Biomedical and Environmental Sciences最新文献

{"title":"Pteropine Orthoreovirus (PRV7S) does not Establish Persistent Infection in NP460 Cells but with Inflammatory Response Triggered","authors":"Mun Khin Alson LOH , Zhen Yun SIEW , Pooi Pooi LEONG , Rhun Yian KOH , Soi Moi CHYE , Siew Tung WONG , Kenny VOON","doi":"10.3967/bes2023.114","DOIUrl":"10.3967/bes2023.114","url":null,"abstract":"Pteropine orthoreovirus (PRV) is a non-enveloped double-stranded RNA (dsRNA) virus of the genus Orthoreovirus under the family Reoviridae","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 886-891"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of CircRNA-Associated CeRNA Networks in Folate Deficiency-Induced Neural Tube Defects","authors":"Shan WANG ,&nbsp;Yu Bing ZENG ,&nbsp;Pei PEI ,&nbsp;Xue Jia HE ,&nbsp;Fan LIU ,&nbsp;Yi WANG ,&nbsp;Ting ZHANG","doi":"10.3967/bes2023.071","DOIUrl":"10.3967/bes2023.071","url":null,"abstract":"<div><h3>Objective</h3><p>Circular RNAs (circRNAs) participate in several important pathological processes and have been used in the diagnosis and treatment of various diseases. This study aimed to investigate the role of circRNAs in neural tube defects (NTDs).</p></div><div><h3>Method</h3><p>We characterized circRNA-associated competitive endogenous RNA (ceRNA) networks in brain tissue of low folate -induced NTDs mouse at embryonic day 13.5 by high-throughput sequencing. The expression levels of Circzfp644, miR-20-5p and <em>Gas7</em> were detected by RT-PCR. <em>Gas7</em> and Circzfp644 functions were determined by miRNA-mimics and inhibitors in mouse teratocarcinoma cells (F9 cells), and luciferase gene reporter assay was assessed in the F9 cells. In addition, the expression levels of Circzfp644, miR-20-5p and <em>Gas7</em> were determined by Nanostring in human NTDs tissues.</p></div><div><h3>Results</h3><p>We detected 57 circRNA transcripts, 16 miRNAs, and 148 mRNAs that were significantly dysregulated in NTDs brain tissues compared with their expression levels in control (normal) tissues. Circzfp644 shared miRNA response elements with the growth arrest specific 7 (<em>Gas7</em>) gene and competitively bound with miR-20-5p to increase the expression of <em>Gas7</em>. Downregulation of Circzfp644 and <em>Gas7</em> and upregulation of miR-20-5p were found in human NTD tissue.</p></div><div><h3>Conclusion</h3><p>This study provides new perspectives on the role of circRNAs in nervous system development and the pathogenesis of NTDs.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 837-849"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Cancer Risk Attributable to Active Smoking in China: A Systematic Review and Meta-Analysis","authors":"Jian ZHAO,&nbsp;Yu Lin SHI,&nbsp;Yu Tong WANG,&nbsp;Fei Ling AI,&nbsp;Xue Wei WANG,&nbsp;Wen Yi YANG,&nbsp;Jing Xin WANG,&nbsp;Li Mei AI,&nbsp;Kui Ru HU,&nbsp;Xia WAN","doi":"10.3967/bes2023.075","DOIUrl":"10.3967/bes2023.075","url":null,"abstract":"<div><h3>Objective</h3><p>No consensus exists on the relative risk (<em>RR</em>) of lung cancer (LC) attributable to active smoking in China. This study aimed to evaluate the unified <em>RR</em> of LC attributable to active smoking among the Chinese population.</p></div><div><h3>Methods</h3><p>A systematic literature search of seven databases was conducted to identify studies reporting active smoking among smokers <em>versus</em> nonsmokers in China. Primary articles on LC providing risk estimates with their 95% confidence intervals (<em>CI</em>s) for “ever” “former” or “current” smokers from China were selected. Meta-analysis was used to estimate the pooled <em>RR</em> of active smoking.</p></div><div><h3>Results</h3><p>Forty-four unique studies were included. Compared with that of nonsmokers, the pooled <em>RR</em> (95% <em>CI</em>) for “ever” “former” and “current” smokers were 3.26 (2.79–3.82), 2.95 (1.71–5.08), and 5.16 (2.58–10.34) among men, 3.18 (2.78–3.63), 2.70 (2.08–3.51), and 4.27 (3.61–5.06) among women, and 2.71 (2.12–3.46), 2.66 (2.45–2.88), and 4.21 (3.25–5.45) in both sexes combined, respectively.