Adicciones最新文献_第2页

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2534

Marta Rodríguez-Arias, Marta Torrens Melich

引用次数: 0

Study of the Pleiotrophin/PTPRZ neurotrophic pathway in the hippocampus of rats exposed to chronic alcohol consumption and/or thiamine deficiency. 长期饮酒和/或硫胺素缺乏大鼠海马中多营养因子/PTPRZ神经营养通路的研究

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2464

Rosario López-Rodríguez, Marta Moya, Esther Gramage, Gonzalo Herradón, Laura Orio

{"title":"Study of the Pleiotrophin/PTPRZ neurotrophic pathway in the hippocampus of rats exposed to chronic alcohol consumption and/or thiamine deficiency.","authors":"Rosario López-Rodríguez, Marta Moya, Esther Gramage, Gonzalo Herradón, Laura Orio","doi":"10.20882/adicciones.2464","DOIUrl":"10.20882/adicciones.2464","url":null,"abstract":"Wernicke's encephalopathy (WE) is caused by thiamine deficiency (TD) whose main risk factor is alcohol use disorder. Pathogenic mechanisms associated with WE include mitochondrial dysfunction, oxidative stress and neuroinflammation. This study aims to explore the gene expression signature of certain candidate genes related to neuroinflammation, mitochondrial dysfunction and thiamine metabolism in the hippocampus from animals exposed to chronic alcohol consumption, thiamine deficiency or the combination of both. Male Wistar rats (n=42) were randomly assigned to 4 experimental groups: control (C) receiving tap water or tap water plus thiamine (0.2 g/L), chronic alcohol (CA) forced ingestion for 36 weeks, TD diet and pyrithiamine for 12 days (TDD) and CA combined with TDD. The relative gene expression of neurotrophic factors (Ptn, Mdk, Ptprz), proinflammatory molecules (Tlr4, Ccl2 and Hmgb1), mitochondrial homeostatic factors (Mfn1 and Mfn2) and thiamine metabolism (Tpk1) was analyzed in RNA isolated from the hippocampus across all experimental groups. Differences in gene expression were assessed using non-parametric tests (Kruskal-Wallis). Ptprz mRNA levels tended to be downregulated in the TDD group compared to controls (p=0.06, non-significant) and levels were significantly decreased related to the CA+TDD group (p<0.05). TDD group showed the lowest expression levels of Ptn across all experimental groups, and this decrease was statistically significant compared to the control and CA groups (p<0.05). Our findings indicate a differential gene expression profile of the PTN-MDK-PTPRZ axis in the hippocampus of rats receiving a TD diet but not in the rest of the WE models analyzed (CA and CA+TDD).","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"383-394"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soy isoflavones for the treatment of cocaine use disorder: an open-label pilot study. 大豆异黄酮治疗可卡因使用障碍：一项开放标签试点研究。

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2428

Roser Martínez-Riera, Francina Fonseca, Rafael De La Torre, Nieves Pizarro, Liliana Galindo, Joan Ignasi Mestre-Pinto, Magí Farré, Marta Torrens

