Biocell最新文献_第10页

Network biology: A promising approach for drug target identification against neurodevelopmental disorders 网络生物学:神经发育障碍药物靶点鉴定的一种有前途的方法

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.029624

Wayez Naqvi, Ananya Singh, Prekshi Garg, P. Srivastava

{"title":"Network biology: A promising approach for drug target identification against neurodevelopmental disorders","authors":"Wayez Naqvi, Ananya Singh, Prekshi Garg, P. Srivastava","doi":"10.32604/biocell.2023.029624","DOIUrl":"https://doi.org/10.32604/biocell.2023.029624","url":null,"abstract":"Biological entities are involved in complicated and complex connections; hence, discovering biological information using network biology ideas is critical. In the past few years, network biology has emerged as an integrative and systems-level approach for understanding and interpreting these complex interactions. Biological network analysis is one method for reducing enormous data sets to clinically useful knowledge for disease diagnosis, prognosis, and treatment. The network of biological entities can help us predict drug targets for several diseases. The drug targets identified through the systems biology approach help in targeting the essential biological pathways that contribute to the progression and development of the disease. The novel strategical approach of system biologyassisted pharmacology coupled with computer-aided drug discovery (CADD) can help drugs fight multifactorial diseases efficiently. In the present review, we have summarized the role and application of network biology for not only unfolding the mechanism of complex neurodevelopmental disorders but also identifying important drug targets for diseases like ADHD, Autism, Epilepsy, and Intellectual Disability. Systems biology has emerged as a promising approach to identifying drug targets and aiming for targeted drug discovery for the precise treatment of neurodevelopmental disorders.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75555611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel prognostic gene signature, nomogram and immune landscape based on tanshinone IIA drug targets for hepatocellular carcinoma: Comprehensive bioinformatics analysis and in vitro experiments 基于丹参酮IIA药物靶点的新型肝细胞癌预后基因特征、形态图和免疫景观:综合生物信息学分析和体外实验

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027026

Bowen Peng, Y. Ge, Gang Yin

引用次数: 0

Glucocorticoid reduces the efficacy of afatinib on the head and neck squamous cell carcinoma 糖皮质激素降低阿法替尼对头颈部鳞状细胞癌的疗效

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.023489

Dongyang Wang, Yi Chen, Jing Huang, You-cai Zhang, Chong-kui Sun, Yingqiang Shen

{"title":"Glucocorticoid reduces the efficacy of afatinib on the head and neck squamous cell carcinoma","authors":"Dongyang Wang, Yi Chen, Jing Huang, You-cai Zhang, Chong-kui Sun, Yingqiang Shen","doi":"10.32604/biocell.2023.023489","DOIUrl":"https://doi.org/10.32604/biocell.2023.023489","url":null,"abstract":"Glucocorticoids (GC) are widely used to counter the adverse events during cancer therapy; nonetheless, previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells, especially in epidermal growth factor receptor (EGFR)-targeted therapy of head and neck squamous cell carcinoma (HNSCC) remaining to be elucidated. The primary aim of the present study was to probe into the GC-induced resistance of EGFR-targeted drug afatinib and the underlying mechanism. HNSCC cell lines (HSC-3, SCC-25, SCC-9, and H-400) and the human oral keratinocyte (HOK) cell lines were assessed for GC receptor (GR) expression. The promoting tumor growth effect of GC was evaluated by the CCK-8 assay and flow cytometry. Levels of signaling pathways participants GR, mTOR, and EGFR were determined by quantitative polymerase chain reaction and western blotting. GC increased the proliferation of HNSCC cells in a GR-dependent manner and promoted AKT/mTOR signaling. But GC failed in counteracting the inhibition of rapamycin in the mTOR signaling pathway. Besides, GC also induced resistance to EGFR-targeted drug afatinib through AKT/mTOR instead of the EGFR/ERK signaling pathway. Thus, GCs reduce the efficacy of afatinib on HNSCC, implicating a cautious use of glucocorticoids in clinical practice.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74710241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic application of mesenchymal stem cells-derived extracellular vesicles in colorectal cancer 间充质干细胞来源的细胞外囊泡在结直肠癌治疗中的应用

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025603

M. Nemati, Yousef Rasmi, J. Rezaie

引用次数: 0

dbSCI: A manually curated database of SARS-CoV-2 inhibitors for COVID-19 dbSCI:人工整理的SARS-CoV-2抗COVID-19抑制剂数据库

