Critical Reviews in Immunology最新文献_第3页

Diagnostic Power of the CD4+/CD8+ Ratio and the Expression of Activation and Memory Markers in Differentiating Sarcoidosis from Tuberculosis, Idiopathic Pulmonary Fibrosis, and Other Interstitial Lung Diseases. CD4+/CD8+比值及激活和记忆标志物表达在结节病与肺结核、特发性肺纤维化及其他肺间质性疾病鉴别中的诊断价值

IF 0.8 4区医学

Critical Reviews in Immunology Pub Date : 2025-01-01 DOI: 10.1615/CritRevImmunol.2025056518

Sara El Fakihi, Aicha El Allam, Hicham Tahoune, Chaimae Kadi, Azeddine Ibrahimi, Jamal-Eddine Bourkadi, Fouad Seghrouchni

{"title":"Diagnostic Power of the CD4+/CD8+ Ratio and the Expression of Activation and Memory Markers in Differentiating Sarcoidosis from Tuberculosis, Idiopathic Pulmonary Fibrosis, and Other Interstitial Lung Diseases.","authors":"Sara El Fakihi, Aicha El Allam, Hicham Tahoune, Chaimae Kadi, Azeddine Ibrahimi, Jamal-Eddine Bourkadi, Fouad Seghrouchni","doi":"10.1615/CritRevImmunol.2025056518","DOIUrl":"10.1615/CritRevImmunol.2025056518","url":null,"abstract":"Background: Sarcoidosis is a complex inflammatory disease of unknown etiology affecting mostly the lungs and poses a significant diagnostic challenge, particularly in regions where tuberculosis (TB) is endemic. The diagnostic complexity intensifies due to shared clinical and radiological features between sarcoidosis and TB, as well as similarities with idiopathic pulmonary fibrosis (IPF) in cases that progress to pulmonary fibrosis. Accurately distinguishing between these diseases is critical for timely and effective patient management.Objective: This study breaks new ground by evaluating the diagnostic power of the bronchoalveolar lavage (BAL) CD4/ CD8 ratio, along with key activation and memory markers to differentiate sarcoidosis from TB, IPF, and other-interstitial lung diseases (ILDs).Methods: A cohort of 68 patients with ILDs, including sarcoidosis (n = 37), TB (n = 19), IPF (n = 6), and Other-ILDs (n = 6) were assessed. The CD4/CD8 ratio and a panel of activation and memory markers were analyzed through flow cytometry.Results: Sarcoidosis exhibited a significantly higher CD4/CD8 ratio compared to those with TB, IPF, and Other-ILDs. An optimal cutoff value of 3.7 for the CD4/CD8 ratio in sarcoidosis with an area under the ROC curve (AUC) of 0.7%, had a specificity of 96.8%, and a sensitivity of 43.2%. In addition, a significant difference was detected in CD38, CD45RA, CD45RO, and CD62L expression.Conclusion: Combining the CD4/CD8 ratio (> 3.7) with the expression of CD38, CD62L, and memory markers is a promising new tool for the differential diagnosis of sarcoidosis.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"45 2","pages":"77-89"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shenling Baizhu Powder Inhibits Lung Metastasis of Breast Cancer via Regulation of Epithelial-Mesenchymal Transition and Ferroptosis. 参苓白术散通过调节上皮-间质转化和铁下垂抑制乳腺癌肺转移。

IF 0.9 4区医学

Critical Reviews in Immunology Pub Date : 2025-01-01 DOI: 10.1615/CritRevImmunol.2025059697

