18F-FDG PET/CT对新诊断弥漫性大B细胞淋巴瘤骨髓浸润的诊断价值*

IF 3 3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences Pub Date : 2023-06-01 DOI:10.3967/bes2023.062

GUO Bo , QIN Ran , GU Zhen Yang , LI Yan Fen , GAO Lei , HUANG Wen Rong

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引用次数: 0

摘要

目的弥漫性大B细胞淋巴瘤（DLBCL）通常与骨髓浸润有关，2-脱氧-2-（18F）氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）对DLBCL的骨髓浸润具有潜在的诊断意义。在最初诊断时进行骨髓活检和18F-FDG PET/CT检查。用Kappa试验评价18F-FDG PET/CT与金标准的一致性，并描述了DLBCL骨髓浸润在PET/CT上的成像特征。结果PET/CT对DLBCL骨髓浸润的诊断敏感性、特异性和Youden指数分别为0.923（95%CI，0.759–0.979）、0.934（95%CI，0.855–0.972）和0.857，分别地结论18F-FDGPET/CT对DLBCL骨髓浸润的诊断具有可比性。PET/CT引导下骨髓活检可减少DLBCL骨髓浸润的误诊。

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Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma*

Objective

Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL.

Methods

A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and ¹⁸F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of ¹⁸F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described.

Results

The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy (P = 0.302) or between the two bone marrow biopsies (P = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% CI, 0.759–0.979), 0.934 (95% CI, 0.855–0.972), and 0.857, respectively.

Conclusion

¹⁸F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.

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来源期刊

Biomedical and Environmental Sciences 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

2.60

自引率

8.60%

发文量

2170

审稿时长

1.0 months

期刊介绍： Biomedical and Environmental Sciences (BES) is a peer-reviewed journal jointly established by the Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, and is published monthly by Elsevier. It is indexed by SCI, PubMed, and CA. Topics covered by BES include infectious disease prevention, chronic and non-communicable disease prevention, disease control based on preventive medicine, and public health theories. It also focuses on the health impacts of environmental factors in people''s daily lives and work, including air quality, occupational hazards, and radiation hazards. Article types considered for publication include original articles, letters to the editor, reviews, research highlights, and policy forum.