Aging-Us最新文献_第3页

Prognostic potential of neutrophil-to-lymphocyte ratio for appendicular skeletal muscle mass reduction in males aged 70 and older.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-06 DOI: 10.18632/aging.206217

Ying-Jen Chen, Chieh-Li Yen, Chern-Horng Lee, Kuo-Chen Liao, Ji-Tseng Fang, Tz-Shiu Tsai, Yi-Ching Chen, Chun-Yen Lin

{"title":"Prognostic potential of neutrophil-to-lymphocyte ratio for appendicular skeletal muscle mass reduction in males aged 70 and older.","authors":"Ying-Jen Chen, Chieh-Li Yen, Chern-Horng Lee, Kuo-Chen Liao, Ji-Tseng Fang, Tz-Shiu Tsai, Yi-Ching Chen, Chun-Yen Lin","doi":"10.18632/aging.206217","DOIUrl":"10.18632/aging.206217","url":null,"abstract":"Inflammation plays a pivotal role in the age-related decline of skeletal muscle mass, leading to sarcopenia in the elderly. The prevalence of sarcopenia notably increases among males aged ≥ 70. However, it remains unclear whether inflammatory indexes are associated with the reduction in skeletal muscle mass in the elderly population. Thirty-one males aged ≥ 70, without severe diseases or dementia, were enrolled in the study. They underwent muscle mass measurements, physical measurements, and hematological tests at the onset of the study and after a one-year follow-up. Twenty-eight participants were successfully followed for one year. Appendicular skeletal muscle mass index (ASMI) decreased by 3.30 ± 2.41% in 14 participants and increased by 2.66 ± 1.61% in the other 14 participants compared to baseline levels. The baseline neutrophil-to-lymphocyte ratio (NLR) was 2.14 ± 0.56 in the ASMI-decreased group and 1.66 ± 0.62 in the ASMI-increased group. A statistically significant negative correlation was found between baseline NLR and the change in ASMI in linear regression analyses. The area under the curve (AUC) of the baseline NLR for predicting ASMI decline was 0.724, with an optimal sensitivity of 64.3% and specificity of 78.6% at a cut-off value of 1.94. NLR emerged as a potential prognostic marker for ASMI reduction in elderly males. However, further studies are necessary to assess its clinical utility.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"863-871"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive aging, preimplantation genetic testing for aneuploidy, and the diameter of blastocysts: does size matter?

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-05 DOI: 10.18632/aging.206215

Jakub Wyroba, Joanna Kochan, Maria Barszcz, Grzegorz Mirocki, Pawel Kordowitzki

{"title":"Reproductive aging, preimplantation genetic testing for aneuploidy, and the diameter of blastocysts: does size matter?","authors":"Jakub Wyroba, Joanna Kochan, Maria Barszcz, Grzegorz Mirocki, Pawel Kordowitzki","doi":"10.18632/aging.206215","DOIUrl":"10.18632/aging.206215","url":null,"abstract":"There is no doubt that maternal aging, also known as reproductive aging, can contribute to the increased rates of aneuploidy observed in blastocysts generated from women of advanced age who undergo in vitro fertilization (IVF). Additionally, the hatching process of the blastocyst, which is crucial for successful implantation, may be impaired in aneuploid embryos. Aneuploid embryos often exhibit abnormal cell division and chromosomal distribution, which can lead to disruptions in the hatching process. Due to ethical restrictions, preimplantation genetic testing for aneuploidy (PGT-A) is unavailable in all countries. Therefore, our retrospective study of 502 couples who underwent intracytoplasmic sperm injection (ICSI) aimed to elucidate if embryonic features, such as the ability to hatch and embryonic diameter, could be a reliable estimator for the success rate after embryo transfer, especially for women aged 26-45 years, and for IVF clinics which do not have access to PGT-A. The small hatching blastocysts (Bl. 5) group had a significant (p < 0.001) higher percentage of euploid embryos (≤35 Y- 73%, >35Y- 51%) compared to large (Bl. 4) counterparts (≤35 Y-58%, >35 Y- 38%). In patients aged 34-38 years, we detected 10% more euploid blastocysts in the hatching group than the expanding ones, which was a significant difference (p < 0.05). In conclusion, when selecting non-PGT-A tested embryos for embryo transfer (ET) or frozen embryo transfer (FET), a small hatching blastocyst seems to be a better choice than a large expanded one, especially for advanced-age patients for whom the risk of aneuploidy is higher.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"630-642"},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-04 DOI: 10.18632/aging.206219