</p></div><div><h3>Conclusion</h3><p>The <em>RR</em> of LC has remained relatively stable (range, 2–6) over the past four decades in China. Early quitting of smoking could reduce the <em>RR</em> to some extent; however, completely refraining from smoking is the best way to avoid its adverse effects.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 850-861"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Leclercia adecarboxylata Producing Carbapenemases in A Newborn Female","authors":"Shuang MENG ,&nbsp;Bei Bei MIAO ,&nbsp;Jie LI ,&nbsp;Jian Wen YIN ,&nbsp;Ze Liang LIU ,&nbsp;Xue Qi JIANG ,&nbsp;Xin Yi GONG ,&nbsp;Juan LI","doi":"10.3967/bes2023.104","DOIUrl":"https://doi.org/10.3967/bes2023.104","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 874-879"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49894469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Guide for Hyperuricemia and Gout Patients (WS/T 560—2017)","authors":"","doi":"10.3967/bes2023.118","DOIUrl":"10.3967/bes2023.118","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 897-898"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Developing Non-Alcoholic Fatty Liver Disease Over Time in a Cohort of the Elderly in Qingdao, China","authors":"Li LIU ,&nbsp;Yu Han SHAO ,&nbsp;En Qiang FENG ,&nbsp;Zhu Gang SHAO ,&nbsp;Dong Ming XING","doi":"10.3967/bes2023.101","DOIUrl":"10.3967/bes2023.101","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 8","pages":"Pages 760-767"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causative Microorganisms Isolated from Patients with Intra-Abdominal Infections and Their Drug Resistance Profiles: An 11-Year (2011–2021) Single-Center Retrospective Study","authors":"Rui DING ,&nbsp;Rui Rui MA ,&nbsp;Ya Li LIU ,&nbsp;Ying ZHAO ,&nbsp;Li Na GUO ,&nbsp;Hong Tao DOU ,&nbsp;Hong Li SUN ,&nbsp;Wen Jing LIU ,&nbsp;Li ZHANG ,&nbsp;Yao WANG ,&nbsp;Ding Ding LI ,&nbsp;Qiao Lian YI ,&nbsp;Ying Chun XU","doi":"10.3967/bes2023.072","DOIUrl":"10.3967/bes2023.072","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the distribution and antimicrobial susceptibility of causative microorganisms recovered from patients with intra-abdominal infections (IAIs).</p></div><div><h3>Methods</h3><p>A total of 2,926 bacterial and fungal strains were identified in samples collected from 1,679 patients with IAIs at the Peking Union Medical College Hospital between 2011 and 2021. Pathogenic bacteria and fungi were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Antimicrobial susceptibility testing (AST) was performed using the VITEK 2 compact system and the Kirby–Bauer method. AST results were interpreted based on the M100-Ed31 clinical breakpoints of the Clinical and Laboratory Standards Institute.</p></div><div><h3>Results</h3><p>Of the 2,926 strains identified, 49.2%, 40.8%, and 9.5% were gram-negative bacteria, gram-positive bacteria, and fungi, respectively. <em>Escherichia coli</em> was the most prevalent pathogen in intensive care unit (ICU) and non-ICU patients; however, a significant decrease was observed in the isolation of <em>E. coli</em> between 2011 and 2021. Specifically, significant decreases were observed between 2011 and 2021 in the levels of extended-spectrum β-lactamase (ESBL)-producing <em>E. coli</em> (from 76.9% to 14.3%) and <em>Klebsiella pneumoniae</em> (from 45.8% to 4.8%). Polymicrobial infections, particularly those involving coinfection with gram-positive and gram-negative bacteria, were commonly observed in IAI patients. Moreover, <em>Candida albicans</em> was more commonly isolated from hospital-associated IAI samples, while <em>Staphylococcus epidermidis</em> had a higher ratio in community-associated IAIs. Additionally, AST results revealed that most antimicrobial agents performed better in non-ESBL-producers than in ESBL-producers, while the overall resistance rates (56.9%–76.8%) of <em>Acinetobacter baumanmii</em> were higher against all antimicrobial agents than those of other common gram-negative bacteria. Indeed, <em>Enterococcus faecium</em>, <em>Enterococcus faecalis</em>, <em>S. epidermidis</em>, and <em>S. aureus</em> were consistently found to be susceptible to vancomycin, teicoplanin, and linezolid. Similarly, <em>C. albicans</em> exhibited high susceptibility to all the tested antifungal drugs.