Aging-Us最新文献

{"title":"Cut-off values for the muscle mass indices determined using DXA in healthy Polish adults - a comparison to EWGSOP2 recommendation.","authors":"Aleksandra Radecka, Waldemar Pluta, Tomasz Miazgowski, Anna Lubkowska","doi":"10.18632/aging.206206","DOIUrl":"10.18632/aging.206206","url":null,"abstract":"<p><strong>Background: </strong>Muscle mass measurements are vital for predicting health outcomes and diagnosing muscle disorders. This study provides reference data for appendicular lean mass (ALM) and total lean mass (TLM) in healthy Polish adults with normal muscle strength and physical performance as per EWGSOP2 guidelines.</p><p><strong>Methods: </strong>The study included healthy volunteers with normal muscle strength and functional status. Lean mass was measured using Hologic Horizon DXA. Mean values of TLM, ALM, fat-free mass (FFM), and indices (TLMI, ALMI, FFMI) were calculated for seven age groups (by decade). Cut-off points equivalent to T-scores of -1 and -2 standard deviations (SDs) below the young adult reference mean (ages 20-39) were determined.</p><p><strong>Results: </strong>Data from 1,111 participants (328 men, 46.3 ± 20 years; 783 women, 43.7 ± 23 years) were analyzed. In young adults, mean ALM was 28.1 kg (men) and 17.2 kg (women), and ALMI was 8.6 kg/m² (men) and 6.1 kg/m² (women). Low muscle mass cut-off points (2 SDs below) were 18 kg and 10.9 kg (ALM) and 6 kg/m² and 4.3 kg/m² (ALMI) for men and women, respectively. Men exhibited significantly greater lean mass than women across all age groups (P < 0.001). Lean mass declined with age in both genders, following a nonlinear pattern, except for ALMI in men.</p><p><strong>Conclusions: </strong>This study provides the first population-based reference values for ALM and TLM in healthy Polish adults aged 20-89 years, integrating criteria for normal muscle strength and physical performance.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"482-496"},"PeriodicalIF":3.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and genetic determination of measures of peripheral vascular health in the Long Life Family Study.","authors":"Deidra R Fricke, Ryan K Cvejkus, Emma Barinas-Mitchell, Mary F Feitosa, Joanne M Murabito, Sandeep Acharya, Michael R Brent, E Warwick Daw, Ryan L Minster, Joseph M Zmuda, Allison L Kuipers","doi":"10.18632/aging.206204","DOIUrl":"10.18632/aging.206204","url":null,"abstract":"<p><p>Peripheral artery disease (PAD) is a major contributor to morbidity in older adults. We aimed to determine genetic and non-genetic determinants of PAD and ankle-brachial index (ABI) in the Long Life Family Study (LLFS). 3006 individuals had ABI assessment, including 1090 probands (mean age 89), 1554 offspring (mean age 60) and 362 spousal controls (mean age 61). Outcomes include minimum of right and left ABIs and PAD (ABI <0.9). Stepwise regression determined independent significant non-genetic correlates of ABI and PAD. Genomewide association and linkage analyses were adjusted for age, sex, study center, significant principal components, and independent predictors. All analyses accounted for familial relatedness. Median ABI was 1.16 and 7.4% had PAD (18.2% probands, 1.0% offspring, 1.9% controls). Correlates of PAD and lower ABI included age, SBP, and creatinine (ABI only); BMI (ABI only), HDL (ABI only) and DBP (PAD only); and antihypertensive use, current smoking, female sex (ABI only), and high school noncompletion (ABI only). Genomewide linkage identified 1 region (15q12-q13) and association identified 3 single nucleotide polymorphisms (rs780213, rs12512857, rs79644420) of interest. In these families, PAD prevalence was low compared to other studies of older adults. We identified four genomic sites that may harbor variants associated with protection from PAD.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"464-481"},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of senescence rejuvenation mechanism of <i>Magnolia officinalis</i> extract including honokiol as a core ingredient.","authors":"Yun Haeng Lee, Eun Young Jeong, Ye Hyang Kim, Ji Ho Park, Jee Hee Yoon, Yoo Jin Lee, So Hun Lee, Yeon Kyung Nam, So Yoon Cha, Jin Seong Park, So Yeon Kim, Youngjoo Byun, Song Seok Shin, Joon Tae Park","doi":"10.18632/aging.206207","DOIUrl":"10.18632/aging.206207","url":null,"abstract":"<p><p>Reactive oxygen species (ROS) contribute to aging by mainly damaging cellular organelles and DNA. Although strategies to reduce ROS production have been proposed as important components of anti-aging therapy, effective mechanisms to lower ROS levels have not yet been identified. Here, we screened natural compounds frequently used as cosmetic