/j.anl.2025.10.011","DOIUrl":"10.1016/j.anl.2025.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>Dysphagia is one of the most significant adverse effects after radiotherapy (RT) for advanced head and neck cancer (HNC). We hypothesized that neck stiffness may impair laryngeal elevation (LE) in HNC patients and contribute to post-RT dysphagia. We evaluated the association between cervical stiffness and swallowing dysfunction after RT for HNC.</div></div><div><h3>Methods</h3><div>Ultrasound and swallowing function tests were conducted before and 6 months after RT for HNC. Stiffness of the sternocleidomastoid muscle (SM) was measured via shear wave elastography (SWE). To assess swallowing function comprehensively, videofluoroscopic swallowing studies were performed; based on these data, we calculated the Penetration–Aspiration Scale (PAS) score and quantified hyoid bone displacement and LE delay time.</div></div><div><h3>Results</h3><div>Of 29 patients, 8 showed post-RT dysphagia. Compared to prophylactic irradiation, a significant increase in neck stiffness was observed in the radical irradiation group (<em>p</em> = 0.018). Multivariable logistic regression analysis indicated that greater reductions in laryngeal elevation distance (LED) were significantly associated with post-RT dysphagia (OR: 0.67, 95 % CI: 0.47–1.10, <em>p</em> = 0.035).</div></div><div><h3>Conclusion</h3><div>SWE demonstrated a significant increase in neck stiffness following radiotherapy. Moreover, a greater reduction in LED was significantly associated with post-RT dysphagia, suggesting that impaired LE function may contribute to its development.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 796-802"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and diagnostic value of symptoms and objective findings in patulous eustachian tube: a large-scale study based on the Japan Otological Society criteria","authors":"Hidetoshi Oshima ,&nbsp;Marin Yoshida ,&nbsp;Hideshi Shindo ,&nbsp;Ryoji Hirai ,&nbsp;Takeshi Oshima","doi":"10.1016/j.anl.2025.09.002","DOIUrl":"10.1016/j.anl.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>To clarify the clinical characteristics of patulous Eustachian tube (PET) based on the Japan Otological Society (JOS) diagnostic criteria and to assess the diagnostic contribution of individual symptoms and objective findings.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients diagnosed with definite PET or non-PET at a subspecialty Eustachian tube clinic between June 2019 and July 2025, excluding possible PET to minimize diagnostic uncertainty. Demographics, background factors, symptoms, and objective test results—including tympanic membrane (TM) flutter, tubo-tympano-aerodynamic graphy, and sonotubometry—were examined. Logistic regression identified independent factors, and receiver operating characteristic (ROC) curves were generated to evaluate diagnostic performance.</div></div><div><h3>Results</h3><div>Among 1009 patients (1613 ears), definite PET was associated with habitual sniffing (OR = 8.18), history of weight loss (OR = 1.78), and, in females, low-dose estrogen–progestin use (OR = 7.31). Lower body mass index and younger age also showed significant associations. Voice autophony (OR = 4.09) and breathing autophony (OR = 9.98) were the most predictive symptoms. Objective findings demonstrated high diagnostic accuracy, with TM flutter showing the highest odds ratio (OR = 42.17). The seven-symptom model achieved an area under the ROC curve (AUC) of 0.862.</div></div><div><h3>Conclusion</h3><div>This large-scale study identified key background factors and symptoms valuable for PET diagnosis and confirmed that objective tests have strong discriminatory ability, supporting earlier and more accurate clinical decision-making.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 651-656"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of transoral injection laryngoplasty in the apneic window","authors":"Nurullah Türe ,&nbsp;Serkan Telli ,&nbsp;Onur Kibar","doi":"10.1016/j.anl.2025.10.009","DOIUrl":"10.1016/j.anl.2025.10.009","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was report the feasibility, safety profile, and within-patient voice outcomes of transoral injection laryngoplasty performed during a protocolized apneic window in unilateral vocal fold paralysis (UVFP)<strong>.