{"title":"Soy isoflavones for the treatment of cocaine use disorder: an open-label pilot study.","authors":"Roser Martínez-Riera, Francina Fonseca, Rafael De La Torre, Nieves Pizarro, Liliana Galindo, Joan Ignasi Mestre-Pinto, Magí Farré, Marta Torrens","doi":"10.20882/adicciones.2428","DOIUrl":"10.20882/adicciones.2428","url":null,"abstract":"Soybeans contain different isoflavones (mainly daidzein) which work as reversible inhibitors of aldehyde-dehydrogenase-2 enzyme (ALDH2). This activity has been related in animal experiments with a reduction of cocaine use. Our aim was to carry out an open-label pilot study to evaluate the possible efficacy of soy isoflavones as natural inhibitor of ALDH2 in cocaine use disorder. Nine subjects with severe cocaine use disorder participated in a single-center, open, non-controlled trial during 12 weeks of treatment and 4 of follow-up. The Substance Use Report (SUR) showed that three subjects (33.3%) reported a cocaine consumption of less than 20% (80% non-use days) from 10 to 12 weeks of the treatment period, from two (22.2%) at baseline, although non-significant. A finding that could not be confirmed by the detection of urine metabolites of cocaine. Seven participants (77.8%) completed the study at 16 weeks and one (1.11%) at 12 weeks. Urine concentrations of isoflavones, demonstrated that eight participants (88.9%) followed the treatment along the study. The Severity Dependence Scale (SDS) score showed a significant decrease between baseline to 12 weeks, baseline to 16 weeks and 12 to 16 weeks; the Brief Substance Craving Scale (BSCS) and Cocaine Selective Severity Assessment (CSSA) decreased their values but not significantly. Significant improvements in different areas of the SF-36 scale were observed: body pain scores decreased from baseline to 16 weeks statistically significant; social function improved its scores from baseline to 12 weeks and from baseline to 16 weeks significantly; the rest of areas increased their scores but not significantly. These findings show lower ratios of cocaine use days, and high retention and adherence to treatment although the acquisition of complete abstinence was not observed. Soy isoflavones could be considered a potential treatment in future research, to be confirmed by placebo-controlled studies with adequate sample size.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"311-322"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of omega-3 fatty acids on CB1 cannabinoid receptor localization in the hippocampal CA1 region following alcohol withdrawal in adolescent male mice. omega-3脂肪酸对青春期雄性小鼠酒精戒断后海马CA1区CB1大麻素受体定位的影响

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2408

Maitane Serrano, Leire Lekunberri, Garazi Ocerin, Miquel Saumell-Esnaola, Gontzal García Del Caño, Nagore Puente, Itziar Bonilla-Del Río, Inmaculada Gerrikagoitia, Pedro Grandes

{"title":"Effects of omega-3 fatty acids on CB1 cannabinoid receptor localization in the hippocampal CA1 region following alcohol withdrawal in adolescent male mice.","authors":"Maitane Serrano, Leire Lekunberri, Garazi Ocerin, Miquel Saumell-Esnaola, Gontzal García Del Caño, Nagore Puente, Itziar Bonilla-Del Río, Inmaculada Gerrikagoitia, Pedro Grandes","doi":"10.20882/adicciones.2408","DOIUrl":"10.20882/adicciones.2408","url":null,"abstract":"Adolescent binge drinking has detrimental effects on brain function, leading to long-lasting impairments in synaptic plasticity, cognition, and behavior. These effects are mediated, in part, by disruption of the endocannabinoid system (ECS) and its cannabinoid type-1 (CB1) receptor. Alcohol consumption also depletes omega-3 fatty acids, which are essential for maintaining cell membrane integrity and supporting brain function. This depletion impairs synaptic plasticity by disrupting endocannabinoid signaling and reducing CB1 receptor expression and function. Conversely, enhancement of the ECS can restore brain function and reverse the loss of endocannabinoid-dependent synaptic plasticity associated with omega-3 deficiency. Notably, omega-3 supplementation has been shown to restore CB1 receptor expression in specific brain regions in adult mice following adolescent alcohol exposure. However, despite the established interplay between alcohol, omega-3, and the ECS, the direct impact of omega-3 supplementation on the subcellular localization of CB1 receptors after alcohol exposure remains poorly understood. In this study, we used immunoelectron microscopy to investigate whether omega-3 supplementation influences CB1 receptor distribution in the hippocampal CA1 region following alcohol withdrawal in adolescent male mice. Our results demonstrate that omega-3 partially restore the excitatory/inhibitory balance disrupted by alcohol, as evidenced by an increased number of excitatory terminals and a significant reduction in inhibitory terminals. However, the distribution and density of CB1 receptors within neuronal and glial compartments remain unchanged following alcohol exposure and omega-3 supplementation. These findings highlight novel structural effects of omega-3 in mitigating alcohol-induced brain damage.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"341-352"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in emotional and cognitive tasks in rats exposed to alcohol binges and controls during early adulthood. 成年早期酗酒和控制的大鼠情绪和认知任务的性别差异。

