Biomedical and Environmental Sciences最新文献_第10页

Impact of the Early Stage of the COVID-19 Pandemic on Smoking Cessation in Beijing 新冠肺炎疫情早期对北京市戒烟的影响

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.054

WANG Yao, LI Xing Ming

引用次数: 1

A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke 一项探讨免疫球蛋白G - n -聚糖与缺血性脑卒中关系的巢式病例对照研究

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.048

WANG Bi Yan , SONG Man Shu , ZHANG Jie , MENG Xiao Ni , XING Wei Jia , WANG You Xin

{"title":"A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke","authors":"WANG Bi Yan , SONG Man Shu , ZHANG Jie , MENG Xiao Ni , XING Wei Jia , WANG You Xin","doi":"10.3967/bes2023.048","DOIUrl":"10.3967/bes2023.048","url":null,"abstract":"<div><h3>Objective</h3><p>This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk.</p></div><div><h3>Methods</h3><p>A nested case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed.</p></div><div><h3>Results</h3><p>A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio (<em>OR</em>) = 0.92, 95% confidence interval (<em>CI</em>): 0.87–0.97; G1<sup>n</sup>: <em>OR</em> = 0.74, 95% <em>CI</em>: 0.63–0.87; G0<sup>n</sup>: <em>OR</em> = 1.12, 95% <em>CI</em>: 1.03–1.22). However, these associations were not found among women.</p></div><div><h3>Conclusion</h3><p>This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 389-396"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China HIV-1在注射吸毒者中的传播主要来源于中国广西当地的流行毒株

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.051

CEN Ping , LIANG Hua Yue , YANG Yuan , ZHANG Fei , YANG Shi Xiong , MO Ju Cong , FENG Yi , HUANG Jie Gang , NING Chuan Yi , HUANG Chun Yuan , YANG Yao , LIANG Na , LIANG Bing Yu , YE Li , LIANG Hao

{"title":"HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China","authors":"CEN Ping , LIANG Hua Yue , YANG Yuan , ZHANG Fei , YANG Shi Xiong , MO Ju Cong , FENG Yi , HUANG Jie Gang , NING Chuan Yi , HUANG Chun Yuan , YANG Yao , LIANG Na , LIANG Bing Yu , YE Li , LIANG Hao","doi":"10.3967/bes2023.051","DOIUrl":"10.3967/bes2023.051","url":null,"abstract":"<div><h3>Objective</h3><p>The mode of human immunodeficiency virus (HIV) transmission <em>via</em> injection drug use (IDU) still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.</p></div><div><h3>Methods</h3><p>We performed a molecular epidemiological investigation of infections across Guangxi from 2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.</p></div><div><h3>Results</h3><p>Among the 535 subjects, CRF08_BC (57.4%), CRF01_AE (28.4%), and CRF07_BC (10.7%) were the top 3 HIV strains; 72.6% of infections were linked to other provinces in the transmission network; 93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces, predominantly Guangdong and Yunnan; 92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.</p></div><div><h3>Conclusion</h3><p>HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces. Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 418-430"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated Classification of Inherited Retinal Diseases in Optical Coherence Tomography Images Using Few-shot Learning 光学相干断层扫描图像中遗传性视网膜疾病的自动分类

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.052

ZHAO Qi , MAI Si Wei , LI Qian , HUANG Guan Chong , GAO Ming Chen , YANG Wen Li , WANG Ge , MA Ya , LI Lei , PENG Xiao Yan

