Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Interleukin-22 in acute pancreatitis: Balancing damage and repair.","authors":"Serge Chooklin, Serhii Chuklin","doi":"10.1016/j.hbpd.2026.02.003","DOIUrl":"https://doi.org/10.1016/j.hbpd.2026.02.003","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis (AP) is a severe inflammatory disorder characterized by the premature activation of digestive enzymes, acinar cell injury, and systemic complications. Interleukin-22 (IL-22), a member of the IL-10 cytokine family, has increasingly been recognized as a critical mediator at the intersection of immune regulation and epithelial protection. Experimental evidence indicates that IL-22 exerts both protective and pathogenic effects depending on disease stage and immune context.</p><p><strong>Data sources: </strong>This review synthesized findings from experimental and clinical studies investigating the role of IL-22 in AP. Literature encompassing murine models, in vitro experiments, and patient cohorts, was analyzed, with emphasis on signaling mechanisms, tissue-protective versus pathogenic functions, and the translational potential of IL-22 as both a therapeutic target and a biomarker.</p><p><strong>Results: </strong>IL-22 safeguards acinar cells through signal transducer and activator of transcription 3 and AKT/mTOR signaling, suppresses excessive autophagy, and promotes the expression of anti-apoptotic proteins (Bcl-2, Bcl-xL). It strengthens intestinal barrier integrity via Reg-IIIβ/γ induction, reduces lung injury by limiting neutrophilic inflammation, and shows hepatoprotective and renoprotective properties. Elevated serum IL-22 levels in patients with severe AP correlate with gastrointestinal failure and systemic complications, supporting its utility as a biomarker. Nonetheless, IL-22 exhibits dual roles: in mild AP, it can exacerbate necrosis, while chronic activity has been linked to fibrosis and tumorigenesis. Regulation by IL-22 binding protein (IL-22BP) is essential for maintaining homeostasis. Preclinical nanotherapeutic strategies have improved IL-22 delivery and stability.</p><p><strong>Conclusions: </strong>IL-22 constitutes both a promising therapeutic candidate and a potential biomarker in AP. Recombinant IL-22 and advanced delivery systems can reduce complications in severe disease, while IL-22 measurement could improve prognostic stratification. However, key challenges remain concerning safety, optimal therapeutic windows, and long-term risks. Large-scale clinical trials are required to establish IL-22 as a cornerstone of precision medicine in AP.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme weather events and liver cancer mortality in Shandong Province, China: Identifying vulnerabilities and health inequalities.","authors":"Ting Gan, Xiao-Lei Guo, Hilary Bambrick, Jie Chu, Wenbiao Hu","doi":"10.1016/j.hbpd.2026.02.002","DOIUrl":"https://doi.org/10.1016/j.hbpd.2026.02.002","url":null,"abstract":"<p><strong>Background: </strong>Cancer remains a major global health issue, yet the effects of climate change, particularly extreme weather events, on people at high risk of cancer are not clear. This study aimed to investigate the short-term effects of heatwaves and cold spells on liver cancer mortality and identify high-risk subpopulations.</p><p><strong>Methods: </strong>Daily liver cancer mortality in Shandong Province from 2012 to 2020 was obtained from the Death Surveillance System. A two-step approach was employed. First, distributed lag non-linear models were applied to quantify the impact of heatwaves and cold spells on liver cancer mortality at a lag of 0-7 days. Second, city-specific relative risk (RR) was pooled using meta-regressions for overall risk estimates. Subgroup analyses were conducted to identify vulnerable groups.</p><p><strong>Results: </strong>A total of 220 613 liver cancer deaths were recorded in Shandong Province from 2012 to 2020. Heatwaves (≥ 90th percentile) were associated with increased liver cancer mortality risk, peaking at a 4-day duration [RR = 1.035, 95% confidence interval (CI): 1.008-1.063]. Cold spells (≤ 2.5th percentile, lasting ≥ 4 days) showed a peaked effect (RR = 1.167, 95% CI: 1.006-1.353). Subgroup analysis revealed heightened risk among females, individuals aged < 45 years and ≥ 65 years, and populations in regions with high incomes and lower healthcare expenditures.</p><p><strong>Conclusions: </strong>Extreme temperature events are associated with increased liver cancer mortality. Vulnerable groups such as females, the elderly, young individuals, and residents in economically advantaged regions and less healthcare investment are disproportionately affected. Findings underscore the importance of targeted interventions to mitigate climate-related health risks in vulnerable populations.