Stephanie N Steinberg, Kelsey C Hewitt, Cady K Block
{"title":"A neuropsychological profile for high-grade primary central nervous system neuroendocrine tumor (CNS NET): A single-case study.","authors":"Stephanie N Steinberg, Kelsey C Hewitt, Cady K Block","doi":"10.1080/13854046.2024.2356281","DOIUrl":"10.1080/13854046.2024.2356281","url":null,"abstract":"<p><p><b>Objective:</b> Neuroendocrine tumors (NETs) are neoplasms that primarily occur in the lungs, appendix, small intestine, pancreas, and rectum, and typically metastasize to the liver or lymph nodes. However, in rare cases NETs can originate in the central nervous system (CNS). Understanding primary CNS NET neuropsychological manifestations aids in recommendations for neurocognitive follow-up, treatment and lifestyle planning, and future research. <b>Method:</b> Given the dearth of neuropsychological research for CNS NETs, we present a case seen in a 43-year-old woman. <b>Results:</b> Initial and 8-month follow-up neuropsychological evaluations of the patient revealed a Major Neurocognitive Disorder where the pattern of findings was consistent with tumor location and additional treatment-related factors. Reliable change indices at her re-evaluation revealed declines in verbal and visual memory, with statistical, yet not clinical, improvements in different domains. Follow-up monitoring of comprehensive care continued to occur after neuropsychological evaluations. <b>Conclusions:</b> This case study assists in the characterization of initial and follow-up neuropsychological presentation of a primary CNS NET, where evaluations helped inform clinical care and functional recommendations. This case demonstrates the importance for neuropsychologists to have awareness of various conditions, even rare conditions, which can inform a systematic approach to research and clinical care with neuro-oncological populations.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"218-232"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosalia Costello, Beatriz MacDonald, Jaclyn L Papadakis, Lizabeth L Jordan
{"title":"Culturally-informed neuropsychological evaluations of patients with spina bifida: Application of the ECLECTIC framework to a complex pediatric medical condition.","authors":"Rosalia Costello, Beatriz MacDonald, Jaclyn L Papadakis, Lizabeth L Jordan","doi":"10.1080/13854046.2024.2372877","DOIUrl":"10.1080/13854046.2024.2372877","url":null,"abstract":"<p><p><b>Objective:</b> The pediatric patient populations in the United States are becoming increasingly diverse in culture. In addition to medical factors, a variety of sociocultural factors (including educational systems, language, immigration status, etc.) can impact a child's cognitive development, performance on traditional neuropsychological measures, provider interactions, differential diagnosis, and recommendations. A culturally-informed neuropsychological evaluation aims to understand the impact of sociocultural factors and integrate them into the assessment approach. Fujii's ECLECTIC framework (acronym for Education & Literacy, Culture/Acculturation, Language, Economic Issues, Communication Style, Testing Situation, Intelligence Conceptualization, and Context of Immigration) can be used to guide culturally-informed neuropsychological evaluations of children with complex medical conditions. <b>Method:</b> Using the ECLECTIC framework, this paper describes clinical considerations and offers practical solutions for providing culturally-informed pediatric neuropsychology evaluations. Four diverse patients with spina bifida are reviewed. <b>Results:</b> The case presentations highlight the application of the ECLECTIC framework within a medically complex pediatric patient population. <b>Conclusions:</b> Spina bifida is one example of a pediatric medical population in which both medical and sociocultural factors can impact cognitive development and the evaluation process. The ECLECTIC framework defines a variety of sociocultural factors that can influence cognitive development and multiple aspects of a pediatric neuropsychological evaluation. Pediatric neuropsychologists should use the ECLECTIC framework to provide culturally-informed evaluations for our increasingly diverse patient populations.