Biocell最新文献

{"title":"Targeting the “undruggable” cancer driver genes: Ras, myc, and tp53","authors":"Xingbo Wu, Dan Pan, Shouyi Tang, Yingqiang Shen","doi":"10.32604/biocell.2023.028790","DOIUrl":"https://doi.org/10.32604/biocell.2023.028790","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"32 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74991655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UCK2 promotes the proliferation, migration, and invasion of trophoblast cells in preeclampsia by activating the STAT3 pathway","authors":"Wei Xia, N. Yang, Xiaoyan Feng, Ting Xin, Yongle Jing, Yuming Li, Chengzhi Lu","doi":"10.32604/biocell.2023.026161","DOIUrl":"https://doi.org/10.32604/biocell.2023.026161","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89789435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, Mpro, and PLpro: A review","authors":"Mohamad Zulkeflee Sabri, J. Bojarska, Fai-Chu Wong, Tsun-Thai Chai","doi":"10.32604/biocell.2023.029272","DOIUrl":"https://doi.org/10.32604/biocell.2023.029272","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"69 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90630938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of micro/nanostructured‒based biomaterials with biomedical applications","authors":"Afaf Alharthi","doi":"10.32604/biocell.2023.027154","DOIUrl":"https://doi.org/10.32604/biocell.2023.027154","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"55 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89292150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration","authors":"Aayushi Randhawa, Sayan Deb Dutta, Keya Ganguly, Tejal V. PATIL, Rachmi Luthfikasari, K. Lim","doi":"10.32604/biocell.2023.026217","DOIUrl":"https://doi.org/10.32604/biocell.2023.026217","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"104 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89332163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scutellarin alleviates complete freund’s adjuvant-induced rheumatoid arthritis in mice by regulating the Keap1/Nrf2/HO-1 pathway","authors":"Jian Li, Qingqing Wang, Xiaoying Zhang","doi":"10.32604/biocell.2023.028714","DOIUrl":"https://doi.org/10.32604/biocell.2023.028714","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"47 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86904989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of STAT5B as a biomarker for an early diagnosis of endometrial carcinoma","authors":"XUELIAN CHEN, YUNZHENG ZHANG, JUNJIAN HE, YIBING LI","doi":"10.32604/biocell.2023.030086","DOIUrl":"https://doi.org/10.32604/biocell.2023.030086","url":null,"abstract":"<b>Background:</b> The late detection of endometrial carcinoma (EC) at an advanced stage often results in a poor patient prognosis. It is hence important to identify reliable biomarkers to facilitate early detection of EC. Signal transducer and activator of transcription (STAT) family members play an important role in several tumors, however, their impact on EC development and progression remains unclear. <b>Methods:</b> Machine learning methods were used to investigate the importance of STAT5B in EC. <b>Results:</b> Hence, we explored the UALCAN data mining platform and found that while STAT1 and STAT2 were upregulated, STAT5A, STAT5B, and STAT6 were downregulated in EC. This high expression of STAT5B and STAT6 predicted favorable clinical outcomes, whereas the increased expression of STAT1 and STAT2 predicted poor clinical outcomes. Subsequent pathway enrichment analysis revealed that the STAT family was mainly involved in apoptosis pathway activation, cell cycle disruption, and epithelial–mesenchymal transition. Drug sensitivity analysis demonstrated that STAT5A/5B expression was negatively correlated with drug resistance in EC. Further, the expression of STAT5B mRNA and protein was correlated with several clinicopathological characteristics. Tumor Immune Estimation Resource (TIMER) analysis revealed that STAT5B expression was positively correlated with the abundance of infiltrating CD8+ T cells and neutrophils while its copy number variation was associated with the overall immune cell infiltration. The data on the correlations between STAT5B expression and related genes in uterine corpus endometrial carcinoma (UCEC) in cBio Cancer Portal showed the closest correlation of STAT5B expression with that of KIAA0753 (also known as moonraker and OFIP), followed by COL27A1 in EC. Pathway enrichment analysis further showed that STAT5B-related genes were involved in the mitogen-activated protein kinase (MAPK) and Ras signaling pathways. <b>Conclusion:</b> Collectively, our findings provided new insights into the role of the STAT family in EC. It also highlighted new targets for future research on diagnostic and prognostic markers and STAT5B as a novel marker for drug sensitivity screening.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"233 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135506341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MED4 gene positively affects preadipocyte differentiation in Chinese red steppe cattle","authors":"MINGHONG WEI, CHENG XIAO, JIAN WU, LIHONG QIN, HONGLIANG LIU, YANG CAO, YUMIN ZHAO","doi":"10.32604/biocell.2023.030364","DOIUrl":"https://doi.org/10.32604/biocell.2023.030364","url":null,"abstract":"<b>Background:</b> The regulatory genes related to lipid metabolism affect the intramuscular fat (IMF) content and improve meat quality traits. Mediator Complex Subunit 4 (MED4), a vitamin D receptor protein, affects vitamin D, livestock growth, carcass traits, and triglyceride deposition. However, the physiological function of the <i>MED4</i> gene on bovine adipocyte differentiation remains unknown. <b>Methods:</b> This study explored the function of the <i>MED4</i> gene in preadipocyte differentiation in Chinese Red Steppe cattle. The overexpression plasmid and the interference sequences of the <i>MED4</i> gene were constructed to detect the effects of the <i>MED4</i> gene on adipogenesis and biomakers using quantitative polymerase chain reaction and western blotting. <b>Results:</b> The <i>MED4</i> gene had significantly high expression during preadipocyte differentiation (<i>p</i> < 0.05). Overexpression of the <i>MED4</i> gene increased the expression of the <i>PPARγ</i> gene, a preadipocyte differentiation biomarker, improved cellular lipid droplets and triglycerides accumulation, and positively accelerated adipocyte maturation (<i>p</i> < 0.05). Interference of the <i>MED4</i> gene can negatively regulate preadipocyte differentiation. <b>Conclusion:</b> This study showed that the <i>MED4</i> gene may affect the preadipocyte differentiation and adipogenesis in Chinese Red Steppe cattle by regulating the <i>PPARγ</i> gene.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135755131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bacterial small RNAs: The new biomarkers of oral microbiota-associated cancers and diseases","authors":"MENGYING MAO, TING DONG, YANJING LIANG, KEYONG YUAN, QIAOQIAO JIN, PENGFEI ZHANG, ZHENGWEI HUANG","doi":"10.32604/biocell.2023.042357","DOIUrl":"https://doi.org/10.32604/biocell.2023.042357","url":null,"abstract":"The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and is highly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balance existing between the oral microbiota and host may be disturbed and result in the development of diseases. Numerous observations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host interactions. Further, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacious therapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria or host cells in oral cancers via small RNAs are hot topics of research. Current studies also have begun to elucidate the key role of oral microbiota in the development of systemic diseases. This article discusses existing findings and nascent mechanisms governing the small RNA-based interactions between oral microbiota and associated diseases. The knowledge of such interactions is key in planning approaches to reverse dysbiosis to achieve health.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation","authors":"ZIPENG LIN, CHUXI TANG, LE KANG, GUANXI LAI, SHIWEN LIU, YIXIANG WU, HUIQUN TIAN, SONG LIU","doi":"10.32604/biocell.2023.030233","DOIUrl":"https://doi.org/10.32604/biocell.2023.030233","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"272 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135557423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}