Australian Endodontic Journal最新文献

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Does the Combination of Calcium Hydroxide and Chlorhexidine Gel Affect Dentinal Tubule Penetration of Epoxy Resin and Tricalcium Silicate-Based Sealers? 氢氧化钙和氯己定凝胶的组合是否影响环氧树脂和硅酸三钙基密封剂对牙本质小管的渗透?
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-06-04 DOI: 10.1111/aej.70093
Ecem Kuscu Baran, Aysenur Oncu, Berkan Celikten
{"title":"Does the Combination of Calcium Hydroxide and Chlorhexidine Gel Affect Dentinal Tubule Penetration of Epoxy Resin and Tricalcium Silicate-Based Sealers?","authors":"Ecem Kuscu Baran, Aysenur Oncu, Berkan Celikten","doi":"10.1111/aej.70093","DOIUrl":"https://doi.org/10.1111/aej.70093","url":null,"abstract":"<p><p>This study evaluated effect of calcium hydroxide (CH) medicaments prepared with distilled water, glycerin and chlorhexidine (CHX) gel on dentinal tubule penetration of epoxy resin- and tricalcium silicate-based sealers using confocal laser scanning microscopy (CLSM). Eighty single-rooted human teeth were included; 60 teeth were allocated to six experimental groups according to sealer type and CH vehicle, and 20 teeth served as control groups. After instrumentation and 7 days of CH application, medicaments were removed and canals were obturated with rhodamine B-labelled sealers. Following a 15-day setting period, samples were sectioned and analysed. Penetration depth and area were evaluated using two-way ANOVA and Tukey tests (p ≤ 0.05). CH vehicle type did not significantly influence sealer penetration (p > 0.05), whereas epoxy resin-based sealers demonstrated greater penetration depth and area compared to tricalcium silicate-based sealers (p < 0.05). Within study limitations, CHX gel did not adversely affect dentinal tubule penetration.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scrolling for Success: Social Media as a Supplementary Resource in Endodontic Education. 滚动成功:社会媒体作为牙髓教育的补充资源。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-05-13 DOI: 10.1111/aej.70089
Cordelia Chan, Anthony Shahata, Zameera Fida, Schuyler DeLuca, Louisiana Espinoza, Matthew Finkelman, Devon Ptak
{"title":"Scrolling for Success: Social Media as a Supplementary Resource in Endodontic Education.","authors":"Cordelia Chan, Anthony Shahata, Zameera Fida, Schuyler DeLuca, Louisiana Espinoza, Matthew Finkelman, Devon Ptak","doi":"10.1111/aej.70089","DOIUrl":"https://doi.org/10.1111/aej.70089","url":null,"abstract":"<p><p>There is growing reliance on digital platforms for education. Today's dental students seek online resources to support clinical learning. The impact of these platforms in endodontic education remains underexplored. This study evaluated social media preferences of predoctoral dental students at Tufts University School of Dental Medicine for supplementing their endodontic education. A survey was distributed to third- and fourth-year dental students (n = 467) assessing usage of institutional and external resources, perceived preparedness for clinical procedures, and frequency of fact-checking supplemental content. 94 students responded (20.1%). YouTube was the most commonly used non-curricular resource (77.7%), with significantly higher usage among third-year students (85.5%) compared to fourth-years (66.7%; p = 0.031). Only 41.5% of students reported fact-checking external content. A significant proportion of dental students rely on external resources to supplement their endodontic education. These findings highlight the need for educators to develop evidence-based multimedia resources to enhance clinical preparedness in endodontics.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Root and Canal Morphology of Maxillary Premolars in a Namibian Population: A Retrospective Cone-Beam Computed Tomography Study. 纳米比亚人群上颌前磨牙的根管形态:回顾性锥束计算机断层扫描研究。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-05-07 DOI: 10.1111/aej.70088
