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Front Cover Image 封面图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-22 DOI: 10.1002/cm.21937
{"title":"Front Cover Image","authors":"","doi":"10.1002/cm.21937","DOIUrl":"https://doi.org/10.1002/cm.21937","url":null,"abstract":"<p>ON THE FRONT COVER: Normal human breast epithelial cells expressing GFP-LIMD1 (green) and tained for F-actin (red) and DNA (blue).</p><p>Credit: Samriddha Ray, Chamika DeSilva, Natasha Cruz-Calderon and Daniel McCollum. University of Massachusetts Chan Medical School Department of Biochemistry and Molecular Biotechnology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"C1"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Back Cover Image 封底内页图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-22 DOI: 10.1002/cm.21939
{"title":"Inner Back Cover Image","authors":"","doi":"10.1002/cm.21939","DOIUrl":"https://doi.org/10.1002/cm.21939","url":null,"abstract":"<p>ON THE INNER BACK COVER: Image of the skeletal muscles showing the striated localization pattern of metastasis associated 1 (MTA1).</p><p>Credit: Chundong Gu (The First Affiliated Hospital of Dalian Medical University, Dalian, China) and Ming-Fei Lang (Medical College, Dalian University, Dalian, China)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"C3"},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the month by Chundong Gu and Ming-Fei Lang 本月图片由 Chundong Gu 和 Ming-Fei Lang 拍摄。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-20 DOI: 10.1002/cm.21931
{"title":"Picture of the month by Chundong Gu and Ming-Fei Lang","authors":"","doi":"10.1002/cm.21931","DOIUrl":"10.1002/cm.21931","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"506"},"PeriodicalIF":2.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the month by Samriddha Ray, Chamika DeSilva, Natasha Cruz-Calderon, and Daniel McCollum 本月图片由 Samriddha Ray、Chamika DeSilva、Natasha Cruz-Calderon 和 Daniel McCollum 拍摄。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-20 DOI: 10.1002/cm.21930
{"title":"Picture of the month by Samriddha Ray, Chamika DeSilva, Natasha Cruz-Calderon, and Daniel McCollum","authors":"","doi":"10.1002/cm.21930","DOIUrl":"10.1002/cm.21930","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"505"},"PeriodicalIF":2.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Profile: Paul Griffin 作者简介：保罗-格里芬
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-10-07 DOI: 10.1002/cm.21919
Paul J. Griffin
{"title":"Author Profile: Paul Griffin","authors":"Paul J. Griffin","doi":"10.1002/cm.21919","DOIUrl":"10.1002/cm.21919","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 11","pages":"695-696"},"PeriodicalIF":2.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the month by Aparna Bhattacharyya and Kenneth Barbee 阿帕纳-巴塔查里亚（Aparna Bhattacharyya）和肯尼斯-巴比（Kenneth Barbee）拍摄的本月图片。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2024-09-25 DOI: 10.1002/cm.21932
{"title":"Picture of the month by Aparna Bhattacharyya and Kenneth Barbee","authors":"","doi":"10.1002/cm.21932","DOIUrl":"10.1002/cm.21932","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"81 9-10","pages":"507"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis HN1 的表达通过极光 A-PLK1-Eg5 轴促进有丝分裂的保真度
IF 2.9 4区 生物学
Cytoskeleton Pub Date : 2024-09-18 DOI: 10.1002/cm.21928
Gülseren Özduman, Faruk Şimşek, Aadil Javed, Kemal Sami Korkmaz
{"title":"HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis","authors":"Gülseren Özduman, Faruk Şimşek, Aadil Javed, Kemal Sami Korkmaz","doi":"10.1002/cm.21928","DOIUrl":"https://doi.org/10.1002/cm.21928","url":null,"abstract":"Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from <jats:italic>Drosophila melanogaster</jats:italic> where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle regulation. Moreover, HN1 overexpression leads to early mitotic exit as well. Other molecular functions and interactions of HN1 are not clear yet. Here, based on our previous analysis where HN1 was shown to cluster supernumerary centrosomes and maintain mitotic spindle assembly, we further investigated the role of HN1 in centrosome maintenance and mitotic fidelity in PC‐3 prostate and MDA‐MB231 mammary cancer cell lines. The maturation‐associated roles of HN1 during cell division by examining the