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Endodontic management considerations for Type III dens invaginatus based on anatomical characteristics: A case series 基于解剖学特征的 III 型牙髓隐窝的牙髓治疗考虑因素：病例系列
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-04-23 DOI: 10.1111/aej.12847
Jia Wang PhD, Chenguang Niu PhD, Pengfei Zhang MD, Shujun Ran PhD, Zhengwei Huang PhD
{"title":"Endodontic management considerations for Type III dens invaginatus based on anatomical characteristics: A case series","authors":"Jia Wang PhD,&nbsp;Chenguang Niu PhD,&nbsp;Pengfei Zhang MD,&nbsp;Shujun Ran PhD,&nbsp;Zhengwei Huang PhD","doi":"10.1111/aej.12847","DOIUrl":"10.1111/aej.12847","url":null,"abstract":"<p>Dens invaginatus (DI) is a developmental anomaly of the teeth characterised by the in-folding of the enamel into the dentin. Oehlers' Type III DI is the most serious form, in which the inherently invaginated channels communicate with periodontal and dental pulp tissue, increasing the risk of bacterial contamination. However, varying and complex anatomical features make diagnosis and treatment challenging. Conventional endodontic therapies promote healing by avoiding unnecessary interventions (e.g., surgical or other invasive treatments). Radiographic examination can reveal the structural details of such malformations. We obtained multiple procedural details for treating Type III DI based on radiographic analyses from our clinical experience. In addition, we introduce a new classification strategy for the management of Type III DI that is more applicable to treatment needs. This study aimed to discuss the anatomical features and current treatment considerations of Type III DI.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"377-387"},"PeriodicalIF":1.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the timing of primary endodontic treatment and dosage of radiation therapy on the filling material removal 初级牙髓治疗的时间和放射治疗的剂量对填充材料去除的影响
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-04-10 DOI: 10.1111/aej.12846
Bruna Venzke Fischer, Luiz Carlos de Lima Dias-Junior, Mariana Comparotto Minamisako, Cristiane Maria Almeida, Luciano Roberto da Silva, Eduardo Antunes Bortoluzzi, Cleonice da Silveira Teixeira, Lucas da Fonseca Roberti Garcia
{"title":"Effect of the timing of primary endodontic treatment and dosage of radiation therapy on the filling material removal","authors":"Bruna Venzke Fischer,&nbsp;Luiz Carlos de Lima Dias-Junior,&nbsp;Mariana Comparotto Minamisako,&nbsp;Cristiane Maria Almeida,&nbsp;Luciano Roberto da Silva,&nbsp;Eduardo Antunes Bortoluzzi,&nbsp;Cleonice da Silveira Teixeira,&nbsp;Lucas da Fonseca Roberti Garcia","doi":"10.1111/aej.12846","DOIUrl":"10.1111/aej.12846","url":null,"abstract":"<p>This study investigated the effect of the timing of primary endodontic treatment and dosage of radiotherapy on the remaining filling material (RFM) during endodontic reintervention. 60 single-rooted human mandibular premolars were distributed into five groups (<i>n</i> = 12), according to the timing and dosage of radiation (55Gy or 70Gy): NegativeCG-non-irradiated teeth; Endo-pre-RT<sub>55/70</sub>-obturation before irradiation (55Gy or 70Gy); Endo-post-RT<sub>55/70</sub>-obturation and reintervention after irradiation (55Gy or 70Gy). Roots were cleaved and analysed under stereomicroscope and Scanning Electron Microscope to quantify (%) the RFM. Experimental groups had a significantly greater amount (<i>p</i> &lt; 0.05) of RFM in the middle and apical thirds than the control group, except for Endo-pre-RT<sub>55</sub> in the middle third (<i>p</i> &lt; 0.0001). The apical third had greater amount of RFM (<i>p</i> &lt; 0.05). Radiation therapy, before and after primary endodontic treatment, increased the amount of RFM, regardless of the dose delivered. When necessary, reintervention preferably must be performed before radiation therapy.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"321-333"},"PeriodicalIF":1.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reviewer acknowledgement 审稿人致谢
