Cisd1与Cisd2协同作用,通过维持线粒体和内质网稳态来调节蛋白质加工。

IF 3.9 3区 医学 Q2 CELL BIOLOGY
Aging-Us Pub Date : 2025-05-08 DOI:10.18632/aging.206249
Yi-Fan Chen, Yuan-Chi Teng, Jian-Hsin Yang, Cheng-Heng Kao, Ting-Fen Tsai
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引用次数: 0

摘要

细胞器之间的连接和串扰对细胞功能起着至关重要的作用。任何一种细胞器的破坏都可能诱发一系列细胞内紊乱,最终导致细胞死亡。由于其亚细胞位置,CDGSH含铁硫结构域蛋白1 (Cisd1)和Cisd2具有与维持线粒体和内质网稳态相关的功能。既往报道显示,Cisd2基因敲除小鼠体重下降,存活率低,主要缺陷发生在骨骼肌。我们之前的研究结果表明,Cisd1缺失会导致Cisd2缺乏小鼠的一系列骨骼肌缺陷,包括线粒体变性、内质网(ER)应激、蛋白质过程改变以及程序性细胞死亡。在Cisd1和Cisd2缺乏的情况下,整个蛋白质的生物合成被破坏,包括翻译、修饰、运输和降解。在Cisd1和Cisd2双敲除小鼠中,免疫反应、氧化还原调节和代谢也发生了变化。总的来说,我们已经证明Cisd1和Cisd2敲除对骨骼肌具有协同作用,并且Cisd2比Cisd1发挥更关键的作用。这些协同效应影响信号调节,中断细胞器的串扰和稳态。这会在各种组织和器官中造成严重的紊乱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cisd1 synergizes with Cisd2 to modulate protein processing by maintaining mitochondrial and ER homeostasis.

Connection and crosstalk among the organelles critically contribute to cellular functions. Destruction of any kind of organelle is likely to induce a series of intracellular disorders and finally lead to cell death. Because of its subcellular locations, CDGSH iron-sulfur domain-containing protein 1 (Cisd1) and Cisd2 have functions that are related to maintaining mitochondria and ER homeostasis. As previous reports have shown, Cisd2 knockout mice have a decreased body weight and poor survival rate, and the primary defects were conducted in skeletal muscle. Our previous findings indicated that Cisd1 deletion causes a range of skeletal muscle defects in mice with Cisd2 deficiency, including mitochondrial degeneration, endoplasmic reticulum (ER) stress, and alteration of protein process, as well as programmed cell death. In Cisd1 and Cisd2 deficient condition, the whole of the protein biosynthesis was damaged, including translation, modification, transport, and degradation. Changes in the immune response, redox regulation, and metabolism were also present in Cisd1 and Cisd2 double knockout mice. Overall, we have demonstrated that Cisd1 and Cisd2 knockout have a synergistic effect on skeletal muscles, and that Cisd2 plays a more critical role than Cisd1. These synergistic effects impact signaling regulation and interrupt the crosstalk and homeostasis of organelles. This creates severe disorders in various tissues and organs.

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来源期刊
Aging-Us
Aging-Us CELL BIOLOGY-
CiteScore
10.00
自引率
0.00%
发文量
595
审稿时长
6-12 weeks
期刊介绍: Information not localized
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