Biomedical and Environmental Sciences最新文献

{"title":"Machine-learning-assisted Investigation into the Relationship between the Built Environment, Behavior, and Physical Health of the Elderly in China","authors":"Xiao Ping WANG , Ze Yan LI , Meng ZHANG , Hong Yong LIU","doi":"10.3967/bes2023.125","DOIUrl":"10.3967/bes2023.125","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 987-990"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001551/pdfft?md5=96116248fe96958848ca46a3b4b70ccd&pid=1-s2.0-S0895398823001551-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Prognostic Marker PRR11 in Immune Infiltration for Facilitating Lung Adenocarcinoma Progression","authors":"Wen Hao WANG , Chang Geng MA , Yun Shang CUI , Bing Yu BAI , Zhi Mei SHENG , Jin LIU , Ao LI , Bao Gang ZHANG","doi":"10.3967/bes2023.111","DOIUrl":"https://doi.org/10.3967/bes2023.111","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 862-868"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49894470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Link between Exposure to Phthalates and Type 2 Diabetes Mellitus: A Study Based on NHANES Data and Bioinformatic Analysis","authors":"Xue Kui LIU , Shan Wen SI , Yan YE , Jia Yi LI , He He LYU , Ya Mei MA , Cai Yan ZOU , Hao Jie SUN , Lei XUE , Wei XU , Hou Fa GENG , Jun LIANG","doi":"10.3967/bes2023.115","DOIUrl":"10.3967/bes2023.115","url":null,"abstract":"Insulin resistance is closely associated with metabolic disorders and the pathogenesis of type 2 diabetes mellitus (T2DM). Accumulating evidence suggests that excess fatty acids due to inappropriate lipolysis increase the risk of insulin resistance, which, in turn, stimulates hyperinsulinemia, worsens metabolism","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 892-896"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and Modification of Ninety-seven Pneumococcal Serotyping Assays Based on Quantitative Real-time Polymerase Chain Reaction","authors":"Jie CHE ,&nbsp;Bo Han CHEN ,&nbsp;Li XU ,&nbsp;Yuan GAO ,&nbsp;Meng Meng YUE ,&nbsp;Zi Man CHEN ,&nbsp;Mao Jun ZHANG ,&nbsp;Zhu Jun SHAO","doi":"10.3967/bes2023.078","DOIUrl":"10.3967/bes2023.078","url":null,"abstract":"<div><h3>Objective</h3><p>To establish and modify quantitative real-time polymerase chain reaction (qPCR)-based serotyping assays to distinguish 97 pneumococcal serotypes.</p></div><div><h3>Methods</h3><p>A database of capsular polysaccharide (<em>cps</em>) loci sequences was generated, covering 97 pneumococcal serotypes. Bioinformatics analyses were performed to identify the <em>cps</em> loci structure and target genes related to different pneumococcal serotypes with specific SNPs. A total of 27 novel qPCR serotyping assay primers and probes were established based on qPCR, while 27 recombinant plasmids containing serotype-specific DNA sequence fragments were constructed as reference target sequences to examine the specificity and sensitivity of the qPCR assay. A panel of pneumococcal reference strains was employed to evaluate the capability of pneumococcal serotyping.</p></div><div><h3>Results</h3><p>A total of 97 pneumococcal serotyping assays based on qPCR were established and modified, which included 64 serotypes previously reported as well as an additional 33 serotypes. Twenty-seven novel qPCR serotyping target sequences were implemented in the pneumococcal qPCR serotyping system. A total of 97 pneumococcal serotypes, which included 52 individual serotypes and 45 serotypes belonging to 20 serogroups, could not be identified as individual serotypes. The sensitivity of qPCR assays based on 27 target sequences was 1–100 copies/μL. The specificity of the qPCR assays was 100%, which were tested by a panel of 90 serotypes of the pneumococcal reference strains.