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Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice 高血糖诱导的心肌纤维化可能与糖尿病小鼠心肌细胞的焦亡和凋亡有关
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.024944
Yao Lu, Qiuyue Wang, Caihui Zhang
{"title":"Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice","authors":"Yao Lu, Qiuyue Wang, Caihui Zhang","doi":"10.32604/biocell.2023.024944","DOIUrl":"https://doi.org/10.32604/biocell.2023.024944","url":null,"abstract":"Myocardial fibrosis is an important manifestation of diabetic cardiomyopathy. This study investigated the potential mechanism of diabetic myocardial fibrosis. Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. At 20 weeks, the mouse heart was harvested and subjected to hematoxylin-eosin staining (HE) and Masson staining to investigate the degree of fibrosis. The expressions of transforming growth factor-beta 1 (TGF-β1), collagen-III, B-cell lymphoma-2 (Bcl2), Bcl2-associated X protein (Bax), cleaved gasdermin D (GSDMD), cysteinyl aspartate specific proteinase-1 (caspase-1), apoptosis-associated speck-like protein containing a CARD (ASC), and nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3) were measured by western blotting. Immunohistochemistry and TdT-mediated dUTP nick end labeling (TUNEL) staining were performed to analyze the development of apoptosis and pyroptosis. A significant increase in body weight and blood glucose in the DB group was observed. Myocardial pathological injury, fibrosis, apoptosis, and pyroptosis were more obvious and serious in the DB group. The expression of anti-apoptotic Bcl2 significantly decreased, while the expression levels of pro-apoptotic Bax, caspase-3, and pyroptosis-related proteins, such as cleaved GSDMD, and caspase-1 in the DB group were significantly increased. Pyroptosis and apoptosis were probably the main mechanisms that caused myocardial fibrosis in mice with diabetes.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90242144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of FZR1 in tumorigenesis: Focus on cell-cycle control FZR1在肿瘤发生中的作用:关注细胞周期控制
4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029373
HUI LI, CHENGFANG ZHOU, MEI KUANG, YUN LIU, JIEPING CHEN
{"title":"The role of FZR1 in tumorigenesis: Focus on cell-cycle control","authors":"HUI LI, CHENGFANG ZHOU, MEI KUANG, YUN LIU, JIEPING CHEN","doi":"10.32604/biocell.2023.029373","DOIUrl":"https://doi.org/10.32604/biocell.2023.029373","url":null,"abstract":"Fizzy-related protein homolog 1 (FZR1) mainly functions as a specific activator of the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and controls the G0 and G1 phases of the cell cycle. We highlight recent work that has studied the role of FZR1 in tumorigenesis, growth, differentiation, and genome stability through cell-cycle control. We summarize the current state of knowledge regarding FZR1 structure, function, and the distinct ways of APC/C dysregulation in solid tumors and hematologic malignancies. We also discuss novel approaches for targeting the FZR1 as a cancer therapy and research area for future work.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The whole-genome survey of Acer griseum, its polymorphic simple sequence repeats development and application 灰槭全基因组调查及其多态简单序列重复序列的开发与应用
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030191
Xiao-jun Zhou, Yu Tian, Rui Li
{"title":"The whole-genome survey of Acer griseum, its polymorphic simple sequence repeats development and application","authors":"Xiao-jun Zhou, Yu Tian, Rui Li","doi":"10.32604/biocell.2023.030191","DOIUrl":"https://doi.org/10.32604/biocell.2023.030191","url":null,"abstract":"Background: Acer griseum Pax is an endangered species endemic to China with both ornamental and economic value. However, the lack of information on its genome size and characteristics hinders further work at the genome level. Methods: This paper applied bioinformatics methods to predict the characteristics and patterns of the A. griseum genome, providing an important basis for formulating its whole-genome sequencing scheme. This study also characterized the simple sequence repeats (SSRs) of A. griseum, laying the foundation for the development and application of genome-wide SSR markers. In this study, PE150 sequencing was performed by the BGI MGISEQ platform, and the sequence files were analyzed by the K-mer method to estimate the characteristic information by GCE software. Results: The genome size was finally determined to be 739.63 Mb, its heterozygosity ratio was 1.33%, and the repetition ratio was 65.68%. A total of 825,960 SSR loci were identified in the assembled genome sequence, and primers were successfully designed for 526,020 loci. To verify the effectiveness of these primers, 100 pairs of primers were randomly selected and synthesized, and 81 pairs successfully amplified the target fragments. Fourteen pairs of primers with good polymorphism were selected for principal component analysis of 31 A. griseum individuals from two populations, showing favorable heterozygosity and PIC values. According to the findings, these SSRs might identify genetic variations based on geographic areas. Conclusion: It is suggested that Illumina + PacBio assembly strategy should be used for whole-genome sequencing due to the high heterozygosity rate and high repetition rate of the genome. In addition, the SSR primers designed in batches in this study laid a foundation for the in-depth study of population structure and population maintenance mechanism of A. griseum, which is helpful for the effective conservation and sustainable utilization of this germplasm resource.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"92 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84522032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of hormone-mediated PI3K/AKT signaling on spermatogenesis in Sertoli cells 激素介导的PI3K/AKT信号在支持细胞精子发生中的作用
