Auris Nasus Larynx最新文献

{"title":"Treatment strategy for intermediate-risk papillary thyroid cancer: Focus on postoperative hypothyroidism following lobectomy","authors":"Akifumi Kariya ,&nbsp;Tomoyasu Tachibana ,&nbsp;Asuka Sato ,&nbsp;Chieko Furukawa ,&nbsp;Yuto Naoi ,&nbsp;Yorihisa Orita ,&nbsp;Mizuo Ando","doi":"10.1016/j.anl.2024.12.005","DOIUrl":"10.1016/j.anl.2024.12.005","url":null,"abstract":"<div><h3>Objective</h3><div>An optimal surgical approach for intermediate-risk papillary thyroid cancer (PTC) has not yet been established. The surgical procedure should be determined based on treatment outcomes and postoperative complications. This study aimed to evaluate appropriate surgical strategies for patients with intermediate-risk PTC by comparing treatment outcomes and postoperative complications following total thyroidectomy and lobectomy.</div></div><div><h3>Methods</h3><div>This retrospective analysis was conducted on 123 patients with intermediate-risk PTC treated in our department between January 2008 and December 2022. The risk of PTC was classified according to the 2024 Guidelines for the Clinical Treatment of Thyroid Nodules from the Japan Association of Endocrine Surgery.</div></div><div><h3>Results</h3><div>Of the 123 patients, 27 underwent total thyroidectomy, and 96 underwent lobectomy. No significant differences were observed between the two surgical groups in terms of survival or recurrence rates. None of the patients showed bilateral recurrent laryngeal nerve (RLN) palsy postoperatively. Postoperative unilateral RLN palsy occurrence differed significantly between the total thyroidectomy and lobectomy groups<strong>,</strong> with five cases in each (5.2 and 18.5 %, respectively; <em>p =</em> 0.04). Permanent hypoparathyroidism was observed in two patients (7.4 %) in the total thyroidectomy group. Postoperative hypothyroidism developed in 42 (43.8 %) lobectomy cases, with 32 requiring the administration of levothyroxine therapy. A significant association was observed between preoperative thyroid-stimulating hormone (TSH) levels (≥2.0 μIU/mL) and postoperative hypothyroidism (<em>p &lt;</em> 0.001).</div></div><div><h3>Conclusion</h3><div>No significant difference in treatment outcomes was observed between patients with intermediate-risk PTC who underwent total thyroidectomy and those who underwent lobectomy. In cases with preoperative TSH levels ≥2.0 μIU/mL, total thyroidectomy may be a more suitable approach, given the increased likelihood of requiring postoperative levothyroxine administration following lobectomy.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 66-70"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of vidian neurectomy in treating chronic rhinosinusitis with nasal polyps combined with allergic rhinitis: A systematic review and meta-analysis","authors":"Ji-Sun Kim ,&nbsp;Gulnaz Stybayeva ,&nbsp;Se Hwan Hwang","doi":"10.1016/j.anl.2024.12.004","DOIUrl":"10.1016/j.anl.2024.12.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of additional vidian neurectomy or posterior nasal neurectomy in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and allergic rhinitis (AR), compared to the outcomes of conventional endoscopic sinus surgery alone.</div></div><div><h3>Methods</h3><div>Up to May 2024, six databases were systematically searched. We evaluated studies that compared the clinical improvement of chronic sinusitis-related symptoms and endoscopic findings between the neurectomy group (endoscopic sinus surgery plus vidian neurectomy or posterior nasal neurectomy) and the control group (endoscopic sinus surgery only).</div></div><div><h3>Results</h3><div>The neurectomy group showed a significant reduction in the Lund-Kennedy endoscopic score (SMD = -1.3163 [-1.6519; -0.9807]; I² = 53.3 %). However, this treatment did not have a significant effect on the Quality-of-life score (SMD = -0.1222 [-0.3427; 0.0983]; I² = 27.5 %) or patient-reported nasal symptom-related VAS scores (SMD = -1.6690 [-3.7062; 0.3682]; I² = 96.3 %). In the subgroup analyses of these results according to time points of measurement, the Lund-Kennedy endoscopic score was statistically lower in the treatment group during treatment periods (postop 6months, 12months, and 24months). However, there were no statistically significant differences in Quality-of-life score and VAS between the treatment and control groups during all treatment periods. There was no significant difference in the recurrent rate of CRS during the following up periods (odds ratio=0.5263 [0.1518; 1.8254], I² = NA) between two groups. Regarding the adverse effect of neurectomy, this additional procedure did not induce the postoperative bleeding (odds ratio=0.8886 [0.3411; 2.3150]; I² = 0.0 %) and dry eye related discomfort (odds ratio=65.3560 [0.1044; 40,908.1619]; I² = 88.9 %) significantly compared to control group.