Biomedical and Environmental Sciences最新文献

{"title":"Academic Conference on Vaccines Preventing Respiratory Infections Successfully Held in Beijing","authors":"Yuan Yuan XU","doi":"10.3967/bes2023.145","DOIUrl":"10.3967/bes2023.145","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001769/pdfft?md5=b1e833782c872d78ce81c454e59edfc4&pid=1-s2.0-S0895398823001769-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon Chain Length Determines Inhibitory Potency of Perfluoroalkyl Sulfonic Acids on Human Placental 3β-Hydroxysteroid Dehydrogenase 1: Screening, Structure-Activity Relationship, and In Silico Analysis","authors":"Lu Ming TANG ,&nbsp;Bai Ping MAO ,&nbsp;Bing Ru ZHANG ,&nbsp;Jing Jing LI ,&nbsp;Yun Bing TANG ,&nbsp;Hui Tao LI ,&nbsp;Ren Shan GE","doi":"10.3967/bes2023.132","DOIUrl":"10.3967/bes2023.132","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to compare 9 perfluoroalkyl sulfonic acids (PFSA) with carbon chain lengths (C4-C12) to inhibit human placental 3β-hydroxysteroid dehydrogenase 1 (3β-HSD1), aromatase, and rat 3β-HSD4 activities.</p></div><div><h3>Methods</h3><p>Human and rat placental 3β-HSDs activities were determined by converting pregnenolone to progesterone and progesterone secretion in JEG-3 cells was determined using HPLC/MS–MS, and human aromatase activity was determined by radioimmunoassay.</p></div><div><h3>Results</h3><p>PFSA inhibited human 3β-HSD1 structure-dependently in the order: perfluorooctanesulfonic acid (PFOS, half-maximum inhibitory concentration, IC₅₀: 9.03 ± 4.83 µmol/L) &gt; perfluorodecanesulfonic acid (PFDS, 42.52 ± 8.99 µmol/L) &gt; perfluoroheptanesulfonic acid (PFHpS, 112.6 ± 29.39 µmol/L) &gt; perfluorobutanesulfonic acid (PFBS) = perfluoropentanesulfonic acid (PFPS) = perfluorohexanesulfonic acid (PFHxS) = perfluorododecanesulfonic acid (PFDoS) (ineffective at 100 µmol/L). 6:2FTS (1H, 1H, 2H, 2H-perfluorooctanesulfonic acid) and 8:2FTS (1H, 1H, 2H, 2H-perfluorodecanesulfonic acid) did not inhibit human 3β-HSD1. PFOS and PFHpS are mixed inhibitors, whereas PFDS is a competitive inhibitor. Moreover, 1–10 µmol/L PFOS and PFDS significantly reduced progesterone biosynthesis in JEG-3 cells. Docking analysis revealed that PFSA binds to the steroid-binding site of human 3β-HSD1 in a carbon chain length-dependent manner. All 100 µmol/L PFSA solutions did not affect rat 3β-HSD4 and human placental aromatase activity.</p></div><div><h3>Conclusions</h3><p>Carbon chain length determines inhibitory potency of PFSA on human placental 3β-HSD1 in a V-shaped transition at PFOS (C8), with inhibitory potency of PFOS &gt; PFDS &gt; PFHpS &gt; PFBS = PFPS = PFHxS = PFDoS = 6:2FTS = 8:2FTS.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001654/pdf?md5=b5ab5012386bac1ba426c1c3ad215137&pid=1-s2.0-S0895398823001654-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychosomatic Traits of “People with the Five Elements in Traditional Chinese Medicine”: A Qualitative Study","authors":"Jia Jia LI ,&nbsp;Xin Yu YANG ,&nbsp;Hong Jun ZHANG ,&nbsp;Dong Qing YIN ,&nbsp;Jin Tao ZHANG ,&nbsp;Jing Wen CUI ,&nbsp;Jing Dong HAN ,&nbsp;Yan MA ,&nbsp;Hong Xiao JIA","doi":"10.3967/bes2023.136","DOIUrl":"10.3967/bes2023.136","url":null,"abstract":"<div><h3>Objective</h3><p>To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of “people with the five elements in traditional Chinese medicine (TCM).”</p></div><div><h3>Methods</h3><p>Data collected from the literature review, two sessions of brainstorming of experts with related experience in “people with the five elements in TCM” from October 2020 to December 2020, and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed. Triangulation was used in this study, and theming and synthesizing were used to analyze the data.