Biomedical and Environmental Sciences最新文献_第9页

Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects* 焦炉排放诱导线粒体DNA拷贝数损伤效应的基准剂量评估*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.060

YAN Zhao Fan , GU Zhi Guang , FAN Ya Hui , LI Xin Ling , NIU Ze Ming , DUAN Xiao Ran , Mallah Ali Manthar , ZHANG Qiao , YANG Yong Li , YAO Wu , WANG Wei

{"title":"Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects*","authors":"YAN Zhao Fan , GU Zhi Guang , FAN Ya Hui , LI Xin Ling , NIU Ze Ming , DUAN Xiao Ran , Mallah Ali Manthar , ZHANG Qiao , YANG Yong Li , YAO Wu , WANG Wei","doi":"10.3967/bes2023.060","DOIUrl":"10.3967/bes2023.060","url":null,"abstract":"<div><h3>Objective</h3><p>The study aimed to estimate the benchmark dose (BMD) of coke oven emissions (COEs) exposure based on mitochondrial damage with the mitochondrial DNA copy number (mtDNAcn) as a biomarker.</p></div><div><h3>Methods</h3><p>A total of 782 subjects were recruited, including 238 controls and 544 exposed workers. The mtDNAcn of peripheral leukocytes was detected through the real-time fluorescence-based quantitative polymerase chain reaction. Three BMD approaches were used to calculate the BMD of COEs exposure based on the mitochondrial damage and its 95% confidence lower limit (BMDL).</p></div><div><h3>Results</h3><p>The mtDNAcn of the exposure group was lower than that of the control group (0.60 ± 0.29 <em>vs.</em> 1.03 ± 0.31; <em>P</em> < 0.001). A dose–response relationship was shown between the mtDNAcn damage and COEs. Using the Benchmark Dose Software, the occupational exposure limits (OELs) for COEs exposure in males was 0.00190 mg/m<sup>3</sup>. The OELs for COEs exposure using the BBMD were 0.00170 mg/m<sup>3</sup> for the total population, 0.00158 mg/m<sup>3</sup> for males, and 0.00174 mg/m<sup>3</sup> for females. In possible risk obtained from animal studies (PROAST), the OELs of the total population, males, and females were 0.00184, 0.00178, and 0.00192 mg/m<sup>3</sup> respectively.</p></div><div><h3>Conclusion</h3><p>Based on our conservative estimate, the BMDL of mitochondrial damage caused by COEs is 0.002 mg/m<sup>3</sup>. This value will provide a benchmark for determining possible OELs.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 6","pages":"Pages 490-500"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved Specificity for Breast Cancer Screening Using an Oncogenic (miRNA-21) and a Gene Suppressor (miRNA-195) miRNA in the Serum for a Point of Care (POC) Screening Solution 在用于护理点（POC）筛查溶液的血清中使用癌原性（miRNA-21）和基因抑制因子（miRNA-195）miRNA提高癌症筛查的特异性

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.067

Krishnamoorthy Kokilavani , Ancy Terryna Chanayiltharayil John , Bindu Salim , Madhulika Vijayakumar , Sankar Ganesh Jeyaraj

引用次数: 0

Trends of Oral Cancer Mortality in China from 1990 to 2019 and a 15-Year Predictive Analysis Based on a Bayesian Age-Period-Cohort Model* 1990～2019年中国口腔癌症死亡率趋势及基于Bayesian Age-Period-Coort模型的15年预测分析*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.068

GU Jian Chang , SONG Ji Wu , LIU Yun , WANG Xiao Lan , XU Shuang Shuang , ZHANG Liang Liang , LIU Yun Xia , DING Gang

引用次数: 0

Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China* 国产贝达奎林联合化疗方案治疗耐多药结核病的成本-效果分析*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.061

XU Cai Hong , QIU Ying Peng , HE Zi Long , HU Dong Mei , YUE Xiao , CHEN Zhong Dan , XU Yuan Yuan , ZHAO Yan Lin

