遵守术后定期随访对肝细胞癌根治性切除术后长期预后的影响: 一项多中心分析。

IF 4.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Lan-Qing Yao , Jin-Bo Gong , Lei Cai , Li-Hui Gu , Ying-Jian Liang , Hong-Wei Guo , Kong-Ying Lin , Zi-Qiang Li , Qi-Xuan Zheng , Ya-Hao Zhou , Ting-Hao Chen , Zhong Chen , Hong Wang , Han Liu , Han Wu , Timothy M Pawlik , Feng Shen , Eric CH Lai , Tian Yang
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引用次数: 0

摘要

背景:尽管手术治疗取得了进展,但术后高复发仍然是肝细胞癌(HCC)患者面临的挑战。本研究旨在探讨接受根治性肝细胞癌切除术患者的定期随访依从性与长期肿瘤预后之间的关系。方法:这项多中心研究纳入了2012年1月至2021年12月在12个肝脏手术中心接受早期HCC根治性切除术的患者。将患者分为常规随访组(前2年每2-3个月随访一次,此后每3-6个月随访一次)和不定期/无随访组。比较两组患者的总生存期(OS)、复发时间(TTR)和复发后生存期(PRS)。结果:1544例患者中,786例(50.9 %)在术后随访中接受了常规随访。常规随访组的OS(中位数:113.4个月vs 94.5个月,P = 0.010)和PRS(中位数:37.9个月vs 16.3个月,P < 0.001)优于不规则/无随访组,尽管TTR相当(中位数:61.4个月vs 66.2个月,P = 0.161)。此外,常规随访组患者的肿瘤复发超过米兰标准的发生率较低(41.6 %对50.4 %,P = 0.013),更有可能接受治愈性复发治疗(56.1 %对49.3 %,P = 0.061)。在多因素分析中,定期随访的依从性是较好的OS[风险比(HR) = 0.777, 95 %可信区间(CI): 0.663-0.910, P = 0.002]和PRS (HR = 0.523, 95 % CI: 0.428-0.638, P < 0.001)的独立因素。结论:术后定期随访可提高HCC根治性切除术后的OS和PRS,突出了术后定期随访对早期发现复发和及时干预的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of compliance to postoperative regular follow-up on long-term prognosis after curative resection for hepatocellular carcinoma: A multicenter analysis

Background

Despite advances in surgical treatment, high recurrence after surgery remains a challenge for patients with hepatocellular carcinoma (HCC). This study aimed to investigate the association between compliance to regular follow-up and long-term oncological outcomes among patients undergoing curative resection for HCC.

Methods

This multicenter study included patients who underwent curative resection for early-stage HCC between January 2012 and December 2021 at 12 liver surgery centers. Patients were stratified into a regular follow-up group (follow-up every 2–3 months for the first 2 years and every 3–6 months thereafter) and an irregular/no follow-up group. Overall survival (OS), time to recurrence (TTR), and post-recurrence survival (PRS) were compared between the two groups.

Results

Among 1544 patients, 786 (50.9%) underwent regular follow-up during postoperative follow-up. The regular follow-up group had better OS (median: 113.4 vs. 94.5 months, P = 0.010) and PRS (median: 37.9 vs. 16.3 months, P < 0.001) than the irregular/no follow-up group, although TTR was comparable (median: 61.4 vs. 66.2 months, P = 0.161). Furthermore, patients in the regular follow-up group had a lower incidence of tumor beyond the Milan criteria at recurrence (41.6% vs. 50.4%, P = 0.013) and were more likely to receive curative treatments for recurrence (56.1% vs. 49.3%, P = 0.061). On multivariate analysis, compliance to regular follow-up was an independent factor associated with better OS [hazard ratio (HR) = 0.777, 95% confidence interval (CI): 0.663–0.910, P = 0.002] and PRS (HR = 0.523, 95% CI: 0.428–0.638, P < 0.001).

Conclusions

Compliance to regular follow-up improved OS and PRS after curative resection for HCC, highlighting the importance of postoperative regular follow-up for early detection of recurrence and timely intervention.
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来源期刊
CiteScore
5.40
自引率
6.10%
发文量
152
审稿时长
3.0 months
期刊介绍: Hepatobiliary & Pancreatic Diseases International (HBPD INT) (ISSN 1499-3872 / CN 33-1391/R) a bimonthly journal published by First Affiliated Hospital, Zhejiang University School of Medicine, China. It publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas under the headings Liver, Biliary, Pancreas, Transplantation, Research, Special Reports, Editorials, Review Articles, Brief Communications, Clinical Summary, Clinical Images and Case Reports. It also deals with the basic sciences and experimental work. The journal is abstracted and indexed in SCI-E, IM/MEDLINE, EMBASE/EM, CA, Scopus, ScienceDirect, etc.
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