{"title":"A Comparative Study of Subcutaneous Connective Tissue Reaction to A Novel Calcium Silicate Based Cement, Biodentine and CEM Cement.","authors":"Omolbanin Shahraki, Alireza Sarhadi, Samira Shahraki, Aslam Dehvari, Eshagh Ali Saberi","doi":"10.1111/aej.70006","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to evaluate the biocompatibility of newly synthesised cement (Nanodentin) in comparison with Biodentine and CEM cement. The cements were implanted in rat skin and tissue reactions were assessed after 7, 30 and 60 days. H&E staining was used to measure the inflammatory response, the number of inflammatory cells and the presence of necrosis. The agar punch method was used for the antibacterial assay. The null hypothesis was that there would be no difference in terms of inflammation between Biodentine, CEM cement and Nanodentin with negative control. All cements induced a mild to moderate inflammatory reaction at day 7, which decreased over time. Nanodentin had the lowest number of inflammatory cells and necrosis among the tested materials. Nanodentin was biocompatible and well tolerated by subcutaneous tissues and had similar or better properties than the commercially available cements. It also exhibited good antibacterial activity compared to controls.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australian Endodontic Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/aej.70006","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
This study aimed to evaluate the biocompatibility of newly synthesised cement (Nanodentin) in comparison with Biodentine and CEM cement. The cements were implanted in rat skin and tissue reactions were assessed after 7, 30 and 60 days. H&E staining was used to measure the inflammatory response, the number of inflammatory cells and the presence of necrosis. The agar punch method was used for the antibacterial assay. The null hypothesis was that there would be no difference in terms of inflammation between Biodentine, CEM cement and Nanodentin with negative control. All cements induced a mild to moderate inflammatory reaction at day 7, which decreased over time. Nanodentin had the lowest number of inflammatory cells and necrosis among the tested materials. Nanodentin was biocompatible and well tolerated by subcutaneous tissues and had similar or better properties than the commercially available cements. It also exhibited good antibacterial activity compared to controls.
期刊介绍：
The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues.
The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses.
The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.
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