ingredients to find substances that reduce ROS levels. <i>Magnolia officinalis</i> (<i>M. officinalis</i>) extract significantly lowered the levels of ROS in senescent fibroblasts. A novel mechanism by which <i>M. officinalis</i> extract restores mitochondrial function to reduce ROS, a byproduct of inefficient electron transport, was discovered. The reduction of ROS by <i>M. officinalis</i> extracts reversed senescence-associated phenotypes and skin aging. Then, honokiol was demonstrated as a core ingredient of <i>M. officinalis</i> extract that exhibits antioxidant effects. Honokiol functions as an oxygen radical scavenger through redox processes, also significantly reduced ROS levels by restoring mitochondrial function. In summary, our study identified a novel mechanism by which <i>M. officinalis</i> extract reverses aging and skin aging by reducing ROS through restoring mitochondrial function. These new findings will not only expand our understanding of aging and associated diseases, but also provide new approaches to anti-aging treatments.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"497-523"},"PeriodicalIF":3.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the use of black phosphorus quantum dots in the treatment of atherosclerosis.","authors":"Shengwei Zhang, Yiran Ji, Bingxuan Xu, Die Hu, Xue Zhang, Yujian Song, Keke Chen, Yilin Wen, Xiaoxin He, Yun Chen, Tingting Zheng","doi":"10.18632/aging.206205","DOIUrl":"10.18632/aging.206205","url":null,"abstract":"<p><p>Atherosclerosis is the pathological basis of cardiovascular disease, and there are no clinical drugs that can safely and efficiently remove atherosclerotic plaques. In this study, black phosphorus quantum dots (BPQDs) were applied to the treatment of atherosclerosis in high fat diet ApoE^-/- model mice that BPQDs were given every other day for 3 weeks without changing the high-fat diet. 45.3% atherosclerotic plaque was cleared efficiently within 3 weeks in BPQDs intravenous administration way every other day. The treatment was more effective than traditional statins. The findings suggest that BPQDs have great potential to be applied for clinical prevention and treatment of AS that does not require dietary changes.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"563-587"},"PeriodicalIF":3.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice.","authors":"Duraipandy Natarajan, Shoba Ekambaram, Stefano Tarantini, Raghavendra Y Nagaraja, Andriy Yabluchanskiy, Andria F Hedrick, Vibhudutta Awasthi, Madhan Subramanian, Anna Csiszar, Priya Balasubramanian","doi":"10.18632/aging.206203","DOIUrl":"10.18632/aging.206203","url":null,"abstract":"<p><p>Microvascular endothelial dysfunction, characterized by impaired neurovascular coupling, reduced glucose uptake, blood-brain barrier disruption, and microvascular rarefaction, plays a critical role in the pathogenesis of age-related vascular cognitive impairment (VCI). Emerging evidence points to non-cell autonomous mechanisms mediated by adverse circulating milieu (an increased ratio of pro-geronic to anti-geronic circulating factors) in the pathogenesis of endothelial dysfunction leading to impaired cerebral blood flow and cognitive decline in the aging population. In particular, age-related adipose dysfunction contributes, at least in part, to an unfavorable systemic milieu characterized by chronic hyperglycemia, hyperinsulinemia, dyslipidemia, and altered adipokine profile, which together contribute to microvascular endothelial dysfunction. Hence, in the present study, we aimed to test whether thermogenic stimulation, an intervention known to improve adipose and systemic metabolism by increasing cellular energy expenditure, could mitigate brain endothelial dysfunction and improve cognition in the aging population. Eighteen-month-old C57BL/6J mice were treated with saline or β3-adrenergic agonist (CL 316, 243, CL) for 6 weeks followed by functional analysis to assess endothelial function and cognition. CL treatment improved neurovascular coupling responses and rescued brain glucose uptake in aged animals. In addition, CL treatment also attenuated blood-brain barrier leakage and associated neuroinflammation in the cortex and increased microvascular density in the hippocampus of aged mice. More importantly, these beneficial changes in microvascular function translated to improved cognitive performance in aged mice. Our results suggest that β3-adrenergic agonist treatment improves multiple aspects of cerebromicrovascular function and can be potentially repurposed for treating age-associated cognitive decline.