IF 1.6 4区 医学
Australian Endodontic Journal Pub Date : 2024-04-06 DOI: 10.1111/aej.12831
{"title":"Reviewer acknowledgement","authors":"","doi":"10.1111/aej.12831","DOIUrl":"https://doi.org/10.1111/aej.12831","url":null,"abstract":"","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 1","pages":"184-185"},"PeriodicalIF":1.6,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of full and partial pulpotomy in permanent teeth with irreversible pulpitis: A systematic review and meta-analysis 对患有不可逆牙髓炎的恒牙进行全牙髓切断术和部分牙髓切断术的比较评估：系统回顾和荟萃分析
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-04-02 DOI: 10.1111/aej.12844
Vishal Kumar MDS, Amrita Chawla MDS, Harsh Priya MDS, Akshat Sachdeva MDS, Sidhartha Sharma MDS, Vijay Kumar MDS, Ajay Logani MDS
{"title":"Comparative evaluation of full and partial pulpotomy in permanent teeth with irreversible pulpitis: A systematic review and meta-analysis","authors":"Vishal Kumar MDS,&nbsp;Amrita Chawla MDS,&nbsp;Harsh Priya MDS,&nbsp;Akshat Sachdeva MDS,&nbsp;Sidhartha Sharma MDS,&nbsp;Vijay Kumar MDS,&nbsp;Ajay Logani MDS","doi":"10.1111/aej.12844","DOIUrl":"10.1111/aej.12844","url":null,"abstract":"<p>The purpose of this systematic review and meta-analysis is to conduct a comparative evaluation of partial and full pulpotomy techniques in cariously exposed teeth with symptoms indicative of symptomatic irreversible pulpitis. Databases such as PubMed, EMBASE, Cochrane, and Web of Science were searched. Studies evaluating and/or comparing clinical and/or radiographic success of partial and full pulpotomy in teeth diagnosed with irreversible pulpitis with a minimum of 12 months follow-up were included. The risk of bias (ROB) tool was used for the assessment of ROB. A meta-analysis was conducted to compare the healing outcome of partial and full pulpotomy. Three studies fulfilled the inclusion criteria, there was a low risk of bias in each of the five domains. Full pulpotomy had a higher success rate than partial pulpotomy, according to meta-analysis, but the difference was not statistically significant.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"388-396"},"PeriodicalIF":1.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of ibuprofen sustained release oral premedication on intraoperative and postoperative pain: A randomised clinical trial 布洛芬缓释口服预处理对术中和术后疼痛的影响：随机临床试验。
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-03-25 DOI: 10.1111/aej.12839
Mariam Ahmed Hossam BDS, Alaa Abdelsalam El Baz BDS, MSc, PhD, Sang Won Kwak DDS, MS, PhD, Hyeon-Cheol Kim DDS, MS, PhD, Mohamed Mohsen Abielhassan BDS, MSc, PhD
{"title":"The effect of ibuprofen sustained release oral premedication on intraoperative and postoperative pain: A randomised clinical trial","authors":"Mariam Ahmed Hossam BDS,&nbsp;Alaa Abdelsalam El Baz BDS, MSc, PhD,&nbsp;Sang Won Kwak DDS, MS, PhD,&nbsp;Hyeon-Cheol Kim DDS, MS, PhD,&nbsp;Mohamed Mohsen Abielhassan BDS, MSc, PhD","doi":"10.1111/aej.12839","DOIUrl":"10.1111/aej.12839","url":null,"abstract":"<p>The aim of this study was to assess the effect of ibuprofen sustained release (SR) oral premedication on the efficacy of buccal infiltration (BI) with intraoperative and postoperative pain after single-visit root canal treatment. Sixty patients diagnosed with symptomatic irreversible pulpitis and apical periodontitis in mandibular molar were divided into two groups. Group SR received ibuprofen SR 800 