Wei Tian, Junquan Han

{"title":"Shenling Baizhu Powder Inhibits Lung Metastasis of Breast Cancer via Regulation of Epithelial-Mesenchymal Transition and Ferroptosis.","authors":"Wei Tian, Junquan Han","doi":"10.1615/CritRevImmunol.2025059697","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2025059697","url":null,"abstract":"Objective: This study aimed to probe the role of Shenling Baizhu powder (SLBZP) in inhibiting breast cancer (BC) lung metastasis, focusing on epithelial-to-mesenchymal transition (EMT) and ferroptosis.Methods: BC 4T1 cells were treated with low (3.13 µg/mL) and high (12.5 µg/mL) doses of SLBZP. Cell proliferation, migration, and invasion were assessed via CCK-8 and transwell assays. Intracellular reactive oxygen species (ROS), malondialdehyde (MDA), and Fe2+ levels were measured using commercial kits. Western blot was used to detect EMT markers (E-cadherin, N-cadherin, Vimentin). In vivo, Balb/c mice injected with 4T1 cells received SLBZP or cyclophosphamide (CTX). Tumor volume, mass, and lung metastases were recorded. MDA, Fe2+, EMT markers, and ferroptosis-related GPX4 were evaluated in tumor tissues.Results: SLBZP dose-dependently suppressed 4T1 cell proliferation, migration, invasion, and EMT, as indicated by upregulated E-cadherin and downregulated N-cadherin and Vimentin. SLBZP increased cellular ROS, MDA, and Fe2+ levels (P < 0.05). In vivo, SLBZP and CTX significantly reduced tumor burden and lung metastases, elevated MDA, Fe2+, and E-cadherin, and decreased N-cadherin, Vimentin, and GPX4 in tumor tissues (P < 0.05).Conclusion: SLBZP inhibits BC lung metastasis by modulating EMT and ferroptosis, highlighting its therapeutic potential.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"45 5","pages":"11-18"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Roles of Tonsil-Derived Mesenchymal Stem Cells. 扁桃体来源间充质干细胞的免疫调节作用。

IF 0.9 4区医学

Critical Reviews in Immunology Pub Date : 2025-01-01 DOI: 10.1615/CritRevImmunol.2025059511

Yue Chen, Xiaorong Sun, Dan Su, Wenjuan Gui, Jinliang Yang

{"title":"Immunomodulatory Roles of Tonsil-Derived Mesenchymal Stem Cells.","authors":"Yue Chen, Xiaorong Sun, Dan Su, Wenjuan Gui, Jinliang Yang","doi":"10.1615/CritRevImmunol.2025059511","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2025059511","url":null,"abstract":"Stemming from human immune organs, tonsil-derived mesenchymal stem cells (TMSCs) hold unique strengths in differentiation potential and immune regulatory functions. These characteristics make them valuable for therapeutic applications, particularly in regenerative medicine and autoimmune disease treatment, as they can modulate immune responses and promote tissue repair. Their ability to interact with various cell types and secrete a range of bioactive molecules further enhances their role in orchestrating healing processes, making them a promising avenue for innovative therapies aimed at restoring balance in the immune system and facilitating recovery from injury or disease. TMSCs are crucial elements of the tonsillar microenvironment, playing a key role in preserving the balance of the immune system. They regulate immune responses by producing cytokines and growth factors, influencing neighboring immune cells, and facilitating communication within tonsillar tissue to maintain a controlled response to pathogens and prevent excessive inflammation. As understanding of TMSCs continues to evolve, their integration into clinical practices could revolutionize approaches to treating a wide array of conditions, highlighting the importance of continued investigation in this promising field.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"45 5","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TREM2 in Regulating Macrophage Inflammatory Responses and Disease Pathogenesis TREM2 在调节巨噬细胞炎症反应和疾病发病机制中的作用

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-08-01 DOI: 10.1615/critrevimmunol.2024054889

Milan Medd

引用次数: 0

Commentary: Ovarian cancer; path to effective treatments 评论：卵巢癌；通往有效治疗之路

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-06-01 DOI: 10.1615/critrevimmunol.2024053766

Anahid Jewett, Sanaz Memarzadeh, Kawaljit Kaur

{"title":"Commentary: Ovarian cancer; path to effective treatments","authors":"Anahid Jewett, Sanaz Memarzadeh, Kawaljit Kaur","doi":"10.1615/critrevimmunol.2024053766","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024053766","url":null,"abstract":"Despite advancements in cancer therapeutics such as checkpoint inhibitors and some targeted therapies, we have not achieved success in effectively treating ovarian cancer, since these therapeutics only benefit a subset of patients, and also provide short-term protection or cure. The use of chemotherapy and radiation therapy can cause depletion and/or lack of immune cells’ function. CAR-T therapy is found effective against several blood-based cancers, but limited success was seen against solid tumors. Targeting fewer antigens and significant side effects of therapy decreases the efficacy of CAR-T cells as immunotherapeutic in solid tumors, even though there is a great drive and significant effort to establish these therapies around the world. Bispecific and tri-specific antibodies have recently been advocated as effective cancer therapeutics. However, these also suffer the fate of CAR-Ts since the loss of antigen on tumor cells will render these therapeutics ineffective. At the moment we should design therapeutics that may have synergistic effects on killing/treating tumors. The only way we can establish that will be by learning the mechanisms of actions of immune therapeutics. Thus, advancement in the knowledge and effective strategies are required to develop cancer immuno-therapeutics","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"100 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N6-methyladenosine (m6A) reader LRPPRC-mediated CXCL11 induces cell inflammation to drive breast cancer cell malignancy N6-甲基腺苷（m6A）阅读器 LRPPRC 介导的 CXCL11 可诱导细胞发炎，从而促使乳腺癌细胞恶变