Sushil K Dubey, Rashmi Dubey, Kyungsik Jung, Alvaro G Hernandez, Mark E Kleinman

{"title":"Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium.","authors":"Sushil K Dubey, Rashmi Dubey, Kyungsik Jung, Alvaro G Hernandez, Mark E Kleinman","doi":"10.18632/aging.206219","DOIUrl":"10.18632/aging.206219","url":null,"abstract":"Aging of the retinal pigment epithelium (RPE) leads to a gradual decline in RPE homeostasis over time, significantly impacting retinal health. Understanding the mechanisms underlying RPE aging is crucial for elucidating the background in which many age-related retinal pathologies develop. In this study, we compared the transcriptomes of young and aged mouse RPE and observed a marked upregulation of immunogenic, proinflammatory, and oxidative stress genes in aging RPE. Additionally, aging RPE exhibited dysregulation of pathways associated with visual perception and extracellular matrix production. Research on aging in post-natal quiescent RPE is hindered by the absence of relevant in vitro models. Here, we evaluated an in vitro model of chronologically aged primary human RPE to address this gap and observed gene expression patterns comparable to native-aged RPE. Gene expression profiling in this model highlighted its potential utility in investigating cellular and molecular mechanisms of RPE aging and in screening of therapeutic compounds. In conclusion, our findings underscore the pivotal role of inflammation, immune activation, and oxidative stress in the aging RPE landscape and provide insights into why age increases the risk of retinal pathologies.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"657-684"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent falls as the presentations of Gitelman syndrome in an octogenarian.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-04 DOI: 10.18632/aging.206216

Chien-Yao Sun, Shang-Han Wu, Chia-Ter Chao, Shih-Hua Lin

{"title":"Recurrent falls as the presentations of Gitelman syndrome in an octogenarian.","authors":"Chien-Yao Sun, Shang-Han Wu, Chia-Ter Chao, Shih-Hua Lin","doi":"10.18632/aging.206216","DOIUrl":"10.18632/aging.206216","url":null,"abstract":"Gitelman syndrome (GS) is the most common hereditary renal tubular disorder, with a higher carrier frequency among Asians often overlooked in older adults. Electrolyte imbalances, such as those seen in GS, are crucial considerations for older adults experiencing recurrent falls. We described an 83-year-old diabetic female on metformin, who was admitted due to recurrent falls with the preceding dizziness and palpitations when standing. She had the history of chronic hypokalemia and hypomagnesemia on regular potassium (K+) and magnesium (Mg++) supplementation for 10 years and gout-like arthritis episodes over her shoulder and ankle joints. Her consciousness was alert with normal blood pressure but reduced tendon reflex over bilateral knees. Pertinent laboratory findings included hypokalemic (K+ 2.2 mmol/L) with metabolic alkalosis and high urine K+ excretion, hypomagnesemia (1.1 mg/dl) with hypermagnesuria, but hypocalciuria (UCa/Cr ratio 0.01 mg/mg), high urine salt excretion, and hyperreninemia. X-ray of bilateral knees and shoulders demonstrated typical chondrocalcinosis with dense calcification band in the joint space. Targeted Sanger sequencing confirmed GS, identifying a biallelic homozygous deletion mutation (2881-2 delAG) in the exon 24 of SLC12A3 gene as the potential causes of recurrent falls. After aggressive electrolytes correction, her potassium and magnesium levels stabilized, and the patient did not experience further falls. This case, probably the oldest documented patient with GS emphasizes the importance of recognizing atypical presentations of GS in older adults. Careful evaluation and management of electrolyte disturbances in this population may prevent fall recurrence and complications.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"872-880"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction for: Machine learning-based B cell-related diagnostic biomarker signature and molecular subtypes characteristic of ulcerative colitis.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-28 DOI: 10.18632/aging.206209

Guo-Liang Wu, Li Li, Xiao-Yao Chen, Wei-Feng Zhang, Jun-Bo Wu, Xiaoning Yu, Hong-Jin Chen

引用次数: 0

Retraction of: KCNQ1OT1 promotes melanoma growth and metastasis.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-28 DOI: 10.18632/aging.206214

Bingyu Guo, Qian Zhang, Hongyi Wang, Peng Chang, Kai Tao

引用次数: 0

Correction for: 1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-28 DOI: 10.18632/aging.206208

Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, Ikuro Maruyama

引用次数: 0

Pan-cancer analysis of Methyltransferase-like 16 (METTL16) and validated in colorectal cancer.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-27 DOI: 10.18632/aging.206210

