Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Novel treatment strategies for pancreatitis: Current status and future prospects.","authors":"Wen-Bin Zou, Sheng-Han Mao, Zhao-Shen Li","doi":"10.1016/j.hbpd.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.06.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute liver failure caused by amino acid or organic acid related inborn errors of metabolism.","authors":"Ying Zhou, Chi Chen, Xin Yang","doi":"10.1016/j.hbpd.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.06.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram to predict massive bleeding requiring intervention in severe acute pancreatitis.","authors":"Xiao-Yu Guo, Fan Xiao, Jie Hu, Hui Lin, Zi-Jian Huang, Liang Zhang, Long Cheng, Gang Wang","doi":"10.1016/j.hbpd.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.06.004","url":null,"abstract":"<p><strong>Background: </strong>Hemorrhage remains a formidable complication of severe acute pancreatitis (SAP), with a high mortality rate. However, there is currently no effective method for identifying SAP patients who are at high risk for massive bleeding. The present study aimed to explore risk factors for predicting massive bleeding in SAP patients and to develop a predictive nomogram, which could facilitate early prediction, and timely appropriate interventions.</p><p><strong>Methods: </strong>We conducted a multivariate logistic regression analysis to examine the relationship between massive bleeding and variables including patient demographics, disease severity, laboratory indexes and local pancreatic complications. A novel nomogram was constructed based on these factors, and was validated both internally and externally assessing its discrimination, calibration, and clinical applicability.</p><p><strong>Results: </strong>The study involved 351 patients in the training cohort, 104 patients in the internal validation cohort, and 123 patients in the external validation cohort. Logistic regression analysis identified several independent risk factors for massive bleeding, including computed tomography severity index score above 8 points, Acute Physiology and Chronic Health Evaluation II score greater than 16 points, abdominal compartment syndrome, pancreatic fistula, and sepsis. The nomogram constructed from these factors yielded an area under the receiver operating characteristic curve (AUC) of 0.896 and a coefficient of determination (R²) of 0.093. The Hosmer-Lemeshow test indicated good model fitness (P = 0.654). Furthermore, the nomogram demonstrated reliable performance in both validation cohorts.</p><p><strong>Conclusions: </strong>The nomogram showed strong predictive capability for massive bleeding and could be a valuable tool for clinicians in identifying SAP patients at high risk for this complication at an early stage.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of prealbumin levels in the early phase of acute pancreatitis are associated with infected pancreatic necrosis.","authors":"Zi-Rui Liu, Yi-Zhe Chen, Yang Liu, Kang Li, Yi-Zhen Xu, Lin Gao, Lu Ke, Wei-Qin Li","doi":"10.1016/j.hbpd.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.06.002","url":null,"abstract":"<p><strong>Background: </strong>Infected pancreatic necrosis (IPN) is a highly morbid local complication following necrotizing pancreatitis. Early enteral nutrition has been proven to be effective in preventing IPN. This study aimed to assess the association between the trajectory of prealbumin (PAB) during the early phase of acute pancreatitis (AP) and the incidence of IPN and other clinical outcomes.</p><p><strong>Methods: </strong>This retrospective, dual-centered study screened patients with AP admitted to the Center of Acute Pancreatitis, Jinling Hospital and the Affiliated Hospital of Zunyi Medical University from January 2018 to December 2022. The PAB levels during the first week after admission were collected. The primary outcome was the incidence of IPN within 90 days after AP onset. Group-based trajectory modelling was performed to describe the trajectory of PAB levels over time. A Cox proportional hazard model was used to facilitate the interpretation of the time-varying hazard ratio (HR) between PAB and outcomes. Fine-Gray sub-distribution hazard model was adopted for sensitivity analysis.</p><p><strong>Results: </strong>A total of 373 patients were included, of whom 82 (22.0%) were diagnosed with IPN within 90 days. The trajectory model assigned 232 patients to the low-level PAB (L-PAB) group and 141 to the high-level PAB (H-PAB) group. The incidence of 90-day IPN in the L-PAB group was significantly higher than that in the H-PAB group (26.7% vs. 14.2%, P = 0.005). The multivariate Cox regression model showed that a high PAB trajectory was associated with a lower incidence of IPN (HR = 0.52, 95% CI: 0.30-0.89; P = 0.017) after adjustment for potential confounders. In the sensitivity analysis, taking death as a competing risk, high PAB trajectory remained significantly associated with a lower incidence of IPN in the Fine-Gray model (HR = 0.55, 95% CI: 0.33-0.92; P = 0.022).</p><p><strong>Conclusions: </strong>A high PAB trajectory within the first week of AP was significantly associated with a lower incidence of IPN within 90 days after AP onset. Dynamic monitoring of PAB levels in the early phase of AP may play an important role in stratifying patients at high risk of developing IPN.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel drug targets for the early treatment of acute pancreatitis: Focusing on calcium signaling.","authors":"Jin-Hao Chen, Robert Sutton, Li Wen","doi":"10.1016/j.hbpd.2025.06.001","DOIUrl":"10.1016/j.hbpd.2025.06.001","url":null,"abstract":"<p><p>Acute pancreatitis (AP) is a common but potentially devastating disease characterized at onset pathophysiologically by premature activation of digestive enzymes within the pancreas. Despite an abundance of preclinical research and, until recently, a series of disappointing clinical trials, no specific disease modifying pharmacological treatment has yet been approved for this condition. Recent novel approaches to understanding the molecular pathogenesis of AP provide us with renewed optimism for translational drug discovery. Although digestive enzyme activation is the hallmark of AP, a critical mechanism that initiates AP is intracellular calcium (Ca²⁺) overload in pancreatic parenchymal cells, which triggers mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and impairs autophagic flux. These processes are pivotal to the disease and present a range of drug targets, associated with the inflammatory responses that drive local and systemic inflammation in AP. Progress in translation has now been made, targeting the ORAI channel with the inhibitor zegocractin (Auxora) to reduce pancreatic injury and inflammatory responses in human AP. Herein we evaluated potential drug targets for the early treatment of AP, focused on intra-acinar mechanisms of injury central to the onset and severity of AP. Our analysis highlights the opportunities and progress in translating these molecular insights into clinical therapies.