Australian Endodontic Journal最新文献

Intentional Replantation of Permanent Teeth for Endodontic Indications: An Umbrella Review of Clinical Outcomes, Prognostic Factors and Evidence Quality. 牙髓指征的恒牙故意再植：临床结果、预后因素和证据质量的综述。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-10-16 DOI: 10.1111/aej.70131

Harshita Wadhwa, Rahul Sharma, Jigyasa Duhan

{"title":"Intentional Replantation of Permanent Teeth for Endodontic Indications: An Umbrella Review of Clinical Outcomes, Prognostic Factors and Evidence Quality.","authors":"Harshita Wadhwa, Rahul Sharma, Jigyasa Duhan","doi":"10.1111/aej.70131","DOIUrl":"https://doi.org/10.1111/aej.70131","url":null,"abstract":"This umbrella review synthesized evidence on the outcomes and prognostic factors of intentional replantation and assessed the methodological quality and primary-study overlap of existing systematic reviews. Systematic reviews with or without meta-analysis evaluating intentional replantation in permanent teeth were included. Seven reviews met the eligibility criteria. Reported pooled survival ranged from 85.9% to 89.1%, while success or healing ranged from 77.23% to 80.2%; however, this consistency must be interpreted cautiously due to very high primary-study overlap across the reviews. Evidence for prognostic factors was inconsistent, with several commonly proposed procedural factors lacking significant associations in pooled analyses. Five reviews had critically low confidence, and one had low confidence according to AMSTAR 2. Intentional replantation can achieve favourable tooth-retention outcomes in selected permanent teeth; however, confidence in current estimates is limited by methodological weaknesses, predominantly observational primary evidence and substantial evidence overlap. Higher-quality prospective and comparative studies are required. Trial Registration: International Prospective Register of Systematic Reviews (PROSPERO): CRD420261453494.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydraulic Calcium Silicate Cement-Root Dentine Interfacial Layer. 水力硅酸钙水泥-牙根质界面层。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-10-14 DOI: 10.1111/aej.70130

Yoon Seon Lee, Soojin Heo, Hiran Perinpanayagam, Yu Gu, Yoshi Terauchi, Chengfei Zhang, Jong Ryul Kim, Qiang Zhu, Abbasali Khademi, Jun-Sang Yoo, Kee-Yeon Kum

{"title":"Hydraulic Calcium Silicate Cement-Root Dentine Interfacial Layer.","authors":"Yoon Seon Lee, Soojin Heo, Hiran Perinpanayagam, Yu Gu, Yoshi Terauchi, Chengfei Zhang, Jong Ryul Kim, Qiang Zhu, Abbasali Khademi, Jun-Sang Yoo, Kee-Yeon Kum","doi":"10.1111/aej.70130","DOIUrl":"https://doi.org/10.1111/aej.70130","url":null,"abstract":"Understanding the interfacial layer (IFL) between hydraulic calcium silicate cements (CSCs) and root dentine is essential for optimising CSC performance and developing next-generation biomaterials. This scholarly review summarises current evidence on IFL composition, formation, structure, and clinical significance. An electronic search of PubMed, Web of Science, and Scopus identified relevant studies using 15 keywords, including 'interfacial layer.' A total of 115 articles were classified into three areas: CSC hydration, IFL formation and structure, and clinical implications. Evidence indicates that the IFL forms through hydration-driven reactions and intratubular mineralisation, creating mechanical interlocking and chemical bonding that improve interfacial integrity and sealing ability. These interactions may reinforce dentine, reduce microleakage, and maintain antibacterial activity against intracanal microorganisms, thereby enhancing endodontic outcomes. Further well-designed studies are needed to clarify the IFL's long-term behaviour under clinical conditions and optimise interfacial stability while preserving dentine integrity.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Language Models for NiTi File-Group Selection in Endodontics: A Two-Stage Comparative Study. 牙髓学中NiTi文件组选择的大型语言模型：两阶段比较研究。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-10-02 DOI: 10.1111/aej.70129

Damla Erkal, Yunus Emre Çakmak, Kürşat Er

引用次数: 0

Effects of Non-Surgical Endodontic Treatment on Inflammatory and Renal Markers in Chronic Kidney Disease and Healthy Patients With Apical Periodontitis. 非手术治疗对慢性肾病和健康根尖牙周炎患者炎症和肾脏标志物的影响。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-28 DOI: 10.1111/aej.70125

