Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Acute cholangitis caused by Hem-o-lok clips migration after laparoscopic left hemihepatectomy","authors":"Guo-Mei Ge , Wei-Le Jia , Chen-Jun He , Zhou Shao , Feng Gao , Jun-Jun Jia , Min Zhang","doi":"10.1016/j.hbpd.2025.07.004","DOIUrl":"10.1016/j.hbpd.2025.07.004","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 5","pages":"Pages 566-569"},"PeriodicalIF":4.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(25)00111-0","DOIUrl":"10.1016/S1499-3872(25)00111-0","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 4","pages":"Pages I-II"},"PeriodicalIF":3.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"circ0006646 serves as a robust prognostic biomarker for post-transplant tumor recurrence and survival in hepatocellular carcinoma patients.","authors":"Rong-Gao Chen, Guan-Rong Chen, Xiao-Xiao Jiang, Ying-Chen Huang, Xin Hu, Wei-Liang Xia, Qi-Yang Cheng, Kun Wang, Xiao Xu, Shu-Sen Zheng","doi":"10.1016/j.hbpd.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.07.002","url":null,"abstract":"<p><strong>Background: </strong>Tumor recurrence severely impacts the prognosis of hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT). We aimed to explore novel and robust biomarkers for precise prediction of tumor recurrence and prognosis following LT.</p><p><strong>Methods: </strong>Cancerous tissues of 252 HCC patients who underwent LT across three centers were included in the study. Tissue microarrays and in situ hybridization were utilized to assess the circ0006646 level. Kaplan-Meier method along with the log-rank test were performed to analyze overall survival and recurrence-free survival. To identify prognostic factors, particularly related to tumor recurrence, we conducted univariate and multivariate Cox regression analyses. Nomogram was constructed to predict the risk of tumor recurrence after LT and subsequently the efficacy of the nomogram was validated.</p><p><strong>Results: </strong>Elevated circ0006646 levels in HCC were associated with reduced survival and increased recurrence rates following LT (5-year overall survival: 60.4 % vs. 29.2 %, P < 0.01; 5-year recurrence-free survival: 63.0 % vs. 42.3 %, P < 0.001). High circ0006646 expression was significantly correlated with higher Child-Pugh grade (P = 0.040), larger total tumor diameter (P = 0.033), and beyond the Milan criteria (P = 0.033). Cox regression analysis unveiled that circ0006646 expression score, preoperative transarterial chemoembolization (TACE), positive HBsAg status, poor tumor differentiation and beyond the Hangzhou criteria were independent risk factors for post-transplant tumor recurrence, leading to the development of a novel nomogram for precise prediction. The nomogram demonstrated a reasonable prognostic effectiveness (area under the receiver operating characteristic curve = 0.7636, C-index = 0.745) and outperformed conventional models like the Milan criteria. Besides, the inclusion of circ0006646 enhanced the precision of the Milan and Hangzhou criteria. Moreover, circ0006646 served as a potent biomarker in alpha fetoprotein (AFP)-negative HCC undergoing LT.</p><p><strong>Conclusions: </strong>circ0006646 is a novel and robust prognostic biomarker for predicting post-transplant survival and tumor recurrence in HCC patients. A nomogram integrating circ0006646 stands as a valuable prognostic instrument in LT for HCC.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfer RNA-derived small RNAs in liver disease.","authors":"Qin-Yuan Huang, Zi-Yan Zhou, Yi-Le Zhang, Yang Zhou, Shi-Wei Duan, Jing-Yin Dong","doi":"10.1016/j.hbpd.