Qi-Yu Zhao , Teng Guo , Jing-Jing Hu , Li-Ting Xie , Wei-Lu Chai , Guo Tian , Tian-An Jiang
{"title":"Safety and effectiveness of balloon catheter-assisted ultrasound-guided percutaneous microwave ablation in difficult-site liver cancer","authors":"Qi-Yu Zhao , Teng Guo , Jing-Jing Hu , Li-Ting Xie , Wei-Lu Chai , Guo Tian , Tian-An Jiang","doi":"10.1016/j.hbpd.2024.09.012","DOIUrl":"10.1016/j.hbpd.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>Balloon catheter isolation is a promising auxiliary method for thermal ablation treatment of liver cancer. We aimed to explore the safety and effectiveness of balloon catheter isolation-assisted ultrasound-guided percutaneous microwave ablation (MWA) in treating liver cancer in difficult anatomical locations.</div></div><div><h3>Methods</h3><div>Data of 132 patients with 145 difficult-site liver cancer treated with ultrasound-guided percutaneous MWA were retrospectively analyzed. Participants were classified into the isolation (<em>n</em> = 40) and non-isolation (<em>n</em> = 92) groups based on whether the patients were treated using a balloon catheter prior to ablation. The major complication rates, local tumor residuals (LTR), and tumor follow-up for local tumor progression (LTP) at 6 and 12 months post-ablation were compared between the two groups.</div></div><div><h3>Results</h3><div>The rates of major postoperative complications did not significantly differ between the isolation and non-isolation groups (2.5% vs. 4.3%, <em>P</em> = 0.609). The postoperative LTR rates were significantly different between the isolation and non-isolation groups (4.8% vs. 17.5%, <em>P</em> = 0.032). Balloon catheter isolation [odds ratio (OR) = 0.225, 95% confidence interval (CI): 0.085–0.595, <em>P</em> = 0.009] and tumor diameter (OR = 2.808, 95% CI: 1.186–6.647, <em>P</em> = 0.019) were identified as independent factors influencing LTR rate. The cumulative LTP rates at 6 and 12 months after ablation showed no significant differences between the isolation and non-isolation groups (2.6% vs. 7.9%, <em>P</em> = 0.661; 4.9% vs. 9.8%, <em>P</em> = 0.676, respectively). Cox proportional hazards regression analysis showed that tumor diameter was an independent risk factor for cumulative LTP rate (OR = 3.445, 95% CI: 1.406–8.437, <em>P</em> = 0.017).</div></div><div><h3>Conclusions</h3><div>Balloon catheter isolation-assisted MWA was safe and effective in the treatment of difficult-site liver cancer. Additionally, tumor diameter significantly influenced LTR and LTP rates after ablation.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 84-91"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheng-Jun Xu , Qiang Wei , Xin Hu , Chang-Biao Li , Zhe Yang , Shu-Sen Zheng , Xiao Xu
{"title":"No-touch recipient hepatectomy in liver transplantation for liver malignancies: A state-of-the-art review","authors":"Sheng-Jun Xu , Qiang Wei , Xin Hu , Chang-Biao Li , Zhe Yang , Shu-Sen Zheng , Xiao Xu","doi":"10.1016/j.hbpd.2024.10.004","DOIUrl":"10.1016/j.hbpd.2024.10.004","url":null,"abstract":"<div><div>Tumor recurrence, the Gordian knot of liver transplantation for malignancies, may be attributed to many parameters. The technique of the “classical” recipient hepatectomy is believed to be one of the potential reasons to cause tumor evasion because of the possible increase of circulating tumor cells, thus leading to an increased recurrent rate. On this background, the no-touch oncological recipient hepatectomy technique has been developed. A comprehensive review of the development and the key surgical steps of the no-touch recipient hepatectomy is presented. This technique might improve clinical outcomes, especially for those recipients who are at a high risk for tumor recurrence. Multicenter prospective studies should be set up to further validate the prognostic role of this technique in patients with liver cancer treated with liver transplantation.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 39-44"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abudusalamu Aini , Qian Lu , Hao Wen , Wen-Tao Wang , Tuerganaili Aji , Zhi-Yu Chen , Lei-Da Zhang , Zhan-Yu Yang , Jia-Yin Yang , Hai-Ning Fan , Wei-Lin Wang , Xiang-Cheng Li , Yu Zhang , Jia-Hong Dong
{"title":"Particular Chinese contributions to extracorporeal liver surgery","authors":"Abudusalamu Aini , Qian Lu , Hao Wen , Wen-Tao Wang , Tuerganaili Aji , Zhi-Yu Chen , Lei-Da Zhang , Zhan-Yu Yang , Jia-Yin Yang , Hai-Ning Fan , Wei-Lin Wang , Xiang-Cheng Li , Yu Zhang , Jia-Hong Dong","doi":"10.1016/j.hbpd.2024.12.005","DOIUrl":"10.1016/j.hbpd.2024.12.005","url":null,"abstract":"<div><div>Extracorporeal liver surgery (ELS), also known as liver autotransplantation, is a hybrid (cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, <em>ex-situ</em> liver resection and autotransplantation (ELRA), <em>ante-situm</em> liver resection and autotransplantation (ALRA) and auxiliary partial liver autotransplantation (APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous efforts done by Chinese surgeons and researchers. Especially, the precision liver surgery paradigm has allowed to transform ELS into a modularized, more simplified, and standardized surgery, to upgrade surgical skills, to improve peri-operative outcome and long-term survival, to increase the capability of surgeons to select more complex diseases and to expand the level of medical service to the population. This review highlights the Chinese contributions to the field of ELS, focusing thereby on features of different surgical types, technical innovations, disease selection and surgical indication, patient prognosis and future perspectives.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 57-66"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bei Lu, Jun-Jie Yin, Jing-Rui Wang, Xiao Xu, Yang Cai