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"37-63"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic coding of neurocognitive disorders: A roadmap to ICD-10-CM.","authors":"Suzan Uysal","doi":"10.1080/13854046.2024.2345925","DOIUrl":"10.1080/13854046.2024.2345925","url":null,"abstract":"<p><p><b>Objective</b>: Diagnosis coding is a core clinical competency. A basic understanding of the structure of the <i>International Classification of Diseases, 10th Revision, Clinical Modification</i> (ICD-10-CM), the conventions and rules for diagnosis coding, and what constitutes accurate coding, is fundamental to the clinician's knowledge base. This commentary seeks to provide a practical framework for clinicians to perform accurate diagnosis coding of neurocognitive disorders. <b>Method</b>: This paper: (1) summarizes the structure of the ICD-10-CM, (2) describes the rules and conventions of diagnosis coding for diagnostic categories relevant to neurocognitive disorders, (3) presents clinical examples and pragmatic recommendations to help readers improve their day-to-day use of diagnosis codes, and (4) describes limitations and discrepancies in the diagnosis coding advice for neurocognitive disorders presented within the <i>Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition, Text Revision</i> (DSM-5-TR) and the <i>DSM-5-TR Neurocognitive Disorders Supplement</i>. Its content originates from the ICD-10-CM itself and its companion document, the <i>ICD-10-CM Official Guidelines for Coding and Reporting</i>. <b>Conclusion</b>: The ICD-10-CM classification scheme is logically organized and easy to navigate for users who understand its structure and rules. Many neuropsychologists rely on the DSM-5-TR diagnosis coding advice, however that advice is limited with respect to the range of diagnosis codes relevant to neurocognitive disorders and their underlying causes. Relying on the ICD-10-CM directly for diagnosis coding of neurocognitive disorders, rather than the DSM-5-TR or other secondary sources, is therefore preferable and aids clinicians in accurate diagnosis coding.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-16"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric S Semmel, Onella S Dawkins-Henry, Jane Holmes Bernstein, David Wypij, Johanna Calderon, David C Bellinger, Jane W Newburger, Michelle Z Gurvitz, Adam R Cassidy
{"title":"Evaluating the factor structure of the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV) in adults with congenital heart disease.","authors":"Eric S Semmel, Onella S Dawkins-Henry, Jane Holmes Bernstein, David Wypij, Johanna Calderon, David C Bellinger, Jane W Newburger, Michelle Z Gurvitz, Adam R Cassidy","doi":"10.1080/13854046.2024.2442424","DOIUrl":"https://doi.org/10.1080/13854046.2024.2442424","url":null,"abstract":"<p><p><b>Objective</b>: While it is generally assumed that common neurobehavioral assessments, such as the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV), function similarly in clinical and non-clinical populations, this has not been validated in adults with congenital heart disease (CHD). In this study, we examined the latent factor structure of the WAIS-IV in adults with d-transposition of the great arteries (d-TGA) who participated in the Boston Circulatory Arrest Study. <b>Method</b>: The WAIS-IV was administered as part of a larger assessment battery. Confirmatory factor analysis was used to fit one-, two-, and four-factor models of general cognitive ability, as well as a second order Full Scale IQ factor, as published in the WAIS-IV manual. <b>Results</b>: Eighty-seven adults with d-TGA were assessed. The four-factor model and second-order models both fit the data well, with all subtests loading significantly and in expected directions onto four latent factors (Verbal Comprehension, Perceptual Reasoning, Working Memory, Processing Speed), similar to the normative population. <b>Conclusions</b>: Among adults with d-TGA, the latent factor structure of the WAIS-IV is similar to the normative sample, suggesting that the WAIS-IV is an appropriate tool to use in adults with d-TGA and, potentially, in other CHD subgroups.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Svetlana Malyutina, Nataliia Zubareva, Olga Buivolova, Yury Zontov, Ekaterina Shestakova, Marina Chernova, Anastasiia Bedo, Alisa Andriushchenko, Victor Savilov, Elena Kurmysheva, Anastasiia Kibardina, Natalie Kotova, Anastasia Sobko, Zukhro Akbarova, Olga Dragoy