{"title":"Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China*","authors":"XU Cai Hong , QIU Ying Peng , HE Zi Long , HU Dong Mei , YUE Xiao , CHEN Zhong Dan , XU Yuan Yuan , ZHAO Yan Lin","doi":"10.3967/bes2023.061","DOIUrl":"10.3967/bes2023.061","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline (BR) and the conventional treatment regimen (CR, not containing Bedaquiline) for the treatment of adults with multidrug-resistant tuberculosis (MDR-TB) in China.</p></div><div><h3>Methods</h3><p>A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years. The model parameter data were synthesized from the literature, the national TB surveillance information system, and consultation with experts. The incremental cost-effectiveness ratio (ICER) of BR <em>vs</em>. CR was determined.</p></div><div><h3>Results</h3><p>BR (<em>vs</em>. CR) had a higher sputum culture conversion rate and cure rate and prevented many premature deaths (decreased by 12.8%), thereby obtaining more quality-adjusted life years (QALYs) (increased by 2.31 years). The per capita cost in BR was as high as 138,000 yuan, roughly double that of CR. The ICER for BR was 33,700 yuan/QALY, which was lower than China’s 1× per capita Gross Domestic Product (GDP) in 2020 (72,400 yuan).</p></div><div><h3>Conclusion</h3><p>BR is shown to be cost effective. When the unit price of Bedaquiline reaches or falls below 57.21 yuan per unit, BR is expected to be the dominant strategy in China over CR.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 6","pages":"Pages 501-509"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10493960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma* 18F-FDG PET/CT对新诊断弥漫性大B细胞淋巴瘤骨髓浸润的诊断价值*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.062

GUO Bo , QIN Ran , GU Zhen Yang , LI Yan Fen , GAO Lei , HUANG Wen Rong

{"title":"Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma*","authors":"GUO Bo , QIN Ran , GU Zhen Yang , LI Yan Fen , GAO Lei , HUANG Wen Rong","doi":"10.3967/bes2023.062","DOIUrl":"https://doi.org/10.3967/bes2023.062","url":null,"abstract":"<div><h3>Objective</h3><p>Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL.</p></div><div><h3>Methods</h3><p>A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and <sup>18</sup>F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of <sup>18</sup>F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described.</p></div><div><h3>Results</h3><p>The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy (<em>P</em> = 0.302) or between the two bone marrow biopsies (<em>P</em> = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% <em>CI</em>, 0.759–0.979), 0.934 (95% <em>CI</em>, 0.855–0.972), and 0.857, respectively.</p></div><div><h3>Conclusion</h3><p><sup>18</sup>F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 6","pages":"Pages 510-516"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49846811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of Ambient Air Pollution on Risk Assessment of Type 2 Diabetes Mellitus via Explainable Machine Learning* 环境空气污染对2型糖尿病风险评估的贡献——基于可解释机器学习*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.069

DING Zhong Ao , ZHANG Li Ying , LI Rui Ying , NIU Miao Miao , ZHAO Bo , DONG Xiao Kang , LIU Xiao Tian , HOU Jian , MAO Zhen Xing , WANG Chong Jian

引用次数: 0

A Rapid and Accurate CRISPR/Cas12b-Mediated Genotyping Assay for the Methylenetetrahydrofolate Reductase Gene Polymorphism C677T* 一种快速准确的CRISPR/Cas12b介导的亚甲基四氢叶酸还原酶基因C677T多态性基因分型方法*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.070

SI Xin Xin , ZHANG Quan , LUO Zhi Dan , ZHANG Zhen Yu , WANG Yan , SHAO Li Pei

引用次数: 0

Differences in Pandemic-Related Factors Associated with Alcohol and Substance Use among Korean Adolescents: Nationwide Representative Study* 韩国青少年与酒精和药物使用相关的流行病相关因素的差异：全国代表性研究*

