Adicciones最新文献

{"title":"Traditional gambling, betting in video games, and financial trading: Associations with gambling severity and associated harm in young adults.","authors":"Ainhoa Coloma-Carmona, Nerea Pons-García, Virtudes Pérez-Jover, Fernando Miró-Llinares, José Luis Carballo","doi":"10.20882/adicciones.2512","DOIUrl":"https://doi.org/10.20882/adicciones.2512","url":null,"abstract":"<p><p>The digitization of gambling has led to the proliferation of gambling-like products in areas such as video games and financial investment platforms. Although these practices share structural mechanisms and risk profiles with gambling, evidence on their relationship with associated harm and their joint role in predicting gambling severity remains limited. This study examined the association between recent participation (within the last 60 days) in these activities, along with traditional forms of gambling, and gambling severity (PGSI) and related harm (SGHS). The sample is derived from a randomized controlled trial (ClinicalTrials.gov ID: NCT06681103), from which only the pre-intervention baseline assessment data were utilized. A total of 1,889 young people aged 18-34 living in Spain were recruited, of whom 53.9% (n=1,018) had recently participated in gambling or similar activities, forming the sample analyzed. Both indicators were modelled using hierarchical ordinal regression, with adjustments made for overall involvement (frequency and number of activities) and sociodemographic factors. The associations with severity remained after all adjustments, with adjusted ORs (aORs) between 1.9 and 3.6 (p<0.01), with video game betting and commodity trading standing out, with magnitudes similar to those observed for slot machines, casinos, and sports betting. In the SGHS, only eSports betting and commodity trading (aOR=2.23, p<0.05) retained their association with a higher number of harms after sociodemographic adjustment, while lotteries showed inverse associations with both indicators (aOR=0.58 in PGSI, and aOR=0.56 in SGHS, p<0.05). The results emphasize the importance of incorporating these new forms of digital spending into the detection and prevention of gambling harm among young adults.</p>","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"51-68"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"False positives in amphetamine drug screening due to dimethyltryptamine.","authors":"Bernardino Barceló Martín, José Manuel Arteaga Armas, Isabel Gomila Muñiz, María Concepción Rubio Aguiló, Miguel Ángel Elorza Guerrero, Elena Jiménez Belio","doi":"10.20882/adicciones.2233","DOIUrl":"https://doi.org/10.20882/adicciones.2233","url":null,"abstract":"","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"69-72"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Receptivity to persuasive narratives in juvenile offenders who use cannabis: influence of motivational variables and engagement.","authors":"Silvia Medina-Anzano, Isabel María Herrera-Sánchez, Samuel Rueda-Méndez","doi":"10.20882/adicciones.2346","DOIUrl":"https://doi.org/10.20882/adicciones.2346","url":null,"abstract":"<p><p>Persuasive narratives have been shown to be effective in influencing health behaviors. However, their impact on at-risk populations, such as justice-involved juveniles who use cannabis, has received limited attention. This study analyzes the response of 93 juveniles with judicial measures in detention centers to persuasive video-based narratives. These narratives were developed in accordance with the Health Action Process Approach (HAPA) and were gender-adapted. Additionally, variables influencing resistance to the persuasive message, assessed in terms of favorability, were examined. Prior to exposure to the narrative, motivational variables such as risk perception, outcome expectancies (both positive and negative) of cannabis non-use, and self-efficacy for action were measured. Following the viewing, generated thoughts (cognitive responses) and engagement with the narrative, focusing on identification with the protagonist and narrative transportation, were assessed. The results revealed that the thoughts generated focused on the message content of the message and personal experiences, with favorable thoughts predominating. No significant differences were found between males and females. Furthermore, narrative transportation acted as a significant mediator between risk perception and message favorability. This study provides empirical evidence on the effect of persuasive narratives in this population, indicating that their design, based on health behavior change theories, enhances receptivity. The findings support their integration into prevention programs within the context of juvenile justice.