Aging-Us最新文献_第2页

Fibroblast growth factor 21 inversely correlates with survival in elderly population - the results of the Polsenior2 study. 成纤维细胞生长因子 21 与老年人的存活率成反比--Polsenior2 研究的结果。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-18 DOI: 10.18632/aging.206114

Gabriela Handzlik, Aleksander J Owczarek, Andrzej Więcek, Małgorzata Mossakowska, Tomasz Zdrojewski, Anna Chudek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek

{"title":"Fibroblast growth factor 21 inversely correlates with survival in elderly population - the results of the Polsenior2 study.","authors":"Gabriela Handzlik, Aleksander J Owczarek, Andrzej Więcek, Małgorzata Mossakowska, Tomasz Zdrojewski, Anna Chudek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek","doi":"10.18632/aging.206114","DOIUrl":"https://doi.org/10.18632/aging.206114","url":null,"abstract":"Fibroblast growth factor 21 (FGF21) is a liver-secreted hormone involved in the regulation of lipid, glucose, and energy metabolism. Its serum concentration increases with age but also is higher in numerous diseases. FGF21 is being investigated for biomarker properties and as a potential therapeutic target. The present study aimed to assess the prognostic value of FGF21 in an older population-based cohort, the PolSenior2 study participants. In the sub-analysis of 3512 individuals, aged 60 and older, stratified according to FGF21 into tertiles, the survival estimate was worse in participants with middle and high levels compared to the lowest tertile. These results were consistent with univariable Cox regression analysis, in which participants in the middle and the high FGF21 tertiles after adjustment for age had 1.43-fold (HR, 1.31; 95% CI, 1.05 - 1.62) and 2.56-fold (HR, 1.94; 95% CI, 1.59 - 2.37) higher risk for mortality, respectively, compared with those in the lowest tertile. In multivariable Cox regression analysis, the highest levels of FGF21 were associated with increased mortality (HR 1.53; 95% CI, 1.22 - 1.92) independently of co-morbidities and blood parameters. These results indicate that higher serum FGF21 concentration is an independent predictor of all-cause mortality in the general population of older adults.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single housing of juveniles accelerates early-stage growth but extends adult lifespan in African turquoise killifish. 单独饲养幼鱼会加速非洲绿松石鳉早期阶段的生长，但会延长成鱼的寿命。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-16 DOI: 10.18632/aging.206111

Chika Takahashi, Emiko Okabe, Masanori Nono, Saya Kishimoto, Hideaki Matsui, Tohru Ishitani, Takuya Yamamoto, Masaharu Uno, Eisuke Nishida

{"title":"Single housing of juveniles accelerates early-stage growth but extends adult lifespan in African turquoise killifish.","authors":"Chika Takahashi, Emiko Okabe, Masanori Nono, Saya Kishimoto, Hideaki Matsui, Tohru Ishitani, Takuya Yamamoto, Masaharu Uno, Eisuke Nishida","doi":"10.18632/aging.206111","DOIUrl":"https://doi.org/10.18632/aging.206111","url":null,"abstract":"Within the same species, individuals exhibiting faster growth tend to have shorter lifespans, even if their fast growth arises from early-life pharmacological interventions. However, in vertebrates, the impact of the early-life environment on the growth rate and lifespan has not been fully elucidated. In this study, by utilizing the short-lived African turquoise killifish, which is suitable for a comprehensive life-stage analysis in a brief timeframe, we explored the effects of housing density during the juvenile stage on holistic life traits. As a result, we found that lower housing densities resulted in faster growth, but led to longer adult lifespan, which was contrary to the common notion. Furthermore, the single-housed adult fish displayed a longer egg-laying period than did their group-housed counterparts. Our transcriptome analysis also demonstrated that, in terms of internal transcriptional programs, the life stage progression and aging process of single-housed fish were slower than those of group-housed fish. Collectively, our results suggest that sharing housing with others in early life might influence whole-life attributes, potentially leading to specific life history traits beyond the typical relationship between the growth rate and lifespan.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the role of leukocyte telomere length-related lncRNA NBR2 in Alzheimer's disease. 白细胞端粒长度相关 lncRNA NBR2 在阿尔茨海默病中的作用研究

IF 5.2 3区医学

Aging-Us Pub Date : 2024-09-16 DOI: 10.18632/aging.206107

Wenjie Li,Haoyan Chen,Xiaofan Yuan,Qi Yao,Mingjiong Zhang

引用次数: 0

Retraction of: Lithium treatment extends human lifespan: findings from the UK Biobank. 撤稿：锂治疗可延长人类寿命：英国生物库的研究结果。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-15 DOI: 10.18632/aging.206118