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.07.001","url":null,"abstract":"<p><p>Transfer RNA-derived small RNA (tsRNA) is a novel class of small non-coding RNAs (sncRNAs) that are generated through precise enzymatic cleavage of mature tRNAs or their precursor molecules. These tsRNAs play a pivotal role in regulating cellular processes such as protein synthesis, translation, and gene expression networks. This review offers a comprehensive overview of the functional characteristics of 24 tsRNAs, highlighting significant changes in their expression profiles across various liver diseases. Notably, 13 tsRNAs are upregulated, while 4 are downregulated in liver diseases compared to healthy controls, providing new insights into their biological roles. A major focus of this review is the latest research on the involvement of tsRNAs in a range of liver diseases, including hepatitis B and C, alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD, or non-alcoholic fatty liver disease, NAFLD), and hepatocellular carcinoma (HCC). This review explored how altered expression of tsRNAs in these conditions contributes to disease progression, along with the underlying regulatory mechanisms. Beyond their molecular roles, this review also examined the potential of tsRNAs as diagnostic and prognostic biomarkers for liver diseases. Due to their unique biological characteristics and functional versatility, tsRNAs hold promise as therapeutic targets in precision medicine. By highlighting their potential for developing more effective, targeted therapies, this review paves the way for future clinical applications of tsRNAs in liver disease treatment.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baicalin and its nanoliposome ameliorate diquat-induced liver injury by promoting PINK1/Parkin-dependent mitophagy","authors":"Han-Ying Zhou ,&nbsp;Ting Li ,&nbsp;Yuan-Qiang Lu","doi":"10.1016/j.hbpd.2025.06.008","DOIUrl":"10.1016/j.hbpd.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div><span>Diquat, a commonly employed </span>bipyridyl<span><span> herbicide, is recognized for its hepatotoxic effects attributed to the generation of reactive oxygen species. </span>Baicalin<span> (BAI), a flavonoid derivative, has garnered significant research interest for its hepatoprotective properties. Nevertheless, the clinical application of BAI is constrained by its limited water solubility and poor bioavailability. To address these challenges, BAI-nanoliposome (BAI-NL) has emerged as a novel drug delivery platform aimed at enhancing therapeutic outcomes.</span></span></div></div><div><h3>Methods</h3><div>We used diquat-induced liver injury mouse model and AML12 hepatocytes to test the protective effect of BAI and BAI-NL on liver inflammation, oxidative stress, and mitochondrial function. The parameters included histological, biochemical, and molecular biological analyses.</div></div><div><h3>Results</h3><div>In the diquat-induced model, both BAI and BAI-NL exhibited effectiveness on attenuating liver inflammation. <em>Ex vivo</em><span><span><span><span> analyses further indicated that BAI-NL was superior to BAI in preserving mitochondrial membrane potential, reducing oxidative stress, and modulating the </span>phosphatase and </span>tensin<span> homolog-induced putative kinase 1 (PINK1)/Parkin RBR E3 ubiquitin-protein ligase (Parkin) signaling pathway. These findings enhanced </span></span>mitophagy and facilitated the removal of damaged mitochondria.</span></div></div><div><h3>Conclusions</h3><div>BAI-NL exhibited superior hepatoprotective effects compared to free BAI, possibly by reducing inflammation, preserving mitochondrial homeostasis<span>, and reinstating autophagic balance through modulation of the PINK1/Parkin signaling pathway. These outcomes indicate a groundbreaking method for addressing liver diseases and underscore the potential of nanoliposome<span> technology in augmenting the efficacy of natural compounds.</span></span></div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 5","pages":"Pages 527-534"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction of mortality in acute cholangitis: Elaboration of a new simple prognostic score","authors":"Karina Hocine ,&nbsp;Anaïs R. Briant ,&nbsp;Thomas Chaigneau ,&nbsp;Wendy Kam ,&nbsp;Thierry Collet ,&nbsp;Jean-Jacques Parienti ,&nbsp;Marie Astrid Piquet ,&nbsp;Benoît Dupont","doi":"10.1016/j.hbpd.2025.06.006","DOIUrl":"10.1016/j.hbpd.2025.