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Inner Back Cover Image 封底内图
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-03-13 DOI: 10.1002/cm.22017
{"title":"Inner Back Cover Image","authors":"","doi":"10.1002/cm.22017","DOIUrl":"https://doi.org/10.1002/cm.22017","url":null,"abstract":"<p>ON THE INNER BACK COVER: Mouse embryonic fibroblasts cultured on fibronectin-coated stiff hydrogels for 1 hour.</p><p>Credit: Yongho Bae (Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 3","pages":"C3"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.22017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover Image 封面图片
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-03-13 DOI: 10.1002/cm.22015
{"title":"Front Cover Image","authors":"","doi":"10.1002/cm.22015","DOIUrl":"https://doi.org/10.1002/cm.22015","url":null,"abstract":"<p>ON THE FRONT COVER: C2C12-myoblasts. Immunofluorescence staining of smooth muscle actin (red) and phalloidin staining (green).</p><p>Credit: Klimenko E.S., Sukhareva K.S (Almazov National Medical Research Centre, Institute of molecular biology and genetics, Saint-Petersburg, Russia)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 3","pages":"C1"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.22015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interplay Between Early Chondrocyte Spreading and Inflammatory Responsivity 早期软骨细胞扩散与炎症反应的相互作用。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2025-03-05 DOI: 10.1002/cm.22011
Tristan Isaiah Pepper, Saitheja Adi Pucha, Lauren Foster, Alan Y. Liu, Meghan Alexander, Jay Milan Patel
{"title":"The Interplay Between Early Chondrocyte Spreading and Inflammatory Responsivity","authors":"Tristan Isaiah Pepper,&nbsp;Saitheja Adi Pucha,&nbsp;Lauren Foster,&nbsp;Alan Y. Liu,&nbsp;Meghan Alexander,&nbsp;Jay Milan Patel","doi":"10.1002/cm.22011","DOIUrl":"10.1002/cm.22011","url":null,"abstract":"<div>\u0000 \u0000 <p>Joint injuries are increasingly common and initiate a degenerative cascade in the cartilage extracellular matrix. Chondrocytes experience both intra- and extra-cellular changes during the initial phases of this process, including inflammatory activation and morphological change, initiating a catabolic feedback cycle that progresses toward osteoarthritis (OA). However, the link between this early morphological spreading and susceptibility to future inflammatory events is unclear. Thus, the objective of this study was to explore the implications of cellular spreading on early inflammatory activation. First, we treated bovine cartilage explants with control or degenerative media for 2 weeks and established early chondrocyte spreading and extracellular matrix loss around chondrocytes. Next, we either seeded chondrocytes on or encapsulated them within gelatin hydrogels of different stiffnesses to allow different degrees of spreading, followed by a short (2 h) inflammatory stimulus to measure inflammatory activation (NF-κB). We found in 2D that stiffer substrates led to greater chondrocyte spreading and NF-κB nuclear localization; however, in 3D, this trend was reversed, with the greatest spreading and activation in cells in the softest hydrogels. Finally, we investigated how hyaluronic acid hydrogel incorporation into these environments could impact this spreading-inflammtory activation relationship, showing that augmentation with HA reduced both facets. In conclusion, chondrocyte spreading, especially in 3D, is linked with reduced matrix stiffness, and this can make chondrocytes more susceptible to inflammation. Thus, future therapies should seek to address not only the inflammation in the joint but also to restore chondrocyte morphology and microenvironmental properties.</p>\u0000 </div>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 9","pages":"592-600"},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Profile: Jashaswi Basu 作者简介：Jashaswi Basu。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-03-04 DOI: 10.1002/cm.22010
Jashaswi Basu
{"title":"Author Profile: Jashaswi Basu","authors":"Jashaswi Basu","doi":"10.1002/cm.22010","DOIUrl":"10.1002/cm.22010","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 4","pages":"274-275"},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Profile: Klimenko Ekaterina Sergeevna 作者简介：Klimenko Ekaterina Sergeevna。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-02-27 DOI: 10.1002/cm.22008
Klimenko Ekaterina Sergeevna