{"title":"The Rey Auditory Verbal Learning Test: adaptation into Russian and a new digital \"RAVLT World\".","authors":"Svetlana Malyutina, Nataliia Zubareva, Olga Buivolova, Yury Zontov, Ekaterina Shestakova, Marina Chernova, Anastasiia Bedo, Alisa Andriushchenko, Victor Savilov, Elena Kurmysheva, Anastasiia Kibardina, Natalie Kotova, Anastasia Sobko, Zukhro Akbarova, Olga Dragoy","doi":"10.1080/13854046.2024.2446028","DOIUrl":"https://doi.org/10.1080/13854046.2024.2446028","url":null,"abstract":"<p><p><b>Objective:</b> The Rey Auditory Verbal Learning Test (RAVLT) is a classic test used to assess episodic verbal memory in research and clinical practice. We aimed to adapt the RAVLT materials into Russian, provide performance norms across the adult lifespan for the Russian adaptation, and develop a mobile application for automated RAVLT administration across languages. <b>Method:</b> We created three psycholinguistically matched alternative versions of the RAVLT materials in Russian and incorporated them into a new <i>RAVLT World</i> tablet application. We tested 354 neurologically healthy 21-to-89-year-old Russian speakers, modeled their performance using multivariate multiple regression, and calculated demographically adjusted norms. We also tested the equivalence of performance across the three alternative Russian versions and between the pen-and-paper and digital form. <b>Results:</b> Performance across three alternative versions and between the pen-and-paper and digital form was equivalent, although test-retest reliability measured via intraclass correlation coefficients was limited. Older age, male gender and fewer years of education were associated with lower performance on both raw trial scores (<i>R<sup>2</sup></i> = .515) and composite scores (<i>R<sup>2</sup></i> = .961). Demographically adjusted norms are now available in a paper form and as part of the <i>RAVLT World</i> application. <b>Conclusions:</b> The new RAVLT adaptation can be used to assess verbal memory in Russian-speaking adults, serving their clinical needs and diversifying research on verbal memory. The equivalent alternative versions can serve for repeated testing in longitudinal designs. The <i>RAVLT World</i> tablet application, with automated administration and scoring, makes the test more accessible to patients and allows to incorporate multiple language versions.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federica Rossetto, Sara Isernia, Giulia Smecca, Marco Rovaris, Francesca Baglio
{"title":"Time efficiency in mental state reasoning of people with multiple sclerosis: The double-sided affective and cognitive Theory of Mind disturbances.","authors":"Federica Rossetto, Sara Isernia, Giulia Smecca, Marco Rovaris, Francesca Baglio","doi":"10.1080/13854046.2024.2446026","DOIUrl":"https://doi.org/10.1080/13854046.2024.2446026","url":null,"abstract":"<p><p><b>Objective:</b> Theory of Mind (ToM) disturbances are recognized as a hallmark of several neurological conditions including multiple sclerosis (MS). People with MS show lower ToM competencies compared to healthy controls (HC) from the earliest stages of the disease. However, the nature of this disturbance is still under investigation. The aims of this study were 1) to explore ToM competencies in people with MS using a single task (the Yoni-48) considering both accuracy and time efficiency according to a multi-level (first- and second-order) and multi-component (affective and cognitive) approach, and 2) to investigate the relationship between ToM and other neurocognitive functions in people with MS. <b>Method:</b> Seventy-seven participants underwent an individual evaluation session to investigate their ToM profile and associated neurocognitive domains (short-term and working memory, and executive functioning). <b>Results:</b> As expected, the comparison between the two groups (MS vs HC) on ToM performance showed a selective decline of accuracy for the second-order level (Cohen's d = 0.46) and the affective (Cohen's d = 0.57) components of ToM, and a pathological reduction in ToM time efficiency in people with MS (Cohen's d > 0.50). Moreover, a link between executive function, memory, and ToM was found. Our results highlight a double-sided selective decline of high levels and affective components of ToM in people with MS, and a broad involvement of time efficiency. <b>Conclusions:</b> These findings provide insights into the contribution of efficiency and automaticity of mental state reasoning in this pathology, suggesting the role of compensation strategies in maintaining adequate performance during social interactions.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-18"},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica C Luedke, Gray Vargas, Laura A Malone, Kathleen H Parker, Rowena Ng
