Brain and Cognition最新文献

Exploring the impact of white matter hyperintensities on gray matter atrophy and cognitive decline 探讨白质高信号对灰质萎缩和认知能力下降的影响

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-05-15 DOI: 10.1016/j.bandc.2025.106316

Zhongfeng Xie , Qiang Yu , Peiying Chen , Xiereniguli Anayiti , Mengling Tao , Yongsheng Xiang , Xiaowen Xu , Peijun Wang

{"title":"Exploring the impact of white matter hyperintensities on gray matter atrophy and cognitive decline","authors":"Zhongfeng Xie , Qiang Yu , Peiying Chen , Xiereniguli Anayiti , Mengling Tao , Yongsheng Xiang , Xiaowen Xu , Peijun Wang","doi":"10.1016/j.bandc.2025.106316","DOIUrl":"10.1016/j.bandc.2025.106316","url":null,"abstract":"<div><div>White matter hyperintensities (WMHs) are linked to gray matter volume (GMV) and cognitive abilities in Alzheimer’s disease (AD). However, the detailed patterns of how WMHs affect brain structure and cognition in AD require more study. We examined 42 AD patients, 54 with mild cognitive impairment, and 59 normal controls. Using various correlation analyses, we explored the relationships between WMHs, GMV, and cognitive function. The findings indicate that WMHs significantly influence brain atrophy in AD, with total WMHs volume, subcortical WMHs volume, and the largest single WMH volume having the most impact. Subcortical WMHs volume notably affected Instrumental Activities of Daily Living scores, while the largest WMH volume influenced cognitive measures. These results highlight that specific WMH subtypes, especially subcortical volume and large lesions, play a pivotal role in GMV atrophy and cognitive decline in AD. our results support a neurovascular mechanism driving neurodegeneration, emphasizing the importance of early interventions targeting vascular issues to slow AD progression.</div><div><strong>Key points:</strong> The study investigated specific subtypes of white matter hyperintensities, revealing their impact on gray matter atrophy and cognitive decline, to identify potential biomarkers for Alzheimer’s disease progression.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106316"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-05-15 DOI: 10.1016/j.bandc.2025.106306

Arman Deep Singh, Mukesh Kumar, B.H. Swathi, P. Bhargavi, Ashwini Godbole, Subash Khushu

{"title":"Age-related cortical changes and cognitive performance in healthy adults","authors":"Arman Deep Singh, Mukesh Kumar, B.H. Swathi, P. Bhargavi, Ashwini Godbole, Subash Khushu","doi":"10.1016/j.bandc.2025.106306","DOIUrl":"10.1016/j.bandc.2025.106306","url":null,"abstract":"<div><div>Aging is a continuous process with cortical thinning as a common consequence. This study aimed to evaluate cortical thickness, volume and area differences associated with age in healthy population.</div><div>Seventy-six healthy individuals were divided into three age groups: younger (25–40 years, n = 25), middle-aged (41–55 years, n = 24), and older (56–80 years, n = 27). The elderly group exhibited significantly reduced cortical gray matter in frontal regions (left rostral middle frontal, bilateral lateral orbitofrontal, precentral gyri), temporal (middle temporal, right superior temporal, right inferior temporal), limbic regions (left insula, left posterior cingulate gyrus), occipital (right cuneus, lateral occipital, right lateral occipital), and parietal (precuneus and left postcentral gyri) compared to the younger group.</div><div>Older adults exhibited age-related decline in performance of auditory verbal learning (AVL) and recall memory, working memory, visuo-motor coordination, compared to younger adults. Thinning of the left posterior cingulate gyrus is positively correlated with auditory verbal learning performance in middle and older age groups. Total and bilateral cortical thickness and volumes were found to be negatively correlated with age.</div><div>The present study shows the impact of aging on cortical thickness, volume and cognitive performance and have implications in the management of cognitive decline in the ageing population including prophylactic interventions thereof.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106306"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of chronic pain on memory: A systematic review and meta-analysis exploring the impact of nociceptive, neuropathic and nociplastic pain 慢性疼痛对记忆的影响：一项系统回顾和荟萃分析，探讨伤害性、神经性和伤害性疼痛的影响

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-05-14 DOI: 10.1016/j.bandc.2025.106305

