Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Effects of triggers of senescence and senolysis in murine pancreatic cancer cells","authors":"Denis Revskij ,&nbsp;Aline Woitas ,&nbsp;Bianca Kölle ,&nbsp;Camilla Umstätter ,&nbsp;Dietmar Zechner ,&nbsp;Faiz M Khan ,&nbsp;Georg Fuellen ,&nbsp;Robert Jaster","doi":"10.1016/j.hbpd.2024.06.001","DOIUrl":"10.1016/j.hbpd.2024.06.001","url":null,"abstract":"<div><h3>Background</h3><div>The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer therapy. Here, we studied the efficacy of the genotoxic agent etoposide (Eto) and irradiation in inducing senescence of Panc02 pancreatic cancer cells, and the capability of the Bcl-2 inhibitor navitoclax (ABT-263; Nav) to trigger senolysis.</div></div><div><h3>Methods</h3><div>Panc02 cells were treated with Eto or irradiated with 5–20 Gy before exposure to Nav. Cell survival, proliferation, and senescence were assessed by trypan blue staining, quantification of DNA synthesis, and staining of senescence-associated β-galactosidase (SA-β-Gal)-positive cells, respectively. Levels of mRNA were determined by real-time polymerase chain reaction, and protein expression was analyzed by immunoblotting. Panc02 cells were also grown as pancreatic tumors in mice, which were subsequently treated with Eto and Nav.</div></div><div><h3>Results</h3><div>Eto and irradiation had an antiproliferative effect on Panc02 cells that was significantly or tendentially enhanced by Nav. <em>In vivo</em>, Eto and Nav together, but not Eto alone, significantly reduced the proportion of proliferating cells. The expression of the senescence marker γH2AX and tumor infiltration with T-cells were not affected by the treatment. <em>In vitro,</em> almost all Eto-exposed cells and a significant proportion of cells irradiated with 20 Gy were SA-β-Gal-positive. Application of Nav reduced the percentage of SA-β-Gal-positive cells after irradiation but not after pretreatment with Eto. In response to triggers of senescence, cultured Panc02 cells showed increased protein levels of γH2AX and the autophagy marker LC3B-II, and higher mRNA levels of <em>Cdkn1a, Mdm2,</em> and <em>PAI-1</em>, while the effects of Nav were variable.</div></div><div><h3>Conclusions</h3><div><em>In vitro</em> and <em>in vivo</em>, the combination of senescence triggers with Nav inhibited tumor cell growth more effectively than the triggers alone. Our data also provide some evidence for senolytic effects of Nav <em>in vitro</em>.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 628-637"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese expert consensus on quantitatively monitoring and assessing immune cell function status and its clinical application (2024 edition)","authors":"Lin Zhou ,&nbsp;Ji-Qiao Zhu ,&nbsp;Jian-Tao Kou ,&nbsp;Wen-Li Xu ,&nbsp;Shao-Cheng Lyu ,&nbsp;Guo-Sheng Du ,&nbsp;Hong-Wei Yang ,&nbsp;Jian-Feng Wang ,&nbsp;Xiao-Peng Hu ,&nbsp;Chun-Zhao Yu ,&nbsp;Chun-Hui Yuan ,&nbsp;Dong-Dong Han ,&nbsp;Cui-Qin Sang ,&nbsp;Bo Li ,&nbsp;Jie Gao ,&nbsp;Hai-Zhi Qi ,&nbsp;Li-Ming Wang ,&nbsp;Ling Lyu ,&nbsp;Hao Liu ,&nbsp;Jian-Yong Wu ,&nbsp;Xian-Liang Li","doi":"10.1016/j.hbpd.2024.10.001","DOIUrl":"10.1016/j.hbpd.2024.10.001","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 551-558"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline resectable giant hepatic cavernous hemangioma and coexisting hemangiomatosis should be a new indication for living donor liver transplantation: A report of two cases","authors":"Sung-Min Kim,&nbsp;Deok-Bog Moon,&nbsp;Young-In Yoon,&nbsp;Sung-Gyu Lee","doi":"10.1016/j.hbpd.2024.08.005","DOIUrl":"10.1016/j.hbpd.2024.08.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 653-657"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of IgG4-related pancreatitis diagnosed preoperatively by endoscopic ultrasound-guided fine needle aspiration","authors":"Jun-Feng Zhou,&nbsp;Zhong Chen","doi":"10.1016/j.hbpd.2024.03.004","DOIUrl":"10.1016/j.hbpd.2024.03.004","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 648-652"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inadvertent perioperative hypothermia and surgical site infections after liver resection","authors":"Yi-De Zhou ,&nbsp;Wen-Yuan Zhang ,&nbsp;Guo-Hao Xie ,&nbsp;Hui Ye,&nbsp;Li-Hua Chu,&nbsp;Yu-Qian Guo,&nbsp;Yi Lou,&nbsp;Xiang-Ming Fang","doi":"10.1016/j.hbpd.2023.12.006","DOIUrl":"10.1016/j.hbpd.2023.12.006","url":null,"abstract":"<div><h3>Background</h3><div>In the overall surgical population, inadvertent perioperative hypothermia has been associated with an increased incidence of surgical site infection<span> (SSI). However, recent clinical trials<span> did not validate this notion. This study aimed to investigate the potential correlation between inadvertent perioperative hypothermia and SSIs following liver resection.