Ryan Van Patten, Min Lu, Tara A Austin, Erica Cotton, Lawrence Chan, John A Bellone, Kristen L Mordecai, Elizabeth W Twamley, Kelsey Sawyer, W Curt LaFrance
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Inclusion criteria were studies documenting relationships between objective cognitive test scores and self-reported (i.e. subjective) mental health, cognition, and/or quality of life in adults with FS. Exclusion criteria were mixed FS/epilepsy samples. A modified Newcastle-Ottawa Scale evaluated risk of bias. This project is registered as CRD42023392385 in PROSPERO. <b>Results</b>: Initially, 4,054 unique reports were identified, with the final sample including 24 articles of 1,173 people with FS. Mean age was 35.9 (SD = 3.9), mean education was 12.6 (SD = 1.3), and proportion of women was 73.9%. Risk of bias was moderate, due in part to inconsistent reporting of confounding demographic variables. Significant relationships were found between global objective cognition and global self-reported mental health (<i>k</i> = 21, Z = -0.23 [0.04], 95% CI = -0.30, -0.16), depression (<i>k</i> = 11, Z = -0.13 [0.05], 95% CI = -0.21, -0.04), cognition (<i>k</i> = 5, Z = -0.16 [0.05], 95% CI = -0.26, -0.06), and quality of life (<i>k</i> = 5, Z = -0.17 [0.05], 95% CI = -0.24, -0.10). Exploratory analyses showed associations between select cognitive and mental health constructs. <b>Conclusions</b>: Objective cognition is reliably associated with self-reported mental health, cognition, and quality of life in people with FS. Scientific and clinical implications are discussed.</p>","PeriodicalId":55250,"journal":{"name":"Clinical Neuropsychologist","volume":" ","pages":"1-26"},"PeriodicalIF":3.0000,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations of cognitive test performance with self-reported mental health, cognition, and quality of life in adults with functional seizures: A systematic review and meta-analysis.\",\"authors\":\"Ryan Van Patten, Min Lu, Tara A Austin, Erica Cotton, Lawrence Chan, John A Bellone, Kristen L Mordecai, Elizabeth W Twamley, Kelsey Sawyer, W Curt LaFrance\",\"doi\":\"10.1080/13854046.2024.2440949\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective:</b> People with functional seizures (FS) have frequent and disabling cognitive dysfunction and mental health symptoms, with low quality of life. However, interrelationships among these constructs are poorly understood. In this meta-analysis, we examined associations between objective (i.e. performance-based) cognitive testing and self-reported (i) mental health, (ii) cognition, and (iii) quality of life in FS. <b>Method</b>: We searched MEDLINE, Embase, PsycINFO, and Web of Science, with the final search on June 10, 2024. Inclusion criteria were studies documenting relationships between objective cognitive test scores and self-reported (i.e. subjective) mental health, cognition, and/or quality of life in adults with FS. Exclusion criteria were mixed FS/epilepsy samples. A modified Newcastle-Ottawa Scale evaluated risk of bias. This project is registered as CRD42023392385 in PROSPERO. <b>Results</b>: Initially, 4,054 unique reports were identified, with the final sample including 24 articles of 1,173 people with FS. Mean age was 35.9 (SD = 3.9), mean education was 12.6 (SD = 1.3), and proportion of women was 73.9%. Risk of bias was moderate, due in part to inconsistent reporting of confounding demographic variables. Significant relationships were found between global objective