Health Psychology最新文献

{"title":"Cognitive behavioral stress management and physical activity in breast cancer survivors: A two-part growth model.","authors":"Ruth G St Fleur, Molly Ream, Mason J Krueger, Tracy Crane, Bonnie B Blomberg, Michael H Antoni","doi":"10.1037/hea0001584","DOIUrl":"10.1037/hea0001584","url":null,"abstract":"<p><strong>Objective: </strong>We modeled changes in both engagement versus nonengagement and frequency of engagement in moderate to vigorous physical activity (MVPA) in women with breast cancer (BC) participating in a trial of cognitive behavioral stress management (CBSM) intervention during the first year of treatment.</p><p><strong>Method: </strong>We recruited 240 women with Stage 0-III BC 2-8 weeks postsurgery and randomly assigned them to either a 10-week group CBSM intervention or 1-day psychoeducational (PE) control before they began adjuvant therapy. A brief version of the Seven-Day Physical Activity (PA) Report measured frequency of MVPA, and a measure of perceived stress management skills assessed stress awareness, relaxation skills, and coping confidence in participants at baseline (T1), 6 months (T2), and 12 months (T3) after randomization. We used a two-part latent growth to model change in both engagement versus nonengagement and frequency of engagement in MVPA.</p><p><strong>Results: </strong>The unconditional model showed significant changes in frequency of engagement in MVPA over time (β = 0.11, <i>p</i> < .01) and significant increase in the likelihood of becoming engaged in MVPA over time (β = 1.40, <i>p</i> < .001). In a fully adjusted model, assignment to CBSM was associated with a greater likelihood of becoming engaged in MVPA over time (β = 0.45, <i>p</i> = .02) compared with PE control, although CBSM did not affect MVPA frequency. Those in CBSM revealed greater increases in confidence in relaxation skills (<i>p</i> < .001) but neither stress awareness nor coping skills versus PE controls. Although greater increases in perceived stress awareness, relaxation skills, and coping confidence over time related to MVPA engagement across the entire sample, they did not mediate the effects of CBSM on changes in MVPA engagement (<i>p</i> > .05).</p><p><strong>Conclusions: </strong>CBSM increased the likelihood of MVPA engagement during primary treatment for BC. However, contrary to hypotheses, perceived stress management skills did not mediate this relationship. Further research should explore additional pathways to better understand how CBSM may have supported physical activity engagement during or after cancer treatment. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"837-847"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of self-compassion on stress and health behaviors in daily life: A randomized controlled trial.","authors":"Jinyi Liu, Mark Conner, Daryl B O'Connor","doi":"10.1037/hea0001633","DOIUrl":"10.1037/hea0001633","url":null,"abstract":"<p><strong>Objective: </strong>Daily stress is closely linked to health behaviors in everyday life, yet few interventions have examined how self-compassion shapes the associations at the daily level. This randomized controlled trial evaluated whether a brief expressive-writing self-compassion intervention impacted daily stress, daily health behaviors, and stress-behavior relationships across 7 days.</p><p><strong>Methods: </strong>Participants were randomly assigned to either a self-compassion writing condition (N = 78) or a control condition (N = 88), followed by a 7-day daily diary assessing daily hassles, uplifts, eating, sleep, physical activity, and alcohol use. Self-compassion was measured at baseline and 1 week after completion of the daily diaries.</p><p><strong>Results: </strong>The manipulation moderated the associations between daily hassles and snacking and between daily uplifts and snacking. In the control condition, higher daily stress and daily positive experiences were associated with greater total and unhealthy snacking, whereas the associations were diminished or absent in the experimental condition. However, participants in the self-compassion condition reported shorter sleep duration on days characterized by higher uplifts. Multilevel mediation analyses revealed no direct or indirect effects of the intervention on daily stress or daily health behaviors. Mixed analyses of variance indicated that although self-compassion increased over time, the intervention condition did not have greater increases in self-compassion compared with the control condition.</p><p><strong>Conclusions: </strong>The findings provide initial evidence that a brief expressive-writing self-compassion intervention may buffer stress-behavior dynamics in daily life. Future research should focus on whether increasing the frequency of self-compassion practices can strengthen and sustain the effects over time and across diverse populations. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating moderators of prognostic awareness and quality of life in advanced cancer.","authors":"Joely A Centracchio, Maria M Llabre, Patricia I Moreno, Ella Caruso, Julia Pepper, Areej El-Jawahri, Hermioni L Amonoo, Lara Traeger","doi":"10.1037/hea0001632","DOIUrl":"10.1037/hea0001632","url":null,"abstract":"<p><strong>Objective: </strong>Prognostic awareness is critical for patients with advanced cancer to make informed end-of-life care decisions. However, evidence linking prognostic awareness to quality of life (QOL) is mixed, partly due to variations in factors such as cancer type, age, and anxiety levels. We evaluated the extent to which these factors moderated the association between prognostic awareness and patient-reported QOL across three theoretically driven domains of prognostic awareness: cognitive acknowledgment (recognition of incurability), emotional coping (emotional processing), and adaptive response (using awareness to guide life and medical decisions).