{"title":"Utility of teleneuropsychology services among pediatric patients with long COVID.","authors":"Jessica C Luedke, Gray Vargas, Laura A Malone, Kathleen H Parker, Rowena Ng","doi":"10.1080/13854046.2024.2445269","DOIUrl":"https://doi.org/10.1080/13854046.2024.2445269","url":null,"abstract":"<p><p><b>Objective:</b> To determine the clinical utility of teleneuropsychology (teleNP) services in screening for cognitive concerns in a population of children and adolescents presenting with long COVID. <b>Method:</b> This cross-sectional study evaluated 76 pediatric patients (64% female, <i>M</i><sub>age</sub> = 13.48, <i>SD</i> = 2.97, range = 5 to 18 years) with long COVID referred for a neuropsychological evaluation due to persistent cognitive symptoms following their COVID infection. Of these 76 patients, 33 were tested in person, while 43 were tested via teleNP at home. Patients were administered a brief testing battery designed for use in-person or through teleNP services. Tests administered included the WASI-II (Intellectual Functioning), D-KEFS Verbal Fluency (Executive Functioning/Shifting), Oral Version of the Symbol Digit Modalities Test (Processing Speed), ChAMP List (Learning and Memory), WAIS-IV/WISC-V Digit Span (Working Memory), and TEA-Ch Score and Score DT (Sustained Auditory Attention and Divided Attention). Differences in scores between those evaluated in-person or teleNP were computed using analyses of variance and Bayesian statistics across measures. Differences in the proportion of those scoring in the below average range (< 9<sup>th</sup> percentile) were also computed. <b>Results:</b> Findings revealed similar performance for patients tested in-person and patients tested by teleNP modality across measures. <b>Conclusions:</b> The present study provides preliminary evidence for the clinical utility of teleNP services in pediatric long COVID patients on a cognitive screening battery. These results lend support for expanding teleNP services to pediatric patients with long COVID to assess neurocognitive functioning, which is particularly important given scarcity of specialty long COVID clinics.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of long-term outcomes of repetitive concussive and subconcussive blast exposures in the military and limitations of the literature.","authors":"Sara M Lippa","doi":"10.1080/13854046.2024.2441395","DOIUrl":"https://doi.org/10.1080/13854046.2024.2441395","url":null,"abstract":"<p><p><b>Objective:</b> The purpose of this review is to summarize the long-term cognitive, psychological, fluid biomarker, and neuroimaging outcomes following repetitive concussive and subconcussive blast exposures sustained through a military career. <b>Method/Results:</b> A review of the literature was conducted, with 450 manuscripts originally identified and 44 manuscripts ultimately included in the review. The most robust studies investigating how repetitive concussive and subconcussive exposures related to cognitive performance suggest there is no meaningful impact. Although there are minimal studies that suggest some small impacts on neuroimaging and fluid biomarkers, most findings have been in very small samples and fail to replicate. Both repetitive blast mTBI and subconcussive blasts appeared to be associated with increased self-reported symptoms. Many of the studies suffered from small sample size, failure to correct for multiple comparisons, and inappropriate control groups. <b>Conclusions:</b> Overall, there is little evidence to support that repetitive blast mTBIs or subconcussive blast exposures have a lasting impact on cognition, neuroimaging, or fluid biomarkers. In contrast, there does appear to be a relationship between these exposures and self-reported psychological functioning, though it is unclear what mechanism drives this relationship. Small sample size, lack of correction for multiple comparisons, limited control groups, lack of consideration of important covariates, limited diversity of samples, and lack of reliable and valid measures for assessment of blast exposure are major limitations restricting this research. Patients should be encouraged that while research is ongoing, there is little to currently suggest long-term cognitive or neurological damage following repetitive blast exposure.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-36"},"PeriodicalIF":3.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alison Datoc, Gavin D Sanders, Tahnae Tarkenton Allen, Jeff Schaffert, Nyaz Didehbani, C Munro Cullum