</strong></div></div><div><h3>Methods</h3><div>This retrospective single-arm cohort study included patients who underwent transoral IL in the apneic window because of UVFP between February 2021 and March 2024. The following parameters were compared before and after the injection: GRBAS, maximum phonation time (MPT,seconds), Turkish Voice Handicap Index-10 (T-VHI-10), Turkish Voice-Related Quality of Life Questionnaire (T-V-RQOL), Turkish Eating Assessment Tool (T-EAT-10), and acoustic analysis parameters (F0, Jitter (%), Shimmer (%), CPPs, AVQI v03.01).</div></div><div><h3>Results</h3><div>Final analysis was made of 27 patients, comprising 19 (70.4 %) females and 8 (29.6 %) males, with a mean age of 58 years (range, 21–75 years). Following the apneic window IL technique, statistically significant decreases were determined in the GRBAS G-score (2.36 vs.0.28, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>), MPT (5.68 vs.13.56 secs, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>), T-VHI-10 (28 vs. 6, <strong><em>p</em></strong> <strong>&lt;</strong> <strong>0.001</strong>), and T-EAT-10 (14 vs. 4, <strong><em>p</em></strong> <strong>&lt;</strong> <strong>0.001</strong>). In the acoustic voice analysis, statistically significant decreases were observed in Jitter % (0.67 vs. 0.3, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>), Shimmer % (5.81 vs.1.6, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>) and AVQI v03.01 (5.9 vs. 2.8, <strong><em>p</em></strong> <strong>&lt; 0.001</strong>).</div></div><div><h3>Conclusion</h3><div>Transoral IL in an apneic window is a feasible and safe tubeless option that yielded significant within-patient improvements across perceptual, aerodynamic, patient-reported, and acoustic domains under a predefined safety workflow. The technique preserves a wide, tube-free operative field and may be considered complementary in selected candidates. Comparative studies versus intubated IL are warranted to establish non-inferiority or superiority.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 750-755"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of Japanese clinical practice guidelines for head and neck cancer - 2025 update edited by the Japan Society for Head and Neck Cancer","authors":"Nobuhiro Hanai ,&nbsp;Mizuo Ando ,&nbsp;Hiroto Ishiki ,&nbsp;Nobuhiro Ueda ,&nbsp;Susumu Okano ,&nbsp;Isaku Okamoto ,&nbsp;Hiroyuki Ozawa ,&nbsp;Satoshi Kano ,&nbsp;Tomonori Kanda ,&nbsp;Yuki Saito ,&nbsp;Hirotaka Shinomiya ,&nbsp;Keisuke Takanari ,&nbsp;Toshifumi Tomioka ,&nbsp;Hiroshi Fuseya ,&nbsp;Yoshitaka Honma ,&nbsp;Atsushi Motegi ,&nbsp;Koichi Yasuda ,&nbsp;Takeshi Kodaira ,&nbsp;Hiroshi Kurita ,&nbsp;Ken-ichi Nibu ,&nbsp;Akihiro Homma","doi":"10.1016/j.anl.2025.09.004","DOIUrl":"10.1016/j.anl.2025.09.004","url":null,"abstract":"<div><div>The Japanese Clinical Practice Guidelines for Head and Neck Cancer – 2025 Edition were developed to provide clear evidence-based recommendations that reflect recent advancements and evolving clinical needs in head and neck cancer care. Advances in immunotherapy, targeted therapies, surgical techniques, and genomic medicine have expanded treatment options and added new complexities. This edition offers practical, up-to-date guidance to support consistent decision making across diverse clinical scenarios. Compared with the 2022 edition, the guidelines have been substantially expanded to 63 clinical questions (CQs) across 14 categories. A new feature is the inclusion of commentary columns that address clinically important topics not suited to the CQ format, such as special patient populations, novel therapies, and rare malignancies. To reflect the growing role of precision oncology, updated recommendations for molecular-targeted treatments have been added based on specific genomic alterations, in alignment with the current approvals in Japan. While maintaining the structure of previous editions, this edition addresses the changing clinical environment while also helping to inform future discussions and directions in head and neck cancer care.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 6","pages":"Pages 709-724"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}