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Acute cholangitis<span> is an infection due to the bile duct obstruction<span>. Despite progress in treatment, acute cholangitis remains potentially fatal. Early diagnosis and treatment improve the patient outcomes. The present study aimed to identify clinical and biological factors at admission associated with 30-day mortality in acute cholangitis, to build an efficient prognostic score based on these parameters and to study the performances of this new score.</span></span></div></div><div><h3>Methods</h3><div>We enrolled all adult patients consecutively hospitalized for acute cholangitis between January 2017 and December 2021. We developed a score system named ProChol using variables significantly associated with 30-day mortality in multivariate logistic analysis and simplified this system (named sProChol) based on a simple points-based approach.</div></div><div><h3>Results</h3><div><span><span>In total, 528 patients were included, with an average age of 77 ± 13 years, a male predominance (54.2%) and a majority of lithiasis etiology (66.5%). Mortality in 30 days was 11.9%. In multivariate logistic analysis, tumor etiology [adjusted odds ratio (aOR) = 15.43, 95% confidence interval (CI): 5.90-40.40], stent obstruction<span> (aOR = 5.12, 95% CI: 2.02-12.99), hypoalbuminemia (aOR = 3.50, 95% CI: 1.25-9.81), renal failure (aOR = 6.51, 95% CI: 2.62-16.18), oxygen therapy (aOR = 4.63, 95% CI: 1.02-20.92) and curative </span></span>anticoagulation<span> (aOR = 2.60, 95% CI: 1.23-5.52) were independently associated with the 30-day mortality while fever was a protective factor (aOR = 0.37, 95% CI: 0.16-0.84). ProChol<span> score using these 7 parameters and sProChol using the 3 robust factors (etiology, renal failure and anticoagulation) presented respectively an area under receiver operating characteristic (ROC) curves (AUC) of 0.81 and 0.77, higher than Tokyo (AUC = 0.72) and Gravito-Soares et al. score (AUC = 0.71). Patients with sProChol ≥ 4 had a significantly higher risk of transfer to intensive care unit (13.3% vs. 5.1%; </span></span></span><em>P</em> &lt; 0.001) and longer length of stay (<em>P</em> = 0.0006).</div></div><div><h3>Conclusions</h3><div>ProChol and sProChol constructed from simple clinico-biological parameters at admission, present interesting performances in predicting the 30-day mortality in acute cholangitis.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 5","pages":"Pages 535-542"},"PeriodicalIF":4.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prognostic nutritional index on survival in periampullary/pancreatic cancer patients undergoing pylorus-preserving pancreaticoduodenectomy: A propensity score-matched analysis","authors":"Yeon-Ju Kim ,&nbsp;Min Kyu Sung ,&nbsp;Chan-Sik Kim ,&nbsp;Jungbok Lee ,&nbsp;Ji-Hyeon Kim ,&nbsp;Ji-Hoon Sim ,&nbsp;Sung-Moon Jeong","doi":"10.1016/j.hbpd.2025.06.007","DOIUrl":"10.1016/j.hbpd.2025.06.007","url":null,"abstract":"<div><h3>Background</h3><div><span>Although the prognostic nutritional index (PNI) may predict surgical outcomes in certain cancers, the impact of PNI on surgical prognosis in patients undergoing pylorus-preserving pancreaticoduodenectomy (PPPD) is unclear. This study aimed to investigate the impact of preoperative PNI on mortality rate and </span>cancer recurrence rate in patients who underwent PPPD.</div></div><div><h3>Methods</h3><div>A total of 718 patients who were diagnosed with periampullary or pancreatic cancer<span><span> and underwent PPPD between January 2012 and December 2016 were analyzed. Patients were categorized into two groups using the optimal cut-off value for PNI, determined by calculating the receiver operating characteristic (ROC) curve and the Youden index. We performed </span>propensity score matching<span> (PSM) analysis to compare the mortality rate and cancer recurrence rate between the two groups. In addition, Cox regression analyses were performed to examine the association of PNI with mortality rate and cancer recurrence rate.