cognition and global self-reported mental health (<i>k</i> = 21, Z = -0.23 [0.04], 95% CI = -0.30, -0.16), depression (<i>k</i> = 11, Z = -0.13 [0.05], 95% CI = -0.21, -0.04), cognition (<i>k</i> = 5, Z = -0.16 [0.05], 95% CI = -0.26, -0.06), and quality of life (<i>k</i> = 5, Z = -0.17 [0.05], 95% CI = -0.24, -0.10). Exploratory analyses showed associations between select cognitive and mental health constructs. <b>Conclusions</b>: Objective cognition is reliably associated with self-reported mental health, cognition, and quality of life in people with FS. 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引用次数: 0
摘要
目的:功能性癫痫发作(FS)患者经常出现致残性认知功能障碍和精神健康症状,生活质量低下。然而,人们对这些因素之间的相互关系知之甚少。在这项荟萃分析中,我们研究了功能性癫痫发作患者的客观(即基于表现的)认知测试与自我报告的(i)心理健康、(ii)认知和(iii)生活质量之间的关系。研究方法:我们检索了 MEDLINE、Embase、PsycINFO 和 Web of Science,最终检索日期为 2024 年 6 月 10 日。纳入标准是记录了FS成人患者客观认知测试得分与自我报告(即主观)心理健康、认知和/或生活质量之间关系的研究。排除标准为FS/癫痫混合样本。修改后的纽卡斯尔-渥太华量表评估了偏倚风险。该项目在 PROSPERO 注册为 CRD42023392385。结果:最初确定了 4,054 份独特的报告,最终样本包括 24 篇文章,涉及 1,173 名 FS 患者。平均年龄为 35.9 (SD = 3.9),平均教育程度为 12.6 (SD = 1.3),女性比例为 73.9%。偏倚风险为中度,部分原因是混杂人口统计学变量的报告不一致。研究发现,总体客观认知与总体自我报告心理健康(k = 21,Z = -0.23 [0.04],95% CI = -0.30,-0.16)、抑郁(k = 11,Z = -0.13 [0.05], 95% CI = -0.21, -0.04)、认知(k = 5, Z = -0.16 [0.05], 95% CI = -0.26, -0.06)和生活质量(k = 5, Z = -0.17 [0.05], 95% CI = -0.24, -0.10)。探索性分析表明,某些认知和心理健康结构之间存在关联。结论客观认知与 FS 患者自我报告的心理健康、认知和生活质量有可靠的关联。本文讨论了其科学和临床意义。
Associations of cognitive test performance with self-reported mental health, cognition, and quality of life in adults with functional seizures: A systematic review and meta-analysis.
Objective: People with functional seizures (FS) have frequent and disabling cognitive dysfunction and mental health symptoms, with low quality of life. However, interrelationships among these constructs are poorly understood. In this meta-analysis, we examined associations between objective (i.e. performance-based) cognitive testing and self-reported (i) mental health, (ii) cognition, and (iii) quality of life in FS. Method: We searched MEDLINE, Embase, PsycINFO, and Web of Science, with the final search on June 10, 2024. Inclusion criteria were studies documenting relationships between objective cognitive test scores and self-reported (i.e. subjective) mental health, cognition, and/or quality of life in adults with FS. Exclusion criteria were mixed FS/epilepsy samples. A modified Newcastle-Ottawa Scale evaluated risk of bias. This project is registered as CRD42023392385 in PROSPERO. Results: Initially, 4,054 unique reports were identified, with the final sample including 24 articles of 1,173 people with FS. Mean age was 35.9 (SD = 3.9), mean education was 12.6 (SD = 1.3), and proportion of women was 73.9%. Risk of bias was moderate, due in part to inconsistent reporting of confounding demographic variables. Significant relationships were found between global objective cognition and global self-reported mental health (k = 21, Z = -0.23 [0.04], 95% CI = -0.30, -0.16), depression (k = 11, Z = -0.13 [0.05], 95% CI = -0.21, -0.04), cognition (k = 5, Z = -0.16 [0.05], 95% CI = -0.26, -0.06), and quality of life (k = 5, Z = -0.17 [0.05], 95% CI = -0.24, -0.10). Exploratory analyses showed associations between select cognitive and mental health constructs. Conclusions: Objective cognition is reliably associated with self-reported mental health, cognition, and quality of life in people with FS. Scientific and clinical implications are discussed.
期刊介绍:
The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.