{"title":"Automated Classification of Inherited Retinal Diseases in Optical Coherence Tomography Images Using Few-shot Learning","authors":"ZHAO Qi , MAI Si Wei , LI Qian , HUANG Guan Chong , GAO Ming Chen , YANG Wen Li , WANG Ge , MA Ya , LI Lei , PENG Xiao Yan","doi":"10.3967/bes2023.052","DOIUrl":"10.3967/bes2023.052","url":null,"abstract":"<div><h3>Objective</h3><p>To develop a few-shot learning (FSL) approach for classifying optical coherence tomography (OCT) images in patients with inherited retinal disorders (IRDs).</p></div><div><h3>Methods</h3><p>In this study, an FSL model based on a student–teacher learning framework was designed to classify images. 2,317 images from 189 participants were included. Of these, 1,126 images revealed IRDs, 533 were normal samples, and 658 were control samples.</p></div><div><h3>Results</h3><p>The FSL model achieved a total accuracy of 0.974–0.983, total sensitivity of 0.934–0.957, total specificity of 0.984–0.990, and total F1 score of 0.935–0.957, which were superior to the total accuracy of the baseline model of 0.943–0.954, total sensitivity of 0.866–0.886, total specificity of 0.962–0.971, and total F1 score of 0.859–0.885. The performance of most subclassifications also exhibited advantages. Moreover, the FSL model had a higher area under curves (AUC) of the receiver operating characteristic (ROC) curves in most subclassifications.</p></div><div><h3>Conclusion</h3><p>This study demonstrates the effective use of the FSL model for the classification of OCT images from patients with IRDs, normal, and control participants with a smaller volume of data. The general principle and similar network architectures can also be applied to other retinal diseases with a low prevalence.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 431-440"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seminal Plasma Biochemical Components Mediate the Inverse Association of Microcystin Exposure with Sperm Motility: A Mediation Analysis in Chinese Men 精液生化成分介导微囊藻毒素暴露与精子活力的负相关:中国男性的中介分析

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.056

XU Di Hui , MA Yu Han , YU Wen , ZHOU Xue , LUO Yang , CHEN Ya Bing , HAN Xiao Dong

引用次数: 0

Geographic Distribution of Coal Enterprises and Workers Exposed to Coal Dust in China in 2020 2020年中国煤炭企业及煤尘暴露人员地理分布

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.058

WANG Yu Tong , LI Xin Xin , HU Wei Jiang , WANG Dan , ZHANG Si Yu , LIU An Qi , SUN Xin , WAN Xia

引用次数: 0

Fine Particulate Matter Exposure Induces Toxicity by Regulating Nuclear Factor-κB/toll-like Receptor 4/myeloid Differentiation Primary Response Signaling Pathways in RAW264.7 Cells 细颗粒物暴露通过调节核因子-κB/toll样受体4/髓样分化初级反应信号通路诱导RAW264.7细胞毒性

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.055

ZHENG Mei Zhu , LU Yao , LU Ting Ting , QIN Peng , LI Yu Qiu , SHI Dong Fang

引用次数: 0

Genotyping Characteristics of Human Fecal Escherichia coli and Their Association with Multidrug Resistance in Miyun District, Beijing 北京市密云区人粪便大肠杆菌的基因分型特征及其与多药耐药性的关系

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.050

ZHANG Wei Wei , ZHU Xiao Lin , DENG Le Le , HAN Ya Jun , LI Zhuo Wei , WANG Jin Long , CHEN Yong Liang , WANG Ao Lin , TIAN Er Li , CHENG Bin , XU Lin Hua , CHEN Yi Cong , TIAN Li Li , HE Guang Xue