</p><p><strong>Method: </strong>Data were obtained from a cross-sectional observational study of prognostic awareness in adults with metastatic solid tumors at Massachusetts General Hospital (2019-2022), including breast (23%), GI (27.6%), GU (24.3%), and lung (25.1%) cancers. Surveys assessed prognostic awareness (Prognostic Awareness Impact Scale), anxiety symptoms (Hospital Anxiety and Depression Scale), and QOL (Functional Assessment of Cancer Therapy). Cancer type was confirmed by chart review. Moderation analyses used multivariable regression.</p><p><strong>Results: </strong>Among 395 participants (<i>M</i>_age = 65.5, 50.9% female, 98% non-Hispanic White), emotional coping (<i>B</i> = 1.73), adaptive response (<i>B</i> = 0.33), and longer time since diagnosis (<i>B</i> = 0.003) were associated with better QOL, regardless of age, anxiety symptoms, or cancer type. Cognitive acknowledgment was not associated with QOL (<i>p</i> = .09).</p><p><strong>Conclusion: </strong>The ability to cope with prognosis (emotional coping) and make informed decisions based on such knowledge (adaptive response) was positively associated with patients' QOL across age, anxiety symptoms, and cancer type, suggesting no specific vulnerabilities or protective factors among the tested moderators. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The perils of partialing optimism: Relationships with personality and health.","authors":"Suzanne C Segerstrom, Donald R Lynam","doi":"10.1037/hea0001635","DOIUrl":"10.1037/hea0001635","url":null,"abstract":"<p><strong>Objective: </strong>The question of whether optimistic or pessimistic items in the Life Orientation Test-Revised better predict psychological and physical outcomes is often addressed by entering both subscales in the same model. This approach risks the \"perils of partialing\" in which partial constructs have lower reliability and different nomological nets than their unpartialed counterparts.</p><p><strong>Methods: </strong>The present studies tested the effects of partialing optimism and pessimism using structural equation modeling to test differences in external validity and intraclass correlations to test similarity of profiles.</p><p><strong>Results: </strong>In Study 1 (<i>N</i> = 2,281 older adults), the optimism-pessimism correlation was modest (<i>r</i> = -.32), but nomological nets for unpartialed and partialed constructs with personality and health were significantly different (all <i>p</i> < .00001). In Study 2 (<i>N</i> = 739 younger and midlife adults), the optimism-pessimism correlation was higher (<i>r</i> = -.61). Nomological nets were significantly different (all <i>p</i> < .00001). Examination of item correlations indicated that partialed constructs may have lost convergent validity with key theoretical elements of trait optimism.</p><p><strong>Conclusion: </strong>Differences between optimism and pessimism were fewer than those between each and its partialed counterpart, and results with partialed optimism and pessimism constructs should be viewed with caution. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress, social support, and long COVID diagnosis and symptom burden in women.","authors":"Darya Likhacheva, Benjamin Hechtman, Heidi Preis, Sarah S Samad, Brittain Mahaffey, Marci Lobel","doi":"10.1037/hea0001626","DOIUrl":"https://doi.org/10.1037/hea0001626","url":null,"abstract":"<p><strong>Objectives: </strong>To examine whether general stress and childcare stress are associated with long COVID status, symptom number, and symptom duration in women, and whether perceived and received social support moderate associations after accounting for sociodemographic and health-related factors.</p><p><strong>Method: </strong>Participants were 2,508 U.S. mothers of young children who completed an online survey in July 2023 as part of a larger longitudinal study begun with pregnant women during the pandemic. All reported at least one prior COVID-19 infection and a subset (<i>n</i> = 280) reported perceived or diagnosed long COVID.</p><p><strong>Results: </strong>Higher general stress (aggregate of past 6 months, past month, current stress) was associated with a greater number of symptoms and higher odds of long COVID, but not with symptom duration. Childcare stress was marginally associated with shorter duration; a greater number of dependent children predicted more symptoms but lower diagnostic odds. Greater perceived support weakened the stress-symptom association but marginally strengthened the stress-long COVID association. Greater received support buffered the stress-long COVID link yet amplified stress-related differences in symptom duration. Overall, childcare stress and interaction effects were not robust to correction for multiple comparisons.</p><p><strong>Conclusions: </strong>Stress is meaningfully linked to long COVID risk, symptom number, and duration among women, but associations vary across outcomes and are modified by different types of social support. Differentiating perceived and diagnosed long COVID revealed potential inequities in illness recognition. Findings underscore the need for gender-sensitive approaches to long COVID research and care that consider potential impacts of stress and social support. