HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province, China, 2014–2020

IF 3 3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences Pub Date : 2023-09-01 DOI:10.3967/bes2023.077

De E YU , Yu Jun XU , Mu LI , Yuan YANG , Hua Yue LIANG , Shan Mei ZHONG , Cai QIN , Ya Nan LAN , Da Wei LI , Ji Peng YU , Yuan PANG , Xue Qiu QIN , Hao LIANG , Kao Kao ZHU , Li YE , Bing Yu LIANG

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引用次数: 0

Abstract

Objective

This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance (HIVDR) in patients with ART failure from 2014 to 2020 in Hainan, China.

Methods

A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan. We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol sequences. Drug resistance mutations (DRMs) were analyzed using the Stanford University HIV Drug Resistance Database.

Results

A total of 307 HIV-infected patients with ART failure were included, and 241 available pol sequences were obtained. Among 241 patients, CRF01_AE accounted for 68.88%, followed by CRF07_BC (17.00%) and eight other subtypes (14.12%). The overall prevalence of HIVDR was 61.41%, and the HIVDR against non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), and protease inhibitors (PIs) were 59.75%, 45.64%, and 2.49%, respectively. Unemployed patients, hypoimmunity or opportunistic infections in individuals, and samples from 2017 to 2020 increased the odd ratios of HIVDR. Also, HIVDR was less likely to affect female patients. The common DRMs to NNRTIs were K103N (21.99%) and Y181C (20.33%), and M184V (28.21%) and K65R (19.09%) were the main DRMs against NRTIs.

Conclusion

The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.

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2014-2020年，中国海南省抗逆转录病毒治疗病毒学失败患者中HIV-1亚型多样性和影响耐药性的因素。

目的：本研究旨在了解海南省2014年至2020年抗逆转录病毒治疗失败患者的HIV-1亚型分布和HIV耐药性。方法：对海南省抗逆转录病毒疗法失败的HIV/AIDS患者进行为期7年的横断面研究。我们使用在线分型工具和最大似然系统发育树来确认具有pol序列的HIV亚型。使用斯坦福大学HIV耐药性数据库对耐药突变（DRM）进行分析。结果：共纳入307名ART失败的HIV感染患者，获得241个可用的pol序列。241例患者中，CRF01_AE占68.88%，其次是CRF07_BC（17.00%）和其他8种亚型（14.12%）。HIVDR的总患病率为61.41%，针对非核苷逆转录酶抑制剂（NNRTI）、核苷酸逆转录酶抑制剂和蛋白酶抑制剂（PI）的HIVDR分别为59.75%、45.64%和2.49%。2017年至2020年的失业患者、个体免疫力低下或机会性感染以及样本增加了HIVDR的奇数比例。此外，HIVDR对女性患者的影响较小。对NNRTI常见的DRMs为K103N（21.99%）和Y181C（20.33%），而M184V（28.21%）和K65R（19.09%）是对NRTI的主要DRMs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Environmental Sciences 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

2.60

自引率

8.60%

发文量

2170

审稿时长

1.0 months

期刊介绍： Biomedical and Environmental Sciences (BES) is a peer-reviewed journal jointly established by the Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, and is published monthly by Elsevier. It is indexed by SCI, PubMed, and CA. Topics covered by BES include infectious disease prevention, chronic and non-communicable disease prevention, disease control based on preventive medicine, and public health theories. It also focuses on the health impacts of environmental factors in people''s daily lives and work, including air quality, occupational hazards, and radiation hazards. Article types considered for publication include original articles, letters to the editor, reviews, research highlights, and policy forum.