</p></div><div><h3>Results</h3><p>A total of 31 experts and 30 interviewees participated in this study. The median age of the experts and interviewees were 48.0 and 38.5 years, respectively; 51.66% and 54.8% of experts and interviewees, respectively, were men. The descriptors of facial diagrams of “people with the five elements in TCM” were complexion, shape, distribution state of facial bones, convergence trend of facial muscles, and facial expression. A theoretical model of “people with the five elements in TCM” was shaped based on these findings.</p></div><div><h3>Conclusions</h3><p>The study suggests a possibility for bridging the gap between personality and bodily state, identifying an avenue for personality research from the perspective of TCM.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001691/pdf?md5=5bc4bc5f8fa164eb515b0fd421052e1c&pid=1-s2.0-S0895398823001691-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Temperature Changes and Cardiovascular Mortality Risk in A High-latitude City in Northeast China","authors":"He Ping LI ,&nbsp;Yu Xia MA ,&nbsp;Peng Peng QIN ,&nbsp;Wan Ci WANG ,&nbsp;Zong Rui LIU ,&nbsp;Yu Han ZHAO ,&nbsp;Li Jie YANG","doi":"10.3967/bes2023.140","DOIUrl":"10.3967/bes2023.140","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001733/pdf?md5=604d679098c1f91a4282211aa53929ef&pid=1-s2.0-S0895398823001733-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Hypertension Day: Healthy Living, Ideal Blood Pressure","authors":"Yuan Yuan XU","doi":"10.3967/bes2023.146","DOIUrl":"10.3967/bes2023.146","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001770/pdfft?md5=e091eaeaac90b3e53a51f41fe6475266&pid=1-s2.0-S0895398823001770-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DJ1 Ameliorates AD-like Pathology in the Hippocampus of APP/PS1 Mice","authors":"Yang Yang PENG ,&nbsp;Meng Xin LI ,&nbsp;Wen Jie LI ,&nbsp;Yuan XUE ,&nbsp;Yu Fan MIAO ,&nbsp;Yu Lin WANG ,&nbsp;Xiao Chen FAN ,&nbsp;Lu Lu TANG ,&nbsp;SONG Han Lu ,&nbsp;Qian ZHANG ,&nbsp;Xing LI","doi":"10.3967/bes2023.133","DOIUrl":"10.3967/bes2023.133","url":null,"abstract":"<div><h3>Objective</h3><p>To explore whether the protein Deglycase protein 1 (DJ1) can ameliorate Alzheimer's disease (AD)-like pathology in Amyloid Precursor Protein/Presenilin 1 (APP/PS1) double transgenic mice and its possible mechanism to provide a theoretical basis for exploring the pathogenesis of AD.</p></div><div><h3>Methods</h3><p>Adeno-associated viral vectors (AAV) of DJ1-overexpression or DJ1-knockdown were injected into the hippocampus of 7-month-old APP/PS1 mice to construct models of overexpression or knockdown. Mice were divided into the AD model control group (MC), AAV vector control group (NC), DJ1-overexpression group (DJ1+), and DJ1-knockdown group (DJ1^–). After 21 days, the Morris water maze test, immunohistochemistry, immunofluorescence, and western blotting were used to evaluate the effects of DJ1 on mice.</p></div><div><h3>Results</h3><p>DJ1+ overexpression decreased the latency and increased the number of platform traversals in the water maze test. DJ1^– cells were cured and atrophied, and the intercellular structure was relaxed; the number of age spots and the expression of AD-related proteins were significantly increased. DJ1⁺ increased the protein expression of Nuclear factor erythroid 2-related factor 2 (NRF2), heme oxygenase-1 (HO-1), light chain 3 (LC3), phosphorylated AMPK (p-AMPK), and B cell lymphoma-2 (BCL-2), as well as the antioxidant levels of total superoxide dismutase (T-SOD), total antioxidant capacity (T-AOC), and Glutathione peroxidase (GSH-PX), while decreasing the levels of Kelch-like hydrates-associated protein 1 (Keap1), mammalian target of rapamycin (mTOR), p62/sequestosome1 (p62/SQSTM1), Caspase3, and malondialdehyde (MDA).