</div></div><div><h3>Conclusions</h3><div>Additional neurectomy shows better efficacy in improving endoscopic findings and is safer in patients with CRSwNP combined with AR; however, more clinical studies are needed to evaluate its long-term symptomatic effects and disease recurrence.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 28-34"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perilymphatic fistula caused by Eustachian tube air inflation","authors":"Taichi Kan,&nbsp;Yasue Uchida,&nbsp;Mayuko Kishimoto,&nbsp;Tetsuya Ogawa,&nbsp;Yasushi Fujimoto","doi":"10.1016/j.anl.2024.12.010","DOIUrl":"10.1016/j.anl.2024.12.010","url":null,"abstract":"<div><div>We present a case of a perilymphatic fistula (PLF) caused by Eustachian tube air inflation (ETAI) that was diagnosed using cochlin-tomoprotein (CTP) testing and successfully treated using transcanal endoscopic ear surgery to seal the inner ear window. A 77-year-old woman developed hearing loss and dizziness after undergoing ETAI at a local ear, nose, and throat clinic. Despite initial bed rest and steroid pulse therapy, the hearing did not improve, and transcanal endoscopic ear surgery was performed to repair the PLF. The CTP test confirmed the diagnosis of PLF, leading to a significant improvement in the patient's hearing and dizziness symptoms postoperatively. This case highlights the importance of considering PLF as a potential complication of ETAI and the value of CTP testing for diagnosing this condition.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 35-38"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological trends in head and neck cancer in Nara Prefecture, Japan, from 2000–2021: The impact of the COVID-19 pandemic","authors":"Takahiro Kimura ,&nbsp;Ichiro Ota ,&nbsp;Hirokazu Uemura ,&nbsp;Kazuhiko Shoji ,&nbsp;Tsuyoshi Kojima ,&nbsp;Tadaaki Kirita ,&nbsp;Kazuhiko Nario ,&nbsp;Masakazu Miyazaki ,&nbsp;Katsunari Yane ,&nbsp;Hideyuki Okamoto ,&nbsp;Naoki Shimizu ,&nbsp;Hiroshi Miyahara ,&nbsp;Tadashi Kitahara","doi":"10.1016/j.anl.2025.01.002","DOIUrl":"10.1016/j.anl.2025.01.002","url":null,"abstract":"<div><h3>Objective</h3><div>Epidemiological surveys were conducted in Nara Prefecture, Japan, to determine the prevalence of head and neck cancer in the region since 1986.</div></div><div><h3>Methods</h3><div>This study examined the dynamics of visits to 18 medical institutions treating head and neck cancer in Nara Prefecture from 2000 to 2021.</div></div><div><h3>Results</h3><div>A total of 8,605 patients were registered, with 4,788 being male and 3,787 female. These included 3,603 thyroid, 2,215 oral, 1,164 laryngeal, 645 hypopharyngeal, 512 oropharyngeal, 326 nasal sinus, and 286 salivary gland cancer cases. A marked increase in subsite was observed in oropharyngeal, oral, and hypopharyngeal cancers, whereas laryngeal cancer remained unchanged. The number of registered patients increased every year, with 547 new patients registered in 2019, compared to 249 in 2000. However, the number of registered cases decreased by nearly 100 cases after 2020 because of the COVID-19 pandemic (453 cases in 2020 and 420 cases in 2021).</div></div><div><h3>Conclusions</h3><div>This study is distinctive as it comprehensively surveys all departments within Nara Prefecture involved in managing head and neck cancer.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 59-65"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence microscopy of parathyroid and thyroid tissues for localization of autofluorescent substances using near-infrared wavelengths","authors":"Yui Mizumoto-Teramura ,&nbsp;Akira Leon Yoshikawa ,&nbsp;Naoyuki Matsumoto ,&nbsp;Yoko Murayama ,&nbsp;Ken Akashi","doi":"10.1016/j.anl.2024.12.007","DOIUrl":"10.1016/j.anl.2024.12.007","url":null,"abstract":"<div><h3>Objective</h3><div>The parathyroid gland emits autofluorescence with a peak at 822 nm when excited using near-infrared light at 785 nm; this observation of autofluorescence using a near-infrared detection device is useful for identifying the parathyroid gland during surgery. We aimed to clarify the localization of autofluorescent substances in parathyroid and thyroid tissues by observing them under a fluorescence microscope through filters that selectively pass specific near-infrared wavelengths.