{"title":"Genotyping Characteristics of Human Fecal Escherichia coli and Their Association with Multidrug Resistance in Miyun District, Beijing","authors":"ZHANG Wei Wei , ZHU Xiao Lin , DENG Le Le , HAN Ya Jun , LI Zhuo Wei , WANG Jin Long , CHEN Yong Liang , WANG Ao Lin , TIAN Er Li , CHENG Bin , XU Lin Hua , CHEN Yi Cong , TIAN Li Li , HE Guang Xue","doi":"10.3967/bes2023.050","DOIUrl":"https://doi.org/10.3967/bes2023.050","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the genotyping characteristics of human fecal <em>Escherichia coli</em> (<em>E. coli</em>) and the relationships between antibiotic resistance genes (ARGs) and multidrug resistance (MDR) of <em>E. coli</em> in Miyun District, Beijing, an area with high incidence of infectious diarrheal cases but no related data.</p></div><div><h3>Methods</h3><p>Over a period of 3 years, 94 <em>E. coli</em> strains were isolated from fecal samples collected from Miyun District Hospital, a surveillance hospital of the National Pathogen Identification Network. The antibiotic susceptibility of the isolates was determined by the broth microdilution method. ARGs, multilocus sequence typing (MLST), and polymorphism trees were analyzed using whole-genome sequencing data (WGS).</p></div><div><h3>Results</h3><p>This study revealed that 68.09% of the isolates had MDR, prevalent and distributed in different clades, with a relatively high rate and low pathogenicity. There was no difference in MDR between the diarrheal (49/70) and healthy groups (15/24).</p></div><div><h3>Conclusion</h3><p>We developed a random forest (RF) prediction model of <em>TEM.1 + baeR + mphA + mphB + QnrS1 + AAC.3-IId</em> to identify MDR status, highlighting its potential for early resistance identification. The causes of MDR are likely mobile units transmitting the ARGs. In the future, we will continue to strengthen the monitoring of ARGs and MDR, and increase the number of strains to further verify the accuracy of the MDR markers.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 406-417"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49843900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential Impact of EIF4E3 and LARP1 on Tumor Immunity in Hepatocellular Carcinoma EIF4E3和LARP1对肝细胞癌肿瘤免疫的潜在影响

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.057

ZHU Wen Li , ZENG Hua , HUANG Dan Ping , OUYANG Wei Jun , WEI Chun Shan , TONG Guang Dong

引用次数: 0

Geographic Variations in the Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Chinese Adults in 2018–2019: A Cross-sectional Study 2018-2019年中国成人血脂异常患病率、认知、治疗和控制的地理差异:一项横断面研究

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-04-01 DOI: 10.3967/bes2023.037

Mei ZHANG , Ke PENG , Xiao ZHANG , Yi Shu LIU , Xiao Ying LIU , Gui Yuan HAN , Yu SHI , Zheng Jing HUANG , Chun LI , Zhen Ping ZHAO , Li Min WANG , Yi Chong LI

{"title":"Geographic Variations in the Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Chinese Adults in 2018–2019: A Cross-sectional Study","authors":"Mei ZHANG , Ke PENG , Xiao ZHANG , Yi Shu LIU , Xiao Ying LIU , Gui Yuan HAN , Yu SHI , Zheng Jing HUANG , Chun LI , Zhen Ping ZHAO , Li Min WANG , Yi Chong LI","doi":"10.3967/bes2023.037","DOIUrl":"10.3967/bes2023.037","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the spatial patterns of the prevalence, awareness, treatment, and control rates of dyslipidemia at the provincial level in China.</p></div><div><h3>Methods</h3><p>A national and provincial representative cross-sectional survey was conducted among 178,558 Chinese adults in 31 provinces in mainland China in 2018–2019, using a multi-stage, stratified, cluster-randomized sampling design. Subjects, as households, were selected, followed by a home visit to collect information. Both descriptive and linear regression procedures were applied in the analyses.</p></div><div><h3>Results</h3><p>The overall prevalence of dyslipidemia was 35.6%, and wide geographic variations of prevalence, treatment, and control rates of dyslipidemia were identified among 178,558 eligible participants with a mean age of 55.1 ± 13.8 years. The highest-lowest difference regarding the provincial level prevalence rates were 19.7% <em>vs.</em> 2.1% for high low-density lipoprotein cholesterol, 16.7% <em>vs.</em> 2.5% for high total cholesterol, 35.9% <em>vs.</em> 5.4% for high triglycerides, and 31.4% <em>vs.</em> 10.5% for low high-density lipoprotein cholesterol. The treatment rate of dyslipidemia was correlated with the socio-demographic index (<em>P</em> < 0.001), urbanization rate (<em>P</em> = 0.01), and affordable basic technologies and essential medicines (<em>P</em> < 0.001).</p></div><div><h3>Conclusion</h3><p>Prevailing dyslipidemia among the Chinese population and its wide geographic variations in prevalence, treatment, and control suggest that China needs both integrated and localized public health strategies across provinces to improve lipid management.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 4","pages":"Pages 313-323"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9738548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0