</span></span></div></div><div><h3>Methods</h3><div><span><span>This retrospective cohort study included all consecutive patients who underwent liver resection between January 2019 and December 2021 at the First Affiliated Hospital, Zhejiang University School of Medicine. Perioperative temperature managements were implemented for all patients included in the analysis. Estimated </span>propensity score matching (PSM) was performed to reduce the baseline imbalances between the normothermia and hypothermia groups. Before and after PSM, </span>univariate analyses were performed to evaluate the correlation between hypothermia and SSI. Multivariate regression analysis was performed to determine whether hypothermia was an independent risk factor for postoperative transfusion and major complications. Subgroup analyses were performed for diabetes mellitus, age &gt; 65 years, and major liver resection.</div></div><div><h3>Results</h3><div>Among 4000 patients, 2206 had hypothermia (55.2%), of which 150 developed SSI (6.8%). PSM yielded 1434 individuals in each group. After PSM, the hypothermia and normothermia groups demonstrated similar incidence rates of SSI (7.0% vs. 6.3%, <em>P</em> = 0.453), postoperative transfusion (13.7% vs. 13.3%, <em>P</em> = 0.743), and major complications (10.1% vs. 9.0%, <em>P</em> = 0.309). Univariate regression analysis revealed no significant effects of hypothermia on the incidence of SSI in the group with the highest hypothermia exposure [odds ratio (OR) = 1.25, 95% confidence interval (CI): 0.84-1.87, <em>P</em> = 0.266], the group with moderate exposure (OR = 1.00, 95% CI: 0.65-1.53, <em>P</em> = 0.999), or the group with the lowest exposure (OR = 1.11, 95% CI: 0.73-1.65, <em>P</em> = 0.628). The subgroup analysis revealed similar results. Regarding liver function, patients in the hypothermia group demonstrated lower γ-glutamyl transpeptidase (37 vs. 43 U/L, <em>P</em><span> &lt; 0.001) and alkaline phosphatase (69 vs. 72 U/L, </span><em>P</em><span> = 0.016). However, patients in the hypothermia group exhibited prolonged activated partial thromboplastin time (29.2 vs. 28.6 s, </span><em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>In our study of patients undergoing liver resection, we found no significant association between mild perioperative hypothermia and SSI. It might be due to the perioperative temperature managements, especially active warming measures, which limited the impact of perioperative hypothermia on the occurrence of SSI.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 579-585"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139072339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure laparoscopic full-size liver transplantation in adult","authors":"Wen-Rui Wu ,&nbsp;Lei-Bo Xu ,&nbsp;Fa-Peng Zhang ,&nbsp;Ming-Bin Feng ,&nbsp;Jun Peng ,&nbsp;Hao-Ming Lin ,&nbsp;Jun Li ,&nbsp;Chao Liu","doi":"10.1016/j.hbpd.2024.08.003","DOIUrl":"10.1016/j.hbpd.2024.08.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 638-643"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(24)00139-5","DOIUrl":"10.1016/S1499-3872(24)00139-5","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Page II"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new surgical approach for pseudocyst of dorsal pancreas","authors":"Cheng-Ji Tang ,&nbsp;Guo-Guang Li ,&nbsp;Chen-Lin Jiang ,&nbsp;Sha-Yong Peng ,&nbsp;Su-Lai Liu","doi":"10.1016/j.hbpd.2024.09.001","DOIUrl":"10.1016/j.hbpd.2024.09.001","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 644-647"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of metabolic disorders on gallstone disease and perioperative recovery after laparoscopic cholecystectomy","authors":"Jun Chen ,&nbsp;Zheng-Tao Liu ,&nbsp;Jing-Ting Lyu ,&nbsp;Guo-Ping Jiang","doi":"10.1016/j.hbpd.2024.08.001","DOIUrl":"10.1016/j.hbpd.