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2450

Leticia López-Valencia, Eva Bonilla, Berta Escudero, Laura Orio

{"title":"Sex differences in emotional and cognitive tasks in rats exposed to alcohol binges and controls during early adulthood.","authors":"Leticia López-Valencia, Eva Bonilla, Berta Escudero, Laura Orio","doi":"10.20882/adicciones.2450","DOIUrl":"10.20882/adicciones.2450","url":null,"abstract":"A sex perspective in the behavioural effects induced by alcohol binge exposure during youth or early adulthood remain limited. This study aimed to evaluate the effects of high doses of ethanol on emotional behaviour and cognition in 8-weeks old rats, from a sex perspective. Male and female animals were exposed to ethanol binges (3 g/kg, i.g.; 3 times/day x 4 days) in a 2days on-2days off paradigm and assessed in the elevated plus maze (EPM), forced swimming test (FST), saccharin preference test (SPT), Morris water maze (MWM) and novel object recognition (NOR) test. Baseline differences between control male and females were observed in emotional, motivational and cognitive tasks. Additionally, Intensive Alcohol Exposure (IAE) exerted sex-specific effects in: a) EPM: males showed anxiety and no effect in females; b) FST: depressive-like symptoms in both sexes but more pronounce immobility time in females; c) NOR test: impairment in a short-term memory in both sexes but females displayed improved performance in a long-term versus their controls. No IAE-related effects were found in the SPT or MWM. These results suggest inherent sex-differences in rodent performance in behavioural tests assessing emotional, motivational and cognitive behaviours. Additionally, IAE may impact male and females differently during abstinence in early adulthood. These findings underscore the importance of considering sex as a critical variable for preclinical studies.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"353-368"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of eating control and cognitive flexibility: Involvement of gut microbiota. 饮食控制和认知灵活性的丧失：肠道微生物群的参与。

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2342

Solveiga Samulenaite, Aurelijus Burokas, José Manuel Fernández-Real, Jordi Mayneris-Perxachs, Elena Martín-García, Rafael Maldonado

{"title":"Loss of eating control and cognitive flexibility: Involvement of gut microbiota.","authors":"Solveiga Samulenaite, Aurelijus Burokas, José Manuel Fernández-Real, Jordi Mayneris-Perxachs, Elena Martín-García, Rafael Maldonado","doi":"10.20882/adicciones.2342","DOIUrl":"https://doi.org/10.20882/adicciones.2342","url":null,"abstract":"Loss of eating control is a crucial factor in developing obesity, which has become a global health concern, causing important cardiovascular, metabolic, emotional, and cognitive co-morbidities. A major cognitive alteration associated with loss of eating control and obesity is the impairment of cognitive flexibility and inhibitory control. An increasing number of studies confirm that gut microbiota is a significant contributor to loss of eating control, obesity, and cognitive function. Therefore, we have investigated whether gut microbiota transfer from humans with impaired/not impaired cognitive flexibility could substantially affect this behavioral response in mice in the context of obesogenic versus standard diet. Mice were pretreated with an antibiotic cocktail and later received a gut microbiota transplant from human subjects. The transferred microbiota was maintained in mice for seven weeks. Afterward, behavioral tests were performed to evaluate different cognitive responses, locomotor activity, anxiety-like, and depression-like behaviors. Antibiotic treatment significantly impaired short-term memory in mice, as previously reported. Furthermore, mice that received microbiota from high and low cognitive flexibility subjects modified their short-term and long-term memory performance depending on the diet exposure. Slight changes were observed in the locomotor activity, primarily in the high-fat diet-fed antibiotic-treated mice, and no significant alterations were observed in anxiety-like or depressive-like behaviors. In summary, this study shows that gut microbiota is a major contributor to cognitive flexibility, which may open novel therapeutic strategies for combating loss of eating control and related metabolic co-morbidities.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"395-408"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blocking the increased reinforcing effects of cocaine induced by social defeat: Effects of palatable food. 阻止社会失败引起的可卡因增强效应：美味食物的作用。