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food consumption and frailty in older adults: A systematic review and meta-analysis.","authors":"Min Pu, Qianying Ma","doi":"10.1037/hea0001628","DOIUrl":"10.1037/hea0001628","url":null,"abstract":"<p><strong>Objective: </strong>Frailty is an age-related syndrome characterized by biological dysfunction and reduced physiological reserve in response to stressors. Its prevalence is increasing as the population ages, resulting in a substantial health burden due to adverse health outcomes. This systematic review and meta-analysis examined the association between ultra-processed food (UPF) intake and the risk of frailty in older adults.</p><p><strong>Method: </strong>This study systematically searched PubMed and Web of Science for all relevant studies published up to January 2026. Random-effects models were employed to analyze the pooled effect sizes and 95% confidence intervals. Ten observational studies involving 105,327 participants, comprising six prospective and four cross-sectional studies, were included in the systematic review. Of these, six studies were eligible for meta-analysis, including 22,821 participants.</p><p><strong>Results: </strong>Six of the 10 studies adjusted for total energy intake, and three adjusted for macronutrient intake. Meta-analysis showed that higher consumption of UPFs was significantly associated with an increased risk of frailty (pooled <i>OR</i> = 1.43, 95% confidence interval [1.02, 2.005], <i>p</i> = .041). Narrative synthesis further supported a positive association between UPF intake and frailty.</p><p><strong>Conclusion: </strong>Our findings suggest that higher consumption of UPFs may increase the risk of frailty, potentially through inflammatory pathways. However, given the high heterogeneity, the results should be interpreted with caution. Overall, our findings suggest that reducing UPF consumption may be a promising target for public health strategies to prevent frailty in aging populations. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health locus of control and cardiovascular risk: A serial mediation analysis.","authors":"Wajiha Masroor, Nguyen P Nguyen, Christine Cao, Nimra Ali Shah","doi":"10.1037/hea0001629","DOIUrl":"https://doi.org/10.1037/hea0001629","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular disease is the leading cause of death worldwide. Health locus of control (HLOC), defined as the degree to which an individual believes they influence health outcomes, has been linked to cardiovascular risk. Yet few studies have examined the mechanisms that explain this relationship.</p><p><strong>Method: </strong>Grounded in the biopsychosocial framework and health beliefs model, the present study explored the longitudinal serial mediation role of self-esteem and pessimism in the relationship between HLOC and cardiovascular risk. Data from the Midlife in the United States study were used. The sample consisted of 517 participants, with the majority identifying as female (57.3%) and White (93.9%).</p><p><strong>Results: </strong>The longitudinal serial mediation revealed that HLOC at timepoint 1 (T1) significantly predicted cardiovascular risk at timepoint 3 (T3), with this pathway partially mediated by self-esteem as mediator 1 (M1) and pessimism as mediator 2 (M2). Participants with greater internal HLOC beliefs had higher self-esteem, endorsed less pessimistic beliefs, and experienced lower cardiovascular risk.</p><p><strong>Conclusions: </strong>These findings highlight the impact of control-related beliefs on cardiovascular health, suggesting that psychological mechanisms, including self-esteem and outlook beliefs, influence engagement in health-promoting behaviors and subsequent health outcomes. This underscores the importance of their inclusion in the assessment and treatment of cardiovascular disease. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting parents' HPV vaccination intentions and behaviors across countries and time.","authors":"Julia V Schulz, Johannes T Doerflinger, Cindy Behm, Nora Heinzelmann, Peter M Gollwitzer, Katrin Platzer, Gabriele Oettingen","doi":"10.1037/hea0001596","DOIUrl":"10.1037/hea0001596","url":null,"abstract":"<p><strong>Objective: </strong>This study compares three models of parental human papillomavirus (HPV) vaccination intentions across United States, United Kingdom, and Germany: A model based on the theory of planned behavior (TPB), a model incorporating variables of the health belief model (HBM), and a model that adds factors identified in previous empirical research. We also examine whether these models predict vaccination behavior 1 year later in the United States and United Kingdom. The goal is to provide insights for designing targeted interventions.</p><p><strong>Method: </strong>A preregistered online study (February-March 2023) surveyed 1,088 parents from United States, United Kingdom, and Germany measuring variables related to the TPB (attitudes, subjective norms, and perceived behavioral control) and the HBM (risk and effectiveness perceptions), factors identified in previous empirical research (e.g., knowledge), and HPV vaccination intentions. One year later, 625 participants (United States and United Kingdom) were recontacted to assess vaccination behavior.</p><p><strong>Results: </strong>Structural equation modeling revealed that TPB accounted for 77% of the variance of vaccination intentions. HBM variables were associated with attitudes (85% variance accounted for). Vaccination intentions, trust in science, and HPV vaccination knowledge predicted vaccination behavior 1 year later (25% variance accounted for).