Australian Endodontic Journal最新文献

Toward Precision in Management of Pulp Diseases: AI-Powered Case Selection for Vital Pulp Therapy. 牙髓疾病精准管理：人工智能驱动牙髓治疗病例选择。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-10-07 DOI: 10.1111/aej.70025

Mohammed Turky, Paul M H Dummer

引用次数: 0

Efficacy of Supplementary Irrigation Methods Against Bacterial Biofilm-Infected Root Canals Prepared With Minimally Invasive and Conventional Techniques. 辅助灌洗方法对微创与常规根管制备的细菌生物膜感染的疗效观察。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-10-07 DOI: 10.1111/aej.70024

Giuliana Soimu, Abhishek Parolia, Anelise V Masiero, Fang Qian, Thomas Moninger, Jeffrey A Banas, Fabricio B Teixeira

引用次数: 0

Evaluation of Histological Response of Human Pulp to MTA as DPC Agent With LLLT-Split Mouth Randomised Controlled Trial. 用lllt -裂口随机对照试验评价MTA作为DPC剂对人牙髓的组织学反应。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-26 DOI: 10.1111/aej.70023

M Shanmuga Priya, Darshan Dakshindas, Manjusha Warhandpande, Akshay Dhobley, Suchitra Gosavi, Aditi Wasule, Dipak Ghatage

引用次数: 0

Cellular and Mechanical Responses to Zinc Polycarboxylate Cement Modified With 5% or 10% Potassium Nitrate: An In Vitro Study. 5%或10%硝酸钾改性聚羧酸锌水泥的细胞和力学反应：体外研究。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-25 DOI: 10.1111/aej.70022

Fatimah Dahlawi, Mohammed AlGharni, Marwa Madi, Neveen M Ayad, Faisal Alonizan, Nada Aldossary, Omar Omar

{"title":"Cellular and Mechanical Responses to Zinc Polycarboxylate Cement Modified With 5% or 10% Potassium Nitrate: An In Vitro Study.","authors":"Fatimah Dahlawi, Mohammed AlGharni, Marwa Madi, Neveen M Ayad, Faisal Alonizan, Nada Aldossary, Omar Omar","doi":"10.1111/aej.70022","DOIUrl":"https://doi.org/10.1111/aej.70022","url":null,"abstract":"This study investigated the biological response of human peripheral blood mononuclear cells (PBMCs) to zinc polycarboxylate (ZP) cement modified with 5% or 10% potassium nitrate (KNO3) and assessed its mechanical properties. Discs of unmodified ZP, ZP + 5% KNO3, ZP + 10% KNO3, or mineral trioxide aggregate (MTA) were indirectly exposed to PBMCs using a transwell system. Cells were incubated with or without lipopolysaccharide (LPS) stimulation. Cytotoxicity (LDH release), viability, IL-6 and TGF-β secretion were evaluated. Material pH, ion release, compressive strength and microhardness were also assessed. ZP + 5% KNO3 significantly reduced LDH and IL-6 levels and increased TGF-β release compared to ZP alone. Mechanical strength was maintained in ZP + 5% KNO3 but decreased at 10% KNO3. MTA showed lower strength but higher cell viability. ZP + 5% KNO3 demonstrated a balanced profile of immunomodulation, regenerative signalling and mechanical integrity, supporting its potential use in vital pulp therapy. Further in vivo investigations are recommended.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Intracanal Medications on the Viability of Human Periodontal Ligament-Derived Mesenchymal Stem Cells. 管内药物对人牙周韧带源性间充质干细胞活力的影响。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-16 DOI: 10.1111/aej.70020

Arian Braido, Walbert de Andrade Vieira, Bruno Cazotti Pereira, Karina Gonzales Silvério, Paulo Henrique Gabriel, Aline Cristine Gomes Matta, Emerson Alves Martins, Adriana de Jesus Soares

