Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Thanks","authors":"","doi":"10.1016/S1499-3872(24)00156-5","DOIUrl":"10.1016/S1499-3872(24)00156-5","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Page I"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular reconstruction provides short-term and long-term survival benefits for patients with hilar cholangiocarcinoma: A retrospective, multicenter study","authors":"Yi-Xian Huang ,&nbsp;Chao Xu ,&nbsp;Cheng-Cheng Zhang ,&nbsp;Guang-Yi Liu ,&nbsp;Xing-Chao Liu ,&nbsp;Hai-Ning Fan ,&nbsp;Bi Pan ,&nbsp;Yuan-Cheng Li","doi":"10.1016/j.hbpd.2024.05.001","DOIUrl":"10.1016/j.hbpd.2024.05.001","url":null,"abstract":"<div><h3>Background</h3><div><span>In patients with hilar cholangiocarcinoma<span> (HCCA), radical resection can be achieved by resection and reconstruction of the </span></span>vasculature<span>. However, whether vascular reconstruction (VR) improves long-term and short-term prognosis has not been demonstrated comprehensively.</span></div></div><div><h3>Methods</h3><div>This was a retrospective multicenter study of patients who received surgery for HCCA with or without VR. Variables associated with overall survival (OS) and recurrence-free survival (RFS) were identified based on Cox regression. Kaplan-Meier curves were used to explore the impact of VR. Restricted mean survival time (RMST) was used for comparisons of short-term survival between the groups. Patients’ intraoperative and postoperative characteristics were compared.</div></div><div><h3>Results</h3><div>Totally 447 patients were enrolled. We divided these patients into 3 groups: VR with radical resections (<em>n</em> = 84); non-VR radical resections (<em>n</em> = 309) and non-radical resection (we pooled VR-nonradical and non-VR nonradical together, <em>n</em><span> = 54). Cox regression revealed that carbohydrate antigen<span> 242 (CA242), vascular invasion, lymph node metastasis and poor differentiation were independent risk factors for OS and RFS. There was no significant difference of RMST between the VR and non-VR radical groups within 12 months after surgery (10.18 vs. 10.76 mon, </span></span><em>P</em> = 0.179), although the 5-year OS (<em>P</em> &lt; 0.001) and RFS (<em>P</em><span> &lt; 0.001) were worse in the VR radical group. The incidences of most complications were not significantly different, but those of bile leakage (</span><em>P</em><span> &lt; 0.001) and postoperative infection (</span><em>P</em><span> = 0.009) were higher in the VR radical group than in the non-VR radical group. Additionally, the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) up to 7 days after surgery tended to decrease in all groups. There was no significant difference in the incidence of postoperative liver failure between the VR and non-VR radical groups.</span></div></div><div><h3>Conclusions</h3><div>Radical resection can be achieved with VR to improve the survival rate without worsening short-term survival compared with resection with non-VR. After adequate assessment of the patient's general condition, VR can be considered in the resection.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 595-603"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of triggers of senescence and senolysis in murine pancreatic cancer cells","authors":"Denis Revskij ,&nbsp;Aline Woitas ,&nbsp;Bianca Kölle ,&nbsp;Camilla Umstätter ,&nbsp;Dietmar Zechner ,&nbsp;Faiz M Khan ,&nbsp;Georg Fuellen ,&nbsp;Robert Jaster","doi":"10.1016/j.hbpd.2024.06.001","DOIUrl":"10.1016/j.hbpd.2024.06.001","url":null,"abstract":"<div><h3>Background</h3><div>The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer therapy. Here, we studied the efficacy of the genotoxic agent etoposide (Eto) and irradiation in inducing senescence of Panc02 pancreatic cancer cells, and the capability of the Bcl-2 inhibitor navitoclax (ABT-263; Nav) to trigger senolysis.