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025310

Qiang Wang, Guo Zhao, Longxiang Xie, Xuan Li, Xixi Yu, Qiongshan Li, Baoping Zheng, Zulipinuer Wusiman, Xiangqian Guo

{"title":"dbSCI: A manually curated database of SARS-CoV-2 inhibitors for COVID-19","authors":"Qiang Wang, Guo Zhao, Longxiang Xie, Xuan Li, Xixi Yu, Qiongshan Li, Baoping Zheng, Zulipinuer Wusiman, Xiangqian Guo","doi":"10.32604/biocell.2023.025310","DOIUrl":"https://doi.org/10.32604/biocell.2023.025310","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of the ongoing coronavirus disease 2019 (COVID-19) global pandemic. Here, by centralizing published cell-based experiments, clinical trials, and virtual drug screening data from the NCBI PubMed database, we developed a database of SARS-CoV-2 inhibitors for COVID-19, dbSCI, which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments, 81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses. dbSCI provides four major functions: (1) search the drug target or its inhibitor for SARS-CoV-2, (2) browse target/inhibitor information collected from cell experiments, clinical trials, and virtual drug screenings, (3) download, and (4) submit data. Each entry in dbSCI contains 18 types of information, including inhibitor/drug name, targeting protein, mechanism of inhibition, experimental technique, experimental sample type, and reference information. In summary, dbSCI provides a relatively comprehensive, credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19. [ FROM AUTHOR]","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74280132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro 在体外实验中，天然产物联合使用对MCF-7细胞的影响超过了他莫昔芬的治疗剂量效应

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026556

Zeinab M. Klaab, Aziza M Hassan, Jawaher J Albaqami, Faizah A. ALMALKI

引用次数: 0

Indian medicinal plants are effective in the treatment and management of COVID-19 印度药用植物在治疗和管理COVID-19方面是有效的

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.026081

Subhash Chandra, S. Palai, Edinardo FAGNER FERREIRA-MATIAS, Ivo CAVALCANTE PITA-NETO, C鞢ERO LUCAS GOMES-RAMALHO, E. Martins de Andrade, Ray Silva de Almeida, M. Iriti, Henrique DOUGLAS MELO-COUTINHO

引用次数: 0

Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders 酮体和炎症调节:生酮饮食在情绪障碍中的潜在机制综述

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027632

Yan Zheng, Sihui Ma, Katsuhiko Suzuki, H. Kato, Huijuan Jia

{"title":"Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders","authors":"Yan Zheng, Sihui Ma, Katsuhiko Suzuki, H. Kato, Huijuan Jia","doi":"10.32604/biocell.2023.027632","DOIUrl":"https://doi.org/10.32604/biocell.2023.027632","url":null,"abstract":": Mental disorders such as depression and anxiety in ﬂ ict signi ﬁ cant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β -hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-in ﬂ ammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the in ﬂ uence of KD and BHB on in ﬂ ammation and their potential roles in managing mental disorders. Both human and animal studies were scrutinized to elucidate possible cellular and molecular mechanisms. Out of the 15 trials, 10 reported reduced levels of at least one in ﬂ ammatory mediator or mRNA post KD or BHB treatment, while two observed an elevation in anti-in ﬂ ammatory agents. These ﬁ ndings suggest that KD and BHB could modulate cellular in ﬂ ammatory pathways, highlighting their potential for therapeutic application in mental disorders.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88557907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis B virus X protein-mediated upregulation of miR-221 activates the CXCL12-CXCR4 axis to promote NKT cells in HBV-related hepatocellular carcinoma 乙型肝炎病毒X蛋白介导的miR-221上调激活CXCL12-CXCR4轴，促进hbv相关肝细胞癌中的NKT细胞

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.027205

Yue Cao, Lin Hu, Yishu Tang

引用次数: 0

AKT regulates IL-1β-induced proliferation and activation of hepatic stellate cells AKT调节il -1β诱导的肝星状细胞的增殖和活化

IF 1.2 4区生物学

Biocell Pub Date : 2023-01-01 DOI: 10.32604/biocell.2023.025365

Yongdae Yoon, Soonjae Hwang, Fatema Tuj Saima, Moon YOUNG KIM, Soon KOO BAIK, Young WOO EOM

引用次数: 0