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030379
Yanshuang Zhao, Wanxiu Yang
{"title":"The effects of hormone-mediated PI3K/AKT signaling on spermatogenesis in Sertoli cells","authors":"Yanshuang Zhao, Wanxiu Yang","doi":"10.32604/biocell.2023.030379","DOIUrl":"https://doi.org/10.32604/biocell.2023.030379","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"50 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91120609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of tendon cell fate in the embryonic limb: A molecular perspective 胚胎肢体肌腱细胞命运的控制:分子视角
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.024625
Jessica CRISTINA MAR蚇-LLERA, Carlos AMAURY JIM蒒EZ-C罵DENAS, JES赟 CHIMAL-MONROY
{"title":"Control of tendon cell fate in the embryonic limb: A molecular perspective","authors":"Jessica CRISTINA MAR蚇-LLERA, Carlos AMAURY JIM蒒EZ-C罵DENAS, JES赟 CHIMAL-MONROY","doi":"10.32604/biocell.2023.024625","DOIUrl":"https://doi.org/10.32604/biocell.2023.024625","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"29 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81637422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Junctional adhesion molecule-A (JAM-A) in gynecological cancers: Current state of knowledge 连接粘附分子- a (JAM-A)在妇科癌症中的作用:目前的研究现状
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025677
Kamila Czubak-Prowizor, M. Swiatkowska
{"title":"Junctional adhesion molecule-A (JAM-A) in gynecological cancers: Current state of knowledge","authors":"Kamila Czubak-Prowizor, M. Swiatkowska","doi":"10.32604/biocell.2023.025677","DOIUrl":"https://doi.org/10.32604/biocell.2023.025677","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"5 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87807544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Tsukamurella tyrosinosolvens P9 on growth, physiology and antioxdant enzyme of peanut under drought stress and after re-watering 旱胁迫及复水处理对花生生长、生理及抗氧化酶的影响
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027485
Changmei Long, Tingting Yang, Yujie Han, Lizhen Han
{"title":"Effects of Tsukamurella tyrosinosolvens P9 on growth, physiology and antioxdant enzyme of peanut under drought stress and after re-watering","authors":"Changmei Long, Tingting Yang, Yujie Han, Lizhen Han","doi":"10.32604/biocell.2023.027485","DOIUrl":"https://doi.org/10.32604/biocell.2023.027485","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"17 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88871101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of foliar spray of plant growth regulators in improving photosynthetic pigments and metabolites in Plantago ovata (Psyllium) under salt stress–A field appraisal 盐胁迫下植物生长调节剂叶面喷施对车前草光合色素和代谢产物的影响
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.023704
Abdul Samad, Kanval Shaukat, M. Ansari, Mereen Nizar, N. Zahra, Ambreen Naz, Hafiz MUHAMMAD WALEED IQBAL, A. Raza, Vladan Pesic, Ivica G. Djalović
{"title":"Role of foliar spray of plant growth regulators in improving photosynthetic pigments and metabolites in Plantago ovata (Psyllium) under salt stress–A field appraisal","authors":"Abdul Samad, Kanval Shaukat, M. Ansari, Mereen Nizar, N. Zahra, Ambreen Naz, Hafiz MUHAMMAD WALEED IQBAL, A. Raza, Vladan Pesic, Ivica G. Djalović","doi":"10.32604/biocell.2023.023704","DOIUrl":"https://doi.org/10.32604/biocell.2023.023704","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"3 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89460736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease 探索外泌体为阿尔茨海默病的治疗和预测提供证据
4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.031226
XIANGYU QUAN, XUETING MA, GUODONG LI, XUEQI FU, JIANGTAO LI, LINLIN ZENG
{"title":"Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease","authors":"XIANGYU QUAN, XUETING MA, GUODONG LI, XUEQI FU, JIANGTAO LI, LINLIN ZENG","doi":"10.32604/biocell.2023.031226","DOIUrl":"https://doi.org/10.32604/biocell.2023.031226","url":null,"abstract":"Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes. In recent years, scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease (AD) across the blood-brain barrier due to their nanoscale size and low immunogenicity. A large amount of evidence shows that exosomes are rich in biomarkers, and it has been found that the changes in biomarker content in blood, cerebrospinal fluid, and urine are often associated with the onset of AD patients. In this paper, some recent advances in the use of exosomes in the treatment of AD are reviewed, and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135504583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress of TRIMs protein family in tumors TRIMs蛋白家族在肿瘤中的研究进展
IF 1.2 4区 生物学
Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025880
Yuanyuan Huang, Hongmei Wu, Ruyuan Liu, Song Jin, Weilai Xiang, Chang Yang, Li Xu, Xiaonian Zhu
{"title":"Research progress of TRIMs protein family in tumors","authors":"Yuanyuan Huang, Hongmei Wu, Ruyuan Liu, Song Jin, Weilai Xiang, Chang Yang, Li Xu, Xiaonian Zhu","doi":"10.32604/biocell.2023.025880","DOIUrl":"https://doi.org/10.32604/biocell.2023.025880","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"34 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77803263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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