Biomedical and Environmental Sciences最新文献

{"title":"Ambient Temperature and Risk of Outpatient Chronic Pharyngitis Visits: A Time-series Analysis in Xinxiang, China","authors":"Wen Juan LIANG , Ling CHAO , Xiang Mei ZHAO , Rong Guang ZHANG , Rui Qing ZHAO , Wei Dong WU , Jie SONG","doi":"10.3967/bes2023.126","DOIUrl":"10.3967/bes2023.126","url":null,"abstract":"Chronic pharyngitis (CP) is a prevalent medical condition in the field of otorhinolaryngology characterized by persistent inflammation of the pharyngeal mucosa, submucosa","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 991-995"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001563/pdfft?md5=025a072df48ebd46e13a297efeea9f83&pid=1-s2.0-S0895398823001563-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Thyroglobulin and Thyroid Function in Pregnant Women between Counties with a Median Urinary Iodine Concentration of 100–149 μg/L and 150–249 μg/L","authors":"Di Qun CHEN ,&nbsp;Ying YE ,&nbsp;Jia Ni WU ,&nbsp;Ying LAN ,&nbsp;Mu Hua WANG ,&nbsp;Xiao Yan WU ,&nbsp;Meng HE ,&nbsp;Li Jin WANG ,&nbsp;Xin Yi ZHENG ,&nbsp;Zhi Hui CHEN","doi":"10.3967/bes2023.076","DOIUrl":"10.3967/bes2023.076","url":null,"abstract":"<div><h3>Objective</h3><p>This study explored whether thyroglobulin and thyroid disease prevalence rates were higher in pregnant Chinese women with a median urinary iodine concentration of 100–149 μg/L, compared with those with a median urinary iodine concentration of 150–249 μg/L maintained through sustainable universal salt iodization.</p></div><div><h3>Methods</h3><p>This was a cross-sectional study in which 812 healthy pregnant women were enrolled to collect samples of their household edible salt, urine, and blood during their routine antenatal care in the 18 counties in Fujian Province, China. The levels of salt iodine concentration, urinary iodine concentration (UIC), free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), thyroid peroxidase antibody and thyroglobulin antibody were assessed during the routine antenatal care visits.</p></div><div><h3>Results</h3><p>The median UIC (mUIC) in pregnant women was 130.8 μg/L (interquartile range = 91.5–198.1 μg/L) in the counties with an mUIC of 100–149 μg/L (Group I), and 172.0 μg/L (interquartile range = 123.5–244.4 μg/L) in the counties with an mUIC of 150–249 μg/L (Group II). Goiter prevalence and thyroid nodule detection rates showed no difference between Group I and Group II (<em>P</em> &gt; 0.05). Except for FT4 values, the TSH, FT4, FT3, Tg and Tg values &gt; 40 (μg/L) and the thyroid diseases prevalence rate (TDR) showed no significant differences between Group I and Group II (<em>P</em> &gt; 0.05), whether or not iodine supplementation measures were taken.</p></div><div><h3>Conclusion</h3><p>Compared with an mUIC of 150–249 μg/L, not only there was no difference in thyroid morphology, but also the Tg value, rate of Tg values &gt; 40 μg/L, and TDR were not higher in pregnant women in the counties with an mUIC of 100–149 μg/L achieved through sustainable universal salt iodization in Fujian Province, China.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 917-929"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001472/pdf?md5=b9ef77215c3fdadb47bb6dffe57445c6&pid=1-s2.0-S0895398823001472-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of TiO2 Nanospikes for Dual Antibacterial Activity","authors":"Ze Ping LI ,&nbsp;Zhi Yuan CHEN ,&nbsp;Ming Yan YANG ,&nbsp;Wei Song YI","doi":"10.3967/bes2023.124","DOIUrl":"10.3967/bes2023.124","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 983-986"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S089539882300154X/pdfft?md5=210167339ee759b0780556f6bb504897&pid=1-s2.0-S089539882300154X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of Pretreatment Inflammation-nutrition Score to Predict Non-response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer","authors":"Guo Chao ZHANG ,&nbsp;Yan Yan XU ,&nbsp;Ying Chao WU ,&nbsp;Nuo CHENG ,&nbsp;Rui LIAN ,&nbsp;Xin WANG","doi":"10.3967/bes2023.121","DOIUrl":"10.3967/bes2023.121","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the value of pretreatment inflammatory-nutritional biomarkers in predicting the pathological response of locally advanced rectal cancer (LARC) after neoadjuvant chemotherapy (nCT).