mg and group PL received placebo capsule 1 h before 3.6 mL articaine BI injection. Pain was recorded using a modified visual analogue scale and postoperatively at intervals 6, 24 and 48 h. Group SR showed a significantly higher anaesthetic success rate (73.3%) compared to group PL (46.7%) (<i>p</i> &lt; 0.05). Intraoperative and postoperative pain was significantly higher in group PL compared to group SR (<i>p</i> &lt; 0.05). Premedication of ibuprofen SR improved the efficacy of primary BI in mandibular molars with symptomatic irreversible pulpitis and decreased postoperative pain at 6 and 48 h.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"227-236"},"PeriodicalIF":1.3,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guided tooth autotransplantation of a palatally impacted maxillary canine into the site of a failed maxillary canine implant 在引导下将腭侧撞击的上颌犬齿自体移植到上颌犬齿植入失败的部位。
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-03-21 DOI: 10.1111/aej.12840
Jesús Moreno-Pérez DDS, MSc, David Rubio Flores DDS, MSc, PhD, Carlos Fernández Villares, Venkateshbabu Nagendrababu BDS, MDS, FDS RCPS (Glasg), PhD, Francesc Abella Sans DDS, PhD
{"title":"Guided tooth autotransplantation of a palatally impacted maxillary canine into the site of a failed maxillary canine implant","authors":"Jesús Moreno-Pérez DDS, MSc,&nbsp;David Rubio Flores DDS, MSc, PhD,&nbsp;Carlos Fernández Villares,&nbsp;Venkateshbabu Nagendrababu BDS, MDS, FDS RCPS (Glasg), PhD,&nbsp;Francesc Abella Sans DDS, PhD","doi":"10.1111/aej.12840","DOIUrl":"10.1111/aej.12840","url":null,"abstract":"<p>The aim of this report is to demonstrate the guided tooth autotransplantation of a palatally impacted maxillary canine into the site of a failed maxillary canine dental implant. A 47-year-old woman visited a dental clinic complaining of loose dental implant in the left maxillary canine site, tooth #11, as well as pain and swelling of the gum around the implant. The clinical examination revealed a mobile implant along with swollen soft tissues with bleeding on probing. A periapical radiograph demonstrated peri-implant marginal bone loss. Cone beam computed tomography sections revealed that tooth #11 was impacted palatally. The implant was removed and replaced with the impacted canine via guided autotransplantation and posterior orthodontic alignment. The patient was recalled at 1, 3, 6, 9, 12, 24 and 48 months after the procedure. During this period, the patient was symptom-free and radiographic examination at 2 years revealed no periapical pathosis or root resorption.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"369-376"},"PeriodicalIF":1.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aej.12840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adhesion and sealing of different universal adhesive systems associated with bulk-fill resins after using endodontic irrigation solutions: An in vitro study 使用牙髓冲洗液后不同通用粘合剂系统与大量填充树脂的粘附性和密封性：体外研究。
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-03-21 DOI: 10.1111/aej.12843
Érika Mayumi Omoto, Anderson Catelan, Paulo Henrique dos Santos, Luciano Tavares Angelo Cintra, Fernanda de Souza e Silva Ramos, Caio César Pavani, André Luiz Fraga Briso, Ticiane Cestari Fagundes