{"title":"Effect of Intracanal Medications on the Viability of Human Periodontal Ligament-Derived Mesenchymal Stem Cells.","authors":"Arian Braido, Walbert de Andrade Vieira, Bruno Cazotti Pereira, Karina Gonzales Silvério, Paulo Henrique Gabriel, Aline Cristine Gomes Matta, Emerson Alves Martins, Adriana de Jesus Soares","doi":"10.1111/aej.70020","DOIUrl":"https://doi.org/10.1111/aej.70020","url":null,"abstract":"This in vitro study evaluated the effects of intracanal medications on the metabolic activity and adhesion of human periodontal ligament-derived mesenchymal stem cells. Tested groups included Control (without medication), Triple Antibiotic Paste (TAP), Double Antibiotic Paste (DAP), calcium hydroxide with saline, calcium hydroxide with 2% chlorhexidine gel and Bio-C Temp. After conditioning, roots were stored in phosphate-buffered saline at 37°C for 21 days. Medications were then removed using 17% EDTA and saline, and dentine samples were used as substrates for cell culture at 3, 5 and 7 days. Metabolic activity was assessed via MTT assay, and adhesion via scanning electron microscopy. None of the medications negatively affected cell viability or adhesion compared to control. TAP showed higher metabolic activity than calcium hydroxide with saline at Day 7. DAP induced earlier cell morphology changes. Bio-C Temp and chlorhexidine gel showed no significant differences at Day 7, confirming overall biocompatibility.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finite Element Analysis of Endodontically Treated Mandibular Second Molars With Variable Root Morphologies: Endocrown vs. Post-And-Core Crown Restorations. 根管治疗下颌第二磨牙不同根形态的有限元分析：内冠与桩核冠修复。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-10 DOI: 10.1111/aej.70019

Shenghao Qiu, Ziteng Long, Min Chen, Weiwei Wu, Jingzhi Ma, Yuan Gao, Lin Peng

{"title":"Finite Element Analysis of Endodontically Treated Mandibular Second Molars With Variable Root Morphologies: Endocrown vs. Post-And-Core Crown Restorations.","authors":"Shenghao Qiu, Ziteng Long, Min Chen, Weiwei Wu, Jingzhi Ma, Yuan Gao, Lin Peng","doi":"10.1111/aej.70019","DOIUrl":"https://doi.org/10.1111/aej.70019","url":null,"abstract":"This study aimed to investigate the biomechanical impact of root canal anatomical variations and restoration techniques on endodontically treated mandibular second molars using finite element analysis. Five root morphologies were modelled: separated-rooted (S), fused-rooted with V-shaped (F-V), U-shaped (F-U) or Ω-shaped (F-Ω) radicular grooves and single-canal fused-rooted (F-O). Micro-CT scans were performed before and after endodontic instrumentation to generate the finite element models: intact teeth, post-and-core crowns with 2- to 3-mm ferrules and endocrowns with 3- to 4-mm pulp chamber extensions. Under axial/oblique loading, von Mises stress distribution was evaluated. Results showed endocrowns had lower peak stresses than post-and-core crowns in common anatomical variations (S, F-U, F-Ω); F-V showed comparable peak stresses; post-and-core crowns with sufficient ferrule height minimised oblique-load stresses in single-canal teeth (F-O). Pronounced stress concentrations were observed at Ω-shaped groove in post-and-core restored teeth. Comprehensive evaluation of root morphology is critical for optimal restoration planning.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Sickle Cell Anaemia Have a Relationship With Avascular Pulp Necrosis? A Systematic Review. 镰状细胞性贫血与无血管性牙髓坏死有关系吗？系统评价。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-08 DOI: 10.1111/aej.70018

Elidiane Elias Ribeiro, Karin Sá Fernandes, Erika Sales Joviano Pereira, Angelica Maria Cupertino Lopes Marinho, Jefferson R Tenório, Márcia Pereira Alves Dos Santos

{"title":"Does Sickle Cell Anaemia Have a Relationship With Avascular Pulp Necrosis? A Systematic Review.","authors":"Elidiane Elias Ribeiro, Karin Sá Fernandes, Erika Sales Joviano Pereira, Angelica Maria Cupertino Lopes Marinho, Jefferson R Tenório, Márcia Pereira Alves Dos Santos","doi":"10.1111/aej.70018","DOIUrl":"https://doi.org/10.1111/aej.70018","url":null,"abstract":"This systematic review examined the relationship between sickle cell disease (SCD), an inherited genetic hemoglobinopathy, and avascular pulp necrosis (APN) in intact teeth. A comprehensive search of eight electronic databases was performed up to December 2024. Eligible studies included observational or interventional designs reporting APN in intact teeth of individuals with SCD. Risk of bias was assessed with the Joanna Briggs Institute Critical Appraisal Checklists, and certainty of evidence with GRADE. The search retrieved 407 records; four observational studies (two cohort and two case-control) met inclusion criteria, comprising 311 individuals with sickle cell anaemia (SCA). There is a relationship between SCA and APN. However, all included studies presented a risk of bias of 30% or higher, and the certainty of evidence was rated very low. These results provide weak scientific support for the association between APN and SCA, underscoring methodological limitations in the current dental literature.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Subcutaneous Connective Tissue Reaction to A Novel Calcium Silicate Based Cement, Biodentine and CEM Cement. 一种新型硅酸钙基水泥、生物牙牙汀和CEM水泥对皮下结缔组织反应的比较研究。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-02 DOI: 10.1111/aej.70006