</p></div><div><h3>Methods</h3><p>This retrospective study included eligible participants who underwent nCT followed by radical surgery. Pretreatment inflammatory nutritional biomarkers were calculated within one week prior to nCT. Correlations between biomarkers and pathological responses were analyzed. The cut-off values of the pretreatment biomarkers for predicting non-response were determined using receiver operating characteristic (ROC) curve analysis. The inflammation-nutrition score was calculated using the lymphocyte level, neutrophil-to-lymphocyte ratio (NLR), and prognostic nutritional index (PNI).</p></div><div><h3>Results</h3><p>A total of 235 patients were retrospectively recruited between January 2017 and September 2022. Lower lymphocyte levels, lymphocyte monocyte ratio (LMR), and PNI, and higher NLR and platelet-to-lymphocyte ratio (PLR) were observed in patients without response. Multivariate logistic regression analysis revealed that NLR could independently predict non-response to nCT in patients with LARC. The sensitivity and specificity of the inflammation-nutrition score for predicting nonresponse were 71.2% and 61.7%, respectively.</p></div><div><h3>Conclusion</h3><p>The pretreatment inflammation-nutrition score is a practical parameter for predicting nonresponse to nCT in patients with LARC. Patients with high scores were more likely to respond poorly to nCT.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 940-948"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001496/pdf?md5=e23f4c249615890ec588687950acdadb&pid=1-s2.0-S0895398823001496-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Tumor Prevention and Control, Building a Healthy China","authors":"","doi":"10.3967/bes2023.129","DOIUrl":"10.3967/bes2023.129","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Page 1001"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001599/pdfft?md5=01f2d7b59024433d8bf88ff48cb8699a&pid=1-s2.0-S0895398823001599-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aurora A Kinase Plays a Key Role in Mitosis Skip during Senescence Induced by Ionizing Radiation","authors":"Xu Rui ZHANG ,&nbsp;Tong Shan ZHANG ,&nbsp;Ya Nan ZHANG ,&nbsp;Jun Rui HUA ,&nbsp;Ju Fang WANG ,&nbsp;Jin Peng HE","doi":"10.3967/bes2023.119","DOIUrl":"10.3967/bes2023.119","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the fate and underlying mechanisms of G2 phase arrest in cancer cells elicited by ionizing radiation (IR).</p></div><div><h3>Methods</h3><p>Human melanoma A375 and 92-1 cells were treated with X-rays radiation or Aurora A inhibitor MLN8237 (MLN) and/or p21 depletion by small interfering RNA (siRNA). Cell cycle distribution was determined using flow cytometry and a fluorescent ubiquitin-based cell cycle indicator (FUCCI) system combined with histone H3 phosphorylation at Ser10 (pS10 H3) detection. Senescence was assessed using senescence-associated-β-galactosidase (SA-β-Gal), Ki67, and γH2AX staining. Protein expression levels were determined using western blotting.</p></div><div><h3>Results</h3><p>Tumor cells suffered severe DNA damage and underwent G2 arrest after IR treatment. The damaged cells did not successfully enter M phase nor were they stably blocked at G2 phase but underwent mitotic skipping and entered G1 phase as tetraploid cells, ultimately leading to senescence in G1. During this process, the p53/p21 pathway is hyperactivated. Accompanying p21 accumulation, Aurora A kinase levels declined sharply. MLN treatment confirmed that Aurora A kinase activity is essential for mitosis skipping and senescence induction.