</p>","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"9-24"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for ALCO-VR Project: A randomized clinical trial evaluating virtual reality cue-exposure Therapy for Treatment-Resistant Alcohol Use Disorder patients.","authors":"Revista Adicciones","doi":"10.20882/adicciones.2564","DOIUrl":"https://doi.org/10.20882/adicciones.2564","url":null,"abstract":"","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"73-74"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion regulation strategies mediate the relationship between excessive alcohol use and suicidal behaviour.","authors":"Celia Antuña Camblor, Gabriel Esteller-Collado, Roger Muñoz-Navarro","doi":"10.20882/adicciones.2418","DOIUrl":"https://doi.org/10.20882/adicciones.2418","url":null,"abstract":"<p><p>Alcohol is one of the most widely consumed substances worldwide. It is hypothesized that people who use alcohol have poor emotional regulation strategies, something shared by people who commit suicide. Therefore, the aim of this work is to study the mediational effect of coping strategies and distress tolerance in the relationship between excessive alcohol use and suicidal risk. A sample of 1014 participants (33.82% male, 66.17% female; M = 33.0, SD = 15.15) were assessed using a custom sociodemographic questionnaire, the Alcohol Use Disorders Identification Test (AUDIT), the Coping with Stress Questionnaire (CSQ), Distress Tolerance Stress (DTS), and Suicide Risk (RS). Two mediation models were performed in which AUDIT scores were used as the independent variable, RS score as the dependent and sex as a covariate. In the first model the mediating variable was the CSQ scores and in the second the DTS scores. The relationship was mediated positively by Negative Auto-Focused, Appraisal and Absorption, and negatively by Social Support Seeking and Tolerance. Emotional regulation is a transdiagnostic strategy that can reduce not only alcohol consumption, but also suicidal risk. Given these results, there is a pressing need to develop preventive programs centered on adaptive emotion regulation strategies. Emotional regulation plays a key role in the relationship between excessive alcohol use and suicidal risk.</p>","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"41-50"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jorge Manzanares: posthumous tribute to a great researcher, teacher, and friend.","authors":"F Navarrete, M S García-Gutiérrez, R Maldonado, G Rubio, E Ambrosio, G Burillo-Putze, M I Colado, J Costas, M J Cuesta-Zorita, M Farré, E García de Jalón, M J García-Fuster, I Gerrikagoitia, P Grandes, G Herradón, M Marcos Martín, J Miñarro, R Muga, L Orio, J B Quintana, M Rodríguez-Arias, C Roncero, J M Ruiz-Idiago, C Spuch, O Valverde, M P Viveros, F Rodríguez de Fonseca, M Torrens","doi":"10.20882/adicciones.2565","DOIUrl":"https://doi.org/10.20882/adicciones.2565","url":null,"abstract":"","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"75-78"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C therapy with pangenotypic direct-acting antivirals: Drug-drug interactions in drug-using HCV patients and antipsychotic-treated HCV patients.","authors":"Juan Turnes, Antonio García-Herola, Marinela Méndez, Cándido Hernández, Alfonsina Trento, Ramón Morillo-Verdugo, Francisco Pascual, Ignacio Hernández","doi":"10.20882/adicciones.2296","DOIUrl":"https://doi.org/10.20882/adicciones.2296","url":null,"abstract":"&lt;p&gt;&lt;p&gt;People who use drugs (PWUD) are at high risk of hepatitis C virus (HCV) infection, and HCV patients often have psychiatric disorders requiring nervous system drugs, including antipsychotics. These medicines can interact with HCV treatment-related metabolic pathways producing DDIs (drug-drug interactions). This analysis focused on potential DDIs between direct-acting antivirals (DAAs) and concomitant medications used in PWUD/antipsychotics-treated HCV patients, alongside associated adverse events (AEs) and clinical interventions in Spain. Electronic medical records (BIG-PAC® database) were used to analyse adult HCV patients treated with glecaprevir/pibrentasvir (GLE/PIB) or sofosbuvir/velpatasvir (SOF/VEL) between 2017-2020. The study included 1,620 HCV patients, 985 identified as PWUD and 187 as antipsychotic users, 75% of whom were also PWUD. In the PWUD cohort, cardiovascular (CV) comorbidities were the most frequent; 22.7% patients were at risk of DDIs with CV, with the risk being higher in GLE/PIB-treated (36.8%) versus SOF/VEL (13.7%) (p&lt;0.001). Cardiovascular AEs were more common in the GLE/PIB group. In the antipsychotic cohort, quetiapine was the most prescribed antipsychotic comedication (26.2%), followed by paliperidone (17.6%) and olanzapine (17.1%). Fifty-one per cent of those on GLE/PIB were at risk of DDIs versus 23% on SOF/VEL (p&lt;0.001). Two AEs were reported in the GLE/PIB group (n=37): one patient on quetiapine at a dose &lt;300mg/day experienced extrapyramidal symptoms, leading to DAA discontinuation, and another paliperidone-treated experienced sedation, necessitating a dose reduction. The findings highlight DDIs risks in HCV patients on antipsychotics or with substance addiction, particularly with GLE/PIB. Comprehensive clinical follow-up is essential to optimise treatment and improve patient safety. Electronic medical records (BIG-PAC® database) were used to analyse adult HCV patients treated with glecaprevir/pibrentasvir (GLE/PIB) or sofosbuvir/velpatasvir (SOF/VEL) between 2017-2020. The study included 1,620 HCV patients, 985 identified as PWUD and 187 as antipsychotic users, 75% of which were also PWUD. In the PWUD cohort, cardiovascular (CV) comorbidities were the most frequent; 22.7% patients were at risk of DDIs with CV, being the risk higher in GLE/PIB-treated (36.8%) versus SOF/VEL (13.7%) (p&lt;0.001). Cardiovascular AEs were more common in the GLE/PIB group. In the antipsychotic cohort, quetiapine was the most prescribed antipsychotic comedication (26.2%), followed by paliperidone (17.6%) and olanzapine (17.1%). Fifty-one per cent of those on GLE/PIB were at risk of DDIs versus 23% on SOF/VEL (p&lt;0.001). Two AEs were reported in the GLE/PIB group (n=37): one patient on quetiapine at a dose &lt;300mg/day experienced