</div></div><div><h3>Methods</h3><div>Panc02 cells were treated with Eto or irradiated with 5–20 Gy before exposure to Nav. Cell survival, proliferation, and senescence were assessed by trypan blue staining, quantification of DNA synthesis, and staining of senescence-associated β-galactosidase (SA-β-Gal)-positive cells, respectively. Levels of mRNA were determined by real-time polymerase chain reaction, and protein expression was analyzed by immunoblotting. Panc02 cells were also grown as pancreatic tumors in mice, which were subsequently treated with Eto and Nav.</div></div><div><h3>Results</h3><div>Eto and irradiation had an antiproliferative effect on Panc02 cells that was significantly or tendentially enhanced by Nav. <em>In vivo</em>, Eto and Nav together, but not Eto alone, significantly reduced the proportion of proliferating cells. The expression of the senescence marker γH2AX and tumor infiltration with T-cells were not affected by the treatment. <em>In vitro,</em> almost all Eto-exposed cells and a significant proportion of cells irradiated with 20 Gy were SA-β-Gal-positive. Application of Nav reduced the percentage of SA-β-Gal-positive cells after irradiation but not after pretreatment with Eto. In response to triggers of senescence, cultured Panc02 cells showed increased protein levels of γH2AX and the autophagy marker LC3B-II, and higher mRNA levels of <em>Cdkn1a, Mdm2,</em> and <em>PAI-1</em>, while the effects of Nav were variable.</div></div><div><h3>Conclusions</h3><div><em>In vitro</em> and <em>in vivo</em>, the combination of senescence triggers with Nav inhibited tumor cell growth more effectively than the triggers alone. Our data also provide some evidence for senolytic effects of Nav <em>in vitro</em>.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 628-637"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese expert consensus on quantitatively monitoring and assessing immune cell function status and its clinical application (2024 edition)","authors":"Lin Zhou ,&nbsp;Ji-Qiao Zhu ,&nbsp;Jian-Tao Kou ,&nbsp;Wen-Li Xu ,&nbsp;Shao-Cheng Lyu ,&nbsp;Guo-Sheng Du ,&nbsp;Hong-Wei Yang ,&nbsp;Jian-Feng Wang ,&nbsp;Xiao-Peng Hu ,&nbsp;Chun-Zhao Yu ,&nbsp;Chun-Hui Yuan ,&nbsp;Dong-Dong Han ,&nbsp;Cui-Qin Sang ,&nbsp;Bo Li ,&nbsp;Jie Gao ,&nbsp;Hai-Zhi Qi ,&nbsp;Li-Ming Wang ,&nbsp;Ling Lyu ,&nbsp;Hao Liu ,&nbsp;Jian-Yong Wu ,&nbsp;Xian-Liang Li","doi":"10.1016/j.hbpd.2024.10.001","DOIUrl":"10.1016/j.hbpd.2024.10.001","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 551-558"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline resectable giant hepatic cavernous hemangioma and coexisting hemangiomatosis should be a new indication for living donor liver transplantation: A report of two cases","authors":"Sung-Min Kim,&nbsp;Deok-Bog Moon,&nbsp;Young-In Yoon,&nbsp;Sung-Gyu Lee","doi":"10.1016/j.hbpd.2024.08.005","DOIUrl":"10.1016/j.hbpd.2024.08.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 653-657"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inadvertent perioperative hypothermia and surgical site infections after liver resection","authors":"Yi-De Zhou ,&nbsp;Wen-Yuan Zhang ,&nbsp;Guo-Hao Xie ,&nbsp;Hui Ye,&nbsp;Li-Hua Chu,&nbsp;Yu-Qian Guo,&nbsp;Yi Lou,&nbsp;Xiang-Ming Fang","doi":"10.1016/j.hbpd.2023.12.006","DOIUrl":"10.1016/j.hbpd.2023.12.006","url":null,"abstract":"<div><h3>Background</h3><div>In the overall surgical population, inadvertent perioperative hypothermia has been associated with an increased incidence of surgical site infection<span> (SSI). However, recent clinical trials<span> did not validate this notion. This study aimed to investigate the potential correlation between inadvertent perioperative hypothermia and SSIs following liver resection.