</p></div><div><h3>Conclusions</h3><p>DJ1-overexpression can ameliorate learning, memory, and AD-like pathology in APP/PS1 mice, which may be related to the activation of the NRF2/HO-1 and AMPK/mTOR pathways by DJ1.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001666/pdf?md5=1f9840624819c67dfbc45a0c42900e24&pid=1-s2.0-S0895398823001666-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Diabetes Day: Global Collaboration against Diabetes Challenges, Building a Health Defense Line","authors":"Yuan Yuan XU","doi":"10.3967/bes2023.147","DOIUrl":"10.3967/bes2023.147","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001782/pdfft?md5=cf265ab024a7847d0ee537e7f9a9e26c&pid=1-s2.0-S0895398823001782-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decontamination Efficacy of Disinfection and Doffing of Medical Protective Clothing: A Combined Mannequin and Personnel Study","authors":"Zhong Yi XIE ,&nbsp;Long Xi LU ,&nbsp;Ye LI ,&nbsp;Ling Feng FAN ,&nbsp;Fan Fan YANG ,&nbsp;Ye LU","doi":"10.3967/bes2023.142","DOIUrl":"10.3967/bes2023.142","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001757/pdf?md5=d1fe858fd6b75df07c637e0ff52482db&pid=1-s2.0-S0895398823001757-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Prealbumin and its Combination with NT-proBNP for Predicting in-hospital Mortality in Patients with Heart Failure: Real-World Research Based on Propensity Score Matching","authors":"Bing LIU,&nbsp;Jia Yi XIE","doi":"10.3967/bes2023.139","DOIUrl":"10.3967/bes2023.139","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001721/pdf?md5=be3088681e8b1fc40a88b16270a506db&pid=1-s2.0-S0895398823001721-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum","authors":"Ke YANG ,&nbsp;Ya WEN ,&nbsp;Lei ZHU,&nbsp;Jia Yu BAO,&nbsp;Shang LI,&nbsp;Ying Hui WANG,&nbsp;Jun FENG,&nbsp;Lei TIAN,&nbsp;Ying JIE","doi":"10.3967/bes2023.131","DOIUrl":"10.3967/bes2023.131","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effect of intense pulsed light (IPL) in the treatment of chronic hordeolum.</p></div><div><h3>Methods</h3><p>Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study. According to the severity of hordeolum, the patients were treated with IPL 3 to 5 times. Patients’ satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected. The number, congestion, long diameter, short diameter and area of nodules were also recorded and measured. Finally, eyelid margin signs, meibum quality, meibomian gland expressibility, meibomian gland dropout, tear meniscus height, and corneal fluorescein staining were scored.</p></div><div><h3>Results</h3><p>20 patients were enrolled in this study. The eyelid margins were congestive and swollen, with blunt rounding or irregularity. The meibum was cloudy or toothpaste-like. The meibomian gland expressibility, meibomian gland dropout and tear meniscus height were reduced. The cornea showed scattered fluorescein staining. After treatment, score of visual analog scale, congestion and size of nodules were significantly reduced. Eyelid margin signs, meibum quality, meibomian gland expressibility, tear meniscus height and corneal fluorescein staining scores were improved. Meibomian gland dropout had no significant change. No side effects occurred during treatment.</p></div><div><h3>Conclusions</h3><p>IPL is beneficial for the treatment of chronic hordeolum.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001642/pdf?md5=216520d321fe68373b11f3a10685f87d&pid=1-s2.0-S0895398823001642-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}