Centrosome-Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease.

Abstract

The centrosome, an evolutionarily conserved organelle in most animal cells, plays a pivotal role in fundamental processes such as cell division and ciliogenesis. Recent evidence increasingly highlights active crosstalk between the centrosome and the signaling pathways, through which cells dynamically detect and respond to diverse extracellular and intracellular cues. In this review, we summarize the roles of the centrosome in multiple signaling pathways, including Hedgehog, Wnt, and Notch that govern cellular growth, division, differentiation, and tissue homeostasis. We also explore how these interactions mold centrosomal behavior, emphasizing its function as a hub for signaling integration.