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"448-463"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP).","authors":"Leah M Roberts, Nola Herlihy, Andres Reig, Shiny Titus, Rolando Garcia-Milian, James Knight, Raziye Melike Yildirim, Cheri K Margolis, Yigit Cakiroglu, Bulent Tiras, Christine V Whitehead, Marie D Werner, Emre Seli","doi":"10.18632/aging.206202","DOIUrl":"10.18632/aging.206202","url":null,"abstract":"<p><p>Intraovarian injection of autologous platelet-rich plasma (PRP) has recently been investigated as a potential treatment for patients with diminished ovarian reserve. In the current study, differential gene expression in cumulus cells obtained from patients treated with PRP was compared to controls. RNA sequencing libraries were constructed from the cumulus cells, and differential expression analysis was performed with a false discovery rate threshold of <i>p</i>-value ≤0.05 and Log2 fold change ≥0.584. RNA sequencing of cumulus cells revealed significant differences in gene expression when comparing those treated with PRP and resulted in a live birth (<i>n</i> = 5) to controls with live birth (<i>n</i> = 5), or to controls with failed implantation (<i>n</i> = 5). Similarly, when all samples treated with PRP (those that resulted in live birth or arrested embryos (<i>n</i> = 10)) were compared to all samples from controls (those that resulted in live birth, no pregnancy, or arrested embryos (<i>n</i> = 13)), gene expression was significantly different. Several pathways were consistently affected by PRP treatment through multiple comparisons, including carbohydrate metabolism, cell death and survival, cell growth and proliferation, and cell-to-cell signaling, all of which have been implicated in human causes of infertility.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"431-447"},"PeriodicalIF":3.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposome-wide association study of environmental chemical exposures and epigenetic aging in the national health and nutrition examination survey.","authors":"Dennis Khodasevich, Nicole Gladish, Saher Daredia, Anne K Bozack, Hanyang Shen, Jamaji C Nwanaji-Enwerem, Belinda L Needham, David H Rehkopf, Andres Cardenas","doi":"10.18632/aging.206201","DOIUrl":"10.18632/aging.206201","url":null,"abstract":"<p><p>Epigenetic clocks can serve as pivotal biomarkers linking environmental exposures with biological aging. However, research on the influence of environmental exposures on epigenetic aging has largely been limited to a small number of chemicals and specific populations. We harnessed data from the National Health and Nutrition Examination Survey 1999-2000 and 2001-2002 cycles to examine exposome-wide associations between environmental exposures and epigenetic aging. A total of 8 epigenetic aging biomarkers were obtained from whole blood in 2,346 participants ranging from 50-84 years of age. A total of 64 environmental exposures including phthalates, metals, pesticides, dioxins, and polychlorinated biphenyls (PCBs) were measured in blood and urine. Associations between log₂-transformed/standardized exposure measures and epigenetic age acceleration (EAA) were assessed using survey-weighted generalized linear regression. A 1 standard deviation (SD) increase in log₂ serum cadmium levels was associated with higher GrimAge acceleration (beta = 1.23 years, p = 3.63e-06), higher GrimAge2 acceleration (beta = 1.27 years, p = 1.62e-05), and higher DunedinPoAm (beta = 0.02, p = 2.34e-05). A 1 SD increase in log₂ serum cotinine levels was associated with higher GrimAge2 acceleration (beta = 1.40 years, p = 6.53e-04) and higher DunedinPoAm (beta = 0.03, p = 6.31e-04). Associations between cadmium and EAA across several clocks persisted in sensitivity models adjusted for serum cotinine levels, and other associations involving lead, dioxins, and PCBs were identified. Several environmental exposures are associated with epigenetic aging in a nationally representative US adult population, with particularly strong associations related to cadmium and cotinine across several epigenetic clocks.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"408-430"},"PeriodicalIF":3.9,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of acylated ghrelin and gut microbiome in delineating cognitive health in the elderly.","authors":"Sudeshna Rout, Rishikesh Dash, Varsha Satish, Giriprasad Venugopal, Bodepudi Narasimha Rao, Debapriya Bandhyopadhyay, Sanjeev Kumar Bhoi, Balamurugan Ramadass","doi":"10.18632/aging.206200","DOIUrl":"10.18632/aging.206200","url":null,"abstract":"<p><strong>Introduction: </strong>With increased life expectancy, there is an increase in aging population and prevalence of dementia. Ghrelin is a key regulator of spatial memory and cognition. The gut microbiome may affect the circulating levels of unacylated ghrelin (UAG) and acylated ghrelin (AG). Thus, we explore the potential association of the gut microbiome, AG, and cognitive health in the aging dementia patient.