Aging-Us最新文献

{"title":"Impact of waist-to-hip and waist-to-height ratios on physical performance: insights from the Longevity Check-up 8+ project.","authors":"Anna Maria Martone, Elena Levati, Francesca Ciciariello, Vincenzo Galluzzo, Sara Salini, Riccardo Calvani, Emanuele Marzetti, Francesco Landi","doi":"10.18632/aging.206260","DOIUrl":"https://doi.org/10.18632/aging.206260","url":null,"abstract":"<p><strong>Background: </strong>Physical performance is crucial for healthy aging. Body composition has gained particular attention. Anthropometric measurements, specifically the waist-to-hip ratio (WHR) and the waist-to-height ratio (WHtR), have emerged as valuable indicators. This study aims to investigate the correlation between abnormal WHR and waist-to-height ratios with physical performance.</p><p><strong>Methods: </strong>Data from the Longevity Check-up 8+ project were analyzed. Anthropometric measurements were used to calculate WHR and WHtR. Physical performance was evaluated through the chair stand test. ANCOVA assessed the impact of WHR and WHtR on physical performance, while Cox proportional-hazards models were used to assess the relation between WHR, WHtR and physical performance. ROC curves analyzed their predictive capability.</p><p><strong>Results: </strong>Among 10690 participants (mean age 57.0 ± 14.8 y; 54% females), men exhibited higher WHR and WHtR and a higher prevalence of abnormal values (61% and 71%). Women took longer to complete the chair stand test (7.9 ± 2.7 vs. 7.6 ± 2.4 seconds, <i>p</i> < 0.01). Abnormal WHR and WHtR were associated with poorer physical performance after adjusting for confounders (HR: 1.28; 95% CI: 1.08-1.53; HR: 1.32; 95% CI: 1.04-1.66). ROC curve analysis showed that WHtR had superior predictive capability to identify lower physical performance across age and gender groups.</p><p><strong>Conclusions: </strong>Individuals with higher WHR and WHtR values demonstrated poorer physical performance, underscoring the importance of monitoring abdominal fat distribution as a predictor of functional health and aging-related outcomes.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking healthcare through aging biology.","authors":"Marco Demaria","doi":"10.18632/aging.206262","DOIUrl":"10.18632/aging.206262","url":null,"abstract":"","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1077-1079"},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peto's paradox's relevance is off the scale.","authors":"Mirre J P Simons","doi":"10.18632/aging.206258","DOIUrl":"https://doi.org/10.18632/aging.206258","url":null,"abstract":"<p><p>Peto's paradox is the disconnect between individual risk of cells to develop malignancy and the absence of a strong increase in cancer incidence with body mass across species. Recently small increases of cancer incidence with body mass across species have been interpreted as a falsification of Peto's paradox. I argue this is a misinterpretation as it is the predicted incredible scale of the increase in cancer incidence with body mass that led to Peto's paradox. The relevance for the biology of cancer and ageing of Peto's paradox is off the scale and remains a highly valid paradigm of study.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty.","authors":"Yuka Okinaka, Yoshihito Suda, Tomoyuki Matsumoto, Ryosuke Kuroda, Yoshiyuki Shinagawa, Sheraz Gul, Carsten Claussen, Ikuko Matsui, Yutaka Matsui, Akihiko Taguchi","doi":"10.18632/aging.206256","DOIUrl":"10.18632/aging.206256","url":null,"abstract":"<p><strong>Background: </strong>Physical frailty is an age-related clinical condition associated with deterioration of physiological capacity. In aged mice, increased RNA expression of metabolism-related genes in circulating white blood cells (WBC) correlates with impaired physical function.</p><p><strong>Methods: </strong>Twenty elderly volunteers were enrolled in this exploratory analysis and the possible link between RNA expression of metabolism-related genes in WBC and impairment of their physical function was investigated (jRCT1050210166. Feb. 02, 2022). In mechanism of action studies, cellular interactions between WBC and cells in muscle tissue were investigated in mice.</p><p><strong>Results: </strong>RNA expression of metabolism-related genes, such as glucose transporter 1 (Glut1), Glut3, AMP-activated protein kinase A, and prolyl hydroxylase 3, was significantly increased in aged individuals with swallowing dysfunction and masticatory disturbance compared to those without these symptoms. The level of metabolism-related RNA expression significantly decreased with walking habits compared to no walking habits. Studies in mice have revealed a direct link between circulating WBC and endothelium/satellite cells via gap junction.