{"title":"Author Profile: Klimenko Ekaterina Sergeevna","authors":"Klimenko Ekaterina Sergeevna","doi":"10.1002/cm.22008","DOIUrl":"10.1002/cm.22008","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 3","pages":"221"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin 肌动蛋白丝尖端：原调蛋白和原肌球蛋白对其组装和拆卸的调控。
IF 1.6 4区 生物学
Cytoskeleton Pub Date : 2025-02-24 DOI: 10.1002/cm.22007
Sawako Yamashiro, Shashank Shekhar, Stefanie M. Novak, Sudipta Biswas, Carol C. Gregorio, Velia M. Fowler
{"title":"Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin","authors":"Sawako Yamashiro,&nbsp;Shashank Shekhar,&nbsp;Stefanie M. Novak,&nbsp;Sudipta Biswas,&nbsp;Carol C. Gregorio,&nbsp;Velia M. Fowler","doi":"10.1002/cm.22007","DOIUrl":"10.1002/cm.22007","url":null,"abstract":"<p>Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed-end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends. We present experimental approaches to selectively assay actin pointed-end regulation using bulk biochemistry, single filament imaging, and live cell microscopy with an emphasis on tropomodulins (Tmods), a conserved family of eukaryotic proteins that specifically cap pointed ends. Average pointed-end assembly/disassembly rates are measured in bulk solution using pyrene-labeled actin and barbed end-capping protein CapZ. Direct rate measurements of individual pointed ends are performed via microfluidic-assisted total internal reflection fluorescence microscopy (mf-TIRF). Actin pointed-end dynamics in living cells are examined in striated muscle cells expressing fluorescent actin, where the regular arrays of 1- to 2-μm-long actin filaments in sarcomeres enable visualization of filament pointed and barbed ends. These assays will also help advance our understanding of other pointed end regulators, including cyclase-associated protein and leiomodins, which have been implicated in filament stabilization, disassembly, and elongation. This work is relevant to the musculoskeletal field, where precise regulation of filament lengths is particularly critical for sarcomere organization and striated muscle contraction.</p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 9","pages":"571-591"},"PeriodicalIF":1.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the Month by E. S. Klimenko 本月图片，E. S. Klimenko。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-02-04 DOI: 10.1002/cm.22001
{"title":"Picture of the Month by E. S. Klimenko","authors":"","doi":"10.1002/cm.22001","DOIUrl":"10.1002/cm.22001","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 3","pages":"223"},"PeriodicalIF":2.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Picture of the Month by E. S. Klimenko 本月图片，E. S. Klimenko。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-02-02 DOI: 10.1002/cm.22000
{"title":"Picture of the Month by E. S. Klimenko","authors":"","doi":"10.1002/cm.22000","DOIUrl":"10.1002/cm.22000","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 3","pages":"222"},"PeriodicalIF":2.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to the Special Issue “Actin-Binding Proteins in Diseases” 特刊“疾病中的肌动蛋白结合蛋白”简介。
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-01-29 DOI: 10.1002/cm.21996
Partha Roy, Yongho Bae
{"title":"Introduction to the Special Issue “Actin-Binding Proteins in Diseases”","authors":"Partha Roy,&nbsp;Yongho Bae","doi":"10.1002/cm.21996","DOIUrl":"10.1002/cm.21996","url":null,"abstract":"","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 3","pages":"79-80"},"PeriodicalIF":2.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Back Cover Image 封底内图
IF 2.4 4区 生物学
Cytoskeleton Pub Date : 2025-01-21 DOI: 10.1002/cm.21991
{"title":"Inner Back Cover Image","authors":"","doi":"10.1002/cm.21991","DOIUrl":"https://doi.org/10.1002/cm.21991","url":null,"abstract":"<p>ON THE INNER BACK COVER: The focal adhesion protein Hic-5 localizes to the distal ends of stress fiber-associated septin filaments. U2OS osteosarcoma cells were stained for Hic-5 (blue), Septin 7 (green), and F-actin (red).</p><p>Credit: Katia Brock (Department of Cell and Developmental Biology, State University of New York Upstate Medical University)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55186,"journal":{"name":"Cytoskeleton","volume":"82 1-2","pages":"C3"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cm.21991","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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