探索外泌体为阿尔茨海默病的治疗和预测提供证据

IF 0.8 4区生物学 Q4 BIOLOGY

Biocell Pub Date : 2023-01-01 DOI:10.32604/biocell.2023.031226

XIANGYU QUAN, XUETING MA, GUODONG LI, XUEQI FU, JIANGTAO LI, LINLIN ZENG

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引用次数: 0

摘要

外泌体是细胞外囊泡，直径30 - 150nm，起源于内泌体。近年来，由于外泌体的纳米级大小和低免疫原性，科学家们将其视为跨越血脑屏障靶向治疗阿尔茨海默病(AD)的理想小分子载体。大量证据表明外泌体富含生物标志物，并且已经发现血液、脑脊液和尿液中生物标志物含量的变化往往与AD患者的发病有关。本文综述了近年来利用外泌体治疗AD的一些研究进展，并对各种外泌体标志物和一些最新的检测方法进行了综述，以期为外泌体检测或治疗AD提供一些依据。

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Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease

Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes. In recent years, scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease (AD) across the blood-brain barrier due to their nanoscale size and low immunogenicity. A large amount of evidence shows that exosomes are rich in biomarkers, and it has been found that the changes in biomarker content in blood, cerebrospinal fluid, and urine are often associated with the onset of AD patients. In this paper, some recent advances in the use of exosomes in the treatment of AD are reviewed, and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes.

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来源期刊

Biocell 生物-生物学

CiteScore

1.50

自引率

16.70%

发文量

259

审稿时长

>12 weeks

期刊介绍： BIOCELL welcomes Research articles and Review papers on structure, function and macromolecular organization of cells and cell components, focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and on the suborganismal and organismal aspects of Vertebrate Reproduction and Development, Invertebrate Biology and Plant Biology.