HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China

IF 3 3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences Pub Date : 2023-05-01 DOI:10.3967/bes2023.051

CEN Ping , LIANG Hua Yue , YANG Yuan , ZHANG Fei , YANG Shi Xiong , MO Ju Cong , FENG Yi , HUANG Jie Gang , NING Chuan Yi , HUANG Chun Yuan , YANG Yao , LIANG Na , LIANG Bing Yu , YE Li , LIANG Hao

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引用次数: 0

Abstract

Objective

The mode of human immunodeficiency virus (HIV) transmission via injection drug use (IDU) still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.

Methods

We performed a molecular epidemiological investigation of infections across Guangxi from 2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.

Results

Among the 535 subjects, CRF08_BC (57.4%), CRF01_AE (28.4%), and CRF07_BC (10.7%) were the top 3 HIV strains; 72.6% of infections were linked to other provinces in the transmission network; 93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces, predominantly Guangdong and Yunnan; 92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.

Conclusion

HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces. Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.

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HIV-1在注射吸毒者中的传播主要来源于中国广西当地的流行毒株

目的人类免疫缺陷病毒（HIV）通过注射吸毒（IDU）传播的模式仍然存在，并且最近与注射吸毒相关的HIV感染传播的转变在很大程度上是未知的。本研究旨在分析广西地区HIV-1通过注射吸毒传播的时空来源和动态。方法对广西2009～2019年感染者进行分子流行病学调查。对HIV-1序列进行系统发育和贝叶斯时间地理分析，结合流行病学数据确认注射吸毒者之间的传播特征。结果535名受试者中，CRF08_BC（57.4%）、CRF01_AE（28.4%）和CRF07_BC（10.7%）为前3名；72.6%的感染与传播网络中的其他省份有关；93.6%的序列传播毒株为本地特有毒株，其余来自其他省份，主要是广东和云南；注射吸毒人群中92.1%的HIV传播倾向于在HIV阳性的注射吸毒者之间传播。结论HIV重组体具有高度的多样性，流行的本地毒株是广西注射吸毒者的传播源。然而，仍有注射吸毒者病例与其他省份有关。应扩大传统预防策略的覆盖范围，并加强广西、云南和广东省之间的省际合作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Environmental Sciences 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

2.60

自引率

8.60%

发文量

2170

审稿时长

1.0 months

期刊介绍： Biomedical and Environmental Sciences (BES) is a peer-reviewed journal jointly established by the Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, and is published monthly by Elsevier. It is indexed by SCI, PubMed, and CA. Topics covered by BES include infectious disease prevention, chronic and non-communicable disease prevention, disease control based on preventive medicine, and public health theories. It also focuses on the health impacts of environmental factors in people''s daily lives and work, including air quality, occupational hazards, and radiation hazards. Article types considered for publication include original articles, letters to the editor, reviews, research highlights, and policy forum.