Himanshi Verma, Shweta Mittal, Sanjay Tewari, Deepak Jain, Vinay Kumar, Jigyasa Duhan, Pankaj Sangwan, Mayank Arora, Nishant Chauhan

{"title":"Effects of Non-Surgical Endodontic Treatment on Inflammatory and Renal Markers in Chronic Kidney Disease and Healthy Patients With Apical Periodontitis.","authors":"Himanshi Verma, Shweta Mittal, Sanjay Tewari, Deepak Jain, Vinay Kumar, Jigyasa Duhan, Pankaj Sangwan, Mayank Arora, Nishant Chauhan","doi":"10.1111/aej.70125","DOIUrl":"https://doi.org/10.1111/aej.70125","url":null,"abstract":"This prospective study evaluated changes in high-sensitivity C-reactive protein (hs-CRP) and renal markers like urea, creatinine and estimated glomerular filtration rate (eGFR) following non-surgical endodontic treatment (NSET) in 37 chronic kidney disease (CKD) and 37 healthy patients with apical periodontitis. Periapical radiographs and serum biomarkers were evaluated at baseline and 6 months using appropriate statistical tests. Following NSET, both groups showed significant reduction in mean PAI score and lesion size. hs-CRP levels reduced significantly in both groups (p < 0.05), with significant proportion of CKD patients in the high-risk hs-CRP category declining from 67% to 39% (p = 0.006). Blood urea levels decreased significantly in CKD patients (p < 0.05). The study demonstrates an association between NSET and improvement in inflammatory and selected renal biomarkers but does not establish causality between apical periodontitis (AP) and CKD. However, timely management of AP in patients with CKD may be clinically prudent and potentially beneficial. Trial Registration: This study has been registered at ClinicalTrials.gov with ID: (Registration number: NCT06446011).","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

iRoot BP Plus Sustains Mitochondrial Homeostasis in Human Dental Pulp Stem Cells Subjected to Oxidative Stress. iRoot BP Plus在氧化应激下维持人牙髓干细胞线粒体稳态。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-25 DOI: 10.1111/aej.70126

Jiahe Li, Yong Wang

{"title":"iRoot BP Plus Sustains Mitochondrial Homeostasis in Human Dental Pulp Stem Cells Subjected to Oxidative Stress.","authors":"Jiahe Li, Yong Wang","doi":"10.1111/aej.70126","DOIUrl":"https://doi.org/10.1111/aej.70126","url":null,"abstract":"Oxidative stress in inflamed pulp tissue compromises dental pulp stem cell survival, yet whether bioceramic materials preserve mitochondrial homeostasis under such conditions remains unclear. The present study demonstrates that iRoot BP Plus, a premixed calcium silicate cement, protects human dental pulp stem cells (hDPSCs) from H2O2-induced oxidative injury through comprehensive mitochondrial protection. iRoot BP Plus significantly restored cell viability, reduced intracellular ROS accumulation, and stabilized mitochondrial membrane potential. Morphometric analysis revealed preserved mitochondrial network integrity with maintained aspect ratio and branching complexity. Mechanistically, iRoot BP Plus upregulated biogenesis regulators (PGC-1α, TFAM, NRF-1), suppressed fission gene DRP1 overexpression, and restored fusion gene MFN2 expression. These findings establish that iRoot BP Plus confers cytoprotection by maintaining mitochondrial homeostasis across structural, functional and transcriptional dimensions, providing mechanistic rationale for its clinical efficacy and highlighting mitochondrial protection as a therapeutic target in vital pulp therapy.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Anatomical Characteristics of C-Shaped Canals in Mandibular Molars in Chile: A Nationwide Multicentre Cross-Sectional Study. 智利下颌磨牙c形管的流行和解剖特征：一项全国性多中心横断面研究。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-25 DOI: 10.1111/aej.70128

Fernando Peña-Bengoa, Pablo Betancourt, Jaime Abarca, Carolina Cáceres, Patricio Meléndez, Claudia Valenzuela, Karin Steinfort, Nicolás Dufey-Portilla, Jorge N R Martins