Omolbanin Shahraki, Alireza Sarhadi, Samira Shahraki, Aslam Dehvari, Eshagh Ali Saberi

引用次数: 0

Biomechanical Behaviour of Simulated External Cervical Resorption Lesions With Varying 3D Extent Before and After Restoration: Finite Element Analysis Study. 不同三维范围模拟颈椎外吸收病变修复前后的生物力学行为：有限元分析研究。

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-09-02 DOI: 10.1111/aej.70017

Mohit Machiwal, Ruchika Roongta Nawal, Sudha Yadav, Sangeeta Talwar, Seema Yadav

{"title":"Biomechanical Behaviour of Simulated External Cervical Resorption Lesions With Varying 3D Extent Before and After Restoration: Finite Element Analysis Study.","authors":"Mohit Machiwal, Ruchika Roongta Nawal, Sudha Yadav, Sangeeta Talwar, Seema Yadav","doi":"10.1111/aej.70017","DOIUrl":"10.1111/aej.70017","url":null,"abstract":"This study investigated the biomechanical behaviour of simulated external cervical resorption (ECR) lesions of varying 3D extent, before and after restoration, using finite element analysis (FEA). Seven maxillary incisors were modelled, representing Patel's classification stages: Group 1-2Bp, 2-2Cp, 3-2Cd, 4-3 Bd, 5-3Cd, 6-3Bp and 7-Control. ECR lesions were restored using Biodentine, with endodontic treatment when the pulp was involved. CBCT scans were used to generate 3D models, and a 240 N bite force was applied to evaluate stress via Von Mises and principal stress values. Pre-treatment, all ECR lesions showed concentrated stress, highest in Group 3Bp (538.11 MPa), correlating directly with lesion height, circumferential spread and pulp proximity. Post-treatment, biodentine reduced stress and improved the safety factor (SF), although most groups still had a failure index > 1, indicating residual fracture risk. Pulp involvement had the greatest biomechanical impact, highlighting the importance of early detection and classification-based treatment planning.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Evaluation of NLRP3 Inflammasome and IL-1β Cytokine in Periapical Lesion Progression Using Wild-Type and TLR2 Knockout Mice. 野生型和TLR2敲除小鼠对NLRP3炎性体和IL-1β细胞因子在根尖周围病变进展中的体内评价

IF 1.5 4区医学

Australian Endodontic Journal Pub Date : 2025-08-28 DOI: 10.1111/aej.70014

Gabriela Reis Alves, Paula Dariana Fernandes Ferreira, Ana Paula Gomes-Moura, Ricardo Barbosa Lima, Angélica Aparecida de Oliveira Denadai, Carolina Maschietto Pucinelli, Marília Pacífico Lucisano, Paulo Nelson Filho, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Silva

{"title":"In Vivo Evaluation of NLRP3 Inflammasome and IL-1β Cytokine in Periapical Lesion Progression Using Wild-Type and TLR2 Knockout Mice.","authors":"Gabriela Reis Alves, Paula Dariana Fernandes Ferreira, Ana Paula Gomes-Moura, Ricardo Barbosa Lima, Angélica Aparecida de Oliveira Denadai, Carolina Maschietto Pucinelli, Marília Pacífico Lucisano, Paulo Nelson Filho, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Silva","doi":"10.1111/aej.70014","DOIUrl":"https://doi.org/10.1111/aej.70014","url":null,"abstract":"This study aimed to investigate the role of Toll-like receptor 2 (TLR2) in the progression of periapical lesions by evaluating NLRP3 inflammasome and interleukin-1 beta (IL-1β) expression in wild-type (WT) and TLR2 knockout (KO) mice. A total of 55 mice (28 WT, 27 TLR2-KO) underwent pulpal exposure of mandibular first molars and were euthanised at 7, 21, or 42 days post-exposure. Histological and immunohistochemical analyses were performed. TLR2-KO mice showed significantly larger periapical lesions and higher IL-1β expression than WT mice after 21 and 42 days, respectively. In contrast, NLRP3 expression was significantly greater in WT mice at both time points. A weak but significant positive correlation between NLRP3 and IL-1β expression was observed only in WT mice. These findings suggest that TLR2 plays a protective role in limiting periapical bone resorption and modulating inflammatory cytokine expression, independent of NLRP3 inflammasome activity.","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0