extrapyramidal symptoms, leading to DAA discontinuation, and another paliperidone-treated experienced sedation, necessitating a dose reduction. The findings highlight DDIs risks in HCV patients on antipsychot","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"25-40"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language and social perception of cannabis: A debate on narrative constructions and their impact on Public Health.","authors":"Víctor José Villanueva-Blasco, Mercè Balcells-Olivero, Clara Oliveras, Manuel Isorna Folgar","doi":"10.20882/adicciones.2563","DOIUrl":"https://doi.org/10.20882/adicciones.2563","url":null,"abstract":"","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"38 1","pages":"3-8"},"PeriodicalIF":1.8,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of sex and gender factors on the modulation of vulnerability to addictions: a narrative review.","authors":"Cristina Rius Leiva, Rut Lucas Dominguez, Judit Tirado Muñoz, Lydia García Gómez, Laura Prieto Arenas, Antonio Vidal Infer","doi":"10.20882/adicciones.2436","DOIUrl":"10.20882/adicciones.2436","url":null,"abstract":"<p><p>This narrative review identifies the sex- and gender-related factors that influence individual vulnerability to developing addictive disorders. Addiction arises from the complex interaction between neurobiological and psychosocial factors. Sex-based brain dimorphisms, shaped by genetic, hormonal, and epigenetic influences, lead to differences in neural circuits involved in reward, emotional regulation, and executive functioning. Pharmacokinetic differences, such as higher blood alcohol levels, faster nicotine metabolism, and slower μ-opioid receptor internalization in women, contribute to earlier medical complications and faster addiction progression. Gender, understood as a system of socially constructed roles and expectations, further modulates these vulnerabilities. Traditional masculine norms are associated with higher substance use, while certain aspects of femininity may increase risk (e.g., emotional repression or partner dependence) or serve as protective factors through help-seeking behavior. Sexual and gender minorities experience the most significant disparities. Lesbian and bisexual women show the highest rates of substance use disorders; gay and bisexual men report greater illicit drug use; and bisexual individuals consistently display the highest overall risk. Transgender and non-binary populations exhibit increased prevalence of tobacco, stimulant, and chemsex-related substance use, often as a response to minority stress and exclusion from cisnormative care systems. Psychiatric comorbidity affects 50-80% of cases. Women show higher rates of anxiety, trauma histories, and adverse clinical outcomes. Many face \"triple stigma\" due to their gender, mental health condition, and substance use. Addressing these disparities requires an intersectional, gender-informed, and culturally competent approach to prevention, diagnosis, and treatment.</p>","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"297-310"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prior stress history shapes adolescent alcohol-induced transcriptional changes in striatal glutamatergic and endocannabinoid pathways.","authors":"Laura Sanchez-Marin, Berke Canoluk, Julia Verheul-Campos, Ana Gavito, Raquel Reviriego, Javier Pavon, Antonia Serrano, Fernando Rodríguez de Fonseca","doi":"10.20882/adicciones.2483","DOIUrl":"10.20882/adicciones.2483","url":null,"abstract":"<p><p>Adolescence is a critical developmental window during which exposure to stress and alcohol can induce long-lasting neurobiological alterations. Binge-like alcohol consumption is particularly disruptive to corticostriatal circuits, but the extent to which prior stress history modulates these effects remains poorly understood. Here, we investigated how acute versus repeated restraint stress before intermittent alcohol exposure during adolescence shapes transcriptional changes in the dorsal striatum of male rats. Animals were exposed either to a single (acute) or five-day (repeated) restraint stress at postnatal day (PND) 32-36, followed by four weeks of intermittent intragastric ethanol (3 g/kg) or saline administration. At adult age, striatal mRNA expression of dopaminergic (Drd1, Drd2, Th), glutamatergic (Gls, Gls2, Gria2, Grin2a, Grin2b), endocannabinoid (Cnr1, Cnr2, Napepld, Faah, Dagla, Daglb, Mgll), neurotrophic (Bdnf, Ntrk2), and glial (Gfap, Aif1) genes was quantified. Alcohol exposure upregulated genes associated with glutamate synthesis and receptor signaling, endocannabinoid metabolism, and astrocytic activation. Acute stress amplified alcohol-induced expression of Gls, Gls2, Gria2, Napepld, Faah, Daglb, Ntrk2, and Gfap, while repeated stress blunted these effects and selectively enhanced Drd1, Drd2, Grin2a, and Bdnf expression. Microglial activation (Aif1) was increased by alcohol independently of stress. These results suggest that acute stress sensitizes glutamatergic and endocannabinoid pathways to alcohol, whereas repeated stress engages adaptive mechanisms consistent with the stress inoculation hypothesis. Overall, stress history critically determines the neurobiological outcomes of adolescent alcohol exposure, with implications for resilience and vulnerability to alcohol-induced psychopathology.</p>","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"37 4","pages":"369-382"},"PeriodicalIF":1.8,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}