</p></div><div><h3>Conclusion</h3><p>Persistent p21 activation during IR-induced G2 phase blockade drives Aurora A kinase degradation, leading to senescence <em>via</em> mitotic skipping.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 903-916"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001460/pdf?md5=1e3a788d7bf8adbbbe9555026d883bc7&pid=1-s2.0-S0895398823001460-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Trends in the Prevalence of Cigarette and E-cigarette Smoking among Korean Adults between 2014–2021: A Representative Serial Study of 1.2 Million Individuals","authors":"Minji Kim ,&nbsp;Wonyoung Cho ,&nbsp;Jinseok Lee ,&nbsp;Yong Sung Choi ,&nbsp;Seung Geun Yeo ,&nbsp;Young Joo Lee ,&nbsp;Sang Youl Rhee ,&nbsp;Chanyang Min ,&nbsp;Dong Keon Yon","doi":"10.3967/bes2023.127","DOIUrl":"10.3967/bes2023.127","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 996-998"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001575/pdfft?md5=56606983df93b27af5b11c24cd675c0a&pid=1-s2.0-S0895398823001575-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive View on the Progress of Organoid Research with an Emphasis on its Relevance to Disease Characterization","authors":"Chandra KISHORE ,&nbsp;Vaishali Ji ,&nbsp;Saurav Mallik ,&nbsp;Ayan MUKHERJI ,&nbsp;Namrata TOMAR ,&nbsp;Soumen Kumar Pati ,&nbsp;Ai Min LI ,&nbsp;Sinthia Roy BANERJEE ,&nbsp;Soumadip GHOSH ,&nbsp;Raza Ali NAQVI","doi":"10.3967/bes2023.083","DOIUrl":"10.3967/bes2023.083","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 959-971"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001514/pdf?md5=545c3e5347ea431a35b7037fc2e504bd&pid=1-s2.0-S0895398823001514-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Containing the GGDEF Domain Affects Motility and Biofilm Formation in Vibrio cholerae and is Negatively Regulated by Fur and HapR","authors":"He GAO ,&nbsp;Li Zhi MA ,&nbsp;Qin QIN ,&nbsp;Yao CUI ,&nbsp;Xiao Han MA ,&nbsp;Yi Quan ZHANG ,&nbsp;Biao KAN","doi":"10.3967/bes2023.080","DOIUrl":"10.3967/bes2023.080","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate whether the VCA0560 gene acts as an active diguanylate cyclase (DGC) in <em>Vibrio cholerae</em> and how its transcription is regulated by Fur and HapR.</p></div><div><h3>Methods</h3><p>The roles of VCA0560 was investigated by utilizing various phenotypic assays, including colony morphological characterization, crystal violet staining, Cyclic di-GMP (c-di-GMP) quantification, and swimming motility assay. The regulation of the VCA0560 gene by Fur and HapR was analyzed by luminescence assay, electrophoretic mobility shift assay, and DNase I footprinting.</p></div><div><h3>Results</h3><p>VCA0560 gene mutation did not affect biofilm formation, motility, and c-di-GMP synthesis in <em>V. cholerae</em>, and its overexpression remarkably enhanced biofilm formation and intracellular c-di-GMP level but reduced motility capacity. The transcription of the VCA0560 gene was directly repressed by Fur and the master quorum sensing regulator HapR.</p></div><div><h3>Conclusion</h3><p>Overexpressed VCA0560 functions as an active DGC in <em>V. cholerae</em>, and its transcription is repressed by Fur and HapR.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 949-958"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001502/pdf?md5=2eab2e0d9bde367f4c794beb1cc65463&pid=1-s2.0-S0895398823001502-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Mitochondrial DNA Methylation and Hypertension Risk: A Cross-sectional Study in Chinese Northern Population","authors":"Lei ZHAO ,&nbsp;Ya Ning JIA ,&nbsp;Qi Si Jing LIU ,&nbsp;Zi Quan LIU ,&nbsp;Hui Shu LIN ,&nbsp;Xin Ying SHUI ,&nbsp;Li Qiong GUO ,&nbsp;Shi Ke HOU","doi":"10.3967/bes2023.122","DOIUrl":"10.3967/bes2023.122","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 10","pages":"Pages 972-978"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0895398823001526/pdfft?md5=9021951294ea0f089df618b76cad783e&pid=1-s2.0-S0895398823001526-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}