{"title":"Prevalence and Anatomical Characteristics of C-Shaped Canals in Mandibular Molars in Chile: A Nationwide Multicentre Cross-Sectional Study.","authors":"Fernando Peña-Bengoa, Pablo Betancourt, Jaime Abarca, Carolina Cáceres, Patricio Meléndez, Claudia Valenzuela, Karin Steinfort, Nicolás Dufey-Portilla, Jorge N R Martins","doi":"10.1111/aej.70128","DOIUrl":"https://doi.org/10.1111/aej.70128","url":null,"abstract":"This retrospective multicentre cross-sectional study aimed to determine the prevalence and characteristics of C-shaped canals in Chilean mandibular molars using cone-beam computed tomography (CBCT) and to assess associations with demographic and geographic variables. A total of 5660 mandibular molars from CBCT scans obtained from imaging centres across different regions of Chile were analysed. External root morphology was categorized according to root fusion, and C-shaped canals were classified using Fan's classification at five axial levels. The prevalence of C-shaped canals was 9.88%, with most cases occurring in mandibular second molars (93.92%) and bilateral occurrence observed in 53.87% of affected individuals. Their distribution differed significantly across geographic regions (p = 0.002). Regression analysis accounting for within-patient clustering showed that female sex was significantly associated with their presence (OR = 1.74), whereas age showed no significant association. All C-shaped canals showed root fusion. These findings provide population-specific data for improving diagnostic accuracy and endodontic treatment planning.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Before 'Expert-Level' Performance: Reproducibility and Reference-Standard Concerns in Evaluating Large Language Models for Endodontic Diagnosis. 在“专家级”表现之前：评估牙髓诊断大语言模型的可重复性和参考标准问题。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-22 DOI: 10.1111/aej.70127

Satya Ranjan Misra, Rupsa Das

{"title":"Before 'Expert-Level' Performance: Reproducibility and Reference-Standard Concerns in Evaluating Large Language Models for Endodontic Diagnosis.","authors":"Satya Ranjan Misra, Rupsa Das","doi":"10.1111/aej.70127","DOIUrl":"https://doi.org/10.1111/aej.70127","url":null,"abstract":"Recent claims of expert-level endodontic diagnostic performance by large language models require cautious interpretation. In a 40-case, text-only comparison, methodological concerns limit reproducibility and clinical generalisability. The reported testing period preceded the public release of GPT-5, making clarification of the exact model version, platform, access dates, and settings essential. Use of a single endodontist as the reference standard demonstrates agreement with one clinician rather than independently verified diagnostic accuracy. Binary yes/no vignettes may also simplify the diagnostic task and do not reflect routine multimodal assessment incorporating radiographic interpretation. Single-query testing prevents evaluation of response consistency, while perfect accuracy in a small sample remains compatible with considerable statistical uncertainty. These findings are therefore best viewed as preliminary evidence of high concordance under controlled conditions. Future studies should use transparent model reporting, repeated runs, consensus reference standards, and clinically representative multimodal cases before expert-level performance is inferred.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy and Operative Time of Three Dynamic Navigation Systems for Fibre Post Removal: An In Vitro Comparative Study. 三种动态导航系统用于纤维桩去除的准确性和手术时间：体外比较研究。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-21 DOI: 10.1111/aej.70123

Jiayun Dai, Fulu Xu, Duo Zhou, Ke Wang, Xingyang Wang, Yiyao Lu, Yifan Ping, Juan Wang

{"title":"Accuracy and Operative Time of Three Dynamic Navigation Systems for Fibre Post Removal: An In Vitro Comparative Study.","authors":"Jiayun Dai, Fulu Xu, Duo Zhou, Ke Wang, Xingyang Wang, Yiyao Lu, Yifan Ping, Juan Wang","doi":"10.1111/aej.70123","DOIUrl":"https://doi.org/10.1111/aej.70123","url":null,"abstract":"This in vitro study compared the accuracy and operative removal time of three dynamic navigation systems for fibre post removal using standardised 3D-printed tooth replicas. Forty-eight identical maxillary incisor replicas containing cemented fibre posts were randomly allocated to three navigation-guided groups and a freehand group (n = 12). Virtual drilling paths were planned from cone-beam computed tomography images, and all procedures were performed by a single operator. Pre- and postoperative micro-computed tomography scans were used to measure coronal, apical and angular deviation. All navigation-guided groups showed significantly lower apical and angular deviation than the freehand group, whereas no significant differences were observed among the three navigation-guided systems. Coronal deviation was similar across groups. One navigation system required significantly less operative removal time than the other groups without compromising accuracy. Within the limitations of this laboratory study, dynamic navigation improved the precision of fibre post removal compared with the freehand technique.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperglycemia Dysregulates Host Responses to Dual Species Endodontic Biofilm-Derived Products: An In Vitro Study. 高血糖失调调节宿主对双物种根管生物膜衍生产品的反应：一项体外研究。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-17 DOI: 10.1111/aej.70121