</p>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-assisted biliary stent length selection for common bile duct strictures in endoscopic retrograde cholangiopancreatography: Model development and validation","authors":"Wen-Lin Zhang ,&nbsp;Xue-Jun Shao ,&nbsp;Xuan-Yuan Dong ,&nbsp;Hong-Ting Shao ,&nbsp;Guang-Chao Li ,&nbsp;Zhen Li ,&nbsp;Ning Zhong ,&nbsp;Rui Ji","doi":"10.1016/j.hbpd.2025.11.004","DOIUrl":"10.1016/j.hbpd.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Biliary stent placement during endoscopic retrograde cholangiopancreatography (ERCP) is important for drainage in common bile duct (CBD) strictures, while the stent length is associated with many stent-related complications. We aimed to develop an artificial intelligence (AI) model for stent length selection during ERCP.</div></div><div><h3>Methods</h3><div>Images of the patients who underwent ERCP and were diagnosed with CBD strictures were collected. Training involved identifying and delineating the duodenoscope, CBD and guidewire, calculating the pixel distance of the target guidewire and determining the required biliary stent length based on the diameter of the duodenoscope. The performance of the model, accuracy for length calculation and the assistance for endoscopists were validated using the testing set.</div></div><div><h3>Results</h3><div>A total of 794 images from 431 patients were included and data augmentation was conducted. The mean intersection over union (mIoU) for duodenoscope, CBD and guidewire were 90.46%, 84.79% and 84.64%, respectively. The accuracy in identifying the strictures was 97.58% (121/124). The accuracy for stent length calculation achieved 85.95% (104/121) with an error margin of ± 1 cm. The mean absolute error (MAE) and mean relative error (MRE) of the AI model was 0.81 cm and 0.13, respectively. The AI model could reduce approximately 202 mGycm² of the radiation exposure for each patient. It significantly improved both MAE and MRE for less experienced endoscopists (<em>P</em> = 0.01 and <em>P</em> = 0.02, respectively).</div></div><div><h3>Conclusions</h3><div>The AI model could accurately identify duodenoscope, CBD and guidewire, enabling accurate strictures identification and stent length selection.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 76-82"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of intestinal microecology in metabolic dysfunction-associated steatotic liver disease","authors":"Fu-Zheng Tao ,&nbsp;Rong-Lin Jiang ,&nbsp;Shui-Fang Jin","doi":"10.1016/j.hbpd.2025.09.009","DOIUrl":"10.1016/j.hbpd.2025.09.009","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 109-111"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel technique of successful living-donor liver transplantation in recipients with situs inversus totalis using a modified right-lobe graft (with video)","authors":"Sung-Min Kim,&nbsp;Deok-Bog Moon,&nbsp;Woo-Hyung Kang,&nbsp;Gil-Chun Park,&nbsp;Byeong-Gon Na,&nbsp;Rak-Kyun Oh,&nbsp;Sung-Gyu Lee","doi":"10.1016/j.hbpd.2025.11.007","DOIUrl":"10.1016/j.hbpd.2025.11.007","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 91-93"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eIF3f plays diagnostic and prognostic roles in hepatocellular carcinoma","authors":"Hong-Yuan Yi ,&nbsp;You-Kang Chen ,&nbsp;Hai-Feng Xu","doi":"10.1016/j.hbpd.2025.12.013","DOIUrl":"10.1016/j.hbpd.2025.12.013","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 1-3"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic liver resection is superior to open liver resection for hepatocellular carcinoma patients with BCLC stage 0-A hepatocellular carcinoma and portal hypertension","authors":"Wu-Gui Yang ,&nbsp;Bin Liang ,&nbsp;Yu-Fu Peng,&nbsp;Yu-Bo Yang,&nbsp;Ya-Ni Liu,&nbsp;Bo Li,&nbsp;Yong-Gang Wei,&nbsp;Fei Liu","doi":"10.1016/j.hbpd.2025.12.001","DOIUrl":"10.1016/j.hbpd.2025.12.001","url":null,"abstract":"<div><h3>Background</h3><div>According to the 2022 update of the BCLC strategy, laparoscopic liver resection (LLR) is considered feasible for BCLC stage 0-A hepatocellular carcinoma (HCC) patients with clinically significant portal hypertension (CSPH). However, there is still no research to explore the outcomes of laparoscopic versus open liver resection (OLR) in the specific patients with BCLC stage 0-A HCC and CSPH.</div></div><div><h3>Methods</h3><div>Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed. Demographic characteristics, pathological findings and postoperative outcomes were compared using propensity score matching (PSM). Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.</div></div><div><h3>Results</h3><div>A total of 409 patients, including 261 LLRs and 148 OLRs, were enrolled in this study. There were imbalances between the groups in baseline information. After 1:1 PSM, 118 patients were included in each group with comparable baseline characteristics. Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group (median 223 vs. 318 mL, <em>P</em> &lt; 0.001), and fewer postoperative complications (33.9% vs. 57.6%, <em>P</em> &lt; 0.001), including lower rates of postoperative liver decompensation (16.9% vs. 28.0%, <em>P</em> = 0.043), postoperative ascites (18.6% vs. 31.4%, <em>P</em> = 0.024) and pulmonary infections (12.7% vs. 29.7%, <em>P</em> = 0.001). The long-term follow-up showed that overall survival (<em>P</em> = 0.154) and recurrence-free survival (<em>P</em> = 0.376) were comparable between the two groups. In subgroup analysis, patients with PLT ≤ 75 × 10⁹/L suffered more postoperative liver decompensation (PLD) and ascites than patiens with PLT &gt; 75 × 10⁹/L.</div></div><div><h3>Conclusions</h3><div>Compared with OLR, LLR had less intraoperative blood loss, fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 32-41"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined liver resection and peritoneal stripping for Echinococcus multilocularis","authors":"Kaitlyn R Musto,&nbsp;Kristopher P Croome","doi":"10.1016/j.hbpd.2025.12.002","DOIUrl":"10.1016/j.hbpd.2025.12.002","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 97-99"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute liver failure caused by amino acid or organic acid related inborn errors of metabolism","authors":"Ying Zhou,&nbsp;Chi Chen,&nbsp;Xin Yang","doi":"10.1016/j.hbpd.2025.06.003","DOIUrl":"10.1016/j.hbpd.2025.06.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 112-114"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-invasive decision tree predicting recurrence-free survival after liver transplantation for hepatocellular carcinoma","authors":"Mo-Dan Yang ,&nbsp;Jian-Yong Zhuo ,&nbsp;Guo-Ying Wang ,&nbsp;Li Zhuang ,&nbsp;Xiao Xu ,&nbsp;Shu-Sen Zheng ,&nbsp;Yang Yang ,&nbsp;Di Lu","doi":"10.1016/j.hbpd.2025.11.001","DOIUrl":"10.1016/j.hbpd.2025.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Liver transplantation (LT) provides an option to radically eliminate hepatocellular carcinoma (HCC) on the premise that recipients are thoroughly evaluated for posttransplant tumor recurrence risk before operation. This study aimed to optimize the Milan criteria (MC) by combining circulating prognostic markers, including interleukin-6 (IL-6) and alpha-fetoprotein (AFP).</div></div><div><h3>Methods</h3><div>We retrospectively enrolled 449 HCC cases receiving LT in three medical centers in China and divided them into the training cohort (<em>n</em> = 254) and the validation cohort (<em>n</em> = 195). Cox regression analysis was applied to identify recurrence-related risk factors based on patients’ clinical and pathological characteristics, pretransplant plasma IL-6 and AFP levels. The collaborative prediction method was presented in the form of a decision tree. Kaplan-Meier analysis showed the predictive results of independent risk factors and the newly established prediction tree.</div></div><div><h3>Results</h3><div>In the training cohort (<em>n</em> = 254), we established a predictive decision tree based on three independent risk factors: pretransplant plasma IL-6 (&gt; 15 pg/mL), AFP (&gt; 60 ng/mL), and the MC (beyond the MC), and named it as MIA (MC-IL-6-AFP) tree. According to the MIA tree, patients beyond the MC but with IL-6 ≤ 15 pg/mL and AFP ≤ 60 ng/mL (<em>n</em> = 39) had comparable 3-year recurrence-free survival (RFS) rates as patients within the MC (<em>n</em> = 121): 66.8% vs. 74.7% (<em>P</em> = 0.520). Likely, in the validation cohort (<em>n</em> = 195), the 3-year RFS rates of patients beyond the MC but with IL-6 ≤ 15 pg/mL and AFP ≤ 60 ng/mL (<em>n</em> = 26) were close to those of patients within the MC (<em>n</em> = 87): 71.8% vs. 76.6% (<em>P</em> = 0.660).</div></div><div><h3>Conclusions</h3><div>We proposed that pretransplant plasma IL-6 and AFP were valid prognostic biomarkers for HCC-related LT. The MIA tree could refine the MC by combining IL-6 and AFP and define an extra subset of eligible candidates without significant sacrifice in RFS.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 23-31"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}