Gunther Arthur Streit, Quenton Wessels, Glynn Dale Buchanan
{"title":"Root and Canal Morphology of Maxillary Premolars in a Namibian Population: A Retrospective Cone-Beam Computed Tomography Study.","authors":"Gunther Arthur Streit, Quenton Wessels, Glynn Dale Buchanan","doi":"10.1111/aej.70088","DOIUrl":"https://doi.org/10.1111/aej.70088","url":null,"abstract":"<p><p>This study examined population-specific morphological variations in human premolar roots and canals and their clinical implications. Cone-beam computed tomography (CBCT) was used with the Ahmed classification system. A retrospective descriptive cross-sectional study analysed 388 maxillary premolars from CBCT scans of 97 participants obtained from participating private dental practices in Swakopmund and Windhoek and from the University of Namibia dental clinic. The root number and canal configuration were classified by the Ahmed system. Associations were assessed by comparing identical tooth types in the right and left maxilla. First premolars were mostly two-rooted (56.2%), and second premolars were mostly single-rooted (88.1%), with key configurations of <sup>1</sup>MP<sup>1</sup>, <sup>1</sup>MP<sup>1-2</sup> and <sup>2</sup>MP B<sup>1</sup>P<sup>1</sup>. Age-related changes showed increased <sup>2</sup>MP B<sup>1</sup>P<sup>1</sup> in first premolars and <sup>1</sup>MP<sup>1-2-1</sup> in second premolars. The dominant configurations in this Namibian sample align with other populations, emphasising the importance of population-specific data for endodontic treatment and supporting the relevance of the Ahmed classification.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality and Accuracy Assessment of YouTube Videos on Vital Pulp Therapy. YouTube重要牙髓治疗视频的质量和准确性评估。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-20 DOI: 10.1111/aej.70085
Divya Nangia, Vasudev Ballal, Prashant Bhasin, Esha Sukhala, Ashima Garg, Meenu G Singla, Hemanshi Kumar
{"title":"Quality and Accuracy Assessment of YouTube Videos on Vital Pulp Therapy.","authors":"Divya Nangia, Vasudev Ballal, Prashant Bhasin, Esha Sukhala, Ashima Garg, Meenu G Singla, Hemanshi Kumar","doi":"10.1111/aej.70085","DOIUrl":"https://doi.org/10.1111/aej.70085","url":null,"abstract":"<p><p>The aim was to assess the quality and accuracy of Vital Pulp Therapy videos on YouTube. First, sixty videos were surfed using five (pulp capping, pulpotomy, vital pulp therapy, and two layman terms) keywords. Quality was assessed using the following validated indices: Modified DISCERN, Global Quality Score (GQS), and Video Information and Quality index (VIQI). Accuracy was evaluated using scoring criteria based on European Society of Endodontology (ESE) and American Association of Endodontists (AAE) position statements. The correlation between the derived metrics was established using Spearman's rank order. The average quality scores were 3.03 (modified DISCERN), 3.1 (GQS), and 11.08 (VIQI). As per the ESE statement, the average accuracy was 44.64%, 25.87%, and 32.8%, respectively, for 'pulpotomy', 'pulp capping', and 'vital pulp therapy' videos. Mean accuracy as per the AAE statement was 24.63%. A positive correlation of accuracy was established with all the metrics derived. The overall quality and accuracy were subpar.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative In Vitro Evaluation of Antibacterial Activity of Ganoderma lucidum– and Psidium guajava–Loaded Drug Delivery Scaffolds Against Enterococcus faecalis Biofilms 灵芝和番石榴载药支架对粪肠球菌生物膜抑菌活性的体外比较研究
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-05 Epub Date: 2025-10-23 DOI: 10.1111/aej.70026
Sheetal Ghivari, Meena Naganath, Girish Kubasad, Manohar S. Kugaji, Ulka Idate