</p><p><strong>Conclusions: </strong>Our results indicate that the level of metabolism-related RNA expression in WBC can serve as a marker of impaired physical function in the elderly and that circulating WBC may have a previously unknown physiological role in maintaining physical function.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1206-1220"},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating telomere length in progeroid syndromes: implications for aging disorders.","authors":"Luma Srour, Abeer Qannan, Junko Oshima, Andre Megarbane, Yosra Bejaoui, Nady El Hajj","doi":"10.18632/aging.206255","DOIUrl":"10.18632/aging.206255","url":null,"abstract":"<p><p>Progeroid syndromes are rare genetic disorders that impact patients' health and lifespans and are characterized by symptoms that mimic the normal aging process. Telomere length is one of the aging hallmarks, a phenomenon linked to cellular aging. Telomere attrition was observed in different progeroid syndromes, such as Nijmegen breakage syndrome patients and Werner syndrome, indicating its contribution to the progeroid phenotype. However, whether it is a common feature in all progeroid syndromes is still unclear. Therefore, in this study, we aimed to estimate telomere length using the DNA methylation-based estimator of human telomere length in publicly available DNA methylation data from patients with Werner Syndrome, Hutchinson-Gilford Progeria Syndrome, Berardinelli-Seip Congenital Lipodystrophy type 2, and Dyskeratosis congenita, along with additional data provided by our laboratory from patients with Cerebroretinal Microangiopathy with Calcifications and Cysts and Wiedemann-Rautenstrauch Syndrome. Our findings revealed that certain progeroid syndromes, including classical Werner Syndrome, Berardinelli-Seip Congenital Lipodystrophy type 2, and Dyskeratosis congenita, have significant telomere attrition conversely to Hutchinson-Gilford Progeria Syndrome, Cerebroretinal Microangiopathy with Calcifications and Cysts, Wiedemann-Rautenstrauch Syndrome, and atypical Werner Syndrome. In conclusion, this study addresses a critical gap by providing new insights into the role of telomere attrition across different progeroid conditions. Further research is needed to elucidate the effect of telomere attrition on progeroid syndromes and its implications.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1190-1205"},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study.","authors":"Konstantin G Arbeev, Olivia Bagley, Svetlana V Ukraintseva, Alexander Kulminski, Eric Stallard, Michaela Schwaiger-Haber, Gary J Patti, Yian Gu, Anatoliy I Yashin, Michael A Province","doi":"10.18632/aging.206259","DOIUrl":"10.18632/aging.206259","url":null,"abstract":"<p><p>Studying the relationships between longitudinal changes in omics variables and event risks requires specific methodologies for joint analyses of longitudinal and time-to-event outcomes. We applied two such approaches (joint models [JM], stochastic process models [SPM]) to longitudinal metabolomics data from the Long Life Family Study, focusing on the understudied associations of longitudinal changes in lysophosphatidylcholines (LPCs) with mortality and aging-related outcomes. We analyzed 23 LPC species, with 5,066 measurements of each in 3,462 participants, 1,245 of whom died during follow-up. JM analyses found that higher levels of the majority of LPC species were associated with lower mortality risks, with the largest magnitude observed for LPC 15:0/0:0 (hazard ratio: 0.71, 95% CI (0.64, 0.79)). SPM applications to LPC 15:0/0:0 revealed that the JM association reflects underlying aging-related processes: a decline in robustness to deviations from optimal LPC levels, higher equilibrium LPC levels in females, and the opposite age-related changes in the equilibrium and optimal LPC levels (declining and increasing, respectively), which lead to increased mortality risks with age. Our results support LPCs as biomarkers of aging and related decline in biological robustness, and call for further exploration of factors underlying age-related changes in LPC in relation to mortality and diseases.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1221-1260"},"PeriodicalIF":3.