Kate Kelly , Emily Keohane , Gemma Davy

{"title":"The effect of chronic pain on memory: A systematic review and meta-analysis exploring the impact of nociceptive, neuropathic and nociplastic pain","authors":"Kate Kelly , Emily Keohane , Gemma Davy","doi":"10.1016/j.bandc.2025.106305","DOIUrl":"10.1016/j.bandc.2025.106305","url":null,"abstract":"<div><div>Chronic pain is becoming increasingly prevalent in modern society. Much research to date has focused on the physical symptoms of pain associated with various conditions, yet living with chronic pain is also known to impact an individual’s cognition. Within cognition, memory is particularly vulnerable to outside factors, yet our understanding of the impact of chronic pain on memory is inconclusive. This systematic review and <em>meta</em>-analysis examined the association between chronic pain type and memory performance. Chronic pain samples were classified as nociceptive, neuropathic or nociplastic and were compared to healthy controls. Studies were sourced from Embase, Web of Science, MEDLINE, PubMed, PsycINFO, Scopus and CINAHL databases between December 2023 and July 2024. A total of 15 good – strong studies with 1865 participants were included (106 who experienced chronic nociceptive pain, 315 who experienced chronic neuropathic pain, 589 who experienced chronic nociplastic pain and 855 healthy controls). Results indicated that individuals with nociceptive and nociplastic pain had impaired short-term and long-term memory performance compared to healthy controls. The same was not true for individuals with neuropathic pain. These findings demonstrate that the type of pain one experiences impacts memory performance. This has profound implications both clinically and with regard to research and offers a new lens for how we can consider chronic pain when trying to understand the impact on cognition.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106305"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic deprivation, brain morphology, and body fat among children and adolescents 儿童和青少年的社会经济剥夺、大脑形态和体脂

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-05-13 DOI: 10.1016/j.bandc.2025.106315

Anting Yang , Hui Jing Lu , Lei Chang

{"title":"Socioeconomic deprivation, brain morphology, and body fat among children and adolescents","authors":"Anting Yang , Hui Jing Lu , Lei Chang","doi":"10.1016/j.bandc.2025.106315","DOIUrl":"10.1016/j.bandc.2025.106315","url":null,"abstract":"<div><div>Given mounting literature linking environmental adversity with neurobiological alterations, other evidence has shown association between excess adiposity and attenuated brain development, leading to our current question of how the developing brain interacts with change in body composition in response to environmental challenges. Using data from the Adolescent Brain Cognitive Development (ABCD®) Study, we conducted mediation analyses and demonstrated that socioeconomic deprivation (SED) was associated with lower total brain and cortical volumes via the mediation of higher waist-to-height ratio (WHtR), and that WHtR likewise mediated the association of SED with global brain structures. The prefrontal structures showed region- and direction-specific pathways, with bilateral superior and middle frontal gyrus being most consistently related with WHtR in addition to the impact of SED. These findings reveal a functional trade-off between brain development and fat deposition in response to environmental deprivation, and may have implications for understanding neurocognitive and somatic development among children and adolescents in different socioeconomic contexts.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106315"},"PeriodicalIF":2.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive efficiency and expertise-dependent automaticity in the working memory performance of bilinguals 双语者工作记忆表现中的认知效率和专业依赖自动性

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-05-12 DOI: 10.1016/j.bandc.2025.106308

Federico Gallo , Liliia Terekhina , Jubin Abutalebi , Yury Shtyrov , Andriy Myachykov