Elisa Araldi, Catherine R Jutzeler, Michael Ristow

引用次数: 0

Correction for: PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis. 更正为PKMYT1会加剧透明细胞肾细胞癌的进展，被认为是诊断和预后的生物标志物。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-15 DOI: 10.18632/aging.206113

Juan Chen, Xiaoliang Hua, Heying Chen, Xiangmin Qiu, Haibing Xiao, Shengdong Ge, Chaozhao Liang, Qin Zhou

引用次数: 0

Retraction of: The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma. 撤回：DDR1 和 STAT3 之间的交叉对话促进了肝细胞癌的发展。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-15 DOI: 10.18632/aging.205988

Ye Lin, Haosheng Jin, Xianqiu Wu, Zhixiang Jian, Xiongfeng Zou, Jianfeng Huang, Renguo Guan, Xiangling Wei

引用次数: 0

Intraovarian PRP injection improves oocyte quality and early embryo development in mouse models of chemotherapy-induced diminished ovarian reserve. 在化疗导致卵巢储备功能减退的小鼠模型中，卵巢内注射 PRP 可改善卵母细胞质量和早期胚胎发育。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-13 DOI: 10.18632/aging.206099

Mauro Cozzolino, Yagmur Ergun, Denis A Seli, Sonia Herraiz

{"title":"Intraovarian PRP injection improves oocyte quality and early embryo development in mouse models of chemotherapy-induced diminished ovarian reserve.","authors":"Mauro Cozzolino, Yagmur Ergun, Denis A Seli, Sonia Herraiz","doi":"10.18632/aging.206099","DOIUrl":"10.18632/aging.206099","url":null,"abstract":"Intraovarian injection of platelet-rich plasma (PRP) has been recently proposed, with encouraging results to provide an alternative option to patients diagnosed with POR or POI. However, the broad spectrum of PRP effects on the reproductive function and the mechanisms of action in follicular activation, response to stimulation, and embryo quality have not yet been studied. In this study, we first induced poor ovarian reserve (POR) and premature ovarian insufficiency (POI) ovarian phenotypes in CD1 mice undergoing PRP or sham intraovarian injection. PRP administration reduced those alterations induced by chemotherapy in ovarian stroma and follicle morphology in both the POR and POI conditions. After ovarian stimulation, we found that PRP did not modify the MII-oocyte yield. Nevertheless, the amount of obtained 2-cell embryos and fertilization rate were increased, being especially relevant for the POI model. Further in vitro embryo culture led to improved blastocyst formation rates and higher numbers of good quality blastocysts in PRP vs. sham females in both the POR and POI conditions. These positive results of PRP injection were also validated in the C57Bl/6 stain. Altogether, our findings suggest a possible effect on oocyte and embryo quality. This effect is likely due to the increase of local paracrine signaling through the released growth factors in PRP-treated ovaries.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation of EFCAB7 after radiofrequency ablation promoting hepatocellular carcinoma metastasis and survival by regulating PARK7. 射频消融术后 EFCAB7 的上调通过调节 PARK7 促进肝细胞癌转移和存活。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-09-12 DOI: 10.18632/aging.206073

Dan Cui, Hongye Wang, Zhi Wang, Zhaorong Wu, Min Ding, Linke Bian, Jiachang Chi, Bo Zhai

{"title":"Upregulation of EFCAB7 after radiofrequency ablation promoting hepatocellular carcinoma metastasis and survival by regulating PARK7.","authors":"Dan Cui, Hongye Wang, Zhi Wang, Zhaorong Wu, Min Ding, Linke Bian, Jiachang Chi, Bo Zhai","doi":"10.18632/aging.206073","DOIUrl":"10.18632/aging.206073","url":null,"abstract":"Background: Radiofrequency ablation (RFA) is an established treatment for unresectable and early-stage hepatocellular carcinoma (HCC). However, in some cases, residual tumor cells undergo malignant transformation following RFA. The molecular mechanisms underlying this phenomenon remain poorly understood. EFCAB7, a member of the EF-hand structure family, is of particular interest due to its association with oncogenesis. Nevertheless, the role of EFCAB7 in oncogenesis remains unclear.Methods: Gene expression level of EFCAB7 in HCC tissues before and after RFA was measured, while in vitro and in vivo experiments were proposed for exploring the roles of EFCAB7 in tumor cell proliferation and metastasis. Mass spectrometry and CO-IP were adopted to validate the interaction between PARK7 and EFCAB7. Finally, PARK7 in EFCAB7 silencing cells was overexpressed and different functions were measured in vitro to determine regulation between two genes.Results: EFCAB7 showed increased expression after RFA in patient samples and EFCAB7 expression correlated with poor prognosis in HCC patients from the TCGA database. Then, EFCAB7 promoted HCC tumor cell proliferation and metastasis while inhibiting apoptosis. Furthermore, Mass spectrometry and Co-IP experiments revealed a direct interaction between EFCAB7 and PARK7. Finally, when we overexpressed PARK7 in EFCAB7 knockdown tumor cells, it rescued proliferation and metastasis, indicating a functional relationship between these two genes.Conclusions: EFCAB7 might be a core contributor to HCC cells' malignant transformation after RFA and could be a potential novel target to provide a therapeutic strategy for the prevention of recurrence after RFA in HCC.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.2 3区医学

