Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study.

IF 3.9 3区 医学 Q2 CELL BIOLOGY
Aging-Us Pub Date : 2025-05-08 DOI:10.18632/aging.206248
Jia-Hung Chen, Lung Chan, Chien-Tai Hong, Chaur-Jong Hu, Yi-Chen Hsieh
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Abstract

Although apolipoprotein E (ApoE) ε4 is a well-established risk factor for Alzheimer disease, its role in the development of post-stroke cognitive impairment (PSCI) remains uncertain. In this prospective cohort study, we recruited patients aged ≥20 years who had ischemic stroke within the past 7 days and measured their ApoE genotype. Baseline characteristics, including age, sex, education level, medical history, stroke severity, stroke etiology, and neuroimaging findings were recorded. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA) and Clinical Dementia Rating (CDR) at 3 and 12 months post-stroke, with PSCI defined as a MoCA score < 26. After adjusting for confounding factors, the ApoE ε4 allele was not associated with the risk of PSCI at 3 or 12 months post-stroke. Other factors, including age, body mass index, education level, and initial stroke severity, were found to be associated with the risk of PSCI at 3 months. In patients who developed PSCI at 12 months, only education level and the MoCA score at 3 months were significantly associated with the risk of PSCI. Our findings suggest that, aside from traditional risk factors, the ApoE ε4 allele does not contribute to the risk of PSCI at 3 or 12 months post-stroke. Further studies with a larger sample size and longer follow-up are warranted.

载脂蛋白E (ApoE) ε4在脑卒中后认知功能障碍中的作用:一项前瞻性队列研究
虽然载脂蛋白E (ApoE) ε4是阿尔茨海默病的一个公认的危险因素,但其在卒中后认知障碍(PSCI)发展中的作用仍不确定。在这项前瞻性队列研究中,我们招募了年龄≥20岁且在过去7天内发生缺血性卒中的患者,并测量了他们的ApoE基因型。记录基线特征,包括年龄、性别、教育程度、病史、脑卒中严重程度、脑卒中病因和神经影像学结果。脑卒中后3个月和12个月采用蒙特利尔认知评估(MoCA)和临床痴呆评分(CDR)评估认知功能,MoCA评分< 26定义PSCI。在调整混杂因素后,ApoE ε4等位基因与脑卒中后3个月或12个月的PSCI风险无关。其他因素,包括年龄、体重指数、教育水平和初始卒中严重程度,被发现与3个月时PSCI的风险相关。在12个月发生PSCI的患者中,只有教育水平和3个月时MoCA评分与PSCI的风险显著相关。我们的研究结果表明,除了传统的危险因素外,ApoE ε4等位基因对中风后3个月或12个月的PSCI风险没有贡献。进一步的研究需要更大的样本量和更长的随访时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging-Us
Aging-Us CELL BIOLOGY-
CiteScore
10.00
自引率
0.00%
发文量
595
审稿时长
6-12 weeks
期刊介绍: Information not localized
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