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Gallstone disease (GSD), nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD), and metabolic syndrome (MetS) are common medical disorders worldwide. This study aimed to ascertain how NAFLD, MAFLD, MetS, and other factors affect the development of GSD, and how the GSD-associated factors influence patient recovery after laparoscopic cholecystectomy (LC).</div></div><div><h3>Methods</h3><div>We included 200 patients who were diagnosed with GSD and underwent LC between January 2017 and February 2022. A total of 200 subjects without GSD and “non-calculous causes” during the same period were also included as controls. We compared the metabolic disorder differences between GSD patients and controls. Furthermore, we sub-grouped patients based on the comorbidities of preoperative NAFLD, MAFLD, and MetS, and compared the impacts of these comorbidities on short-term post-LC functional recovery of the patients.</div></div><div><h3>Results</h3><div>The prevalence of NAFLD and MetS were higher in GSD patients (<em>P</em> &lt; 0.05). Based on multivariate logistic regression analysis, hyperglycemia [odds ratio (OR) = 2.2, 95% confidence interval (CI): 1.4–3.4, <em>P</em> = 0.001] and low high-density lipoprotein cholesterol (HDL-C) level (OR = 1.8, 95% CI: 1.1–3.1, <em>P</em> = 0.048) were linked to GSD. NAFLD and MetS linked to liver enzymes after LC (<em>P</em> &lt; 0.05). MetS also linked to the levels of inflammatory indicators after LC (<em>P</em> &lt; 0.05). The obesity, hyperlipidemia, low HDL-C level, and hyperglycemia linked to liver enzymes after LC (<em>P</em> &lt; 0.05). Hyperlipidemia, low HDL-C level, and hypertension linked to inflammation after LC (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The prevalence of GSD may be linked to NAFLD and MetS. Hyperglycemia and low HDL-C level were independent risk factors of GSD.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 604-612"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding after endoscopic papillectomy and its risk factors: A single center experience of 196 cases","authors":"Jin Ho Choi,&nbsp;Won Chul Kim,&nbsp;Joo Kyung Park,&nbsp;Jong Kyun Lee,&nbsp;Kyu Taek Lee,&nbsp;Kwang Hyuck Lee","doi":"10.1016/j.hbpd.2024.02.001","DOIUrl":"10.1016/j.hbpd.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><div><span><span>Endoscopic papillectomy (EP) is an effective method to remove an </span>ampulla of Vater<span> (AoV) adenoma with minimal invasiveness. We reviewed the clinical outcomes and prognosis of patients undergoing EP, including </span></span>tumor recurrence and adverse events.</div></div><div><h3>Methods</h3><div>A total of 196 patients who underwent EP from January 2004 to December 2017 were included. Clinical information was collected through electronic medical records<span>, and risk factors to predict post-procedural bleeding were analyzed using a multivariate logistic regression model.</span></div></div><div><h3>Results</h3><div><span><span>A total of 93.9% patients (184/196) underwent complete resection. During the follow-up period, 14.7% patients (27/184) experienced tumor recurrence, and two of seven surgically resected tumors were malignant. A total of 45.4% patients (89/196) experienced adverse events related to EP. Delayed bleeding occurred in 16.3% of the patients (32/196), and they were all successfully treated with endoscopic hemostasis and conservative management. The most frequent site of delayed bleeding was the distal end of the papillary orifice, and 56.3% (18/32) patients of delayed bleeding were classified as having mild severity, the others had moderate severity. </span>Familial adenomatous polyposis (FAP) [odds ratio (OR) = 3.80, 95% confidence interval (CI): 1.01-14.29; </span><em>P</em> &lt; 0.05] and male sex (OR = 2.82, 95% CI: 1.04-7.63; <em>P</em> = 0.04) showed statistical significance in predicting delayed post-EP bleeding.</div></div><div><h3>Conclusions</h3><div>EP for AoV adenoma was a highly effective and safe procedure. The risk of post-EP delayed bleeding was increased in patients with FAP syndrome and male patients, and post-EP bleeding occurred most commonly in the distal part of the AoV.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 6","pages":"Pages 613-619"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}