Aging-Us Pub Date : 2024-09-10 DOI: 10.18632/aging.205954

Weiwei Yang,Shengli Xu,Ming Zhou,Piu Chan

{"title":"Aging-related biomarkers for the diagnosis of Parkinson's disease based on bioinformatics analysis and machine learning.","authors":"Weiwei Yang,Shengli Xu,Ming Zhou,Piu Chan","doi":"10.18632/aging.205954","DOIUrl":"https://doi.org/10.18632/aging.205954","url":null,"abstract":"Parkinson's disease (PD) is a multifactorial disease that lacks reliable biomarkers for its diagnosis. It is now clear that aging is the greatest risk factor for developing PD. Therefore, it is necessary to identify novel biomarkers associated with aging in PD. In this study, we downloaded aging-related genes from the Human Ageing Gene Database. To screen and verify biomarkers for PD, we used whole-blood RNA-Seq data from 11 PD patients and 13 healthy control (HC) subjects as a training dataset and three datasets retrieved from the Gene Expression Omnibus (GEO) database as validation datasets. Using the limma package in R, 1435 differentially expressed genes (DEGs) were found in the training dataset. Of these genes, 29 genes were found to occur in both DEGs and 307 aging-related genes. By using machine learning algorithms (LASSO, RF, SVM, and RR), Venn diagrams, and LASSO regression, four of these genes were determined to be potential PD biomarkers; these were further validated in external validation datasets and by qRT-PCR in the peripheral blood mononuclear cells (PBMCs) of 10 PD patients and 10 HC subjects. Based on the biomarkers, a diagnostic model was developed that had reliable predictive ability for PD. Two of the identified biomarkers demonstrated a meaningful correlation with immune cell infiltration status in the PD patients and HC subjects. In conclusion, four aging-related genes were identified as robust diagnostic biomarkers and may serve as potential targets for PD therapeutics.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CIB2 mediates acquired gefitinib resistance by inducing ZEB1 expression and epithelial-mesenchymal transition. CIB2通过诱导ZEB1的表达和上皮-间质转化介导获得性吉非替尼耐药性。

IF 5.2 3区医学

Aging-Us Pub Date : 2024-09-10 DOI: 10.18632/aging.206086

Feng-Mei Zhou,Kun-Kun Wang,Li-Hong Wang,Jian-Ge Qiu,Wei Wang,Wen-Jing Liu,Lin Wang,Bing-Hua Jiang

{"title":"CIB2 mediates acquired gefitinib resistance by inducing ZEB1 expression and epithelial-mesenchymal transition.","authors":"Feng-Mei Zhou,Kun-Kun Wang,Li-Hong Wang,Jian-Ge Qiu,Wei Wang,Wen-Jing Liu,Lin Wang,Bing-Hua Jiang","doi":"10.18632/aging.206086","DOIUrl":"https://doi.org/10.18632/aging.206086","url":null,"abstract":"EGFR-TKIs have been used as frontline treatment in patients with advanced non-small cell lung cancer (NSCLC) suffering from the EGFR mutation. Gefitinib, the first-generation EGFR-TKI, has greatly improved survival rates in lung cancer patients, whereas acquired gefitinib resistance is still a critical issue that needs to be overcome. In our research, high expression levels of CIB2 were found in gefitinib-resistant lung cancer cells. CIB2 knockout rendered gefitinib-resistant cells more sensitive to gefitinib, and overexpression of CIB2 in parental cells was sufficient to induce more resistance to gefitinib. Inhibition of CIB2 in gefitinib-resistant lung cancer cells significantly induced cell apoptosis. To clarify the major molecular mechanism by which CIB2 increases gefitinib resistance, we demonstrated that raised CIB2 in lung cancer cells promoted epithelial-to-mesenchymal transition (EMT) through upregulation of ZEB1. Moreover, FOSL1 transcriptionally regulated CIB2 expression. Finally, CIB2 rendered tumors resistant to gefitinib treatment in vivo. Our results explored a new mechanism: upregulated CIB2 promoted EMT through ZEB1 to regulate gefitinib resistance, which could be a candidate therapeutic target for overcoming acquired resistance to EGFR-TKIs in NSCLC patients.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0