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Myosins on the Move: A Special Issue on Myosins and Myosin-Dependent Cell Processes 运动中的肌球蛋白：关于肌球蛋白和依赖肌球蛋白的细胞过程的特刊。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-11-05 DOI: 10.1002/cm.21953
Joanna Moraczewska, Julian Guttman
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引用次数: 0
The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation 异位基因 CCDC11 通过 RhoA 调节对细胞分裂很重要
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-31 DOI: 10.1002/cm.21952
Saurabh S. Kulkarni, Rachel E. Stephenson, Sarah Amalraj, Angelo Arrigo, Ewelina Betleja, James J. Moresco, John R. Yates III, Moe R. Mahjoub, Ann L. Miller, Mustafa K. Khokha
{"title":"The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation","authors":"Saurabh S. Kulkarni,&nbsp;Rachel E. Stephenson,&nbsp;Sarah Amalraj,&nbsp;Angelo Arrigo,&nbsp;Ewelina Betleja,&nbsp;James J. Moresco,&nbsp;John R. Yates III,&nbsp;Moe R. Mahjoub,&nbsp;Ann L. Miller,&nbsp;Mustafa K. Khokha","doi":"10.1002/cm.21952","DOIUrl":"10.1002/cm.21952","url":null,"abstract":"<p>Mutations in <i>CCDC11</i> (<i>cfap53</i>) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In <i>Xenopus</i>, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit multiple cilia per cell. Unexpectedly, we found that Ccdc11 is necessary for successful cytokinesis, explaining the multiciliation phenotype observed in Ccdc11-depleted cells. The small GTPase RhoA is critical for cytokinesis, and our Ccdc11 depletion phenotypes are reminiscent of RhoA loss of function. Here, we demonstrate that during cytokinesis CCDC11 is localized to the cytokinetic contractile ring overlapping with RhoA, and CCDC11 regulates total RhoA protein levels. Our results connect CCDC11 to cytokinesis and LR patterning via RhoA regulation, providing a potential mechanism for heterotaxy disease pathogenesis.</p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 6","pages":"360-371"},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the Month by Pongpratch Puapatanakul 本月图片 作者：Pongpratch Puapatanakul。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-28 DOI: 10.1002/cm.21945
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引用次数: 0
Picture of the Month by Ewa Langner 本月图片，作者：Ewa Langner。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-28 DOI: 10.1002/cm.21946
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引用次数: 0
Picture of the Month by Mohona Gupta Mohona Gupta 拍摄的 "本月图片"。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-23 DOI: 10.1002/cm.21947
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引用次数: 0
Back Cover Image 封底图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-22 DOI: 10.1002/cm.21940
{"title":"Back Cover Image","authors":"","doi":"10.1002/cm.21940","DOIUrl":"https://doi.org/10.1002/cm.21940","url":null,"abstract":"<p>ON THE BACK COVER: DA-Raf inhibits ERK activation, resulting in the suppression of collective cell migration and invasion of KRAS-mutant cancer cells. In human pancreatic carcinoma MIA PaCa-2 cells, phospho-ERK1/2 (magenta) is suppressed by the expression of EGFP-DA-Raf (green). EGFP-DA-Raf is concentrated on the plasma membrane.</p><p>Credit: Aoi Matsuda and Takeshi Endo (Chiba University, Japan)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"C4"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Front Cover Image 封面内页图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-22 DOI: 10.1002/cm.21938
{"title":"Inner Front Cover Image","authors":"","doi":"10.1002/cm.21938","DOIUrl":"https://doi.org/10.1002/cm.21938","url":null,"abstract":"<p>ON THE INNER FRONT COVER: Actin filaments (green) terminating in focal adhesions stained for vinculin (red) in bovine aortic endothelial cells cultured on polydimethylsiloxane. Nuclei are stained using dapi (blue).</p><p>Credit: Aparna Bhattacharyya (Johns Hopkins University; formerly Drexel University), and Kenneth Barbee (Drexel University)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"C2"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover Image 封面图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-22 DOI: 10.1002/cm.21937
{"title":"Front Cover Image","authors":"","doi":"10.1002/cm.21937","DOIUrl":"https://doi.org/10.1002/cm.21937","url":null,"abstract":"<p>ON THE FRONT COVER: Normal human breast epithelial cells expressing GFP-LIMD1 (green) and tained for F-actin (red) and DNA (blue).</p><p>Credit: Samriddha Ray, Chamika DeSilva, Natasha Cruz-Calderon and Daniel McCollum. University of Massachusetts Chan Medical School Department of Biochemistry and Molecular Biotechnology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"C1"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Back Cover Image 封底内页图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-22 DOI: 10.1002/cm.21939
{"title":"Inner Back Cover Image","authors":"","doi":"10.1002/cm.21939","DOIUrl":"https://doi.org/10.1002/cm.21939","url":null,"abstract":"<p>ON THE INNER BACK COVER: Image of the skeletal muscles showing the striated localization pattern of metastasis associated 1 (MTA1).</p><p>Credit: Chundong Gu (The First Affiliated Hospital of Dalian Medical University, Dalian, China) and Ming-Fei Lang (Medical College, Dalian University, Dalian, China)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"C3"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the month by Chundong Gu and Ming-Fei Lang 本月图片由 Chundong Gu 和 Ming-Fei Lang 拍摄。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-20 DOI: 10.1002/cm.21931
{"title":"Picture of the month by Chundong Gu and Ming-Fei Lang","authors":"","doi":"10.1002/cm.21931","DOIUrl":"10.1002/cm.21931","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"506"},"PeriodicalIF":2.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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