</p></div><div><h3>Conclusion</h3><p>A total of 27 novel qPCR assays were established and modified to analyze 97 pneumococcal serotypes.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 787-799"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition Guidelines of Complementary Feeding for Infants and Toddlers (WS/T 678—2020)","authors":"","doi":"10.3967/bes2023.117","DOIUrl":"10.3967/bes2023.117","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 899-901"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Clinical Characteristics of Non-neonatal Tetanus Patients in Guangxi, China: An 11-year Retrospective Study (2011–2021)","authors":"Yi Wen KANG ,&nbsp;Guo Feng MAI ,&nbsp;Xiao Ling ZHU ,&nbsp;Shang Qin DENG ,&nbsp;Shi Xiong YANG ,&nbsp;Hong Li TENG ,&nbsp;Zong Xiang YUAN ,&nbsp;Chu Ye MO ,&nbsp;Jian Yan LIN ,&nbsp;Li YE ,&nbsp;Hua Min TANG","doi":"10.3967/bes2023.113","DOIUrl":"10.3967/bes2023.113","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 880-885"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Mutations in Genes Related to Rifampicin and Isoniazid Resistance in Multidrug-resistant Mycobacterium tuberculosis Strains from Hangzhou, China","authors":"Yin Yan HUANG,&nbsp;Li XIE,&nbsp;Yi Fei WU,&nbsp;Qing Jun JIA,&nbsp;Qing Lin CHENG,&nbsp;Qing Chun LI,&nbsp;Li Yun AI,&nbsp;Xue Xin BAI","doi":"10.3967/bes2023.112","DOIUrl":"https://doi.org/10.3967/bes2023.112","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 869-873"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49894471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of the Effects of B7-H4 Gene rs10754339 and miR-125a Gene rs12976445 on Cancer Susceptibility","authors":"Yu Chen JIN ,&nbsp;Li Juan DONG ,&nbsp;Qin Yue YANG ,&nbsp;Wei Ning XIONG ,&nbsp;Wei Yi WANG ,&nbsp;Xian Hong FENG ,&nbsp;Wei YU ,&nbsp;Wei HUANG ,&nbsp;Bi Feng CHEN","doi":"10.3967/bes2023.074","DOIUrl":"https://doi.org/10.3967/bes2023.074","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the effects of the <em>B7-H4</em> gene rs10754339 and <em>miR-125a</em> gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.</p></div><div><h3>Methods</h3><p>A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. The meta-analysis was performed by pooling the data from previous related studies and the present study.</p></div><div><h3>Results</h3><p>The results of this study showed that in the Hubei Han Chinese population, the rs10754339 gene was significantly associated with the risk of lung and gastric cancer but not liver cancer, and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer. The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk.</p></div><div><h3>Conclusion</h3><p>The <em>B7-H4</em> gene rs10754339 and <em>miR-125a</em> gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population, which should be validated in future studies with larger sample sizes in other ethnic populations.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 814-825"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49894472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Prognosis of Different Reperfusion Strategies for ST-Segment Elevation Myocardial Infarction in Chinese County-Level Hospitals: Insight from China Acute Myocardial Infarction Registry","authors":"Chao WU ,&nbsp;Qiong Yu ZHANG ,&nbsp;Ling LI ,&nbsp;Xu Xia ZHANG ,&nbsp;Yong Chen CAI ,&nbsp;Jin Gang YANG ,&nbsp;Hai Yan XU ,&nbsp;Yan Yan ZHAO ,&nbsp;Yang WANG ,&nbsp;Wei LI ,&nbsp;Chen JIN ,&nbsp;Xiao Jin GAO ,&nbsp;Yue Jin YANG ,&nbsp;Shu Bin QIAO","doi":"10.3967/bes2023.110","DOIUrl":"10.3967/bes2023.110","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) treated with different reperfusion strategies in Chinese county-level hospitals</p></div><div><h3>Methods</h3><p>A total of 2,514 patients with STEMI from 32 hospitals participated in the China Acute Myocardial Infarction registry between January 2013 and September 2014. The success of fibrinolysis was assessed according to indirect measures of vascular recanalization. The primary outcome was 2-year mortality.