</p><p><strong>Methods: </strong>40 dementia patients and 40 controls were recruited. Fecal Microbiome analysis using 16S rRNA sequencing was performed on 18 samples. A mixed-method approach was employed for robust interpretation.</p><p><strong>Results: </strong>Dementia patients had an increased serum AG and AG/UAG ratio. With the increase in AG among dementia subjects, a significant decrease in species richness was observed. <i>Bifidobacterium longum, Eubacterium biforme, Fecalibacterium prausnitzii, Lactobacillus ruminis</i>, and <i>Prevotella copri</i> contributed to substantial differences in beta-diversity. <i>Blautia obeum</i> was associated with Mini-Mental State Examination (MMSE), and <i>Fecalibacterium prausnitzii</i> was associated with Montreal Cognitive Assessment (MoCA) Scale.</p><p><strong>Discussion: </strong>This pilot study indicates a complex interaction between AG, gut microbiome, and cognitive scores. Increased AG corresponds to both dementia and gut dysbiosis, intricately interconnecting the gut-brain axis. The circulating AG and associated gut microbiome might be a putative biomarker for dementia.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"393-407"},"PeriodicalIF":3.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction, iron accumulation, lipid peroxidation, and inflammasome activation in cellular models derived from patients with multiple sclerosis.","authors":"Raquel García-Salas, Paula Cilleros-Holgado, Anna Di Spirito, David Gómez-Fernández, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Mónica Álvarez-Córdoba, Diana Reche-López, Ana Romero-González, Alejandra López-Cabrera, José Antonio Sánchez-Alcázar","doi":"10.18632/aging.206198","DOIUrl":"10.18632/aging.206198","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Despite advancements in managing relapsing active illness, effective treatments for the irreversible progressive decline in MS remain limited. Research employing skin fibroblasts obtained from patients with neurological disorders revealed modifications in cellular stress pathways and bioenergetics. However, research using MS patient-derived cellular models is scarce. In this study, we collected fibroblasts from two MS patients to investigate cellular pathological alterations. We observed that MS fibroblasts showed a senescent morphology associated with iron/lipofuscin accumulation and altered expression of iron metabolism proteins. In addition, we found increased lipid peroxidation and downregulation of antioxidant enzymes expression levels in MS fibroblasts. When challenged against erastin, a ferroptosis inducer, MS fibroblasts showed decreased viability, suggesting increased sensitivity to ferroptosis. Furthermore, MS fibroblasts presented alterations in the expression levels of autophagy-related proteins. Interestingly, these alterations were associated with mitochondrial dysfunction and inflammasome activation. These findings were validated in 7 additional patient-derived cell lines. Our findings suggest that the underlying stress phenotype of MS fibroblasts may be disease-specific and recapitulate the main cellular pathological alterations found in the disease such as mitochondrial dysfunction, iron accumulation, lipid peroxidation, inflammasome activation, and pro-inflammatory cytokine production.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"365-392"},"PeriodicalIF":3.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carriers of Parkinson's disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study.","authors":"Aarthi Santhanakrishnan, Yi Jayne Tan, Seyed Ehsan Saffari, Yi Zhao, Ebonne Y L Ng, Samuel Y E Ng, Nicole S Y Chia, Xinyi Choi, Dede Heng, Shermyn Neo, Zheyu Xu, Kay Yaw Tay, Wing Lok Au, Eng-King Tan, Louis C S Tan, Adeline S L Ng","doi":"10.18632/aging.206196","DOIUrl":"10.18632/aging.206196","url":null,"abstract":"<p><p>Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients grouped into long (<i>n</i> = 111) vs. short (<i>n</i> = 97) Rep1 allele carriers. Long Rep1 carriers demonstrated faster decline in global cognition (<i>p</i> = 0.023) and increasing apathy (<i>p</i> = 0.027), with greater decline in attention and memory domains (<i>p</i> = 0.001), highlighting the utility of Rep1 polymorphism in stratifying patients at risk of non-motor symptom decline.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"357-364"},"PeriodicalIF":3.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}