AuroraA‐PLK1 axis involving a plus end kinesin, Eg5 as well as pericentriolar matrix protein (PCM1) as components of centrosomes were established. We found that HN1 co‐localized to centrioles with Eg5 and Aurora A to suppress aberrant spindle formation to ensure the fidelity of centriole/centrosome duplication when overexpressed. Consistently, depleting the HN1 expression using siRNA or shRNA resulted in an increased number of dysregulated mitotic spindle structures, where Aurora A as well as PLK1 co‐localizations with Eg5 and PCM1 were disrupted. Further, the PLK1 and Aurora A kinase's phosphorylations also decreased, confirming the hypothesis that the cells struggle in mitotic progression, display nuclear and cytokinetic abnormalities with supernumerary but immature mononucleated centrosomes. In summary, we described the role of HN1 in centrosome nucleation/maturation in PLK1‐Eg5 axis and concomitant mitotic spindle formation in human cells.","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"52 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing our Associate Editorial Board Chair: An interview with Justin Parreno, University of Delaware, Newark, USA 介绍我们的编委会副主席：美国特拉华大学纽瓦克分校贾斯汀-帕雷诺访谈录
IF 2.9 4区 生物学
Cytoskeleton Pub Date : 2024-09-18 DOI: 10.1002/cm.21916
Paul Trevorrow, Justin Parreno
{"title":"Introducing our Associate Editorial Board Chair: An interview with Justin Parreno, University of Delaware, Newark, USA","authors":"Paul Trevorrow, Justin Parreno","doi":"10.1002/cm.21916","DOIUrl":"https://doi.org/10.1002/cm.21916","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"11 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small organic osmolytes accelerate actin filament assembly and stiffen filaments 小型有机渗透溶解物可加速肌动蛋白丝的组装，并使丝状物更加坚硬
IF 2.9 4区 生物学
Cytoskeleton Pub Date : 2024-09-14 DOI: 10.1002/cm.21927
Bryan Demosthene, Pavlo Kravchuk, Connor L. Harmon, Abdulrazak Kalae, Ellen H. Kang
{"title":"Small organic osmolytes accelerate actin filament assembly and stiffen filaments","authors":"Bryan Demosthene, Pavlo Kravchuk, Connor L. Harmon, Abdulrazak Kalae, Ellen H. Kang","doi":"10.1002/cm.21927","DOIUrl":"https://doi.org/10.1002/cm.21927","url":null,"abstract":"Actin filament assembly and mechanics are crucial for maintenance of cell structure, motility, and division. Actin filament assembly occurs in a crowded intracellular environment consisting of various types of molecules, including small organic molecules known as osmolytes. Ample evidence highlights the protective functions of osmolytes such as trimethylamine‐N‐oxide (TMAO), including their effects on protein stability and their ability to counteract cellular osmotic stress. Yet, how TMAO affects individual actin filament assembly dynamics and mechanics is not well understood. We hypothesize that, owing to its protective nature, TMAO will enhance filament dynamics and stiffen actin filaments due to increased stability. In this study, we investigate osmolyte‐dependent actin filament assembly and bending mechanics by measuring filament elongation rates, steady‐state filament lengths, and bending persistence lengths in the presence of TMAO using total internal reflection fluorescence microscopy and pyrene assays. Our results demonstrate that TMAO increases filament elongation rates as well as steady‐state average filament lengths, and enhances filament bending stiffness. Together, these results will help us understand how small organic osmolytes modulate cytoskeletal protein assembly and mechanics in living cells.","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"33 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing our Associate Editorial Board: An interview with Sawako Yamashiro, Kyoto University, Kyoto, Japan 介绍我们的副编辑委员会：专访日本京都大学的山城泽子（Sawako Yamashiro
IF 2.9 4区 生物学
Cytoskeleton Pub Date : 2024-09-12 DOI: 10.1002/cm.21911
Paul Trevorrow, Sawako Yamashiro
{"title":"Introducing our Associate Editorial Board: An interview with Sawako Yamashiro, Kyoto University, Kyoto, Japan","authors":"Paul Trevorrow, Sawako Yamashiro","doi":"10.1002/cm.21911","DOIUrl":"https://doi.org/10.1002/cm.21911","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"2 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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