Aging-Us最新文献_第2页

Sildenafil and risk of Alzheimer disease: a systematic review and meta-analysis.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-17 DOI: 10.18632/aging.206222

Wei Yu Chua, Lincoln Kai En Lim, James Jia Dong Wang, Aaron Shengting Mai, Ling-Ling Chan, Eng-King Tan

{"title":"Sildenafil and risk of Alzheimer disease: a systematic review and meta-analysis.","authors":"Wei Yu Chua, Lincoln Kai En Lim, James Jia Dong Wang, Aaron Shengting Mai, Ling-Ling Chan, Eng-King Tan","doi":"10.18632/aging.206222","DOIUrl":"https://doi.org/10.18632/aging.206222","url":null,"abstract":"Background: Alzheimer Disease (AD) affects more than 50 million people worldwide, with 10 million new diagnosis each year. The link between Sildenafil, a Phosphodiesterase-5 (PDE5) inhibitor, and risk of AD has been debated. We conducted the first meta-analysis on the association between Sildenafil use and risk of AD.Methods: We searched MEDLINE and Embase from inception to March 11, 2024 to identify cohort, case-control studies comparing the frequency of AD in patients taking Sildenafil with those without. We computed risk ratios (RR) and hazard ratios (HR) with accompanying 95% Confidence Intervals (CIs) for each study, and pooled the results using a random-effects meta-analysis.Results: Out of 415 studies that were screened initially, 5 studies comprising 885,380 patients were included for analysis. Sildenafil use was associated with a reduced risk of developing AD by two-fold compared to non-use (HR: 0.47, 95% CI: 0.27-0.82, p<0.001). There was a similar association in risk reduction of AD in patients on PDE5 inhibitors compared to non-use (RR: 0.55, 95% CI: 0.38-0.80, p=0.002).Conclusions: Our meta-analysis showed that the use of Sildenafil is associated with a reduced risk of developing AD by two-fold. Further randomized control trials to ascertain the effect of Sildenafil on AD pathology would be useful.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-14 DOI: 10.18632/aging.206221

Natalia Carreras-Gallo, Rita Dargham, Shealee P Thorpe, Steve Warren, Tavis L Mendez, Ryan Smith, Greg Macpherson, Varun B Dwaraka

{"title":"Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial.","authors":"Natalia Carreras-Gallo, Rita Dargham, Shealee P Thorpe, Steve Warren, Tavis L Mendez, Ryan Smith, Greg Macpherson, Varun B Dwaraka","doi":"10.18632/aging.206221","DOIUrl":"https://doi.org/10.18632/aging.206221","url":null,"abstract":"Aging interventions have progressed in recent years due to the growing curiosity about how lifestyle impacts longevity. This study assessed the effects of SRW Laboratories' Cel System nutraceutical range on epigenetic methylation patterns, inflammation, physical performance, body composition, and epigenetic biomarkers of aging. A 1-year study was conducted with 51 individuals, collecting data at baseline, 3 months, 6 months, and 12 months. Participants were encouraged to walk 10 minutes and practice 5 minutes of mindfulness daily. Significant improvements in muscle strength, body function, and body composition metrics were observed. Epigenetic clock analysis showed a decrease in biological age with significant reductions in stem cell division rates. Immune cell subset analysis indicated significant changes, with increases in eosinophils and CD8T cells and decreases in B memory, CD4T memory, and T-regulatory cells. Predicted epigenetic biomarker proxies (EBPs) showed significant changes in retinol/TTHY, a regulator of cell growth, proliferation, and differentiation, and deoxycholic acid glucuronide levels, a metabolite of deoxycholic acid generated in the liver. Gene ontology analysis revealed significant CpG methylation changes in genes involved in critical biological processes related to aging, such as oxidative stress-induced premature senescence, pyrimidine deoxyribonucleotide metabolic process, TRAIL binding, hyaluronan biosynthetic process, neurotransmitter loading into synaptic vesicles, pore complex assembly, collagen biosynthetic process, protein phosphatase 2A binding activity, and activation of transcription factor binding. Our findings suggest that the Cel System supplement range may effectively reduce biological age and improve health metrics, warranting further investigation into its mechanistic pathways and long-term efficacy.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA methylation entropy is a biomarker for aging.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-12 DOI: 10.18632/aging.206220

Jonathan Chan, Liudmilla Rubbi, Matteo Pellegrini

引用次数: 0

Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-07 DOI: 10.18632/aging.206218

Cong Wang, Jill B De Vis, Kirsten Nguyen, Brigitte Jia, Mason Alford, Marjan Rafat, Bapsi Chakravarthy, Xiao-Ou Shu