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous liver transplantation for right liver fragmentation and left lobe ischemia for 46 hours.","authors":"Xiao-Yan Hu, Zi-Biao Zhong, Wei Wang, Zhi-Ping Xia, Jun-Tao Liang, Zhong-Zhong Liu, Shao-Jun Ye, Qi-Fa Ye","doi":"10.1016/j.hbpd.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.05.007","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant chemotherapy improves post-transplant outcome in patients with hepatocellular carcinoma.","authors":"Heng-Kai Zhu, Hai-Bo Mou, Zhuo-Yi Wang, Wu Zhang, Dan Zhu, Si-Yi Zhong, Shu-Sen Zheng, Li Zhuang","doi":"10.1016/j.hbpd.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.05.004","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) recurrence following liver transplantation (LT) remains a major challenge. This study aimed to investigate the effect of adjuvant chemotherapy (ACT) with the modified FOLFOX-6 (mFOLFOX-6) regimen on the post-transplant prognosis of HCC patients.</p><p><strong>Methods: </strong>HCC patients who underwent LT at our institution from June 2017 to December 2019 were enrolled. The cohort was divided into the ACT group (n = 57) and the non-ACT group (n = 93). The median post-transplant follow-up period was 54.0 months. The study endpoints were HCC recurrence and patient mortality following LT. The association between ACT and recurrence/mortality were evaluated through univariate and multivariate analyses utilizing a Cox proportional hazards model, propensity score adjustment, propensity score matching, and inverse probability of treatment weighting (IPTW) analyses. A stratification analysis was performed to determine the interaction effects.</p><p><strong>Results: </strong>The ACT group was younger and had worse tumor characteristics including tumor number, tumor size, portal vein tumor thrombosis, pathological differentiation and microvascular invasion (MVI). The ACT group also demonstrated a lower risk of mortality than the non-ACT group (hazard ratio = 0.36, P = 0.017). It was consistent across sensitivity analyses utilizing propensity score adjustment and matching. There was a significant stronger association between ACT and recurrence-free benefit in patients with grade M2 of MVI compared to patients with grade M0/1 (P for interaction = 0.002).</p><p><strong>Conclusions: </strong>ACT with mFOLFOX-6 regimen decreased the recurrence and mortality risks following LT for HCC patients. ACT may be considered in HCC patients with high risk of recurrence and mortality after LT.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing factors in patients with hepatocellular carcinoma after transarterial chemoembolization.","authors":"Yan Zheng, Fei-Yan Huang, Li-Xia Cai, Chong Peng, Tong-Yin Zhu","doi":"10.1016/j.hbpd.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.05.006","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosome-mediated regulation of macrophage polarization: A novel therapeutic strategy for diabetic wound healing.","authors":"Jia-Le Ma, Ling-Xiao Wang, Hao Yu, Zhi-Kang Zhu, Jia-Hong Xu, Jia-Qi Lou, Shou-Jie Wang","doi":"10.1016/j.hbpd.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.05.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of large pancreatic radiolucent stone.","authors":"Dan Wang, Wei An, Jin-Hui Yi, Fan Wang, Zhao-Shen Li, Liang-Hao Hu","doi":"10.1016/j.hbpd.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.05.003","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have not clarified the treatment of large pancreatic radiolucent stones (≥ 5 mm). The primary objective of this study was to assess the clinical features and therapeutic efficacy in patients with chronic pancreatitis who have large radiolucent stones, and to propose a treatment strategy.</p><p><strong>Methods: </strong>This analysis examined the data of patients with large pancreatic ductal stones (≥ 5 mm) from March 2011 to June 2018. Patients with radiolucent stones were classified as the radiolucent stones group, while those with pancreatic radiopaque stones presented at the same time were randomly selected as controls in a 1:2 ratio. Data on demographics, disease courses and treatment details were retrieved, and stone clearance and pain relief during the follow-up were compared between the two groups.</p><p><strong>Results: </strong>A total of 52 patients with large radiolucent stones and 104 patients with large radiopaque stones were included in the study. Pancreatic extracorporeal shock wave lithotripsy (ESWL) was the initial treatment for large radiopaque stone. Endoscopic retrograde cholangiopancreatography (ERCP) was the first-step treatment for all patients in the radiolucent stones group, of which one patient received medication after failed ERCP cannulation, and four who failed stone extraction were treated with ESWL following the placement of a nasopancreatic catheter. There was no significant difference in the complete stone clearance rate (75.0% vs. 78.8%; P = 0.553) between the two groups. Among the 51 patients in the large radiolucent stones group who were followed up for 5.8 years (range 2.1-12.6), complete pain relief was achieved in 42 patients (82.4%), with no significant difference compared with the radiopaque group (82.4 vs. 76.4%; P = 0.409).</p><p><strong>Conclusions: </strong>ERCP is an effective endotherapy for large radiolucent stone and should be considered the first-step treatment. When stone extraction failed during ERCP, ESWL is recommended following the placement of a nasopancreatic catheter.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}