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-06-01 DOI: 10.1615/critrevimmunol.2024053166

Qing Li, Changchun Zhang, Li Li

{"title":"N6-methyladenosine (m6A) reader LRPPRC-mediated CXCL11 induces cell inflammation to drive breast cancer cell malignancy","authors":"Qing Li, Changchun Zhang, Li Li","doi":"10.1615/critrevimmunol.2024053166","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024053166","url":null,"abstract":"Background: Breast cancer (BC) is among the most prevalent malignant cancers in women. This paper proposed to investigate the function as well as the regulatory mechanism of N6-methyladenosine (m6A) reader leucine rich pentatricopeptide repeat containing (LRPPRC) in BC inflammation and progression.\u0000Methods: The levels of LRPPRC and C-X-C motif chemokine ligand 11 (CXCL11) were detected via qRT-PCR. The regulatory mechanisms between LRPPRC and CXCL11 were investigated by RIP, MeRIP, and mRNA stability experiments. Moreover, the bio-functions of LRPPRC and CXCL11 in BC cells were explored through the CCK8, wound healing, Transwell assays. ELISA was utilized to evaluate pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) levels.\u0000Results: LRPPRC had a considerably higher level in BC samples than in healthy samples, and LRPPRC overexpression predicted poor prognosis. LRPPRC lowexpression diminished BC cell viability, migration, and invasion, whereas overexpression facilitated malignancy. LRPPRC exerted its stimulative effect through CXCL11 m6A modification. CXCL11 upregulating suppressed the LRPPRC silencing’s antitumor effect on BC cells malignancy. CXCL11 upregulation enhances inflammatory factors secretion by BC cells.\u0000Conclusion: This study demonstrated that LRPPRC aggravated BC inflammation and malignancy by upregulating m6A modification of CXCL11. These findings offered a potential to be a target for BC patients’ therapy.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"153 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SLE Conundrum: A Comprehensive Analysis of Pathogenesis, Re-cent Developments, and the Future of Therapeutic Interventions 系统性红斑狼疮的难题：发病机理、最新进展和未来治疗干预的全面分析

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024053504

Uddeshya Sharma

引用次数: 0

The effect of supplementation of vitamin D on hyperlipidemia and bone mass in the pediatric with obesity 补充维生素 D 对小儿肥胖症患者高脂血症和骨量的影响

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024052129

Feifan Wang, Lingshan Bei, Xiaoyan Zhang, Yangxi Fu

{"title":"The effect of supplementation of vitamin D on hyperlipidemia and bone mass in the pediatric with obesity","authors":"Feifan Wang, Lingshan Bei, Xiaoyan Zhang, Yangxi Fu","doi":"10.1615/critrevimmunol.2024052129","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024052129","url":null,"abstract":"Objective\u0000Vitamin D deficiency is known to be a significant factor in metabolic diseases such as obesity and diabetes. However, there is currently a lack of evidence regarding the effects of vitamin D on hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity.\u0000Methods\u0000Our study aimed to determine the relationship between Serum 25(OH)D and metabolic syndrome, as well as investigate the effect of Vitamin D3 supplementation on hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity. We conducted a cross-sectional study between January 2018 and January 2020, with a total of 723 children invited to participate. Of these, 283 were in the supplemented group (SG) and 440 were in the placebo group (PG). We evaluated blood pressure, fasting glucose, high-density lipoprotein, total cholesterol, low-density lipoprotein, and bone mineral density (BMD) among all subjects.\u0000Results\u0000We found that cholesterol, triglyceride, and glucose levels were strongly associated with 25(OH)D3 levels at baseline. After vitamin D3 supplementation, we observed a significant increase in body mass index (BMI) (P=0.02) and serum 25(OH)D3(P<0.01) levels in the vitamin D3 group compared to the placebo group. Additionally, serum lipids such as total cholesterol(P<0.01), HDL-c(P<0.01), Total cholesterol/HDL-c (P<0.01), LDL-c/HDL-c (P<0.01), Triglycerides/HDL-c(P<0.01) were significantly decreased in the Vit D group compared to the placebo group. Serum 25(OH)D was inversely associated with cholesterol, triglycerides, and fasting glucose.\u0000Conclusion\u0000Our results suggest that vitamin D3 supplementation can enhance the beneficial effect of hyperlipi","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the mechanism of Isoforskolin against asthma based on network pharmacology and experimental verification 基于网络药理学和实验验证的异佛司可林抗哮喘机制探索

