CytoskeletonPub Date : 2025-01-21DOI: 10.1002/cm.21989
{"title":"Front Cover Image","authors":"","doi":"10.1002/cm.21989","DOIUrl":"https://doi.org/10.1002/cm.21989","url":null,"abstract":"<p>ON THE FRONT COVER: The focal adhesion protein Paxillin localizes to the distal ends of stress fiber-associated septin filaments. U2OS osteosarcoma cells were stained for Paxillin (blue), Septin 7 (green), and F-actin (red).</p><p>Credit: Katia Brock (Department of Cell and Developmental Biology, State University of New York Upstate Medical University)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 1-2","pages":"C1"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CytoskeletonPub Date : 2025-01-21DOI: 10.1002/cm.21990
{"title":"Inner Front Cover Image","authors":"","doi":"10.1002/cm.21990","DOIUrl":"https://doi.org/10.1002/cm.21990","url":null,"abstract":"<p>ON THE INNER FRONT COVER: Endogenous tropomyosin Tpm4.2 tagged with APEX at its C-terminus is incorporated into actin filament bundles in homozygous mouse embryo fibroblasts. The endogenous Tpm4.2-APEX shown in red were visualised by an anti-Tpm4.2 antibody and actin filaments shown in green were visualised by phalloidin.</p><p>Credit: Jeff Hook (Cytoskeleton Therapeutics Research Unit, School of Biomedical Sciences, UNSW Sydney, Australia)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 1-2","pages":"C2"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21990","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CytoskeletonPub Date : 2025-01-21DOI: 10.1002/cm.21992
{"title":"Back Cover Image","authors":"","doi":"10.1002/cm.21992","DOIUrl":"https://doi.org/10.1002/cm.21992","url":null,"abstract":"<p>ON THE BACK COVER: DA-Raf inhibits ERK activation, resulting in the suppression of collective cell migration and invasion of KRASmutant cancer cells. In human pancreatic carcinoma MIA PaCa-2 cells, phospho-ERK1/2 (magenta) is suppressed by the expression of EGFP–DA-Raf (green). EGFP–DA-Raf is concentrated on the plasma membrane.</p><p>Credit: Aoi Matsuda and Takeshi Endo (Chiba University, Japan)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 1-2","pages":"C4"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CytoskeletonPub Date : 2025-01-20DOI: 10.1002/cm.21982
{"title":"Picture of the Month by Katia Brock","authors":"","doi":"10.1002/cm.21982","DOIUrl":"10.1002/cm.21982","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 1-2","pages":"71"},"PeriodicalIF":2.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CytoskeletonPub Date : 2025-01-11DOI: 10.1002/cm.21983
{"title":"Picture of the Month by Jeff Hook","authors":"","doi":"10.1002/cm.21983","DOIUrl":"10.1002/cm.21983","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 1-2","pages":"72"},"PeriodicalIF":2.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CytoskeletonPub Date : 2025-01-06DOI: 10.1002/cm.21970
Tianchi Chen, Cecilia H Fernández-Espartero, Grégory Giannone
{"title":"Single-Molecule Tracking and Super-Resolution Microscopy Unveil Actin-Driven Membrane Nanotopography Shaping Stable Integrin Adhesions in Developing Tissue","authors":"Tianchi Chen, Cecilia H Fernández-Espartero, Grégory Giannone","doi":"10.1002/cm.21970","DOIUrl":"10.1002/cm.21970","url":null,"abstract":"<p>Single molecule tracking and super-resolution microscopy of integrin adhesion proteins and actin in developing Drosophila muscle attachment sites reveals that nanotopography triggered by Arp2/3-dependent actin protrusions promotes stable adhesion formation. The nanodomains formed during this process confine the diffusion of integrins and promote their immobilization. Spatial confinement is also applied to the motion of actin filaments, resulting in enhanced mechanical connection with the integrin adhesion complex. Fabricated nano-structured surfaces mimicking the nanotopography observed in living tissue are able to recapitulate the formation of these adhesions in isolated muscle cells and the confinement of integrin diffusion. These results emphasize the importance of geometrical regulation of tissue morphogenesis at a single molecule level.</p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 7","pages":"471-474"},"PeriodicalIF":2.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}