{"title":"Cognitive efficiency and expertise-dependent automaticity in the working memory performance of bilinguals","authors":"Federico Gallo , Liliia Terekhina , Jubin Abutalebi , Yury Shtyrov , Andriy Myachykov","doi":"10.1016/j.bandc.2025.106308","DOIUrl":"10.1016/j.bandc.2025.106308","url":null,"abstract":"<div><div>The concepts of cognitive efficiency (CE) and expertise-dependent automaticity are central to the understanding of cognitive adaptations related to bilingual experiences. This study examined their behavioral manifestations in bilingual young adults by manipulating the cognitive load of a working memory task; the possibility to manipulate the difficulty of a cognitive task is necessary to observe behavioral outcomes associated with CE and automaticity. To this end, participants completed an n-back task ranging in difficulty from 0-back to 3-back, with the 3-back condition being commonly recognized as being a highly cognitively demanding one. We aimed to determine whether degree of bilingual experience could predict performance outcomes – accuracy, reaction times, and the speed/accuracy tradeoff – reflecting bilingualism’s putative dynamic impact on CE and automaticity in working memory. The results showed a positive relationship between degree of bilingual experience and working memory performance, particularly when the task-induced cognitive load increased. More experienced bilinguals demonstrated a smaller decline in performance when task difficulty intensified, a behavioral manifestation compatible with increased CE. Additionally, a relationship with expertise-dependent automaticity emerged, with the speed/accuracy tradeoff trajectory unfolding differentially across varying task difficulties at different degrees of bilingual experience.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106308"},"PeriodicalIF":2.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter identification and spatial localization during visual working memory are enabled by unique sequences of stimulus-dependent neural operations 视觉工作记忆中的字母识别和空间定位是由独特的刺激依赖神经操作序列实现的

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-05-07 DOI: 10.1016/j.bandc.2025.106302

Mckenzie Haller , Hope Nyarady , Thomas J. Covey

{"title":"Letter identification and spatial localization during visual working memory are enabled by unique sequences of stimulus-dependent neural operations","authors":"Mckenzie Haller , Hope Nyarady , Thomas J. Covey","doi":"10.1016/j.bandc.2025.106302","DOIUrl":"10.1016/j.bandc.2025.106302","url":null,"abstract":"<div><div>Working memory (WM) is often conceptualized as consisting of a supervisory central executive and the short-term storage of information over a brief period of time. In the present study, we examined the sequence of neural operations that are engaged for visual-verbal and visual-spatial information during demanding WM performance. Participants completed verbal and spatial 3-back tasks (visually presented stimuli), and event-related potentials (ERPs) were obtained for task performance. There was enhancement of anterior N1/posterior P1, P2, P3, and late anterior negative (400+ msec post-stimulus) component amplitude for the spatial compared to verbal 3-back task. We interpret these effects as reflecting spatial orienting (N1/P1, P2 effects) and updating of stimulus location during WM (anterior P3, late negativity effects). In contrast, the verbal compared to spatial 3-back task exhibited enhancement of an anterior P150/posterior N150 component, frontal N2 amplitude, a broader P3 component morphology with posterior localization, and a late anterior positivity/posterior negativity (550+ msec). We interpret these effects as reflecting identification of letter features (anterior P150/posterior N150), stimulus conflict monitoring (N2 effect), stimulus categorization (posterior P3 effect), and rehearsal/updating over the retention interval (late positivity/posterior negativity). These ERP effects likely reflect activity of the distinct ventral and dorsal visual processing streams associated with verbal/object and spatial information.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106302"},"PeriodicalIF":2.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-04-30 DOI: 10.1016/j.bandc.2025.106301

Julie D. Henry , Sarah P. Coundouris , Izelle Labuschagne , Kirra Liu , Simon J. Haines , Sarah A. Grainger , Juan F. Domínguez , Alex Puckett , Peter G. Rendell , Jessica Taubert

{"title":"Age-related differences in neural integrity are unrelated to prospective memory age effects","authors":"Julie D. Henry , Sarah P. Coundouris , Izelle Labuschagne , Kirra Liu , Simon J. Haines , Sarah A. Grainger , Juan F. Domínguez , Alex Puckett , Peter G. Rendell , Jessica Taubert","doi":"10.1016/j.bandc.2025.106301","DOIUrl":"10.1016/j.bandc.2025.106301","url":null,"abstract":"<div><div>Prospective memory refers to memory for future intentions. In general, prospective memory appears to decline with age when tested in laboratory settings but is preserved or enhanced when tasks need to be completed in daily life. No study to date has tested whether age-related differences in specific brain structures and networks mediate prospective memory age effects in both settings. Here, measures of regional brain volume (anterior prefrontal cortex, frontoparietal networks, and temporal lobes), white matter integrity (prefrontal white matter hypointensities) and prospective memory were obtained from 41 younger and 41 older adults. The results showed that, as expected, older age was associated with smaller regional brain volumes, as well as poorer prefrontal white matter integrity. In addition, age was negatively associated with prospective memory function in the laboratory-based assessment, but positively associated with performance on the task completed in daily life. However, none of these behavioural effects were mediated by age-related differences in neural integrity. These data show that, in contrast to literature focused on neurodegenerative disease in which neural losses have been shown to be predictive of PM impairment, age-related differences in brain integrity may not be the best indicator of <em>normal</em> variation in prospective memory function.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106301"},"PeriodicalIF":2.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective role of education in white matter lesions and cognitive decline 教育对白质病变和认知能力下降的保护作用