{"title":"Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors.","authors":"Cong Wang, Jill B De Vis, Kirsten Nguyen, Brigitte Jia, Mason Alford, Marjan Rafat, Bapsi Chakravarthy, Xiao-Ou Shu","doi":"10.18632/aging.206218","DOIUrl":"https://doi.org/10.18632/aging.206218","url":null,"abstract":"Breast cancer (BC) survivors may experience accelerated aging due to detrimental effects of BC and/or its treatments. Our study aims to evaluate Phenotypic Age Acceleration (PAA), a biological age measure, among BC patients and assess its associations with cancer characteristics and treatments. In this study including 1264 BC patients (age 54.7±11.7) and 429 cancer-free controls (age 49.9±12.4), we evaluated the differences in PAA (ΔPAA) by BC characteristics and treatments at multiple time points using linear mixed models. Overall, BC survivors had a higher PAA than controls at diagnosis (ΔPAA=3.73, p<0.001), 1-year (ΔPAA=1.68, p=0.001), and 10-year (ΔPAA=1.16, p=0.03) post-diagnosis. At 10-year post-diagnosis, stage III/IV (vs 0), intermediate- and high- (vs low-) grade BC were associated with a higher PAA of 4.48 (p<0.001), 1.26 (p=0.03), and 1.95 (p=0.001), respectively; triple-negative (vs hormone receptor+/HER2-) BC was associated with a lower PAA (ΔPAA=-1.96, p=0.004). Compared with patients receiving surgery with or without radiotherapy, higher PAA was observed at 1-year post-diagnosis among those receiving additional chemotherapy (ΔPAA=4.26, p<0.001) and at 10-year post-diagnosis for endocrine therapy (ΔPAA=2.89, p=0.001). In conclusion, BC patients had accelerated aging up to 10 years post-diagnosis, especially among those with stage III/IV and high/intermediate-grade BC, and receiving systemic treatment.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 3","pages":"643-656"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic potential of neutrophil-to-lymphocyte ratio for appendicular skeletal muscle mass reduction in males aged 70 and older.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-06 DOI: 10.18632/aging.206217

Ying-Jen Chen, Chieh-Li Yen, Chern-Horng Lee, Kuo-Chen Liao, Ji-Tseng Fang, Tz-Shiu Tsai, Yi-Ching Chen, Chun-Yen Lin

{"title":"Prognostic potential of neutrophil-to-lymphocyte ratio for appendicular skeletal muscle mass reduction in males aged 70 and older.","authors":"Ying-Jen Chen, Chieh-Li Yen, Chern-Horng Lee, Kuo-Chen Liao, Ji-Tseng Fang, Tz-Shiu Tsai, Yi-Ching Chen, Chun-Yen Lin","doi":"10.18632/aging.206217","DOIUrl":"https://doi.org/10.18632/aging.206217","url":null,"abstract":"Inflammation plays a pivotal role in the age-related decline of skeletal muscle mass, leading to sarcopenia in the elderly. The prevalence of sarcopenia notably increases among males aged ≥ 70. However, it remains unclear whether inflammatory indexes are associated with the reduction in skeletal muscle mass in the elderly population. Thirty-one males aged ≥ 70, without severe diseases or dementia, were enrolled in the study. They underwent muscle mass measurements, physical measurements, and hematological tests at the onset of the study and after a one-year follow-up. Twenty-eight participants were successfully followed for one year. Appendicular skeletal muscle mass index (ASMI) decreased by 3.30 ± 2.41% in 14 participants and increased by 2.66 ± 1.61% in the other 14 participants compared to baseline levels. The baseline neutrophil-to-lymphocyte ratio (NLR) was 2.14 ± 0.56 in the ASMI-decreased group and 1.66 ± 0.62 in the ASMI-increased group. A statistically significant negative correlation was found between baseline NLR and the change in ASMI in linear regression analyses. The area under the curve (AUC) of the baseline NLR for predicting ASMI decline was 0.724, with an optimal sensitivity of 64.3% and specificity of 78.6% at a cut-off value of 1.94. NLR emerged as a potential prognostic marker for ASMI reduction in elderly males. However, further studies are necessary to assess its clinical utility.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive aging, preimplantation genetic testing for aneuploidy, and the diameter of blastocysts: does size matter?

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-05 DOI: 10.18632/aging.206215

Jakub Wyroba, Joanna Kochan, Maria Barszcz, Grzegorz Mirocki, Pawel Kordowitzki

{"title":"Reproductive aging, preimplantation genetic testing for aneuploidy, and the diameter of blastocysts: does size matter?","authors":"Jakub Wyroba, Joanna Kochan, Maria Barszcz, Grzegorz Mirocki, Pawel Kordowitzki","doi":"10.18632/aging.206215","DOIUrl":"https://doi.org/10.18632/aging.206215","url":null,"abstract":"There is no doubt that maternal aging, also known as reproductive aging, can contribute to the increased rates of aneuploidy observed in blastocysts generated from women of advanced age who undergo in vitro fertilization (IVF). Additionally, the hatching process of the blastocyst, which is crucial for successful implantation, may be impaired in aneuploid embryos. Aneuploid embryos often exhibit abnormal cell division and chromosomal distribution, which can lead to disruptions in the hatching process. Due to ethical restrictions, preimplantation genetic testing for aneuploidy (PGT-A) is unavailable in all countries. Therefore, our retrospective study of 502 couples who underwent intracytoplasmic sperm injection (ICSI) aimed to elucidate if embryonic features, such as the ability to hatch and embryonic diameter, could be a reliable estimator for the success rate after embryo transfer, especially for women aged 26-45 years, and for IVF clinics which do not have access to PGT-A. The small hatching blastocysts (Bl. 5) group had a significant (p < 0.001) higher percentage of euploid embryos (≤35 Y- 73%, >35Y- 51%) compared to large (Bl. 4) counterparts (≤35 Y-58%, >35 Y- 38%). In patients aged 34-38 years, we detected 10% more euploid blastocysts in the hatching group than the expanding ones, which was a significant difference (p < 0.05). In conclusion, when selecting non-PGT-A tested embryos for embryo transfer (ET) or frozen embryo transfer (FET), a small hatching blastocyst seems to be a better choice than a large expanded one, especially for advanced-age patients for whom the risk of aneuploidy is higher.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-04 DOI: 10.18632/aging.206219