Mirela Cesar de Barros, Prabha Lal, Flaviana Bombarda de Andrade, Anil Kishen

{"title":"Hyperglycemia Dysregulates Host Responses to Dual Species Endodontic Biofilm-Derived Products: An In Vitro Study.","authors":"Mirela Cesar de Barros, Prabha Lal, Flaviana Bombarda de Andrade, Anil Kishen","doi":"10.1111/aej.70121","DOIUrl":"https://doi.org/10.1111/aej.70121","url":null,"abstract":"This study investigated the effects of hyperglycemia on mitochondrial metabolic activity and inflammatory responses in periodontal ligament fibroblasts (PdLFs) and THP-1-derived macrophages exposed to endodontic biofilm supernatants. PdLFs and macrophages were TGF-β1-cultured in a Transwell system and exposed for 48 h to normoglycemic or hyperglycemic conditions (HG + AGEs), with or without supernatants from 7-day mono- or dual-species biofilms of Enterococcus faecalis (E. faecalis) and Fusobacterium nucleatum (F. nucleatum). Biofilm biomass, colony-forming units, mitochondrial metabolic activity, and cytokine production were assessed. E. faecalis showed higher bacterial counts, whereas F. nucleatum produced greater biomass. Hyperglycemia intensified the inhibitory effect of E. faecalis and the stimulatory effect of F. nucleatum on mitochondrial activity. The dual-species supernatant induced an intermediate metabolic response but the most dysregulated inflammatory profile under hyperglycemia, with increased TNF-α and reduced TGF-β1. Hyperglycemia reprograms host responses to biofilm-derived products, while polymicrobial interactions amplify inflammatory dysregulation.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Root Canal Retreatment Protocols on Initial Fracture Force and Colour Changes in Internally Bleached Mandibular Anterior Teeth. 根管再治疗方案对内漂白下颌前牙初始断裂力和颜色变化的影响。

IF 1.7 4区医学

Australian Endodontic Journal Pub Date : 2026-09-15 DOI: 10.1111/aej.70122

Nilsu Pierovi, Betül Eren Kaya, Esma Nair, Emel Uzunoğlu Özyürek

{"title":"Influence of Root Canal Retreatment Protocols on Initial Fracture Force and Colour Changes in Internally Bleached Mandibular Anterior Teeth.","authors":"Nilsu Pierovi, Betül Eren Kaya, Esma Nair, Emel Uzunoğlu Özyürek","doi":"10.1111/aej.70122","DOIUrl":"https://doi.org/10.1111/aej.70122","url":null,"abstract":"This in vitro study evaluated the effects of root canal retreatment protocols (with or without solvents) on the fracture resistance, failure patterns and colour behaviour of stained and internally bleached mandibular anterior teeth. Ninety specimens were allocated to six groups: control, access cavity, primary treatment, mechanical retreatment, chloroform-assisted retreatment and orange oil-assisted retreatment. Following coffee staining and sodium perborate bleaching, fracture force and colour differences were analysed. The results showed significant group × time interactions for colour (p < 0.001); retreatment groups exhibited greater staining than control groups. Mechanical retreatment specimens yielded the lowest fracture resistance, whereas access cavity specimens yielded the highest. Lower failure loads significantly correlated with restorable fracture patterns (p < 0.001). Retreatment reduced fracture force in bleached teeth, particularly via mechanical methods. Solvent-assisted protocols showed numerically higher fracture resistance than mechanical retreatment alone. Retreatment-related structural changes increase susceptibility to discolouration more than they impact bleaching efficacy.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0