{"title":"Comparative In Vitro Evaluation of Antibacterial Activity of Ganoderma lucidum– and Psidium guajava–Loaded Drug Delivery Scaffolds Against Enterococcus faecalis Biofilms","authors":"Sheetal Ghivari,&nbsp;Meena Naganath,&nbsp;Girish Kubasad,&nbsp;Manohar S. Kugaji,&nbsp;Ulka Idate","doi":"10.1111/aej.70026","DOIUrl":"10.1111/aej.70026","url":null,"abstract":"<div>\u0000 \u0000 <p>This in vitro study evaluated the antibacterial efficacy of novel herbal intracanal medicaments, specifically <i>Ganoderma lucidum</i> (GL) and <i>Psidium guajava</i> (PG) extracts, incorporated into Pluronic F127 drug delivery scaffolds, against <i>Enterococcus faecalis</i> biofilms. Biofilms were established on standardised dentine specimens and treated with herbal-loaded hydrogels, calcium hydroxide (CH), modified triple antibiotic paste (mTAP) or saline (control). Antibacterial activity was assessed via colony-forming unit (CFU) counts, quantitative real-time PCR (qPCR), and confocal laser scanning microscopy (CLSM). Results revealed significant antibacterial effects in all medicated groups compared to control, with mTAP exhibiting the highest efficacy, followed by CH and PG. PG's performance was comparable to CH and superior to GL. The study supports the potential of PG and GL herbal-loaded scaffolds as alternative intracanal medicaments pending further in vivo research.</p>\u0000 </div>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"52 1","pages":"9-16"},"PeriodicalIF":1.5,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Intracanal Medicaments on Cell Cycle, Viability and Differentiation of Human Apical Papilla Mesenchymal Stem Cells (hAP-MSCs) 肛管内药物对人根尖乳头间充质干细胞(hAP-MSCs)细胞周期、活力和分化的影响
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-05 Epub Date: 2025-11-10 DOI: 10.1111/aej.70033
Morankar Rahul, Pankaj Keshari, Riyaz Ahmed Mir, Nitesh Tewari, Vijay Mathur, Jhunjhunwala Garima, Kalpana Bansal, Rahul Yadav
{"title":"Impact of Intracanal Medicaments on Cell Cycle, Viability and Differentiation of Human Apical Papilla Mesenchymal Stem Cells (hAP-MSCs)","authors":"Morankar Rahul,&nbsp;Pankaj Keshari,&nbsp;Riyaz Ahmed Mir,&nbsp;Nitesh Tewari,&nbsp;Vijay Mathur,&nbsp;Jhunjhunwala Garima,&nbsp;Kalpana Bansal,&nbsp;Rahul Yadav","doi":"10.1111/aej.70033","DOIUrl":"10.1111/aej.70033","url":null,"abstract":"<div>\u0000 \u0000 <p>This in vitro experiment evaluated cell cycle, viability and osteogenic differentiation of human apical papilla-derived mesenchymal stem cells (hAP-MSCs) by intracanal medicaments used in regenerative endodontic treatment. Apical papilla tissues of immature extracted tooth roots were digested, trypsinized and resuspended as a single cell suspension stained with CD146, CD73 and CD90 antibodies. Results revealed that apical papilla tissue harbours hAP-MSCs, and they can be cultured and characterised. Low-concentration intracanal medicaments (0.025 mg/mL) were less cytotoxic compared to higher concentrations (0.1 mg/mL and above). Calcium hydroxide was better in terms of viability as well as osteogenic differentiation (at 0.025, 0.05 and 0.1 mg/mL concentration) than triple antibiotic paste (TAP), modified TAP, and DAP (double antibiotic paste) at 24, 48, and 72 h. Thus, calcium hydroxide was less cytotoxic compared to the different antibiotic paste combinations.</p>\u0000 </div>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"52 1","pages":"110-123"},"PeriodicalIF":1.5,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular and Mechanical Responses to Zinc Polycarboxylate Cement Modified With 5% or 10% Potassium Nitrate: An In Vitro Study 5%或10%硝酸钾改性聚羧酸锌水泥的细胞和力学反应:体外研究。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-05 Epub Date: 2025-09-25 DOI: 10.1111/aej.70022
Fatimah Dahlawi, Mohammed AlGharni, Marwa Madi, Neveen M. Ayad, Faisal Alonizan, Nada Aldossary, Omar Omar