{"title":"Combination of ultrasonic lithotripsy system and video-assisted retroperitoneal debridement in treatment of laterally located pancreatic walled-off necrosis","authors":"Bei Lu, Jun-Jie Yin, Jing-Rui Wang, Xiao Xu, Yang Cai","doi":"10.1016/j.hbpd.2024.05.004","DOIUrl":"10.1016/j.hbpd.2024.05.004","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 104-107"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141255865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qi-Fu Yan , Wei Yang , Jian-Ming Ma , Zhaxiyundan , Yong-Zhi Chen , Rui Tang
{"title":"Mixed reality technology improves liver surgery in lower-volume medical center","authors":"Qi-Fu Yan , Wei Yang , Jian-Ming Ma , Zhaxiyundan , Yong-Zhi Chen , Rui Tang","doi":"10.1016/j.hbpd.2024.05.002","DOIUrl":"10.1016/j.hbpd.2024.05.002","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 117-118"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma","authors":"Chu-Li Fu , Zheng-Wei Zhao , Qiang-Nu Zhang","doi":"10.1016/j.hbpd.2024.08.004","DOIUrl":"10.1016/j.hbpd.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><div>Within the tumor microenvironment, survival pressures are prevalent with potent drivers of tumor progression, angiogenesis, and therapeutic resistance. N6-methyladenosine (m<sup>6</sup>A) methylation has been recognized as a critical post-transcriptional mechanism regulating various aspects of mRNA metabolism. Understanding the intricate interplay between survival pressures and m<sup>6</sup>A modification provides new insights into the molecular mechanisms underlying hepatocellular carcinoma (HCC) progression and highlights the potential for targeting the survival pressures-m<sup>6</sup>A axis in HCC diagnosis and treatment.</div></div><div><h3>Data sources</h3><div>A literature search was conducted in PubMed, MEDLINE, and Web of Science for relevant articles published up to April 2024. The keywords used for the search included hepatocellular carcinoma, cellular survival, survival pressure, N6-methyladenosine, tumor microenvironment, stress response, and hypoxia.</div></div><div><h3>Results</h3><div>This review delves into the multifaceted roles of survival pressures and m<sup>6</sup>A RNA methylation in HCC, highlighting how survival pressures modulate the m<sup>6</sup>A landscape, the impact of m<sup>6</sup>A modification on survival pressure-responsive gene expression, and the consequent effects on HCC cell survival, proliferation, metastasis, and resistance to treatment. Furthermore, we explored the therapeutic potential of targeting this crosstalk, proposing strategies that leverage the understanding of survival pressures and m<sup>6</sup>A RNA methylation mechanisms to develop novel, and more effective treatments for HCC.</div></div><div><h3>Conclusions</h3><div>The interplay between survival pressures and m<sup>6</sup>A RNA methylation emerges as a complex regulatory network that influences HCC pathogenesis and progression.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 67-75"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhe Yang , Jian-Peng Liu , Jun-Li Chen , Shu-Sen Zheng
{"title":"China Liver Transplant Registry plays an important role in liver transplantation","authors":"Zhe Yang , Jian-Peng Liu , Jun-Li Chen , Shu-Sen Zheng","doi":"10.1016/j.hbpd.2024.11.006","DOIUrl":"10.1016/j.hbpd.2024.11.006","url":null,"abstract":"<div><div>In China, liver transplantation is an important discipline in the field of organ transplantation. China Liver Transplant Registry (CLTR) is a scientific project that has been set up to advance surgical techniques and procedures and to improve both short- and long-term post-transplant follow-up and outcome of the liver recipients. CLTR also serves as a robust data support platform for the National Liver Transplant Quality Control Center in the quest to upscale its quality control protocols. The mission of CLTR is to register all liver transplantation activities in the mainland of China and to conduct scientific analyses of the collected data. The huge number of compiled cases and the scientific research conducted over the past decade based on this database drastically revolutionized the clinical practice in the country. All CLTR activities and projects will be a guarantee to foster progresses of liver transplantation in China in a more scientific way, to standardize the systematic care in the field of liver transplantation.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 14-17"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}