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Front Cover Image 封面图片
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 DOI: 10.1002/cm.70122
{"title":"Front Cover Image","authors":"","doi":"10.1002/cm.70122","DOIUrl":"https://doi.org/10.1002/cm.70122","url":null,"abstract":"<p>ON THE FRONT COVER: RPE cells immunostained for alpha-tubulin to label (growing) microtubules (yellow), CEP135 to label centrioles (cyan), and stained with DAPI to label DNA (magenta).</p><p>Credit: Catarina Peneda, Gulbenkian Institute for Molecular Medicine (GIMM), Oeiras, Portugal.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ARC Expands the DAAM1 Microexon-Mediated Actin–RHOA/ROCK Interplay ARC扩展了DAAM1 microexon介导的肌动蛋白- rhoa /ROCK相互作用。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 Epub Date: 2025-06-09 DOI: 10.1002/cm.22051
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia
{"title":"ARC Expands the DAAM1 Microexon-Mediated Actin–RHOA/ROCK Interplay","authors":"Patryk Poliński,&nbsp;Marta Miret Cuesta,&nbsp;Manuel Irimia","doi":"10.1002/cm.22051","DOIUrl":"10.1002/cm.22051","url":null,"abstract":"<p>Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.</p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":"123-127"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Profile: Jivesh Garg 作者简介：Jivesh Garg。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 Epub Date: 2026-03-06 DOI: 10.1002/cm.70113
Jivesh Garg
{"title":"Author Profile: Jivesh Garg","authors":"Jivesh Garg","doi":"10.1002/cm.70113","DOIUrl":"10.1002/cm.70113","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":"165-166"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back Cover Image 封底图像
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 DOI: 10.1002/cm.70126
{"title":"Back Cover Image","authors":"","doi":"10.1002/cm.70126","DOIUrl":"https://doi.org/10.1002/cm.70126","url":null,"abstract":"<p>ON THE BACK COVER: Section of U2OS cells centrioles obtained using Transmission Electron Microscopy.</p><p>Credit: Catarina Peneda, Gulbenkian Institute for Molecular Medicine (GIMM), Oeiras, Portugal.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynein: A Multifaceted Therapeutic Target and Its Dysregulation in Aberrant Cell Proliferation 动力蛋白：一个多方面的治疗靶点及其在异常细胞增殖中的失调。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 Epub Date: 2025-05-26 DOI: 10.1002/cm.22041
Jivesh Garg, Laleh Alisaraie
{"title":"Dynein: A Multifaceted Therapeutic Target and Its Dysregulation in Aberrant Cell Proliferation","authors":"Jivesh Garg,&nbsp;Laleh Alisaraie","doi":"10.1002/cm.22041","DOIUrl":"10.1002/cm.22041","url":null,"abstract":"<p>This review examines the diverse functions of dyneins, a family of motor proteins involved in intracellular transport processes, the maintenance of cell polarity, and critical signaling pathways essential for cell cycle progression. Dyneins' significant impact on critical cellular functions is mediated through their interactions with an array of organelles, including centrosomes, chromosomes, and endosomes. Dyneins also influence autophagy and immune evasion within the complex environment of cancer. This review underscores the significance of dyneins as an avenue of exploration for comprehending the intricate mechanisms that underpin cancer.</p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":"93-122"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.22041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Front Cover Image 内封面图像
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 DOI: 10.1002/cm.70124
{"title":"Inner Front Cover Image","authors":"","doi":"10.1002/cm.70124","DOIUrl":"https://doi.org/10.1002/cm.70124","url":null,"abstract":"<p>ON THE INNER FRONT COVER: Section of U2OS cells centrioles obtained using Transmission Electron Microscopy.</p><p>Credit: Catarina Peneda, Gulbenkian Institute for Molecular Medicine (GIMM), Oeiras, Portugal.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the Month by Catarina Peneda 卡塔琳娜·佩内达的月度图片。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 Epub Date: 2026-02-23 DOI: 10.1002/cm.70116
{"title":"Picture of the Month by Catarina Peneda","authors":"","doi":"10.1002/cm.70116","DOIUrl":"10.1002/cm.70116","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Back Cover Image 封底内图
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 DOI: 10.1002/cm.70125
{"title":"Inner Back Cover Image","authors":"","doi":"10.1002/cm.70125","DOIUrl":"https://doi.org/10.1002/cm.70125","url":null,"abstract":"<p>ON THE INNER BACK COVER: RPE cells immunostained for alpha-tubulin to label microtubules (cyan), Pericentrin to label centrosomes (yellow), and stained with DAPI to label DNA (magenta).</p><p>Credit: Catarina Peneda, Gulbenkian Institute for Molecular Medicine (GIMM), Oeiras, Portugal.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.70125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspective: Examining MAP1B Structure With an Evolutionary Perspective 视角：从进化的角度研究MAP1B结构。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 Epub Date: 2025-07-10 DOI: 10.1002/cm.70000
Itzhak Fischer
{"title":"Perspective: Examining MAP1B Structure With an Evolutionary Perspective","authors":"Itzhak Fischer","doi":"10.1002/cm.70000","DOIUrl":"10.1002/cm.70000","url":null,"abstract":"<div>\u0000 \u0000 <p>Microtubule Associated Protein MAP1B is expressed at high levels during the early development of the nervous system, playing important roles in axonal growth, neuronal migration, and branching, as well as dendritic spine morphogenesis and synapse formation. MAP1B belongs to the MAP1 family, which includes MAP1A and MAP1S, as well as a known homolog in <i>Drosophila</i> (the <i>Futsch</i> gene). MAP1B is a polyprotein that undergoes proteolytic processing into heavy (HC) and light chains (LC1). It is composed of seven exons, including microtubule- and actin-binding domains, and conserved regions of both the N- and C-termini. In this Perspective, we investigated the structure of MAP1B from an evolutionary perspective, emphasizing the significance of conserved domains across different species. Through sequence analysis and alignment, exon structures, prediction of protein folding, and database searches, we identified key structural features of MAP1B and constructed a model based on these data. This approach allowed us to refine our understanding of known domains and uncover unrecognized, highly conserved domains that may have novel functions, providing valuable reference data for future research. In the process of searching for homolog proteins in vertebrates and invertebrates, we traced the deep roots of MAP1B as far back as the octopus, sea urchin, and <i>Caenorhabditis elegans</i>, underscoring the highly conserved properties of MAP1B. When compared to the other members of the MAP1 family, MAP1A and MAP1S, we found that they are far less conserved than MAP1B, even among vertebrates, supporting the conclusion that MAP1B represents the most ancient ancestral member of this family.</p>\u0000 </div>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":"140-150"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Profile: Catarina Peneda 作者简介：Catarina Peneda。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2026-03-16 Epub Date: 2026-02-27 DOI: 10.1002/cm.70114
Catarina Peneda
{"title":"Author Profile: Catarina Peneda","authors":"Catarina Peneda","doi":"10.1002/cm.70114","DOIUrl":"10.1002/cm.70114","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"83 3","pages":"167-168"},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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