</p><p><strong>Conclusions: </strong>TPB was strongly associated with parental HPV vaccination intentions, with attitudes and norms as key correlates. HBM variables were associated with attitudes but did not improve behavior predictions. Trust in science and HPV knowledge directly predicted vaccination behavior 1 year later. These findings suggest that interventions should target TPB and HBM variables to shape intentions and attitudes while fostering vaccination knowledge to sustain long-term behavior. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"761-772"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-rated health and inflammation: Associations among partnered sexual minority and heterosexual adults.","authors":"Lisa M Christian, Rebecca R Andridge, Juan Peng, Thomas W McDade, Wendy D Manning, Claire M Kamp Dush","doi":"10.1037/hea0001594","DOIUrl":"10.1037/hea0001594","url":null,"abstract":"<p><strong>Objective: </strong>Self-rated health (SRH), as measured by a single item, is a well-established and remarkably robust predictor of morbidity and mortality, yet few studies have examined its biological correlates across diverse sexual orientation identities.</p><p><strong>Method: </strong>Using data from the population-representative National Couples' Health and Time study (NCHAT) and its biospecimen substudy (NCHAT-BIO), this study explored the relationship between lesbian, gay, bisexual, queer, or other nonheterosexual identities (LGBQ+), SRH, and systemic inflammation. Among 3,477 partnered (married or cohabiting) cisgender adults, 42.6% identified as LGBQ+, and a subset of 652 (41.3% LGBQ+) provided dried blood spot samples analyzed for interleukin-6 (IL-6) and C-reactive protein (CRP).</p><p><strong>Results: </strong>In the full NCHAT sample, LGBQ+ respondents reported significantly poorer SRH than their heterosexual peers (LGBQ+ vs. heterosexual: <i>t</i> = 3.3574, <i>df</i> = 3,466, <i>p</i> value < .001). In the NCHAT-BIO subsample, poorer SRH was significantly related to both higher IL-6 (β = -.23, <i>SE</i> = .042, <i>p</i> < .0001) and higher CRP (β = -.41, SE = .054, <i>p</i> < .0001), supporting the hypothesis that subjective health assessments may capture interoceptive awareness of inflammatory status. Importantly, the strength of the association between SRH and inflammation did not differ across groups based on sexual orientation and gender (Interaction <i>p</i> value for IL-6: .46, for CRP: .39). The associations between SRH and inflammatory markers were slightly attenuated after inclusion of key health and behavioral covariates, suggesting potential mediating factors warranting future investigation.</p><p><strong>Conclusions: </strong>These findings replicate prior research on SRH and inflammation and extend them to LGBQ+ plus adults, underscoring the importance of inclusive health measurement. Given SRH's robust predictive power for future morbidity and mortality, integrating assessments of sexual orientation and biological markers offers critical insight for understanding and addressing health disparities. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"748-760"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative affect and peripheral inflammation: The role of cognitive reappraisal and expressive suppression.","authors":"E Lydia Wu-Chung, Peter J Gianaros, Anna L Marsland","doi":"10.1037/hea0001587","DOIUrl":"10.1037/hea0001587","url":null,"abstract":"<p><p>The association between global negative affect and inflammation is inconsistently observed in healthy, community samples.</p><p><strong>Objectives: </strong>Identifying person-level characteristics that influence this association may help clarify how negative affect confers risk of morbidity and mortality and which individuals may benefit from early intervention. One such characteristic that may influence the negative affect-inflammation association includes the use of emotion regulation strategies. Here, we examined whether regular use of emotion regulation strategies, namely reappraisal and suppression, moderated the association between global negative affect and peripheral inflammation.</p><p><strong>Method: </strong>Proinflammatory biomarkers (interleukin-6 [IL-6] and C-reactive protein) and self-reported negative affect and emotion regulation usage were assessed at the baseline visit of three study cohorts completed between 2008 and 2021. Age, sex, body mass index, and education were included as covariates in multiple regression models.</p><p><strong>Results: </strong>In a healthy sample of midlife adults (<i>N</i> = 1,033), expressive suppression (<i>p</i> = .049) and cognitive reappraisal (<i>p</i> = .044) moderated the association between negative affect and IL-6, such that negative affect was positively associated with IL-6 levels only among adults who reported more frequent use of expressive suppression or cognitive reappraisal. Patterns remained consistent after controlling for perceived stress and negative life events and excluding participants based on immune-related medical history. No significant associations were observed with C-reactive protein.</p><p><strong>Conclusions: </strong>Findings suggest that, among otherwise healthy adults, the more frequent-and possibly contextually invariant-use of suppression or reappraisal may partly influence the variable coupling between negative affect and IL-6. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"736-747"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}