{"title":"Adhesion and sealing of different universal adhesive systems associated with bulk-fill resins after using endodontic irrigation solutions: An in vitro study","authors":"Érika Mayumi Omoto,&nbsp;Anderson Catelan,&nbsp;Paulo Henrique dos Santos,&nbsp;Luciano Tavares Angelo Cintra,&nbsp;Fernanda de Souza e Silva Ramos,&nbsp;Caio César Pavani,&nbsp;André Luiz Fraga Briso,&nbsp;Ticiane Cestari Fagundes","doi":"10.1111/aej.12843","DOIUrl":"10.1111/aej.12843","url":null,"abstract":"<p>This study aimed to evaluate the interface of universal adhesive (UA) with bulk-fill resin (BF) and dentin, after endodontic irrigation. The pulp chamber of 96 molars was irrigated with chlorhexidine 2% (CHX) or sodium hypochlorite 5.25% (NaOCl) and restored according to three restorative protocols. Microtensile bond strength (μTBS) and nanoleakage tests were performed after 24 h of thermocycling. Kruskal Wallis, Mann–Whitney and Wilcoxon were performed (<i>p</i> &lt; 0.05). Comparing restorative systems, a difference was found only when irrigated with CHX after 24 h. CHX provided higher μTBS than NaOCl after 24 h for two restorative protocols; after thermocycling, NaOCl provided the greatest μTBS than CHX for one group. Decreased μTBS was observed for all restorative systems when CHX was used after thermocycling. NaOCl demonstrated the highest nanoleakage. The composition of UA influenced the immediate adhesion and sealing to BF when CHX was used; ageing has a deteriorating effect on adhesion and sealing for all restorative systems.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"309-320"},"PeriodicalIF":1.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection, characterisation and management of complex root canal configurations in the mesiobuccal roots of maxillary first molars: A case series 上颌第一磨牙中颊根复杂根管结构的检测、特征描述和处理：病例系列。
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-03-21 DOI: 10.1111/aej.12842
Michael Arnold Dipl.-Stom., Hany Mohamed Aly Ahmed BDS, HDD (Endo), PhD, FICD, MDTFEd (RCSEd), FPFA, FADI
{"title":"Detection, characterisation and management of complex root canal configurations in the mesiobuccal roots of maxillary first molars: A case series","authors":"Michael Arnold Dipl.-Stom.,&nbsp;Hany Mohamed Aly Ahmed BDS, HDD (Endo), PhD, FICD, MDTFEd (RCSEd), FPFA, FADI","doi":"10.1111/aej.12842","DOIUrl":"10.1111/aej.12842","url":null,"abstract":"<p>This report presents the detection, characterisation, instrumentation and filling of complex canal configurations in the mesiobuccal (MB) root of maxillary first molars. Three patients were referred for root canal treatment in first maxillary molars. Medical history, age, sex and clinical findings were recorded. Intraoral periapical radiographs and cone beam computed tomography (CBCT) were used for diagnosis and pre-operative assessment. Using Ahmed et al. (2017) classification system, codes <sup>3</sup>MaxM MB<sup>3-5-4-2</sup> DB<sup>1-2-1</sup> P<sup>1</sup> (case 1), <sup>3</sup>MaxM MB<sup>2-5-3-2</sup> DB<sup>1</sup> P<sup>1</sup> (case 2) and <sup>3</sup>MaxM MB<sup>1-4-2-1-2</sup> DB<sup>1</sup> P<sup>1</sup> (case 3) were identified. Using the dental operating microscope, CBCT (if indicated) and troughing up to 3 mm allowed identification of more than three canals in the MB root of maxillary first molars. The coding system proposed by Ahmed et al. (2017) allows the classification of MB roots with highly complex canal configurations.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"359-368"},"PeriodicalIF":1.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of melatonin against experimentally induced apical periodontitis in rats 褪黑素对大鼠实验性根尖牙周炎的影响
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-03-21 DOI: 10.1111/aej.12841
D. Kırmızı DDS, PhD, A. Ö. Sehirli PhD, S. Sayiner DVM, K. Orhan DDS, PhD, A. Sebai DDS, PhD, U. Aksoy DDS, PhD