</div></div><div><h3>Methods</h3><div>Four cases of parathyroid and three cases of thyroid were examined under a fluorescence microscope. The frozen, formalin-fixed paraffin-embedded, and unfixed, unstained sections of parathyroid were observed through filters that selectively pass specific near-infrared wavelengths. Images were acquired at excitation 775 ± 50 nm and absorption 845 ± 55 nm in five randomly selected fields of view, avoiding tumor and inflammatory areas. Autofluorescence was measured as the ratio of fluorescent area to tissue area using hybrid cell counting.</div></div><div><h3>Results</h3><div>Autofluorescence was observed in all sections. In the parathyroid tissue, the frozen sections showed significantly more autofluorescence than the formalin-fixed paraffin-embedded sections, and in the thyroid tissue, although no significant difference was observed, the frozen sections showed more autofluorescence than the formalin-fixed paraffin-embedded sections. In addition, the single unfixed, unstained section showed stronger autofluorescence than the frozen sections, although no significant difference was found. The areas of autofluorescence in the parathyroid and thyroid tissues were thought to be the Golgi area and lipofuscin, respectively.</div></div><div><h3>Conclusion</h3><div>Fluorescence microscopy of parathyroid and thyroid tissues revealed the localization of autofluorescent substances in each tissue.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 71-75"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-operative vestibular function outcomes evaluated by video Head Impulse Test in patients with non-vestibular schwannoma cerebellopontine angle tumors","authors":"Keishi Fujiwara ,&nbsp;Shinya Morita ,&nbsp;Hiroaki Motegi ,&nbsp;Shigeru Yamaguchi ,&nbsp;Yukitomo Ishi ,&nbsp;Kimiko Hoshino ,&nbsp;Atsushi Fukuda ,&nbsp;Hideaki Takeda ,&nbsp;Yuji Nakamaru ,&nbsp;Miki Fujimura ,&nbsp;Akihiro Homma","doi":"10.1016/j.anl.2024.12.003","DOIUrl":"10.1016/j.anl.2024.12.003","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate post-operative semicircular canal function in patients with non-vestibular schwannoma (VS) cerebellopontine angle (CPA) tumors by video Head Impulse Test (vHIT).</div></div><div><h3>Methods</h3><div>Fourteen patients with non-VS CPA tumors who underwent surgery. The gain in vestibulo-ocular reflex (VOR) was examined pre- and post-operatively for the semicircular canals in patients with non-VS CPA tumors.</div></div><div><h3>Results</h3><div>Ten of 14 patients showed semicircular canal dysfunction in one or more of the semicircular canals pre-operatively and VOR gain was significantly correlated with hearing function. Two patients showed improvement in one or more semicircular canals at 1 month after surgery compared to the pre-operative results. Significant improvements in VOR gain were observed when comparing VOR gain at 1 month and 6 months after surgery.</div></div><div><h3>Conclusions</h3><div>Detailed evaluation of semicircular canal function was achieved by using vHIT in patients with non-VS CPA tumors. The good prognosis for vestibular function as evaluated by vHIT post-operatively was confirmed in patients with non-VS CPA tumors when compared to those in patients with VS. As improvement may occur post-operatively, surgical approaches that preserve the vestibular nerves and semicircular canals should be chosen for patients with non-VS CPA tumors, regardless of preoperative vestibular function. Even if vestibular function deteriorates immediately after surgery, it may improve over time if the nerve is preserved.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 50-58"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of olfactory training with olfactory bulb morphology in adults with post-viral long-lasting olfactory dysfunction: A COVID-19 related prospective study","authors":"Mustafa Baran ,&nbsp;Mahmut Tayyar Kalcioglu ,&nbsp;Ahmet Mutlu ,&nbsp;Basak Atalay ,&nbsp;Mahmut Bilal Dogan ,&nbsp;Guler Ozturk","doi":"10.1016/j.anl.2025.01.006","DOIUrl":"10.1016/j.anl.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>In this prospective case-controlled study, we aimed to examine changes in olfactory bulb (OB) morphology due to COVID-19 infection and to examine the effects of olfactory training (OT).</div></div><div><h3>Methods</h3><div>This study included 29 patients with anosmia or hyposmia due to COVID-19 infection (Group 1), 24 normosmic patients after COVID-19 infection (Group 2), and 25 normosmic subjects without COVID-19 infection (Group 3). OB volumes, thickness, length, sulcus depth, and signal intensity were evaluated using magnetic resonance imaging (MRI). Psychophysical tests (odor discrimination, thresholds, and odor identification) and a survey of olfactory symptoms were performed. After 12 weeks of OT, the MRI data and odor scores of Group 1 were compared with those of the other groups.