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-04-26 DOI: 10.1016/j.bandc.2025.106304

Odelia Elkana , Iman Beheshti , for the Alzheimer’s Disease Neuroimaging Initiative

{"title":"The protective role of education in white matter lesions and cognitive decline","authors":"Odelia Elkana , Iman Beheshti , for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.bandc.2025.106304","DOIUrl":"10.1016/j.bandc.2025.106304","url":null,"abstract":"<div><div>Cognitive reserve, often reflected by education, may protect against cognitive decline linked to brain pathology. White matter lesions (WMLs), common in aging, are associated with the progression from healthy cognitive status (HC) to mild cognitive impairment (MCI). This study explores education’s role, as a proxy for cognitive reserve, in moderating the relationship between WML burden and the HC to MCI transition. Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed for 153 cognitively healthy adults. Participants were divided into two groups: one (n = 85) remained cognitively healthy for at least seven years, while the other (n = 68) progressed to MCI. WML volumes were assessed using MRI scans and analyzed with linear regression models including age, sex, and an intraction term between group status and education to examine moderation effects. Both WM-hyper and WM-hypo showed a similar pattern across analyses. A significant interaction between group and education for both WML types (WM-hyper: β = -0.097, p = 0.047; WM-hypo: β = -0.070, p = 0.037) was found, suggesting that among individuals who progressed to MCI, higher education was associated with lower WML burden.This suggest that education plays a protective role against white matter pathology among individuals at risk for cognitive impairment.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106304"},"PeriodicalIF":2.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative life events during early adolescence are associated with neural deactivation to emotional stimuli 青少年早期的负面生活事件与神经对情绪刺激的失活有关

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-04-25 DOI: 10.1016/j.bandc.2025.106303

Mizan Gaillard , Scott A. Jones , Dakota Kliamovich , Arturo Lopez Flores , Bonnie J. Nagel

{"title":"Negative life events during early adolescence are associated with neural deactivation to emotional stimuli","authors":"Mizan Gaillard , Scott A. Jones , Dakota Kliamovich , Arturo Lopez Flores , Bonnie J. Nagel","doi":"10.1016/j.bandc.2025.106303","DOIUrl":"10.1016/j.bandc.2025.106303","url":null,"abstract":"<div><div>Negative life events (NLEs) have been shown to perturb neurodevelopment and are correlated with poor mental health outcomes in adolescence, the most common period of psychopathology onset. Emotion regulation is a critical component of psychological response to NLEs and interacts, neurobiologically and behaviorally, with working memory. This study leveraged an emotional n-back task to examine how NLEs influence emotion- and working memory-related brain activation using data from 2150 youth in the Adolescent Brain Cognitive Development (ABCD) Study. Greater incidence of NLEs was associated with less activation in the amygdala and more pronounced deactivation in other limbic and frontal brain regions previously implicated in emotion-related cognition; however, this association was present only during emotion processing conditions of the task. While NLEs were not significantly associated with task performance in the final sample, behavioural analyses including youth excluded for low task accuracy and poor neuroimaging data quality showed a significant negative association between NLEs and overall task performance. While behavioural findings across the entire sample support prior work, somewhat incongruent with prior literature, imaging results may suggest that during early adolescence the effects of negative experiences on patterns of neural activation are specific to contexts necessitating emotion processing.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106303"},"PeriodicalIF":2.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise, brain and cognition interaction in humans 人类运动，大脑和认知的相互作用

IF 2.2 3区心理学

Brain and Cognition Pub Date : 2025-04-21 DOI: 10.1016/j.bandc.2025.106299

Terry McMorris, Chong Chen

引用次数: 0