Sushil K Dubey, Rashmi Dubey, Kyungsik Jung, Alvaro G Hernandez, Mark E Kleinman

{"title":"Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium.","authors":"Sushil K Dubey, Rashmi Dubey, Kyungsik Jung, Alvaro G Hernandez, Mark E Kleinman","doi":"10.18632/aging.206219","DOIUrl":"https://doi.org/10.18632/aging.206219","url":null,"abstract":"Aging of the retinal pigment epithelium (RPE) leads to a gradual decline in RPE homeostasis over time, significantly impacting retinal health. Understanding the mechanisms underlying RPE aging is crucial for elucidating the background in which many age-related retinal pathologies develop. In this study, we compared the transcriptomes of young and aged mouse RPE and observed a marked upregulation of immunogenic, proinflammatory, and oxidative stress genes in aging RPE. Additionally, aging RPE exhibited dysregulation of pathways associated with visual perception and extracellular matrix production. Research on aging in post-natal quiescent RPE is hindered by the absence of relevant in vitro models. Here, we evaluated an in vitro model of chronologically aged primary human RPE to address this gap and observed gene expression patterns comparable to native-aged RPE. Gene expression profiling in this model highlighted its potential utility in investigating cellular and molecular mechanisms of RPE aging and in screening of therapeutic compounds. In conclusion, our findings underscore the pivotal role of inflammation, immune activation, and oxidative stress in the aging RPE landscape and provide insights into why age increases the risk of retinal pathologies.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent falls as the presentations of Gitelman syndrome in an octogenarian.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-03-04 DOI: 10.18632/aging.206216

Chien-Yao Sun, Shang-Han Wu, Chia-Ter Chao, Shih-Hua Lin

{"title":"Recurrent falls as the presentations of Gitelman syndrome in an octogenarian.","authors":"Chien-Yao Sun, Shang-Han Wu, Chia-Ter Chao, Shih-Hua Lin","doi":"10.18632/aging.206216","DOIUrl":"https://doi.org/10.18632/aging.206216","url":null,"abstract":"Gitelman syndrome (GS) is the most common hereditary renal tubular disorder, with a higher carrier frequency among Asians often overlooked in older adults. Electrolyte imbalances, such as those seen in GS, are crucial considerations for older adults experiencing recurrent falls. We described an 83-year-old diabetic female on metformin, who was admitted due to recurrent falls with the preceding dizziness and palpitations when standing. She had the history of chronic hypokalemia and hypomagnesemia on regular potassium (K+) and magnesium (Mg++) supplementation for 10 years and gout-like arthritis episodes over her shoulder and ankle joints. Her consciousness was alert with normal blood pressure but reduced tendon reflex over bilateral knees. Pertinent laboratory findings included hypokalemic (K+ 2.2 mmol/L) with metabolic alkalosis and high urine K+ excretion, hypomagnesemia (1.1 mg/dl) with hypermagnesuria, but hypocalciuria (UCa/Cr ratio 0.01 mg/mg), high urine salt excretion, and hyperreninemia. X-ray of bilateral knees and shoulders demonstrated typical chondrocalcinosis with dense calcification band in the joint space. Targeted Sanger sequencing confirmed GS, identifying a biallelic homozygous deletion mutation (2881-2 delAG) in the exon 24 of SLC12A3 gene as the potential causes of recurrent falls. After aggressive electrolytes correction, her potassium and magnesium levels stabilized, and the patient did not experience further falls. This case, probably the oldest documented patient with GS emphasizes the importance of recognizing atypical presentations of GS in older adults. Careful evaluation and management of electrolyte disturbances in this population may prevent fall recurrence and complications.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction for: Machine learning-based B cell-related diagnostic biomarker signature and molecular subtypes characteristic of ulcerative colitis.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-28 DOI: 10.18632/aging.206209

Guo-Liang Wu, Li Li, Xiao-Yao Chen, Wei-Feng Zhang, Jun-Bo Wu, Xiaoning Yu, Hong-Jin Chen

引用次数: 0

Retraction of: KCNQ1OT1 promotes melanoma growth and metastasis.

IF 3.9 3区医学

Aging-Us Pub Date : 2025-02-28 DOI: 10.18632/aging.206214

Bingyu Guo, Qian Zhang, Hongyi Wang, Peng Chang, Kai Tao

引用次数: 0