</div></div><div><h3>Results</h3><div>OB volumes were significantly smaller in Group 1 (54.01±2.92 mm3) compared with the other groups (group 2:56.7±3.2 mm3 and group 3:59.45±3.09 mm3). The OB thicknesses and lengths differed significantly between Group 1 and Groups 2 and 3. Group 1 had abnormalities in the OB signal intensity in the form of diffusely increased signal intensity compared with the others groups. Following OT, OB volume (right, p= 0.002; left, p=0.021) and Threshold Discrimination Identification score (p&lt; 0.001) significantly increased in Group 1 patients.</div></div><div><h3>Conclusion</h3><div>These findings suggest that post-COVID olfactory loss is associated with smaller OB volumes and increased OB signal intensity. Additionally, this study provides evidence supporting the effectiveness of OT in improving olfactory function and OB volume in patients with long-lasting post-COVID-19 symptoms.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 76-83"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes of primary salivary gland squamous cell carcinoma: A multi-institutional retrospective study in Japan","authors":"Ryosuke Sato ,&nbsp;Takumi Kumai ,&nbsp;Takahiro Kusaka ,&nbsp;Satoshi Kano ,&nbsp;Akira Ohkoshi ,&nbsp;Satoshi Kubota ,&nbsp;Yuya Miyakura ,&nbsp;Kosuke Murayama ,&nbsp;Ai Tagawa ,&nbsp;Shino Godo ,&nbsp;Daisuke Matsushita ,&nbsp;Hiroki Tomizawa ,&nbsp;Satoshi Toyoma ,&nbsp;Akina Shirotori ,&nbsp;Miki Takahara","doi":"10.1016/j.anl.2024.12.008","DOIUrl":"10.1016/j.anl.2024.12.008","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Primary salivary gland squamous cell carcinoma (SCC) is extremely rare, accounting for 0.3–10.4 % of all salivary gland malignancies. Due to this rarity, the clinical characteristics of primary salivary gland SCC remain unelucidated. In the present study, we conducted a multi-institutional retrospective analysis—including a large number of cases compared with that of previous studies—to reveal the prognosis, treatment outcomes, and prognostic factors of primary salivary gland SCC.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The clinical course of patients with primary salivary gland SCC between January 2012 and December 2022 was retrospectively investigated. Thirteen university hospitals and cancer centers in Japan participated in this study. The diagnosis of primary salivary gland SCC was based on the following criteria: 1) pathological diagnosis of SCC and exclusion of other histological types and 2) exclusion of metastatic SCCs from other organs. Progression-free and overall survival rates were compared using Kaplan–Meier curves and log-rank tests. Treatment outcomes were assessed using univariate and multivariate analyses with Cox proportional hazards models.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In total, 723 patients with salivary gland cancer were admitted to the participating institutions. Among them, 63 patients (8.7 %) were diagnosed with primary salivary gland SCC. The clinical courses of the 58 patients that received definitive treatment and had complete data were analyzed. Primary treatments included surgery in 35 patients (60.3 %), chemoradiotherapy in 16 (27.6 %), radiotherapy in 5 (8.6 %), and chemotherapy in 2 (3.4 %). Complete response and objective response rates to chemoradiotherapy were 62.5 % and 93.8 %, respectively. Five-year progression-free and overall survival rates were 30.1 % and 60.1 %, respectively. Five-year progression-free survival rates for each treatment were 37.7 % (surgery), 33.0 % (chemoradiotherapy), 0 % (radiotherapy), and 0 % (chemotherapy). Overall survival rates were 71.5 % (surgery), 39.5 % (chemoradiotherapy), 53.3 % (radiotherapy), and 0 % (chemotherapy). Multivariate analysis revealed that age ≥70 years, &lt;em&gt;N&lt;/em&gt; classification ≥1, and surgery were independent predictors of progression-free (hazard ratios: 3.75, 2.46, and 0.33, respectively) and overall survival (hazard ratios: 3.11, 6.24, and 0.32, respectively). Adjuvant radiotherapy significantly improved progression-free and overall survival in patients with stage Ⅳ cancer or positive surgical margins. Log-rank tests revealed no significant difference between patients with or without elective neck dissection in progression-free and overall survival; however, a relatively high percentage