IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026881

Jiawei Fu, Chunshuai Wu, Guanhua Xu, Jinlong Zhang, Yiqiu Li, Chunyan Ji, Zhiming Cui

引用次数: 0

Analysis of tumor-draining vein secretome: A direct access to tumor-derived extracellular vesicles in surgical lung cancer patients 肿瘤引流静脉分泌组分析:肺癌手术患者肿瘤源性细胞外囊泡的直接通路

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027718

引用次数: 0

Abstracts from XXIV Annual Meeting of the Argentinean Society of Biology (SAB) 阿根廷生物学会(SAB)第24届年会摘要

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.s0124

引用次数: 0

Columbianetin acetate inhibits the occurrence and development of pancreatic cancer cells by down-regulating the expression of Meiotic nuclear divisions 1 乙酸柱莲素通过下调减数分裂核分裂的表达抑制胰腺癌细胞的发生和发展

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.023553

K. Sun, Dongqin Wang, Zhiqiang Zhang, Yinlong Huang, Xiaofu Lian, Jia Hua, Jing Zhang, Chaoqun Lian

{"title":"Columbianetin acetate inhibits the occurrence and development of pancreatic cancer cells by down-regulating the expression of Meiotic nuclear divisions 1","authors":"K. Sun, Dongqin Wang, Zhiqiang Zhang, Yinlong Huang, Xiaofu Lian, Jia Hua, Jing Zhang, Chaoqun Lian","doi":"10.32604/biocell.2023.023553","DOIUrl":"https://doi.org/10.32604/biocell.2023.023553","url":null,"abstract":"Columbianetin acetate (CE) is one of the effective components of Angelica pubescens. So far, the specific role and molecular mechanism of CE in pancreatic cancer are not clear. Thus, this study aimed to explore the specific mechanism of CE on pancreatic cancer. The target genes combined with CE were predicted through the PharmMapper database and the 3D molecular structure of CE. Then, the Cancer Genome Atlas (TCGA) and Cistrome data browser (DB) databases were used to screen Meiotic nuclear divisions 1 (MND1)-related genes, transcription factors, and transcription factor data sets, and the intersection of the above data sets. The “limma” package in the R and gene expression profiling interactive analysis (GEPIA) databases were used to analyze the correlation and survival difference between the target genes and MND1 to predict the degree of association between CE and MND1. Western blotting and RT-PCR experiments revealed the regulatory relationship among CE, E2F1, and MND1 at the cellular level. The specific effects of CE on pancreatic cancer cells were explored through CCK8, wound healing, migration, and flow cycle experiments. E2F1, also the predictive transcription factor of MND1, was also the predictive target protein of CE. At the same time, E2F1 and MND1 were closely related in pancreatic tissue. In the cell function experiment, CE and interference with E2F1 expression could reduce the gene and protein expression of MND1, which was closely associated with cell proliferation, migration, and cycle development. Similarly, interfering with the expression of mnd1 can also inhibit the further development of tumor cells. CE may inhibit the development of pancreatic cancer cells by reducing the expression of MND1. This implies that CE may be a potential novel agent for the treatment of pancreatic cancer.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"100 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83348294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive bioinformatics analysis of CYB561 expression in breast cancer: Link between prognosis and immune infiltration 乳腺癌CYB561表达的综合生物信息学分析:预后与免疫浸润的关系

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027103

Xi Yang, Huixian Wu, Chao-Liang Xiong, Bo Zhao, Meilian Liu, J. Qin, Meihai Deng

引用次数: 0

Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice 高血糖诱导的心肌纤维化可能与糖尿病小鼠心肌细胞的焦亡和凋亡有关

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.024944

Yao Lu, Qiuyue Wang, Caihui Zhang

{"title":"Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice","authors":"Yao Lu, Qiuyue Wang, Caihui Zhang","doi":"10.32604/biocell.2023.024944","DOIUrl":"https://doi.org/10.32604/biocell.2023.024944","url":null,"abstract":"Myocardial fibrosis is an important manifestation of diabetic cardiomyopathy. This study investigated the potential mechanism of diabetic myocardial fibrosis. Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. At 20 weeks, the mouse heart was harvested and subjected to hematoxylin-eosin staining (HE) and Masson staining to investigate the degree of fibrosis. The expressions of transforming growth factor-beta 1 (TGF-β1), collagen-III, B-cell lymphoma-2 (Bcl2), Bcl2-associated X protein (Bax), cleaved gasdermin D (GSDMD), cysteinyl aspartate specific proteinase-1 (caspase-1), apoptosis-associated speck-like protein containing a CARD (ASC), and nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3) were measured by western blotting. Immunohistochemistry and TdT-mediated dUTP nick end labeling (TUNEL) staining were performed to analyze the development of apoptosis and pyroptosis. A significant increase in body weight and blood glucose in the DB group was observed. Myocardial pathological injury, fibrosis, apoptosis, and pyroptosis were more obvious and serious in the DB group. The expression of anti-apoptotic Bcl2 significantly decreased, while the expression levels of pro-apoptotic Bax, caspase-3, and pyroptosis-related proteins, such as cleaved GSDMD, and caspase-1 in the DB group were significantly increased. Pyroptosis and apoptosis were probably the main mechanisms that caused myocardial fibrosis in mice with diabetes.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90242144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of FZR1 in tumorigenesis: Focus on cell-cycle control FZR1在肿瘤发生中的作用:关注细胞周期控制

4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029373

HUI LI, CHENGFANG ZHOU, MEI KUANG, YUN LIU, JIEPING CHEN

引用次数: 0

Microfluidic platform for circulating tumor cells isolation and detection 循环肿瘤细胞分离与检测的微流控平台

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028628

Jiahao Zhang, J. Ren, Zirui Li, Yixing Gou

引用次数: 1

Effects of Tsukamurella tyrosinosolvens P9 on growth, physiology and antioxdant enzyme of peanut under drought stress and after re-watering 旱胁迫及复水处理对花生生长、生理及抗氧化酶的影响