IF 1.8 4区医学

Adicciones Pub Date : 2025-12-23 DOI: 10.20882/adicciones.2462

Francisco Ródenas-González, María Del Carmen Blanco-Gandía, Ezequiel Monferrer, María Pascual, Marta Rodriguez-Arias

{"title":"Blocking the increased reinforcing effects of cocaine induced by social defeat: Effects of palatable food.","authors":"Francisco Ródenas-González, María Del Carmen Blanco-Gandía, Ezequiel Monferrer, María Pascual, Marta Rodriguez-Arias","doi":"10.20882/adicciones.2462","DOIUrl":"10.20882/adicciones.2462","url":null,"abstract":"Preclinical studies suggest that stimulation of the brain's reward system by high-fat diets (HFD) could act as an alternative reinforcer. The main aim of the present study was to evaluate the effect of a limited and intermittent exposure to an HFD administered during and after exposure to Social Defeat (SD) on a non-effective dose of cocaine-induced Conditioned Place Preference (CPP). Experiment 1 consisted of modulating SD episodes with three different patterns of HFD access: 1h access before each session of SD; 2h access three days a week during the two weeks of SD exposure; and 2h access 4h after each SD. Experiment 2 consisted of modulating the effects of stress on CPP acquisition with three patterns of HFD access: 1h access before each conditioning session; 2h access three days a week throughout the two-week period of the CPP; and 2h access three days a week from the last SD episode to the end of CPP. HFD administered during the period of SD episodes counteracted the increased sensitivity that SD produces on the reinforcing effects of cocaine. Access to HFD before the conditioning session or three days a week (CPP-SD-MWF) during the acquisition of CPP blocked this increased sensitivity. In the striatum, SD induced a decrease in the cannabinoid 1 receptor (Cb1r) gene expression, not affected by HFD, and increased corticotrophin releasing hormone receptor 1 (Crhr1) gene expression, except for those mice fed on HFD after SD encounters. Our findings indicate that a small intake of HFD may attenuate the social stress-induced increase in the rewarding properties of cocaine.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"323-340"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1R drugs and alcohol use disorder: A definitive therapeutic solution or just another unfulfilled promise? GLP-1R药物与酒精使用障碍：一个明确的治疗方案或只是另一个未实现的承诺？

IF 1.8 4区医学

Adicciones Pub Date : 2025-09-22 DOI: 10.20882/adicciones.2497

Albert Batalla, Hugo López-Pelayo, Ramón Bataller Albelora

引用次数: 0

A relational model of wellbeing-centered recovery in alcohol use disorder. 以幸福为中心的酒精使用障碍康复的关系模型

IF 1.8 4区医学

Adicciones Pub Date : 2025-09-22 DOI: 10.20882/adicciones.2037

Laura Esteban Rodríguez, Ana Sion, Enrique Rubio, Daniel Maldonado Sánchez, Víctor Armada, Gabriel Rubio, Rosa Jurado Barba, In Recovery Group