{"title":"Cellular and Mechanical Responses to Zinc Polycarboxylate Cement Modified With 5% or 10% Potassium Nitrate: An In Vitro Study","authors":"Fatimah Dahlawi,&nbsp;Mohammed AlGharni,&nbsp;Marwa Madi,&nbsp;Neveen M. Ayad,&nbsp;Faisal Alonizan,&nbsp;Nada Aldossary,&nbsp;Omar Omar","doi":"10.1111/aej.70022","DOIUrl":"10.1111/aej.70022","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigated the biological response of human peripheral blood mononuclear cells (PBMCs) to zinc polycarboxylate (ZP) cement modified with 5% or 10% potassium nitrate (KNO<sub>3</sub>) and assessed its mechanical properties. Discs of unmodified ZP, ZP + 5% KNO<sub>3</sub>, ZP + 10% KNO<sub>3</sub>, or mineral trioxide aggregate (MTA) were indirectly exposed to PBMCs using a transwell system. Cells were incubated with or without lipopolysaccharide (LPS) stimulation. Cytotoxicity (LDH release), viability, IL-6 and TGF-β secretion were evaluated. Material pH, ion release, compressive strength and microhardness were also assessed. ZP + 5% KNO<sub>3</sub> significantly reduced LDH and IL-6 levels and increased TGF-β release compared to ZP alone. Mechanical strength was maintained in ZP + 5% KNO<sub>3</sub> but decreased at 10% KNO<sub>3</sub>. MTA showed lower strength but higher cell viability. ZP + 5% KNO<sub>3</sub> demonstrated a balanced profile of immunomodulation, regenerative signalling and mechanical integrity, supporting its potential use in vital pulp therapy. Further in vivo investigations are recommended.</p>\u0000 </div>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"52 1","pages":"59-69"},"PeriodicalIF":1.5,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Supplementary Irrigation Methods Against Bacterial Biofilm-Infected Root Canals Prepared With Minimally Invasive and Conventional Techniques 辅助灌洗方法对微创与常规根管制备的细菌生物膜感染的疗效观察。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-05 Epub Date: 2025-10-07 DOI: 10.1111/aej.70024
Giuliana Soimu, Abhishek Parolia, Anelise V. Masiero, Fang Qian, Thomas Moninger, Jeffrey A. Banas, Fabricio B. Teixeira
{"title":"Efficacy of Supplementary Irrigation Methods Against Bacterial Biofilm-Infected Root Canals Prepared With Minimally Invasive and Conventional Techniques","authors":"Giuliana Soimu,&nbsp;Abhishek Parolia,&nbsp;Anelise V. Masiero,&nbsp;Fang Qian,&nbsp;Thomas Moninger,&nbsp;Jeffrey A. Banas,&nbsp;Fabricio B. Teixeira","doi":"10.1111/aej.70024","DOIUrl":"10.1111/aej.70024","url":null,"abstract":"<div>\u0000 \u0000 <p>This study evaluated the effectiveness of the GentleWave system (GWS), laser-activated irrigation (LAI), ultrasonic-activated irrigation (UAI) and sonic irrigation (SI) in removing a three-species biofilm from infected root canals prepared using minimally invasive techniques (MIT) and conventional instrumentation techniques (CIT). One hundred and ten single-canalled mandibular premolars were infected with the biofilm and assigned to five groups based on the supplementary irrigation method used. Biofilm removal was assessed using confocal laser scanning microscopy and scanning electron microscopy. In the CIT group, GWS resulted in a significantly higher proportion of dead cells compared to UAI and SI (<i>p</i> &lt; 0.05), with no significant difference between GWS and LAI. In the MIT group, no significant differences were observed among the irrigation methods (<i>p</i> &gt; 0.05). Although none of the approaches completely eliminated the biofilm, GWS and LAI were more effective than UAI and SI.</p>\u0000 </div>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"52 1","pages":"46-58"},"PeriodicalIF":1.5,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast 牙髓螯合剂依地膦酸钠对牙周韧带成纤维细胞的细胞毒性研究。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-05 Epub Date: 2025-10-29 DOI: 10.1111/aej.70029
Bruno Vila Nova de Almeida, Patrícia de Almeida Rodrigues, Geovanni Pereira Mitre, Maria Sueli da Silva Kataoka, João de Jesus Viana Pinheiro, Talita Tartari, Oscar Faciola Pessoa
