Biocell最新文献_第10页

DNA polymerase θ (POLQ): A druggable DNA polymerase for homologous recombination-deficient cancer cells DNA聚合酶θ (POLQ):一种可用于同源重组缺陷癌细胞的药物性DNA聚合酶

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025747

Meran Keshawa Ediriweera

引用次数: 0

The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro 在体外实验中，天然产物联合使用对MCF-7细胞的影响超过了他莫昔芬的治疗剂量效应

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026556

Zeinab M. Klaab, Aziza M Hassan, Jawaher J Albaqami, Faizah A. ALMALKI

引用次数: 0

Network biology: A promising approach for drug target identification against neurodevelopmental disorders 网络生物学:神经发育障碍药物靶点鉴定的一种有前途的方法

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029624

Wayez Naqvi, Ananya Singh, Prekshi Garg, P. Srivastava

{"title":"Network biology: A promising approach for drug target identification against neurodevelopmental disorders","authors":"Wayez Naqvi, Ananya Singh, Prekshi Garg, P. Srivastava","doi":"10.32604/biocell.2023.029624","DOIUrl":"https://doi.org/10.32604/biocell.2023.029624","url":null,"abstract":"Biological entities are involved in complicated and complex connections; hence, discovering biological information using network biology ideas is critical. In the past few years, network biology has emerged as an integrative and systems-level approach for understanding and interpreting these complex interactions. Biological network analysis is one method for reducing enormous data sets to clinically useful knowledge for disease diagnosis, prognosis, and treatment. The network of biological entities can help us predict drug targets for several diseases. The drug targets identified through the systems biology approach help in targeting the essential biological pathways that contribute to the progression and development of the disease. The novel strategical approach of system biologyassisted pharmacology coupled with computer-aided drug discovery (CADD) can help drugs fight multifactorial diseases efficiently. In the present review, we have summarized the role and application of network biology for not only unfolding the mechanism of complex neurodevelopmental disorders but also identifying important drug targets for diseases like ADHD, Autism, Epilepsy, and Intellectual Disability. Systems biology has emerged as a promising approach to identifying drug targets and aiming for targeted drug discovery for the precise treatment of neurodevelopmental disorders.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"5 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75555611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AKT regulates IL-1β-induced proliferation and activation of hepatic stellate cells AKT调节il -1β诱导的肝星状细胞的增殖和活化

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025365

Yongdae Yoon, Soonjae Hwang, Fatema Tuj Saima, Moon YOUNG KIM, Soon KOO BAIK, Young WOO EOM

引用次数: 0

Therapeutic application of mesenchymal stem cells-derived extracellular vesicles in colorectal cancer 间充质干细胞来源的细胞外囊泡在结直肠癌治疗中的应用

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025603

M. Nemati, Yousef Rasmi, J. Rezaie

引用次数: 0

Hepatitis B virus X protein-mediated upregulation of miR-221 activates the CXCL12-CXCR4 axis to promote NKT cells in HBV-related hepatocellular carcinoma 乙型肝炎病毒X蛋白介导的miR-221上调激活CXCL12-CXCR4轴，促进hbv相关肝细胞癌中的NKT细胞

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027205

Yue Cao, Lin Hu, Yishu Tang

引用次数: 0

Anti-fibrotic and anti-inflammatory effect of mesenchymal stromal cell-derived extracellular vesicles in chronic kidney disease 间充质间质细胞来源的细胞外囊泡在慢性肾病中的抗纤维化和抗炎作用

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.028121

Giulia Chiabotto, S. Bruno

引用次数: 0

A novel prognostic gene signature, nomogram and immune landscape based on tanshinone IIA drug targets for hepatocellular carcinoma: Comprehensive bioinformatics analysis and in vitro experiments 基于丹参酮IIA药物靶点的新型肝细胞癌预后基因特征、形态图和免疫景观:综合生物信息学分析和体外实验

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027026

Bowen Peng, Y. Ge, Gang Yin

引用次数: 0

Transcriptome analysis reveals potential genes associated with plant height in rice 转录组分析揭示了水稻株高相关的潜在基因

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.023543

Can Chen, Rui Feng, Zongqiong Zhang, Xiuzhong Xia, B. Nong, Yu Zeng, Hui Guo, Xinghai Yang, Danting Li

{"title":"Transcriptome analysis reveals potential genes associated with plant height in rice","authors":"Can Chen, Rui Feng, Zongqiong Zhang, Xiuzhong Xia, B. Nong, Yu Zeng, Hui Guo, Xinghai Yang, Danting Li","doi":"10.32604/biocell.2023.023543","DOIUrl":"https://doi.org/10.32604/biocell.2023.023543","url":null,"abstract":"Plant height (PH) is a complex trait regulated by the environment and multiple genes. PH directly affects crop yield, harvest index, and lodging resistance. From plant dwarf mutants, many genes related to PH have been identified and described. Nonetheless, the molecular mechanism of height regulation in high-culm rice mutants has not been well studied. By using transcriptome and weighted gene co-expression network analysis (WGCNA), we identified the differentially expressed genes (DEGs) between high-culm rice mutants (MUT) and wild-type (WT) and explored the key pathways and potential candidate genes involved in PH regulation. Transcriptome analysis identified a total of 2,184 DEGs, of which 1,317 were identified at the jointing stage and 1,512 were identified at the heading stage. Kyoto Encyclopedia of Genes and Genomes enrichment showed that the enrichment pathways were mainly involved in plant hormone signal transduction, ABC transportation, and steroid hormone biosynthesis. Among these metabolic pathways, LOC_Os05g43910 and LOC_Os01g35030 were auxin (IAA)-related genes, up-regulated in MUT and LOC_Os02g08500 (LEPTO1), LOC_Os11g04720, and LOC_Os12g04500 were cytokinin (CK)-related genes, downregulated in MUT. The WGCNA identified four modules (light cyan, dark grey, grey, and pale turquoise) closely related to PH, and seven key genes were screened from these modules, of which two were up-regulated cell wallrelated genes (LOC_Os01g26174 (OsWAK5), LOC_Os06g05050) in MUT, and one gibberellic acid (GA) gene (LOC_Os06g37364, OsKO2) was also up-regulated. These genes might be closely related to PH regulation. These findings help us better understand the transcriptional regulation of rice plant growth and development and provide a theoretical basis for mapping and cloning the PH regulatory genes.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"33 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88145390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database 基于GEO数据库的子宫内膜异位症关键枢纽基因EML4的鉴定及其分子机制和潜在药物预测

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.030565

Xianbao Fang, M. Tang, Ziyang Yu, Jiaqi Ding, Chong Cui, Hong Zhang

引用次数: 0