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024050244

Yan Fang, Shibo Sun, Chuang Xiao, Min Li, Yuanyuan Zheng, Anju Zu, Zhuang Luo

{"title":"Exploring the mechanism of Isoforskolin against asthma based on network pharmacology and experimental verification","authors":"Yan Fang, Shibo Sun, Chuang Xiao, Min Li, Yuanyuan Zheng, Anju Zu, Zhuang Luo","doi":"10.1615/critrevimmunol.2024050244","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024050244","url":null,"abstract":"Objective: In this study, network pharmacology combined with biological experimental verification was utilized to screen the targets of Isoforskolin (ISOF) and investigate the potential underlying mechanism of ISOF acting on asthma.\u0000Methods: Asthma-related targets were screened from the Genecards and DisGeNET databases. SEA and Super-PRED databases were used to obtain the targets of ISOF. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to identify key targets and enriched regulatory pathways of ISOF acting on asthma. Then, a protein-protein interaction (PPI) network was constructed via STRING database and hub genes of ISOF against asthma were further screened using molecular docking. Finally, CCK-8, qPCR, and western blotting were performed to assess the targets of ISOF in treating asthma.\u0000Results: A total of 96 drug-related-disease targets from the relevant databases were screened out. KEGG pathway enrichment analysis predicted that the target genes might be involved in the PI3K-Akt pathway. The core targets of ISOF in treating asthma were identified by the PPI network and molecular docking, including MAPK1, mTOR, and NFKB1. Consistently, in vitro experiments showed that ISOF acting on asthma was involved in inflammatory response by reducing the expression of MAPK1, mTOR, and NFKB1.\u0000Conclusions: The present study reveals that MAPK1, mTOR, and NFKB1 might be key targets of Isoforskolin in asthma treatment and the anti-asthma effect might be related to the PI3K-AKT signaling pathway.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"38 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer 预测结肠癌存活率和肿瘤细胞进展的无丝分裂和有丝分裂相关基因特征

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024053203

Jian Shen, Minzhe Li

{"title":"Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer","authors":"Jian Shen, Minzhe Li","doi":"10.1615/critrevimmunol.2024053203","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024053203","url":null,"abstract":"Background: Anoikis is a specialized form of programmed cell death and is also related mitophagy process.\u0000Objective:We aimed to identify an anoikis and mitophagy-related genes (AMRGs) prognostic model and explore the role of SPHK1 in colon cancer (CC).\u0000Methods: Bioinformatic methods were used to screen the AMRGs. Based on these genes, all the samples were divided into different subtypes. Furthermore, LASSO was conducted to optimized the AMRGs. Based on the optimal genes, a prognostic risk score model was established and evaluated. Finally, the effects of downregulated SPHK1 on the CC cell proliferation, migration, invasion, and anoikis were investigated.\u0000Results: Based on the AMRGs, all the CC samples were divided into subtype 1 and subtype 2. An AMRGs signature containing three key genes (SPHK1, CDC25C, and VPS37A) that exhibiting predicting ability in CC survival is confirmed. Subtype2 and low-risk groups exhibited better survival and higher immune cell infiltration. Moreover, down-regulated SPHK1 is related to lower cell proliferation, migration, and invasion ability, as well as higher anoikis in CC cell line (P < 0.01).\u0000Conclusion: The AMRGs risk score model exhibits promising predicting ability on patients with CC. SPHK1 might inhibit CC cell growth, migration, and invasion through stimulating anoikis.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"10 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0