</span></span></div></div><div><h3>Results</h3><div>Using the 1-year mortality as an endpoint, the area under the ROC curve for PNI was 0.620 (optimal cut-off value: 41.7). We observed significant differences in 1-year (<em>P</em> = 0.001), 5-year (<em>P</em> = 0.002), and overall (<em>P</em> = 0.001) mortality; 1-year (<em>P</em> = 0.013), 5-year (<em>P</em> = 0.032), and overall (<em>P</em> = 0.017) cancer recurrence between groups after PSM. High PNI was significantly associated with reduced 1-year [adjusted hazard ratio (HR) = 0.44, 95% confidence interval (CI): 0.26-0.74, <em>P</em> = 0.020], 5-year (HR = 0.66, 95% CI: 0.52-0.84, <em>P</em> &lt; 0.001), and overall (HR = 0.71, 95% CI: 0.57-0.88, <em>P</em> = 0.002) mortality; 1-year (HR = 0.70, 95% CI: 0.52-0.93, <em>P</em> = 0.016), 5-year (HR = 0.78, 95% CI: 0.62-0.97, <em>P</em> = 0.027) and overall (HR = 0.78, 95% CI: 0.63-0.97, <em>P</em> = 0.024) cancer recurrence.</div></div><div><h3>Conclusions</h3><div>Preoperative PNI may serve as an independent factor for short- and long-term surgical prognosis in cancer patients undergoing PPPD.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 5","pages":"Pages 550-557"},"PeriodicalIF":4.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel treatment strategies for pancreatitis: Current status and future prospects","authors":"Wen-Bin Zou ,&nbsp;Sheng-Han Mao ,&nbsp;Zhao-Shen Li","doi":"10.1016/j.hbpd.2025.06.005","DOIUrl":"10.1016/j.hbpd.2025.06.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 4","pages":"Pages 355-358"},"PeriodicalIF":3.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute liver failure caused by amino acid or organic acid related inborn errors of metabolism.","authors":"Ying Zhou, Chi Chen, Xin Yang","doi":"10.1016/j.hbpd.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.hbpd.2025.06.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram to predict massive bleeding requiring intervention in severe acute pancreatitis","authors":"Xiao-Yu Guo ,&nbsp;Fan Xiao ,&nbsp;Jie Hu ,&nbsp;Hui Lin ,&nbsp;Zi-Jian Huang ,&nbsp;Liang Zhang ,&nbsp;Long Cheng ,&nbsp;Gang Wang","doi":"10.1016/j.hbpd.2025.06.004","DOIUrl":"10.1016/j.hbpd.2025.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Hemorrhage remains a formidable complication of severe acute pancreatitis (SAP), with a high mortality rate. However, there is currently no effective method for identifying SAP patients who are at high risk for massive bleeding. The present study aimed to explore risk factors for predicting massive bleeding in SAP patients and to develop a predictive nomogram, which could facilitate early prediction, and timely appropriate interventions.</div></div><div><h3>Methods</h3><div>We conducted a multivariate logistic regression analysis to examine the relationship between massive bleeding and variables including patient demographics, disease severity, laboratory indexes and local pancreatic complications. A novel nomogram was constructed based on these factors, and was validated both internally and externally assessing its discrimination, calibration, and clinical applicability.</div></div><div><h3>Results</h3><div>The study involved 351 patients in the training cohort, 104 patients in the internal validation cohort, and 123 patients in the external validation cohort. Logistic regression analysis identified several independent risk factors for massive bleeding, including computed tomography severity index score above 8 points, Acute Physiology and Chronic Health Evaluation II score greater than 16 points, abdominal compartment syndrome, pancreatic fistula, and sepsis. The nomogram constructed from these factors yielded an area under the receiver operating characteristic curve (AUC) of 0.896 and a coefficient of determination (R²) of 0.093. The Hosmer-Lemeshow test indicated good model fitness (<em>P</em> = 0.654). Furthermore, the nomogram demonstrated reliable performance in both validation cohorts.</div></div><div><h3>Conclusions</h3><div>The nomogram showed strong predictive capability for massive bleeding and could be a valuable tool for clinicians in identifying SAP patients at high risk for this complication at an early stage.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 4","pages":"Pages 388-395"},"PeriodicalIF":3.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}