系统性红斑狼疮的难题：发病机理、最新进展和未来治疗干预的全面分析

IF 0.8 4区医学 Q4 IMMUNOLOGY

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI:10.1615/critrevimmunol.2024053504

Uddeshya Sharma

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引用次数: 0

摘要

系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，各种易感因素之间存在多因素相互作用。人们在了解系统性红斑狼疮的发病机制方面取得了长足进步，从而开发出了靶向疗法并探索出了替代疗法。新疗法的批准扩大了患者的治疗选择，正在进行的临床试验有望进一步改善治疗状况。系统性红斑狼疮治疗的未来在于个性化的靶向疗法，这种疗法能最大限度地减少副作用并改善患者的预后。本综述根据最新的研究、专利、临床试验和配方，全面分析了系统性红斑狼疮的现状和前景。持续的研究和临床试验对于发现新的治疗方案并最终改变系统性红斑狼疮的治疗格局至关重要。通过不懈的努力和医学科学的进步，我们可以提高系统性红斑狼疮患者的生活质量和生存率。

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The SLE Conundrum: A Comprehensive Analysis of Pathogenesis, Re-cent Developments, and the Future of Therapeutic Interventions

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder with multifactorial interactions among various susceptibility factors. Significant strides have been made in under-standing the pathogenesis of SLE, leading to the development of targeted therapies and the exploration of alternative treatments. The approval of new therapies has expanded patient treatment options, and ongoing clinical trials promise to enhance the treatment landscape fur-ther. The future of SLE treatment lies in personalized, targeted therapies that minimize side effects and improve patient outcomes. This review comprehensively analyzes SLE’s current and prospects based on recent studies, patents, clinical trials, and formulations. Continued research and clinical trials are crucial to uncovering new therapeutic options and ultimately transforming the treatment landscape for SLE. With sustained efforts and advancements in medical science, we can offer a better quality of life and improved survival rates for SLE pa-tients.

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来源期刊

Critical Reviews in Immunology 医学-免疫学

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Immunology covers a broad spectrum of investigations at the genes, molecular, cellular, organ and system levels to reveal defense mechanisms against pathogens as well as protection against tumors and autoimmune diseases. The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in medical sciences. Critical ReviewsTM in Immunology (CRI) seeks to present a balanced overview of contemporary adaptive and innate immune responses related to autoimmunity, tumor, microbe, transplantation, neuroimmunology, immune regulation and immunotherapy from basic to translational aspects in health and disease. The articles that appear in CRI are mostly obtained by invitations to active investigators. But the journal will also consider proposals from the scientific community. Interested investigators should send their inquiries to the editor before submitting a manuscript.