</p></div><div><h3>Results</h3><p>Reperfusion therapy was used in 1,080 patients (42.9%): fibrinolysis (<em>n</em> = 664, 61.5%) and primary percutaneous coronary intervention (PCI) (<em>n</em> = 416, 38.5%). The most common reason for missing reperfusion therapy was a prehospital delay &gt; 12 h (43%). Fibrinolysis [14.5%, hazard ratio (<em>HR</em>): 0.59, 95% confidence interval (<em>CI</em>) 0.44–0.80] and primary PCI (6.8%, <em>HR</em> = 0.32, 95% <em>CI</em>: 0.22–0.48) were associated with lower 2-year mortality than those with no reperfusion (28.5%). Among fibrinolysis-treated patients, 510 (76.8%) achieved successful clinical reperfusion; only 17.0% of those with failed fibrinolysis underwent rescue PCI. There was no difference in 2-year mortality between successful fibrinolysis and primary PCI (8.8% <em>vs.</em> 6.8%, <em>HR</em> = 1.53, 95% <em>CI</em>: 0.85–2.73). Failed fibrinolysis predicted a similar mortality (33.1%) to no reperfusion (33.1% <em>vs.</em> 28.5%, <em>HR</em> = 1.30, 95% <em>CI</em>: 0.93–1.81).</p></div><div><h3>Conclusion</h3><p>In Chinese county-level hospitals, only approximately 2/5 of patients with STEMI underwent reperfusion therapy, largely due to prehospital delay. Approximately 30% of patients with failed fibrinolysis and no reperfusion therapy did not survive at 2 years. Quality improvement initiatives are warranted, especially in public health education and fast referral for mechanical revascularization in cases of failed fibrinolysis.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 826-836"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41125234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province, China, 2014–2020","authors":"De E YU ,&nbsp;Yu Jun XU ,&nbsp;Mu LI ,&nbsp;Yuan YANG ,&nbsp;Hua Yue LIANG ,&nbsp;Shan Mei ZHONG ,&nbsp;Cai QIN ,&nbsp;Ya Nan LAN ,&nbsp;Da Wei LI ,&nbsp;Ji Peng YU ,&nbsp;Yuan PANG ,&nbsp;Xue Qiu QIN ,&nbsp;Hao LIANG ,&nbsp;Kao Kao ZHU ,&nbsp;Li YE ,&nbsp;Bing Yu LIANG","doi":"10.3967/bes2023.077","DOIUrl":"10.3967/bes2023.077","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance (HIVDR) in patients with ART failure from 2014 to 2020 in Hainan, China.</p></div><div><h3>Methods</h3><p>A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan. We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with <em>pol</em> sequences. Drug resistance mutations (DRMs) were analyzed using the Stanford University HIV Drug Resistance Database.</p></div><div><h3>Results</h3><p>A total of 307 HIV-infected patients with ART failure were included, and 241 available <em>pol</em> sequences were obtained. Among 241 patients, CRF01_AE accounted for 68.88%, followed by CRF07_BC (17.00%) and eight other subtypes (14.12%). The overall prevalence of HIVDR was 61.41%, and the HIVDR against non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), and protease inhibitors (PIs) were 59.75%, 45.64%, and 2.49%, respectively. Unemployed patients, hypoimmunity or opportunistic infections in individuals, and samples from 2017 to 2020 increased the odd ratios of HIVDR. Also, HIVDR was less likely to affect female patients. The common DRMs to NNRTIs were K103N (21.99%) and Y181C (20.33%), and M184V (28.21%) and K65R (19.09%) were the main DRMs against NRTIs.</p></div><div><h3>Conclusion</h3><p>The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 800-813"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}