</span></span></div></div><div><h3>Methods</h3><div><span><span>This retrospective cohort study included all consecutive patients who underwent liver resection between January 2019 and December 2021 at the First Affiliated Hospital, Zhejiang University School of Medicine. Perioperative temperature managements were implemented for all patients included in the analysis. Estimated </span>propensity score matching (PSM) was performed to reduce the baseline imbalances between the normothermia and hypothermia groups. Before and after PSM, </span>univariate analyses were performed to evaluate the correlation between hypothermia and SSI. Multivariate regression analysis was performed to determine whether hypothermia was an independent risk factor for postoperative transfusion and major complications. Subgroup analyses were performed for diabetes mellitus, age &gt; 65 years, and major liver resection.</div></div><div><h3>Results</h3><div>Among 4000 patients, 2206 had hypothermia (55.2%), of which 150 developed SSI (6.8%). PSM yielded 1434 individuals in each group. After PSM, the hypothermia and normothermia groups demonstrated similar incidence rates of SSI (7.0% vs. 6.3%, <em>P</em> = 0.453), postoperative transfusion (13.7% vs. 13.3%, <em>P</em> = 0.743), and major complications (10.1% vs. 9.0%, <em>P</em> = 0.309). Univariate regression analysis revealed no significant effects of hypothermia on the incidence of SSI in the group with the highest hypothermia exposure [odds ratio (OR) = 1.25, 95% confidence interval (CI): 0.84-1.87, <em>P</em> = 0.266], the group with moderate exposure (OR = 1.00, 95% CI: 0.65-1.53, <em>P</em> = 0.999), or the group with the lowest exposure (OR = 1.11, 95% CI: 0.73-1.65, <em>P</em> = 0.628). The subgroup analysis revealed similar results. Regarding liver function, patients in the hypothermia group demonstrated lower γ-glutamyl transpeptidase (37 vs. 43 U/L, <em>P</em><span> &lt; 0.001) and alkaline phosphatase (69 vs. 72 U/L, </span><em>P</em><span> = 0.016). However, patients in the hypothermia group exhibited prolonged activated partial thromboplastin time (29.2 vs. 28.6 s, </span><em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>In our study of patients undergoing liver resection, we found no significant association between mild perioperative hypothermia and SSI. It might be due to the perioperative temperature managements, especially active warming measures, which limited the impact of perioperative hypothermia on the occurrence of SSI.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 579-585"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139072339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of IgG4-related pancreatitis diagnosed preoperatively by endoscopic ultrasound-guided fine needle aspiration","authors":"Jun-Feng Zhou,&nbsp;Zhong Chen","doi":"10.1016/j.hbpd.2024.03.004","DOIUrl":"10.1016/j.hbpd.2024.03.004","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 648-652"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure laparoscopic full-size liver transplantation in adult","authors":"Wen-Rui Wu ,&nbsp;Lei-Bo Xu ,&nbsp;Fa-Peng Zhang ,&nbsp;Ming-Bin Feng ,&nbsp;Jun Peng ,&nbsp;Hao-Ming Lin ,&nbsp;Jun Li ,&nbsp;Chao Liu","doi":"10.1016/j.hbpd.2024.08.003","DOIUrl":"10.1016/j.hbpd.2024.08.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 638-643"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(24)00139-5","DOIUrl":"10.1016/S1499-3872(24)00139-5","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Page II"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new surgical approach for pseudocyst of dorsal pancreas","authors":"Cheng-Ji Tang ,&nbsp;Guo-Guang Li ,&nbsp;Chen-Lin Jiang ,&nbsp;Sha-Yong Peng ,&nbsp;Su-Lai Liu","doi":"10.1016/j.hbpd.2024.09.001","DOIUrl":"10.1016/j.hbpd.2024.09.001","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 644-647"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}