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI: 10.3967/bes2023.066

Hyunju Yon , Sangil Park , Jung U Shin , Ai Koyanagi , Louis Jacob , Lee Smith , Chanyang Min , Jinseok Lee , Rosie Kwon , Guillaume Fond , Laurent Boyer , Sunyoung Kim , Namwoo Kim , Sang Youl Rhee , Jae Il Shin , Dong Keon Yon , Ho Geol Woo

引用次数: 1

Clinical Evaluation of a Vancomycin Dosage Strategy Based on a Serum Trough Concentration Model in Elderly Patients with Severe Pneumonia 基于血清谷浓度模型的老年重症肺炎万古霉素剂量策略的临床评价

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.049

YAN Wei , SUN Xiao Yan , WANG Meng, ZHAO Fei Fan, ZHOU Qing Tao

{"title":"Clinical Evaluation of a Vancomycin Dosage Strategy Based on a Serum Trough Concentration Model in Elderly Patients with Severe Pneumonia","authors":"YAN Wei , SUN Xiao Yan , WANG Meng, ZHAO Fei Fan, ZHOU Qing Tao","doi":"10.3967/bes2023.049","DOIUrl":"10.3967/bes2023.049","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate the clinical benefits of a vancomycin dosage strategy based on a serum trough concentration model in elderly patients.</p></div><div><h3>Methods</h3><p>This prospective single-center, open-label, randomized controlled trial categorized 66 elderly patients with severe pneumonia into study and control groups. The control group received vancomycin using a regimen decided by the attending physician. Meanwhile, the study group received individualized vancomycin therapy with a dosing strategy based on a serum trough concentration model. The primary endpoint was the proportion of patients with serum trough concentrations reaching the target values. The secondary endpoints were clinical response, vancomycin treatment duration, and vancomycin-associated acute kidney injury (VA-AKI) occurrence.</p></div><div><h3>Results</h3><p>All patients were at least 60 years old (median age = 81 years). The proportion of patients with target trough concentration achievement (≥ 15 mg/L) with the initial vancomycin regimen was significantly higher in the study group compared to the control group (75.8% <em>vs</em>. 42.4%, <em>P</em> = 0.006). Forty-five patients (68.2%) achieved clinical success, the median duration of vancomycin therapy was 10.0 days, and VA-AKI occurred in eight patients (12.1%). However, there were no significant differences in these parameters between the two groups. The model for predicting vancomycin trough concentrations was upgraded to: serum trough concentration (mg/L) = 17.194 − 0.104 × creatinine clearance rate (mL/min) + 0.313 × vancomycin daily dose [(mg/(kg·d)].</p></div><div><h3>Conclusion</h3><p>A vancomycin dosage strategy based on a serum trough concentration model can improve the proportion of patients achieving target trough concentrations in elderly patients with severe pneumonia.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 397-405"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional Chinese Medicine Treatment, Gua Sha, can Induce Subtle Molecular Changes in Gene Expression 中药治疗，瓜沙，可以诱导基因表达的细微分子变化

3区医学

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI: 10.3967/bes2023.053

QI Fei , CAI Ye , CHEN Jun Jie , CHEN Chun Li , HAN Xue Er , XIA Qiu , KAPRANOV Philipp

{"title":"Traditional Chinese Medicine Treatment, Gua Sha, can Induce Subtle Molecular Changes in Gene Expression","authors":"QI Fei , CAI Ye , CHEN Jun Jie , CHEN Chun Li , HAN Xue Er , XIA Qiu , KAPRANOV Philipp","doi":"10.3967/bes2023.053","DOIUrl":"10.3967/bes2023.053","url":null,"abstract":"<div><h3>Objective</h3><p>Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies — yet remaining almost entirely unexplored by the modern-day high-throughput methods of the <em>-omics</em> sciences.</p></div><div><h3>Methods</h3><p>We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.</p></div><div><h3>Results</h3><p>We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.</p></div><div><h3>Conclusion</h3><p>The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 441-451"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0