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated efficacy and safety of CDK4/6 inhibitors plus endocrine therapy in elderly women with HR+/HER-2 metastatic or advanced breast cancer: patient-level network meta-analysis.","authors":"Henry Wc Leung, Mei-Ching Tsai, Shin-Hang Leung, Shyh-Yau Wang, Agnes Lf Chan","doi":"10.18632/aging.206257","DOIUrl":"10.18632/aging.206257","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) is the most common cancer in women worldwide. More than 80% of new cases of invasive BC are diagnosed among women aged 50 years or older, and they mainly comprise estrogen receptor (ER)-positive and HER2-negative subtypes of the disease. About 91% of deaths occur in this age demographic. Treatment with cyclin-dependent kinase 4/6 inhibitors has resulted in significantly increased survival benefits in terms of progression-free survival and overall survival (OS), but evidence for their use in treating older women with metastatic BC is limited. Therefore, we evaluated the efficacy and safety of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors combined with endocrine therapy in older women with HR+/HER-2 metastatic or advanced BC.</p><p><strong>Methods: </strong>We conducted a comprehensive search of the PubMed and EMBASE databases between January 2018 and December 2024 for phase II or III randomized controlled trials (RCTs) investigating treatment modalities in HR+/HER-2 metastatic or advanced BC. Kaplan-Meier curves for progression-free survival (PFS) and overall survival (OS) were reconstructed to retrieve individual patient-level data to strengthen the comparison of the benefits of all treatment modalities of interest. In this network meta-analysis (NMA), each study was pooled in a fixed-effects or randomized-effects model based on the individual study quality. We also performed a subgroup analysis and reported the incidence of ≧grade 3 adverse events in elderly patients (≧65 years). The primary endpoints were the pooled PFS, OS, and comparable safety rankings. The treatment modalities were ranked using SUCRA scores.</p><p><strong>Results: </strong>We identified 15 phase II and III randomized controlled trials with seven treatment modalities that met the inclusion criteria. From these trials, rates of PFS and OS for 1799 and 1568 patients, respectively, were included in the analysis. In terms of PFS, Palbociclib + Letrozole (Let) ranked highest among all treatment modalities, followed by Ribociclib + Fulvestrant (Ful). Meanwhile, Palbociclib plus Ful showed superior OS ranking compared to other treatments in older women with mBC. Regarding safety, Palbociclib plus Endocrine (letrozole or fulvestrant) (79.3%), Ribociclib plus Let (87%), and Abemaciclib + ET (letrozole or anastrozole) were associated with a relatively high incidence of ≧grade 3 adverse events (AEs) compared to placebo plus endocrine therapy.</p><p><strong>Conclusions: </strong>In this network meta-analysis, the combination of Palbociclib with Letrozole or Fulvestrant was found to have an effect on PFS and OS, and Ribociclib + Let was found to be a relatively safe treatment option for elderly women with HR+/HER2 metastatic or advanced BC. However, given the limited evidence in older populations, comprehensive, well-designed, large-scale randomized controlled trials are needed to address this issue.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1313-1327"},"PeriodicalIF":3.9,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the detection of frailty in older adults: a multicenter cohort machine learning-based study protocol.","authors":"Samuel Fernández-Carnero, Oliver Martínez-Pozas, Daniel Pecos-Martín, Armando Pardo-Gómez, Juan Nicolás Cuenca-Zaldívar, Eleuterio A Sánchez-Romero","doi":"10.18632/aging.206254","DOIUrl":"10.18632/aging.206254","url":null,"abstract":"<p><strong>Background: </strong>This study aims to investigate the relationship between muscle activation variables assessed via ultrasound and the comprehensive assessment of geriatric patients, as well as to analyze ultrasound images to determine their correlation with morbimortality factors in frail patients.</p><p><strong>Methods: </strong>The present cohort study will be conducted in 500 older adults diagnosed with frailty. A multicenter study will be conducted among the day care centers and nursing homes. This will be achieved through the evaluation of frail older adults via instrumental and functional tests, along with specific ultrasound images to study sarcopenia and nutrition, followed by a detailed analysis of the correlation between all collected variables.</p><p><strong>Discussion: </strong>This study aims to investigate the correlation between ultrasound-assessed muscle activation variables and the overall health of geriatric patients. It addresses the limitations of previous research by including a large sample size of 500 patients and measuring various muscle parameters beyond thickness. Additionally, it aims to analyze ultrasound images to identify markers associated with higher risk of complications in frail patients. The study involves frail older adults undergoing functional tests and specific ultrasound examinations. A comprehensive analysis of functional, ultrasound, and nutritional variables will be conducted to understand their correlation with overall health and risk of complications in frail older patients.