{"title":"Effects of melatonin against experimentally induced apical periodontitis in rats","authors":"D. Kırmızı DDS, PhD,&nbsp;A. Ö. Sehirli PhD,&nbsp;S. Sayiner DVM,&nbsp;K. Orhan DDS, PhD,&nbsp;A. Sebai DDS, PhD,&nbsp;U. Aksoy DDS, PhD","doi":"10.1111/aej.12841","DOIUrl":"10.1111/aej.12841","url":null,"abstract":"<p>Apical periodontitis is an inflammatory condition resulting from microbial invasion in the root canal system, causing periapical tissue destruction and bone resorption. This study investigated melatonin's effects, known for its antioxidant and anti-inflammatory properties, on experimentally induced apical periodontitis in rats. Three groups of rats were studied: control, apical periodontitis and apical periodontitis with melatonin treatment. Proinflammatory cytokines and enzyme levels in blood serum were measured, and micro-CT analysis assessed bone resorption. Results showed significantly elevated cytokines and enzyme levels in the apical periodontitis group compared to the control. However, in the melatonin-treated group, these levels were significantly reduced (<i>p</i> &lt; 0.01–0.001). Micro-CT analysis indicated decreased periapical resorption cavity volume and surface area with melatonin treatment. This suggests that systemic melatonin administration can mitigate inflammation and reduce bone resorption in experimentally induced apical periodontitis in rats, potentially holding promise for human endodontic disease treatment pending further research.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"218-226"},"PeriodicalIF":1.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones BMP2、BMP4、SMAD6 和 RUNX2 基因多态性与牙髓结石的研究。
IF 1.3 4区 医学
Australian Endodontic Journal Pub Date : 2024-03-10 DOI: 10.1111/aej.12835
Katherine Azevedo Batistela Rodrigues Thuller DDS, MSc, Lívia Azeredo Alves Antunes DDS, MSc, PhD, Prescila Mota de Oliveira Kublitski DDS, MSc, PhD, João Armando Brancher DDS, MSc, PhD, Flares Baratto-Filho DDS, MSc, PhD, Erika Calvano Küchler DDS, MSc, PhD, Alice Corrêa Silva-Sousa DDS, MSc, Manoel Damião Sousa-Neto DDS, MSc, PhD, Marilisa Carneiro Leão Gabardo DDS, MSc, PhD, Leonardo Santos Antunes DDS, MSc, PhD
{"title":"Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones","authors":"Katherine Azevedo Batistela Rodrigues Thuller DDS, MSc,&nbsp;Lívia Azeredo Alves Antunes DDS, MSc, PhD,&nbsp;Prescila Mota de Oliveira Kublitski DDS, MSc, PhD,&nbsp;João Armando Brancher DDS, MSc, PhD,&nbsp;Flares Baratto-Filho DDS, MSc, PhD,&nbsp;Erika Calvano Küchler DDS, MSc, PhD,&nbsp;Alice Corrêa Silva-Sousa DDS, MSc,&nbsp;Manoel Damião Sousa-Neto DDS, MSc, PhD,&nbsp;Marilisa Carneiro Leão Gabardo DDS, MSc, PhD,&nbsp;Leonardo Santos Antunes DDS, MSc, PhD","doi":"10.1111/aej.12835","DOIUrl":"10.1111/aej.12835","url":null,"abstract":"<p>This study aimed to assess the association between genetic polymorphisms in <i>BMP2</i> (rs1005464 and rs235768), <i>BMP4</i> (rs17563), <i>SMAD6</i> (rs2119261 and rs3934908) and <i>RUNX2</i> (rs59983488 and rs1200425) and pulp stones (PS). A total of 117 participants, consisting of 63 individuals with PS and 54 without PS, were included. Digital radiographs and a demographic/clinical questionnaire were used. Genomic DNA from salivary cells was genotyped via real-time polymerase chain reaction. Statistical analyses, including Chi-Square, Fisher's exact tests, Poisson regression and dimensionality reduction, were conducted. The rs2119261 polymorphism in the <i>SMAD6</i> gene showed an association with genotype distribution in the recessive model (<i>p</i> = 0.049). The T–T haplotype in the <i>SMAD6</i> gene (rs2119261 and rs3934908) was more prevalent in the control group and significantly linked with PS (<i>p</i> = 0.029). No associations were found between PS risk and genetic polymorphisms in <i>BMP2</i>, <i>BMP4</i> and <i>RUNX2</i>. Polymorphisms in the SMAD6 gene were associated with PS.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"50 2","pages":"299-308"},"PeriodicalIF":1.3,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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