{"title":"A relational model of wellbeing-centered recovery in alcohol use disorder.","authors":"Laura Esteban Rodríguez, Ana Sion, Enrique Rubio, Daniel Maldonado Sánchez, Víctor Armada, Gabriel Rubio, Rosa Jurado Barba, In Recovery Group","doi":"10.20882/adicciones.2037","DOIUrl":"https://doi.org/10.20882/adicciones.2037","url":null,"abstract":"Wellbeing is a key element among the prevailing definitions of recovery from alcohol use disorder. However, there is an increasing need to develop a unified framework for recovery conceptualization and characterization of its components, as well as the mechanisms to achieve it. The objective of the study was to test a model relating the dimensions involved in recovery. A total of 348 participants with different periods of abstinence (range:1 month-28 years) were assessed using self-reports of psychological well-being, quality of life, negative emotionality and coping strategies. Statistical analyses entailed an exploratory factor analysis (EFA) to uncover the underlying dimensions of psychological measures and a structural equation model (SEM) to elucidate their interrelations. The EFA identified 3 factors that explained 54.95% of the variance: i) Coping; ii) Functional Discomfort (emotional management and recovery capital); iii) Positive Mental Health (well-being and quality of life). The SEM demonstrated robust fit indices (GFI = 1.00, SRMR = .137) and explained 85% of the variance in well-being (R2 = .85). The results suggest that during recovery in AUD, abstinence duration propels coping strategies which can ameliorate negative emotionality and enable an increase in personal and social resources. This process ultimately contributes to heightened well-being and an enhanced quality of life. The study represents a first methodologically sound proposal in Spain for a clinical recovery model centered on well-being. Its comprehensive paradigm not only reshapes our understanding of AUD recovery but also establishes a robust foundation for more efficacious clinical interventions and evaluations.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 3","pages":"237-254"},"PeriodicalIF":1.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALCO-VR Project: A randomized clinical trial evaluating virtual reality cue-exposure Therapy for Treatment-Resistant Alcohol Use Disorder patients. ALCO-VR项目：一项随机临床试验，评估虚拟现实提示暴露治疗难治性酒精使用障碍患者。

IF 1.8 4区医学

Adicciones Pub Date : 2025-09-22 DOI: 10.20882/adicciones.1958

Alexandra Ghiţă, Olga Hernández-Serrano, Jolanda Fernández-Ruiz, Mariano Gacto-Sánchez, Miquel Monras, Antoni Gual, Bruno Porras-García, Marta Ferrer-García, José Gutiérrez-Maldonado

{"title":"ALCO-VR Project: A randomized clinical trial evaluating virtual reality cue-exposure Therapy for Treatment-Resistant Alcohol Use Disorder patients.","authors":"Alexandra Ghiţă, Olga Hernández-Serrano, Jolanda Fernández-Ruiz, Mariano Gacto-Sánchez, Miquel Monras, Antoni Gual, Bruno Porras-García, Marta Ferrer-García, José Gutiérrez-Maldonado","doi":"10.20882/adicciones.1958","DOIUrl":"10.20882/adicciones.1958","url":null,"abstract":"The management of \"treatment-resistant\" alcohol use disorder (AUD) often presents significant challenges. Virtual reality (VR) applications, specifically VR cue exposure therapy (VR-CET), offer a potentially complementary approach to the standard treatment (TAU). This randomized clinical trial (RCT) aimed to assess VR-CET's effectiveness when added to TAU, compared to TAU alone, in reducing alcohol craving and anxiety among individuals with treatment-resistant AUD. The study also sought to determine anxiety and craving levels during VR-CET sessions and to explore long-term effects. Eighty-five AUD patients from the Clinic Hospital of Barcelona participated. They were randomly assigned to either an experimental group (EG), receiving VR-CET plus TAU, or a control group (CG), receiving TAU alone. The EG completed six VR-CET sessions alongside TAU, while the CG continued with only TAU. Alcohol craving and anxiety were assessed before and after treatment for both groups, and during VR-CET sessions for the EG. Relapses were monitored at 3-, 6-, and 12-months post-treatment. Results indicated no significant main effects of \"type of treatment\" (EG vs. CG) on craving or anxiety. However, a significant \"time\" factor was observed, showing reductions in craving and anxiety from pre-test to post-test, regardless of the treatment type. Within VR-CET sessions, EG participants reported minimal anxiety and craving by the end of the therapy. Importantly, no statistically significant differences in relapse rates were found between the EG and CG at any follow-up period (3, 6, 12 months). The clinical implications of the study, limitations, and research directions are further discussed.","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 3","pages":"199-216"},"PeriodicalIF":1.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0