{"title":"Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast","authors":"Bruno Vila Nova de Almeida,&nbsp;Patrícia de Almeida Rodrigues,&nbsp;Geovanni Pereira Mitre,&nbsp;Maria Sueli da Silva Kataoka,&nbsp;João de Jesus Viana Pinheiro,&nbsp;Talita Tartari,&nbsp;Oscar Faciola Pessoa","doi":"10.1111/aej.70029","DOIUrl":"10.1111/aej.70029","url":null,"abstract":"<p>Etidronic acid (HEBP) causes fewer alterations in dentine and can be used mixed with sodium hypochlorite during root canal preparation. This study investigated the cytotoxicity effects of the HEDP and EDTA on human periodontal ligament fibroblast cells. Primary culture was established from human periodontal ligament tissue of one donor and was characterised by immunofluorescence and real-time quantitative polymerase chain reaction. The half-maximal inhibitory concentration (IC<sub>50</sub>) was tested: 9% HEBP, 18% HEBP, 24% HEBP, 15% EDTA, 17% EDTA, 24% EDTA, and control. Exposure times were 1, 4, and 24 h. The Kruskal-Wallis test, followed by Dunn's post hoc, assessed multiple comparisons between the groups (<i>α</i> = 0.05). All experimental groups showed a lower IC<sub>50</sub> effect after 24 h, except 9% HEBP. EDTA cytotoxicity depends on the contact time, regardless of the concentration. In conclusion, 9% HEBP is a biocompatible alternative to EDTA as an endodontic chelator, particularly for protocols requiring longer exposure times.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"52 1","pages":"84-91"},"PeriodicalIF":1.5,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Solubility, pH, Antimicrobial Action and Cytotoxicity of Calcium Hydroxide Paste Associated With Ambroxol Hydrochloride 盐酸氨溴索与氢氧化钙膏体的溶解度、pH、抗菌作用及细胞毒性分析。
IF 1.5 4区 医学
Australian Endodontic Journal Pub Date : 2026-04-05 Epub Date: 2025-11-22 DOI: 10.1111/aej.70039
Thaís Ferreira Rodrigues Mota, Ana Flávia Balestrero Cassiano, Pedro César Gomes Titato, Pedro Henrique Souza Calefi, Murilo Priori Alcalde, Gisele Faria, Marco Antonio Hungaro Duarte
{"title":"Analysis of Solubility, pH, Antimicrobial Action and Cytotoxicity of Calcium Hydroxide Paste Associated With Ambroxol Hydrochloride","authors":"Thaís Ferreira Rodrigues Mota,&nbsp;Ana Flávia Balestrero Cassiano,&nbsp;Pedro César Gomes Titato,&nbsp;Pedro Henrique Souza Calefi,&nbsp;Murilo Priori Alcalde,&nbsp;Gisele Faria,&nbsp;Marco Antonio Hungaro Duarte","doi":"10.1111/aej.70039","DOIUrl":"10.1111/aej.70039","url":null,"abstract":"<p>This study evaluated the association of ambroxol hydrochloride with calcium hydroxide paste as intracanal medication to enhance antimicrobial action on biofilm without affecting pH, solubility and cytotoxicity. Calcium hydroxide (CH) paste and formulations with different ambroxol concentrations were placed into artificial teeth conditioned in distilled water. pH and solubility were measured. Dentine discs infected with <i>E. faecalis</i> were covered with pastes, and biofilm viability was analysed using live/dead assay and confocal microscope. Cytotoxicity was analysed using MTT assay on fibroblast and osteoblast-like cells. Data were statistically compared (<i>p</i> &lt; 0.05). Ambroxol showed an acidic pH after 7 days, compared to CH, but the 30% concentration became more alkaline after 30 days. While CH's pH decreased over time, ambroxol groups maintained stability. Solubility decreased for all groups over time. All groups showed significant antimicrobial differences from the control group. The association did not alter CH's cytotoxicity. Further research is needed for optimal ambroxol concentration.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"52 1","pages":"148-155"},"PeriodicalIF":1.5,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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