Ling Liu, Siying Wang, Xuyu Chen, Qian Luo, Zhaoxia Wang, Juan Li

{"title":"Pan-cancer analysis of Methyltransferase-like 16 (METTL16) and validated in colorectal cancer.","authors":"Ling Liu, Siying Wang, Xuyu Chen, Qian Luo, Zhaoxia Wang, Juan Li","doi":"10.18632/aging.206210","DOIUrl":"10.18632/aging.206210","url":null,"abstract":"Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative studies of the relevance of METTL16 across diverse tumors remain sparse. We comprehensively investigated the effect of METTL16 expression on tumor prognosis across human malignancies by analyzing multiple cancer-related databases like Tumor Immune Estimation Resource (TIMER) and human protein atlas (HPA). Bioinformatics data indicated that METTL16 was overexpressed in most of these human malignancies and was significantly associated with the prognosis of patients with cancer, especially in colorectal cancer (CRC). Subsequently, In vitro experiments, the utility of METTL16 that downregulation of its expression could result in reduced proliferation and migration of CRC cells. Our findings reveal novel insights into METTL16 expression and its biological functions in diverse cancer types, indicating that METTL16 could serve as a prognostic biomarker and plays an important role in colorectal cancer.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"588-606"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variability in radiotherapy outcomes across cancer types: a comparative study of glioblastoma multiforme and low-grade gliomas.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-27 DOI: 10.18632/aging.206212

Alexander Veviorskiy, Garik V Mkrtchyan, Andreyan N Osipov, Evgeny Izumchenko, Ivan V Ozerov, Alex Aliper, Alex Zhavoronkov, Morten Scheibye-Knudsen

{"title":"Variability in radiotherapy outcomes across cancer types: a comparative study of glioblastoma multiforme and low-grade gliomas.","authors":"Alexander Veviorskiy, Garik V Mkrtchyan, Andreyan N Osipov, Evgeny Izumchenko, Ivan V Ozerov, Alex Aliper, Alex Zhavoronkov, Morten Scheibye-Knudsen","doi":"10.18632/aging.206212","DOIUrl":"10.18632/aging.206212","url":null,"abstract":"Radiotherapy is a crucial treatment option for various cancers. However, the results of radiotherapy can vary widely across different cancer types and even among patients with the same type of cancer. This variability presents a major challenge in optimizing treatment strategies and improving patient survival. Here, we collected radiotherapy phenotype and expression data from 32 TCGA cancer datasets and performed overall survival analysis for 32 cancer types. Additionally, we conducted a signaling pathway enrichment analysis to identify key pathways involved in radiotherapy resistance and sensitivity. Our findings show that radiotherapy improves survival outcomes in certain cancer types, such as glioblasoma multiforme (GBM), while worsening outcomes in others, such as low-grade glioma (LGG). Next, we focused on exploring the differences in radiotherapy outcomes between GBM and LGG, focusing on the molecular mechanisms contributing to these variations. We identify differential regulation of pathways related to programmed cell death, DNA repair, telomere maintenance, chromosome condensation, antiviral responses, and interferon signaling between GBM and LGG patients perhaps explaining radiotherapy efficacy. A genetic analysis confirmed the importance of immune response and radiotherapy outcome for LGG patients. These insights underscore the importance of personalized treatment approaches and the need for further research to improve radiotherapy outcomes in cancer patients.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"550-562"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-27 DOI: 10.18632/aging.206211

Hoang Van M Nguyen, Eleana Cabello, David Dyer, Chloe Fender, Manuel Garcia-Jaramillo, Norman G Hord, Steven Austad, Arlan Richardson, Archana Unnikrishnan

{"title":"Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model.","authors":"Hoang Van M Nguyen, Eleana Cabello, David Dyer, Chloe Fender, Manuel Garcia-Jaramillo, Norman G Hord, Steven Austad, Arlan Richardson, Archana Unnikrishnan","doi":"10.18632/aging.206211","DOIUrl":"10.18632/aging.206211","url":null,"abstract":"We evaluated the impact of sex and mitochondrial-haplotype on the age-related changes in the fecal gut microbiome of the genetically heterogeneous rodent model, the OKC-HETB/W rat. The age-related changes in the microbiome differed markedly between male and female rats. Five microbial species changed significantly with age in male rats compared to nine microbial species in female rats. Only three of these microbes changed with age in both male and female rats. The mitochondrial-haplotype of the rats also affected how aging altered the microbiome. Interestingly, most of the microbial species that changed significantly with age were mitochondrial-haplotype and sex specific, i.e., changing in one sex and not the other. We also discovered that sex and mitochondrial-haplotype significantly affected the age-related variations in content of fecal short-chain fatty acids and plasma metabolites that influence or are regulated by the microbiome, e.g., tryptophan derived metabolites and bile acids. This study demonstrates that the host's sex plays a significant role in how the gut microbiome evolves with age, even within a genetically diverse background. Importantly, this is the first study to show that the mitochondrial-haplotype of a host impacts the age-related changes in the microbiome.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"524-549"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0