of occult lymph node metastasis (50.0 %) was observed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Surgical resection is a favorable first-line treatment option in salivary gland SCC, and definitive chemoradiotherapy would show acceptable comple","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 1","pages":"Pages 43-49"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and neck cancer registry of Japan","authors":"Daisuke Kawakita ,&nbsp;Seiichi Yoshimoto ,&nbsp;Munenaga Nakamizo ,&nbsp;Megumi Kitayama ,&nbsp;Tadaaki Kirita ,&nbsp;Takeshi Kodaira ,&nbsp;Toshifumi Tomioka ,&nbsp;Ryosuke Kamiyama ,&nbsp;Hideaki Takahashi ,&nbsp;Hideki Nakayama ,&nbsp;Yoshio Ohyama ,&nbsp;Yuji Murakami ,&nbsp;Ken-Ichi Nibu","doi":"10.1016/j.anl.2025.01.007","DOIUrl":"10.1016/j.anl.2025.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>The Head and Neck Cancer Registry, supported by the Japan Society for Head and Neck Cancer, was re-established in 2012 after renewal of the contents and methods of registration.</div></div><div><h3>Methods</h3><div>The registry registers patients with previously untreated, histologically confirmed malignant tumors of the head and neck, including the oral cavity, larynx, hypopharynx, oropharynx, nasopharynx, nasal cavity and paranasal sinus, major salivary gland, and cervical nodal involvement with an unknown primary.</div></div><div><h3>Results</h3><div>The total number of registered patients reached more than 150,000 as of June 2024. We have published reports of important real-world evidence from the registry data.</div></div><div><h3>Conclusion</h3><div>We believe that this nation-wide, organ-based registry aids understanding of the epidemiology and treatment strategies of head and neck cancer, in addition to hospital-based and national cancer registries in Japan.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 122-126"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of gross extranodal extension into major neck structures on the prognosis of papillary thyroid carcinoma","authors":"Sueyoshi Moritani,&nbsp;Masao Takenobu,&nbsp;Masakazu Yasunaga,&nbsp;Katsuyuki Kawamoto,&nbsp;Taihei Fujii,&nbsp;Hiroya Kitano","doi":"10.1016/j.anl.2024.12.012","DOIUrl":"10.1016/j.anl.2024.12.012","url":null,"abstract":"<div><h3>Objective</h3><div>The AJCC-8 staging system for papillary thyroid carcinoma (PTC) excludes certain lymph node characteristics from stage determinants due to insufficient evidence of their prognostic impact. This study aimed to examine the influence of gross extranodal extension (N-Ex) on survival and recurrence by comparing outcomes of extrathyroidal extension (T-Ex) and N-Ex cases.</div></div><div><h3>Methods</h3><div>Patients with PTC who underwent initial surgical treatment and had T-Ex or N-Ex were selected. Their survival and recurrence rates were compared, focusing on age and stage classification. Patients younger than 55 years without distant metastasis (DM) are classified as Stage I, regardless of T-Ex or N-Ex. Patients aged 55 years or older without DM are classified as Stage II if they have N-Ex without T-Ex and Stage III or IVA if they have T-Ex. The prognoses of the T-Ex and N-Ex groups stratified by age were compared. Using the T-classification by organ involvement, older patients with N-Ex were subgrouped, and their prognoses were compared with those of the T-Ex group.</div></div><div><h3>Results</h3><div>The study included 183 T-Ex and 50 N-Ex without T-Ex cases. The disease-specific survival (DSS) and disease-free survival (DFS) of the two groups did not differ for the younger patients without distant metastases (Stage I in both groups). For the older patients without distant metastasis, the 10-year DSS was 80.6% and 48.5% for Stages III and IVA (with T4bAnyNM0; T-Ex group) and 74.7% for Stage II (with T1-3N-ExM0; N-Ex group). The 10-year DFS were 68.2%, 0%, and 64.5% for Stages III, IVA (T-Ex group), and II (N-Ex group), respectively. The DSS and DFS did not differ for Stages III and IVA (T-Ex group) and II (N-Ex group). The prognoses of the N-Ex subgroups and the older T-Ex group did not also differ.</div></div><div><h3>Conclusions</h3><div>The patients aged 55 years or older without DM had comparable prognoses, although cases with N-Ex without T-Ex were classified as Stage II, and those with T-Ex were classified as Stage III or IVA. The recurrence rates for the N-Ex and T-Ex stages were also comparable. These suggest that N-Ex is an important prognostic factor.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 127-131"},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}