</p></div><div><h3>Conclusion</h3><p>The distribution and antimicrobial susceptibility of the causative microorganisms from patients with IAIs were altered between 2011 and 2021. This finding is valuable for the implementation of evidence-based antimicrobial therapy and provides guidance for the control of hospital infections.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 8","pages":"Pages 732-742"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic Mesenchymal Stem Cells Promote Diabetic Wound Healing in Rats by Increasing VEGF Secretion","authors":"Su Jing ZHUANG,&nbsp;Xu Yan SUN,&nbsp;Meng LUO,&nbsp;Zhong WANG,&nbsp;Xue Juan ZHANG,&nbsp;Zong Sheng GAO,&nbsp;Jian LIU,&nbsp;Xin Ran LIU,&nbsp;Shi Ze LIU,&nbsp;Xiao Peng JIA","doi":"10.3967/bes2023.100","DOIUrl":"10.3967/bes2023.100","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 8","pages":"Pages 756-759"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The China Cardiovascular Health Index 2023 was Grandly Released","authors":"","doi":"10.3967/bes2023.107","DOIUrl":"10.3967/bes2023.107","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 8","pages":"Page 783"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Burden among Informal Caregivers of Hospitalized Lung Cancer Patients and Its Influencing Factors","authors":"Chun Yan LI ,&nbsp;Yu Jian SONG ,&nbsp;Lan ZHAO ,&nbsp;Mu Hong DENG ,&nbsp;Rui Xin LI ,&nbsp;Xiao Ling ZHANG ,&nbsp;Qiong Xuan LI ,&nbsp;Ying SHI ,&nbsp;Heng Yu LUAN ,&nbsp;Yuan Yuan SUN ,&nbsp;Yi HU ,&nbsp;Xiao Yong SAI","doi":"10.3967/bes2023.099","DOIUrl":"10.3967/bes2023.099","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to reveal the insomnia burden and relevant influencing factors among informal caregivers (ICs) of hospitalized patients with lung cancer.</p></div><div><h3>Methods</h3><p>A cross-sectional study on ICs of hospitalized patients with lung cancer was conducted from December 31, 2020 to December 31, 2021. ICs’ burden was assessed using the Caregiver Reaction Assessment (CRA), Hospital Anxiety and Depression Scale (HADS), and Insomnia Severity Index (ISI). Linear and logistic regression models were used to identify the influencing factors.</p></div><div><h3>Results</h3><p>Among 289 ICs of hospitalized patients with lung cancer, 83 (28.72%), 53 (18.34%), and 14 (4.84%) ICs experienced mild, moderate, and severe insomnia, respectively. The scores concerning self-esteem, lack of family support, financial problems, disturbed schedule, and health problems were 4.32 ± 0.53, 2.24 ± 0.79, 2.84 ± 1.14, 3.63 ± 0.77, and 2.44 ± 0.95, respectively. ICs with higher Activities of Daily Living Scale (ADLS) scores were associated with a lower risk of insomnia, with an odd ratio (<em>OR</em>) and 95% confidence interval (<em>CI</em>) of 0.940 (0.898–0.983). Among the ICs, female gender (<em>OR</em> = 2.597), alcohol consumption (<em>OR</em> = 3.745), underlying medical conditions (<em>OR</em> = 11.765), long-term caregiving experience (<em>OR</em> = 37.037), and higher monthly expenses (<em>OR</em> = 5.714) were associated with a high risk of insomnia.</p></div><div><h3>Conclusion</h3><p>Of the hospitalized patients with lung cancer, 51.9% experienced insomnia. Patients’ ADL, ICs gender, alcohol consumption, underlying medical conditions, caregiving duration, and monthly expenses were influencing factors. Therefore, prompt screening and early intervention for ICs of patients with lung cancer is necessary.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 8","pages":"Pages 715-724"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}