{"title":"Relationship between self-reported concussion history, cognition, and mood among former collegiate athletes.","authors":"Alison Datoc, Gavin D Sanders, Tahnae Tarkenton Allen, Jeff Schaffert, Nyaz Didehbani, C Munro Cullum","doi":"10.1080/13854046.2024.2440113","DOIUrl":"https://doi.org/10.1080/13854046.2024.2440113","url":null,"abstract":"<p><p><b>Objective</b>: This study explored the relationship between concussion history and cognition/mood in former collegiate athletes in middle-to-later adulthood. <b>Method</b>: 407 former collegiate athletes aged 50+ (<i>M</i> = 61.4; 62.7% male) participated in the College Level Aging AThlete Study (CLEAATS) and completed the Cognitive Function Instrument (CFI), 40-item Telephone Interview for Cognitive Status (TICS-40), PHQ-8, GAD-7, and self-report questionnaires, including concussion history. Kruskal-Wallis tests assessed for differences among groups based on concussion history (0, 1-2, 3-4, 5+ concussions). Hierarchical multiple regressions including demographic factors as covariates examined relationships between concussion history, emotional symptoms, and subjective/objective cognition. <b>Results</b>: Participants with 5+ concussions reported significantly greater subjective cognitive concerns and depressive symptoms than other concussion groups, but no differences were found in objective cognition. Hierarchical regression revealed concussion history and emotional symptoms explained 29% and 15% of the variance in subjective and objective cognition, respectively. The number of concussions accounted for unique variance in subjective cognition but was not significantly associated when mood symptoms were added to the model. Neither diagnosed concussions nor emotional symptoms were associated with objective cognition. <b>Conclusions</b>: When accounting for concussion history, those with 5+ concussions reported greater subjective cognitive symptoms than those with 0-2 concussions, and greater depressive symptoms than those with 0 concussions. Concussion history was not significantly related to subjective cognition when compared to mood, and concussion history and mood symptoms were not associated with objective cognition. Results highlight the importance of considering mood symptoms when evaluating the relationship between concussion history and cognition in former athletes.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Van Patten, Min Lu, Tara A Austin, Erica Cotton, Lawrence Chan, John A Bellone, Kristen L Mordecai, Elizabeth W Twamley, Kelsey Sawyer, W Curt LaFrance
{"title":"Associations of cognitive test performance with self-reported mental health, cognition, and quality of life in adults with functional seizures: A systematic review and meta-analysis.","authors":"Ryan Van Patten, Min Lu, Tara A Austin, Erica Cotton, Lawrence Chan, John A Bellone, Kristen L Mordecai, Elizabeth W Twamley, Kelsey Sawyer, W Curt LaFrance","doi":"10.1080/13854046.2024.2440949","DOIUrl":"10.1080/13854046.2024.2440949","url":null,"abstract":"<p><p><b>Objective:</b> People with functional seizures (FS) have frequent and disabling cognitive dysfunction and mental health symptoms, with low quality of life. However, interrelationships among these constructs are poorly understood. In this meta-analysis, we examined associations between objective (i.e. performance-based) cognitive testing and self-reported (i) mental health, (ii) cognition, and (iii) quality of life in FS. <b>Method</b>: We searched MEDLINE, Embase, PsycINFO, and Web of Science, with the final search on June 10, 2024. Inclusion criteria were studies documenting relationships between objective cognitive test scores and self-reported (i.e. subjective) mental health, cognition, and/or quality of life in adults with FS. Exclusion criteria were mixed FS/epilepsy samples. A modified Newcastle-Ottawa Scale evaluated risk of bias. This project is registered as CRD42023392385 in PROSPERO. <b>Results</b>: Initially, 4,054 unique reports were identified, with the final sample including 24 articles of 1,173 people with FS. Mean age was 35.9 (SD = 3.9), mean education was 12.6 (SD = 1.3), and proportion of women was 73.9%. Risk of bias was moderate, due in part to inconsistent reporting of confounding demographic variables. Significant relationships were found between global objective cognition and global self-reported mental health (<i>k</i> = 21, Z = -0.23 [0.04], 95% CI = -0.30, -0.16), depression (<i>k</i> = 11, Z = -0.13 [0.05], 95% CI = -0.21, -0.04), cognition (<i>k</i> = 5, Z = -0.16 [0.05], 95% CI = -0.26, -0.06), and quality of life (<i>k</i> = 5, Z = -0.17 [0.05], 95% CI = -0.24, -0.10). Exploratory analyses showed associations between select cognitive and mental health constructs. <b>Conclusions</b>: Objective cognition is reliably associated with self-reported mental health, cognition, and quality of life in people with FS. Scientific and clinical implications are discussed.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-26"},"PeriodicalIF":3.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}