</p><p><strong>Trial registration: </strong>The study was approved by the Research Ethics Committee of the Hospital Universitario Puerta de Hierro, Madrid, Spain (Act nº 18/2023). In addition, the study was registered with https://clinicaltrials.gov/ (NCT06218121).</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1328-1339"},"PeriodicalIF":3.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term moderate caloric restriction in the rhesus macaque attenuates markers of ovarian aging in select populations.","authors":"Emma S Gargus, Rhea Sharma, Rebecca Gu, Camille Mulcahy, Brian W Johnson, Jing Song, Jungwha Lee, Mary Zelinski, Francesca E Duncan","doi":"10.18632/aging.206253","DOIUrl":"10.18632/aging.206253","url":null,"abstract":"<p><p>Ovarian aging results in decreased fertility and endocrine function. In mice, caloric restriction (CR) maintains ovarian function. In this study, we determined whether CR also has a beneficial effect on reproductive longevity in the nonhuman primate (NHP). Ovaries were collected from young (10-13 years) and old (19-26 years) rhesus macaques who were either on a diet of moderate caloric restriction or a control diet for three years. To test the effect of CR on follicle number, follicles were analyzed in histological sections from animals across experimental cohorts: Young Control, Young CR, Old Control, Old CR (<i>n</i> = 4-8/group). In control animals, there was an age-dependent decrease in follicle numbers across all follicle stages (<i>P</i> < 0.05). Although there was no effect of diet on total follicle number, the follicle distribution in the Old CR cohort more closely resembled that of young animals. The subset of Old CR animals that were still cycling, albeit irregularly, had more primordial follicles than controls (<i>P</i> < 0.05). Assessment of collagen and hyaluronic acid matrices revealed that CR attenuated age-related changes to the ovarian microenvironment. Overall, CR may improve aspects of reproductive longevity in the NHP, but the timing of when it occurs during the reproductive lifespan is likely critical.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1164-1189"},"PeriodicalIF":3.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aspartate superpathway in gut microbiota-related metabolic pathways mediates immune cell protection against COPD and IPF: a Mendelian randomization analysis.","authors":"Lei Chen, Haoyan Chen, Qin Li, Jun Ma, Yanzhi Feng, Shenghua Zhang, Yu Han, Jie Pan, Mingjiong Zhang, Kai Sun, Shuangshuang Wu","doi":"10.18632/aging.206250","DOIUrl":"10.18632/aging.206250","url":null,"abstract":"<p><strong>Background: </strong>Both genetic and environmental factors can influence idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) development. The gut microbiota plays crucial roles in maintaining tissue homeostasis. Dysregulation of the gut microbiota can result in disease. However, whether the alteration of the gut microbiota influences IPF and COPD remains unknown.</p><p><strong>Research question: </strong>What is the causal relationship between IPF, COPD and the gut microbiota-related metabolic pathways? What are the potential intermediate mediators in this relationship?</p><p><strong>Study design and methods: </strong>Intersect the gut microbiota and its metabolic pathways associated with IPF and COPD. Utilizing summary data from GWAS in public databases, a two-sample Mendelian randomization (MR) analysis was conducted on the gut microbiota-related metabolic pathway, the aspartate superpathway, in relation to IPF and COPD. Furthermore, we employed a two-step MR to quantify the proportion of influence mediated by monocytes and cDCs on the aspartate superpathway in relation to IPF and COPD.</p><p><strong>Results: </strong>The MR analysis found that the aspartate superpathway decreased the risk of developing IPF and COPD. Monocytes and cDCs acted as intermediary substances, participating in this with influence proportions of 7.88% and 6.27%, respectively.</p><p><strong>Interpretation: </strong>There is a causal link between the gut microbiota-related metabolic pathway, the aspartate superpathway, and IPF and COPD, where the influence is partially mediated by monocytes and cDCs. In clinical practice, we increase the focus on gut microbiota-mediated immune cells in relation to IPF and COPD.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"1298-1312"},"PeriodicalIF":3.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}